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1 ACN ASX Release 29 July 2016 JUNE QUARTER 2016 APPENDIX 4C Adelaide, 29 July, 2016: Reprductive Health Science Limited (ASX:RHS) ( RHS r the Cmpany ) annunces its secnd quarter cash flw reprt fr the quarter ending 30 June Highlights Cash n hand at 30 June 2016 was $0.6 Millin. Net perating cash utflws fr the quarter ttalled ($499K). During the quarter, the Cmpany: Subsequent t 30 June 2016; Received cash revenue f $7K fr Preimplantatin Genetic Screening (PGS) services and inviced a further $13.5k t be received in July. Received the secnd instalment f $23K frm an Exprt Marketing Develpment Grant. Ldged 2015 Research & Develpment Tax Incentive applicatin. The amunt f the claim is $278K and is expected t be received within the next quarter. Cntinued t cntrl perating csts clsely during this cmmercialisatin stage f peratins. Grss perating cash expenses fr the half year nw ttal ($890K). Annunced that InVitr Fertilisatin (IVF) prvider flindersfertility publicised the early success f their new PGS service ffered in cllabratin with RHS using EmbryCellect TM. The PGS service had significantly imprved clinical pregnancy rates fr patients with previus unsuccessful IVF histries (refer t ASX Annuncement 4 th April 2016). Presented scientific papers at the largest reprductin cnference, Eurpean Sciety f Human Reprductin and Embrylgy cnference ( ESHRE ) in Helsinki n 3 rd 6 th July, attended by 9,600 delegates frm arund the wrld and the Preimplantatin Genetic Diagnsis Internatinal Sympsium ( PGDIS ) in Blgna n 9 th 11 th May. Exhibited at the Asia Pacific Initiative n Reprductin ( ASPIRE ) meeting held in Jakarta n 8 th 10 th April and presented at a precnference meeting hsted by Mrula IVF attended by staff frm their 4 clinics as well as representatives frm clinics in ther Asian cuntries. At ESHRE, RHS released a reprt n the validatin f EmbryCellect TM using euplid and aneuplid single cell and 510 cell aliquts. This study is the mst cmprehensive f its type published and demnstrates the high degree f accuracy f this RHS prduct. The reprt is available n the RHS website ( Als at ESHRE, the Cmpany launched its secnd prduct, DOPlify TM, which is used fr the lysis and whle genme amplificatin f single r small numbers f cells. This kit uses RHS advanced DOPPCR develped fr and initially validated as part f EmbryCellect TM. The prduct has als been validated fr Next Generatin Sequencing (NGS). Perfrmance data
2 fr DOPlify TM using NGS was presented at the cnference by RHS Chief Scientific Officer, Dr Melinda Jasper. RHS cntinues t hld discussins with a clinic in Eurpe regarding establishment f an inhuse PGS service. With the launch f DOPlify TM, RHS is in discussins with Australian clinics regarding expansin f ur PGS services t include micrarray and NGS assessment. The Cmpany has als cmmenced technical and cmmercial discussins with tw verseas clinical grups n the establishment f a reginal PGS service using RHS prducts. With expiry f IP rights that have prevented RHS frm entering the USA market until July 2016, RHS is nw entering this market with bth prducts. This includes frmal discussins with significant service prviders wh perfrm genetic testing services fr IVF clinics in the USA. The USA marketing strategy will be augmented by RHS exhibiting at the American Sciety fr Reprductive Medicine ( ASRM ) meeting in Salt Lake City in September Crprate presentatins are planned fr the Bishares Bitech Summit in Queenstwn, New Zealand 29 th 30 th July 2016 and Australia Bitech Invest in Melburne 26 th 27 th Octber Training curses are planned fr August and Nvember These training curses are an imprtant avenue fr increasing RHS brand awareness fr DOPlify TM and EmbryCellect TM. The August training schedule