Container Closure Integrity
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1 The Parenteral Drug Association presents PDA Europe Workshop Container Closure Integrity Regulations, Theory, Test Methods and Applications of CCI Innovations including Hands-On Activities 6-7 November 2014 Ramada Hotel Messe Munich Germany Register by 12 September and SAVE! CONFERENCE 4-5 Nov EXHIBITION 4-5 Nov WORKSHOPS 6-7 Nov TRAINING COURSES 6-7 Nov
2 Two-Day Workshop Course description: Container Closure Integrity (CCI) is an essential part of the quality of parenteral products. The Two-Day PDA Workshop on CCI will address: Regulatory and pharmacopeia requirements CCI verification as a necessary component of the product life cycle Various test methods for evaluating the integrity of container closure systems: Microbial challenge ingress test Tracer liquid leak test (dye test) Tracer gas detection Electrical conductivity and capacitance (HVLD) Vacuum decay leak detection Laser-based gas headspace analysis Mass extraction leak test Residual seal force seal quality test Airborne ultrasound seal quality test NIR-methods and others The pros, cons and limitations of these methods Test methods used for different container closure systems Instrument suppliers / manufacturers are invited and will present their newest innovations Participants may actively be trained by hands-on activities about the newest innovations Most common issues and how to avoid them will be discussed. Faculty Dana Guazzo, PhD President, RxPax, LLC 920 Ardsley Lane Bridgewater, NJ P: dguazzo@rxpax.com Dana Guazzo is the founder and president of RxPax, LLC a consulting firm committed to providing package development and package integrity testing support to pharmaceutical and medical device firms since its inception in Dr. Guazzo also serves as the acting director of the package integrity testing lab of Whitehouse International Laboratories, located in Whitehouse, NJ. Dana is a member of the USP Packaging, Storage and Distribution Expert Committee, and she actively volunteers for PDA and ASTM. Prior to becoming a consultant, Dana worked for 22 years in pharmaceutical industry R&D. Dana holds graduate degrees from Rutgers University and a pharmacy degree from the University of Kentucky. 2
3 Two-Day Workshop Agenda Thursday, 6 November :00-18:00 9:00 Welcome and Introduction 9:0 Part 1 - Introduction Definitions - Maximum allowable leakage limit as a function of product-package - Maximum allowable leakage limit and microbial/liquid ingress 10:0 Coffee Break 11:00 Part 2 - Test Methods Introduction - Deterministic leak test methods - Probabilistic leak test methods - Seal quality test methods 12:0 Lunch Break 1:0 Explanation and Introduction of the Hands-On Activities Hands-On Activities 15:0 Coffee Break 16:00 Hands-On Activities 17:0 Q&A 18:00 End of Day 1 Friday, 7 November :00-16:00 9:00 Summing up of Day 1 9:0 Part - Test Method Selection and Application Product life cycle and CCI testing - Test method selection criteria - Test application examples 10:0 Coffee Break 11:00 Examples: Vials, Bags, Syringes 12:0 Lunch Break 1:0 Part 4 - Test Method Development and Validation Positive and negative controls, masters, blanks - Instrument/equipment qualification - Method development - Method validation 15:00 Part 5 - Wrap-Up Current regulations: US, EU - Future direction - USP <1207> proposed revision - PDA TR 27 revision 16:00 End of Training Course
4 4 WAYS TO REGISTER PDA Europe Workshop Container Closure Integrity 6-7 November 2014 Munich Germany Your Contact Information ONLINE: FAX: petzholdt@pda.org MAIL: PDA Europe, Adalbertstr. 9, Glienicke/Berlin, Germany If this form is an update to a previously submitted form, please check here. Mr. Ms. Dr. Nonmember This PDF-file provides an automatic fill-in function. Your signature, however, is needed in writing. Thank you. Your Contact Person is Antje Petzholdt at PDA Europe Name (Last, First, MI) * PDA Member ID Number Job Title * Company* Department Mailing Address City Postal Code Country * Business Phone Fax Substituting for (Check only if you are substituting for a previously enrolled colleague; a nonmember substituting for member must pay the membership fee.) * This information will be published in the conference attendee list. Should you not wish us to publish these details, please contact us. Information about Visa Matters 2 Registration No PDA membership included All registrations which will involve visa matters will have to be submitted to PDA EU four weeks prior to the start of the event at the latest. For later registrations, PDA Europe will be unable to assist participants in any visa affairs. All costs incurring in connection with visa affairs shall be borne by registrants. (This applies in particular to costs for submitting documents by courier.) Potential participants must be clients of UPS shipping agency and submit their UPS customer reference number to PDA EU (together with their registration). Payment Options All fees given in Euro and excluding VAT (7 %) Two-Day Workshop (6-7 November) All Participants 195 Conference + Two-Day Workshop (4-7 November) By 12 Sept 2014 After 12 Sept 2014 PDA Member Nonmember By Credit Card American Express MasterCard VISA For your credit card information safety: Please send your details by fax only ( ) or register online. By Bank Transfer Beneficiary: PDA Europe ggmbh IBAN: DE BIC (SWIFT-Code): DEUTDEDBBER Bank Address: Deutsche Bank, Welfenallee -7, D-1465 Berlin, Germany By Purchase Order Purchase Order Number Group Registration Discount