includes a webbased training sessin, which will be attended by 25 staff frm 9 cllinics in ne f ur key territries. Further webbased training curses are being planned this quarter. The Cmpany has cmmenced and is in late stage planning fr strategic reciprcal evaluatins with significant verseas cmpanies in NGS t explre the capabilities f DOPlify TM as a part f a range f single cell NGS wrkflws. DOPlify TM is als being assessed as a way t expand the capabilities f sme existing multicell analysis prducts frm these cmpanies t prvide them with a mechanism t enter the grwing single cell market. It is intended that sme f these evaluatins will be cmpleted in time fr the ASRM meeting in 15 th 19 th Octber. RHS is hlding a launch event fr DOPlify TM n 23 rd August at which key Australian research grups will be given an pprtunity t trial the prduct. The Cmpany received trademark apprval fr EmbryCellect TM in the US. RHS filed a prvisinal patent n cmbined whle genme amplificatin and single gene specific PCR. This prvides a unique and valuable apprach t cmbined Preimplantatin Genetic Diagnsis (PGD) and PGS. This addresses an unmet market need in the IVF applicatin and serves as a mdel fr expansin int brader applicatins, including cancer. Fr further infrmatin please cntact: Dr Michelle Fraser CEO and Managing Directr Tel: (+61 8) michelle.fraser@rhsc.cm.au Dr David Brkes Chairman Tel:(+61 8) david.brkes@rhsc.cm.au Reprductive Health Science Ltd. ACN ASX: RHS Issued Capital 59 millin shares 13.1 millin ptins Registered Office Level One, BiSA Incubatr, 4046 West Thebartn Rad, Thebartn, SA 5031 Tel: Fax: Directrs Dr David Brkes (Chairman) Sue MacLeman Jhnathn Matthews Dr Michelle Fraser (CEO) Finance Officer & Cmpany Secretary Raymnd Ridge WEB
3 Abut Reprductive Health Science RHS is a develper f advanced single cell genmic technlgies fcussed n imprving health and research utcmes, with ver 10 years f technical experience in the field. EmbryCellect TM is the Cmpany s lead prduct designed t increase the chance f a successful IVF cycle by selecting the mst viable embrys fr transfer by screening fr aneuplidy. This is knwn as Preimplantatin Genetic Screening (PGS). RHS has launched its secnd prduct, DOPlify TM fr whle genme amplificatin f single r small numbers f cells in DOPlify TM is applicable t the glbal Next Generatin Sequencing market. Reprductive Health Science Ltd. ACN ASX: RHS Issued Capital 59 millin shares 13.1 millin ptins Registered Office Level One, BiSA Incubatr, 4046 West Thebartn Rad, Thebartn, SA 5031 Tel: Fax: Directrs Dr David Brkes (Chairman) Sue MacLeman Jhnathn Matthews Dr Michelle Fraser (CEO) Finance Officer & Cmpany Secretary Raymnd Ridge WEB
4 Quarterly reprt fr entities admitted n the basis f cmmitments Rule 4.7B Quarterly reprt fr entities admitted n the basis f cmmitments Intrduced 31/03/00 Amended 30/09/01, 24/10/05, 17/12/10 Name f entity REPRODUCTIVE HEALTH SCIENCE LIMITED ABN June 2016 Quarter ended ( current quarter ) Cnslidated statement f cash flws Cash flws related t perating activities Current quarter Year t date 1.1 Receipts frm custmers Payments fr (a) staff csts (b) advertising & marketing (c) research & develpment (d) leased assets (e) ther wrking capital (246) (4) (28) (37) (226) (483) (7) (54) (66) (310) 1.3 Dividends received 1.4 Interest and ther items f a similar nature 5 13 received 1.5 Interest and ther csts f finance paid (2) (5) 1.6 Incme taxes (R&D Tax Offset) 1.7 Other (includes Exprt Market Develpment Grant) Net perating cash flws (499) (816) + See chapter 19 fr defined terms. 17/12/2010 Page 1