Register 4 people from the same site as a group (at the same time) for this event and receive the 5th registration FREE. Special rates are available for multiple attendees from the same organization. For more information on group discounts please contact Antje Petzholdt at petzholdt@pda.org. Other discounts cannot be applied. PDA Europe VAT I.D.: DE Billing Same as contact information address above. Address: If not, please send your billing address to: petzholdt@pda.org Your VAT I.D.: This number starts by your country code (example: PDA Europe s VAT ID number = DE ) Discount for Exhibiting Companies Please mark here if your company is an exhibitor to this event and you will receive the conference ticket at the special price of 995 Euro per ticket. No further discounts are applicable with this option (as PDA Membership Discount or Group Ticket discount). This special rate does not include one-year PDA membership. Date Mandatory Signature CONFIRMATION: Transmitting your filled-in registration form constitutes a binding application for the specific event. PDA Europe will send you a confirmation including payment details. A legally binding contract is concluded once PDA Europe has sent a written invoice by mail to you. A letter of confirmation will be sent to you once payment is received. You must have this written confirmation to be considered enrolled in a PDA event. Please allow one week for receipt of confirmation letter. Payment must be received or guaranteed by Purchase Order or credit card details on 1st day of event, at the very latest. SUBSTITUTIONS: If you are unable to attend, substitutions are welcome and can be made at any time, including on site at the prevailing rate. If you are pre-registering as a substitute attendee, please indicate this on the registration form. Changes are free of charge until weeks prior to the start of the event. After this date, there will be a charge of 100 per name change. REFUNDS: Refund requests must be in writing and faxed to PDA at +49 (056) If your written request is received on or before 10 October 2014, you will receive a full refund minus a 150 excl. VAT handling fee. After that time, no refund or credit requests will be approved. If you are an unpaid registrant and do not attend the event, you are responsible for paying the registration fee. On-site registrants are not guaranteed to receive conference materials until all advanced registered attendees receive them. To process refunds PDA Europe's suppliers for credit card transactions save the provided credit card details (credit card holder, credit card number, expiration date) for a period of 12 months. EVENT CANCELLATION: PDA reserves the right to modify the material or speakers/instructors without notice, or to cancel an event. If an event must be canceled, registrants will be notified by PDA as soon as possible and will receive a full refund. PDA will not be responsible for airfare penalties or other costs incurred due to cancellation. For more details, contact PDA at info-europe@pda.org or fax to +49 (056) DOCUMENTATION: With your signature you give complete picture usage right to PDA and allow to film your exhibition space and intervention in the event, including the recording of your presentation for video purposes (with your slides, voice and image). This right extends also to the use of the resulting images in film documentation for webinars and similar items produced by PDA.
5 Helpful Hints When Registering for PDA Europe Events MAKING IT EASIER FOR BOTH OF US 1 Please include your member ID number on registration form if available/known If uncertain about your member ID number and/or your membership status, call or Ms. Antje Petzholdt. +49 (0) petzholdt@pda.org 2 Do not send money in advance Please wait until we send our invoice to you. It is helpful to reference our invoice number in your bank transfer details. Complete and sign the event registration form Please note the registration and cancellation policies at the bottom of the form. 4 Payment by credit card For your credit card information safety: Please send your details by fax only ( ). 5 Purchase orders Registration cannot be completed by sending Purchase Order alone. A Purchase Order is only accepted if a complete registration form is enclosed or follows very soon. 6 Please state the correct billing address on the registration form This is particularly important if billing address and site address are different. Contact your accounting department for correct address and company name. There could be special requirements for accounting. Changes in the billing address (if induced by participating company) will be charged 50,- if imposed weeks prior to the start of the event. 7 Confirmation of your registration Credit card charges are confirmed immediately if successfully approved. Bank transfers are confirmed within one week. 8 Refund/Credit notes Refunds to credit card can be done immediately if payment had been done by credit card and details are available. Refunds to bank accounts can be done if payment had been done by bank transfer and the following details are provided: a) IBAN b) Swift/BIC code c) Routing number (US) 9 Substitutions If an participant is unable to attend, substitutions are welcome at any time. Changes are free of charge until weeks prior to the start of the event. After this date, there will be a charge of 100 per name change. 10 For assistance contact: Antje Petzholdt, PDA Europe Tel: +49 (0) petzholdt@pda.org THANK YOU FOR YOUR COOPERATION!
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