5 Quarterly reprt fr entities admitted n the basis f cmmitments Current quarter Year t date 1.8 Net perating cash flws (carried frward) (499) (816) Cash flws related t investing activities 1.9 Payment fr acquisitin f: (a) businesses (item 5) (b) equity investments (c) intellectual prperty (d) physical nncurrent assets (e) ther nncurrent assets 1.10 Prceeds frm dispsal f: (a) businesses (item 5) (b) equity investments (c) intellectual prperty (d) physical nncurrent assets (e) ther nncurrent assets 1.11 Lans t ther entities 1.12 Lans repaid by ther entities 1.13 Other (prvide details if material) Net investing cash flws (16) (24) 1.14 Ttal perating and investing cash flws (515) (840) (16) (25) 1 Cash flws related t financing activities 1.15 Prceeds frm issues f shares, ptins, etc Prceeds frm sale f frfeited shares 1.17 Prceeds frm brrwings 1.18 Repayment f brrwings (8) (17) 1.19 Dividends paid 1.20 Other Net financing cash flws (8) (17) Net increase (decrease) in cash held (523) (857) 1.21 Cash at beginning f quarter/year t date 1,121 1, Exchange rate adjustments t item Cash at end f quarter See chapter 19 fr defined terms. Page 2 17/12/2010
6 Quarterly reprt fr entities admitted n the basis f cmmitments Payments t directrs f the entity and assciates f the directrs Payments t related entities f the entity and assciates f the related entities Current quarter $A' Aggregate amunt f payments t the parties included in item Aggregate amunt f lans t the parties included in item Explanatin necessary fr an understanding f the transactins Executive directr salary, directrs fees and superannuatin. Nncash financing and investing activities 2.1 Details f financing and investing transactins which have had a material effect n cnslidated assets and liabilities but did nt invlve cash flws 2.2 Details f utlays made by ther entities t establish r increase their share in businesses in which the reprting entity has an interest Financing facilities available Add ntes as necessary fr an understanding f the psitin. Amunt available Amunt used 3.1 Lan facilities Credit standby arrangements + See chapter 19 fr defined terms. 17/12/2010 Page 3
7 Quarterly reprt fr entities admitted n the basis f cmmitments Recnciliatin f cash Recnciliatin f cash at the end f the quarter (as shwn in the cnslidated statement f cash flws) t the related items in the accunts is as fllws. Current quarter Previus quarter 4.1 Cash n hand and at bank Depsits at call 4.3 Bank verdraft 4.4 Other (prvide details) Ttal: cash at end f quarter (item 1.23) 530 1, ,121 Acquisitins and dispsals f business entities 5.1 Name f entity 5.2 Place f incrpratin r registratin 5.3 Cnsideratin fr acquisitin r dispsal 5.4 Ttal net assets 5.5 Nature f business Acquisitins (Item 1.9(a)) Dispsals (Item 1.10(a)) + See chapter 19 fr defined terms. Page 4 17/12/2010
8 Quarterly reprt fr entities admitted n the basis f cmmitments Cmpliance statement 1 This statement has been prepared under accunting plicies which cmply with accunting standards as defined in the Crpratins Act. 2 This statement des give a true and fair view f the matters disclsed. Sign here:... Date: 29 July 2016 Ray Ridge Cmpany secretary Ntes 1. The quarterly reprt prvides a basis fr infrming the market hw the entity s activities have been financed fr the past quarter and the effect n its cash psitin. An entity wanting t disclse additinal infrmatin is encuraged t d s, in a nte r ntes attached t this reprt. 2. The definitins in, and prvisins f, AASB 107: Statement f Cash Flws apply t this reprt except fr any additinal disclsure requirements requested by AASB 107 that are nt already itemised in this reprt. 3. Accunting Standards. ASX will accept, fr example, the use f Internatinal Financial Reprting Standards fr freign entities. If the standards used d nt address a tpic, the Australian standard n that tpic (if any) must be cmplied with. + See chapter 19 fr defined terms. 17/12/2010 Page 5
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