Life Science Journal, 2011;8(2)

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1 Jou, 2011;8(2) ://o ou o u o 1 uu o o u o u o uox *, x ou, Ju, Jx Z, o o, B, Xuju, Xu o o o, o U, Xx ,, x@u b: + /uo oo (1) o o o + uo ju o bo o u 1 o u u uo o 1 u, u- o + /uo oo o o u o u - o, u 2856 b o 113 b 5'-u o, 766 b 3'-u o, 1977 b o (O) o 658 o o u o o o (9070%), o o bb (7140%) ou b o 3- o o u o o o o -O uu o o o 5 ( ) o uo b bou o uu o, ob + -b o o o 2 9 b, uo o uo o ou o uu oou o bo o o u o, ouo o uu o o [uox, x ou, Ju, Jx Z, o o, B, Xuju, Xu o ou o u o 1 uu o o u o u o Jou 2011;8(2): ] (: ) ://o o: 1; u ; o uu; u o 1 ouo + /ub oo (o o) o ou oo o o b o oo uo, o b oo o B o u, b o o o (z, 1994) o o uz o ou o oo o ub oo u, o,, o, ooo,, u (z, 1994;, 1998) o, u ou-uo o (1) o o b z b o ou ou o () o, ou-o o () ou-o o (u) o ou-o o () bo ou o b ub (, 1998;, 1998; Zu, 2001;, 1997) 1 z u o ub 2:1 ou-ub oo u o ou-o o b u 1:1 (Zu, 2001;, 1997;, 1997) o, o o 1 ou ou u o o ou o u oo o 264 ou (, 2000) - + /uo oo (1) (, 1996) o b o ou: ou o () (, 2004) o 700 u (, 2004; u, 1997) 1, bo o oooou 5 (5), bu x (B, 2008;, 1998), o (, 1989) jo uo o 1 o uu u o oo o o + -ou o o b + o o o b u o uo o uo o 1 ou u uo o, ou uo/o boo (, 1996), 1 b u o o b (u, 2008; bo-, 2010) u 1 uo o o uo-u o oo 1 ub o b u o (u, 2009) ://ub/ 204 j@o

2 Jou, 2011;8(2) ://o uu o bo ou ou/o o () b o (, 2008) o, u o + /uo oo o u, 1 o o u o ubu u o ob o ou o + /uo oo o uu uu o 1 o o b ouo o 2 o o u, o bo o (126±038) u x, 200- o o o (O: 62±02 /) 12/12 / ooo u oo (268±068) u o o o, o ou (8:30, 11:30, 14:30 17:30) o o, o o b u x ubu, o ob b o, o o, o u oo ou u oo o o xo 5' 3' u u oz u o u o x o zo (u o o) o (5) u o z - u (o o) oo- () 18 (o o) 20µ o, o o uu' uo 1 b o ou o 50µ, o 10 - (90), 50, 125 2, 02, 1 u o o (o, J), 40o o o 5µ (b 1) o o 3 94 oo b 35 (uo 95 o 35, u o 35 xo 72 o 2 ), xo o u o o o 1 o b (b ) ou o o 1% o oo oo o u bo o b/ o b 1 u o oouo u o o o () Oouo u (5' 3') (b) 3' ' ' ou 23 3' 32 5' ' ' ou 23 5' 34 o: b o 1 u o Zb o o B o u o o o b oo o 1 u x o 1% o u u xo (o, J) u 1 o - o (o o, U), u ob o o o J109 o, 4-6 o o 1 u b B3730 u 13+/-u (o, J) 3 u oo o o 1 b o o o o o 1 b o u o zb, o, ou,, u, b, o, bo bb 1 o B o, ://ub/ 205 j@o

3 Jou, 2011;8(2) ://o u- 1 o o o 5'- 3'- u u o ob u- (u 1) o o u o o uo o o u o 1974-b o (O), 113-b 5'-u o 766-b 3'-u o u o (), o u o o 658 o (u 2) 2000b 1 500b 2 u 1 u o - o 1, u o 5 -, u bou 2000b ; B, u o 3 -, u bou 500b ; 1, 2000b ; 2, 100b u 2 uo u o u o + /uo oo o u o u o o o o 658 o o 5'-u o 113 uo ://ub/ 206 j@o

4 Jou, 2011;8(2) ://o u o o 1 u o o 1 u X oo o 658 o ou o ox 729 o o o 635 o uu o u 1 o u z o o b o u 20 (U) (u 3) ou b o o u u u O ( o o o uu o b ou o o u ) (u 4) 1 o 4726% o α-x, 1717% o x, 274% o β-u 32% o o o u 3 o uu o 14 b o o 1 b o 1 ou o o u 4 O u o 1 o u o 1 o 4726% o α-x, 1717% o x, 274% o β- u 32% o o o 30 o 1 oo o (-) u ( ) (u 5) u 5 30 o 1 oo o (-) u ( ) ooo o o 1 1 u u b ub o B o o U32891 u oo o B u o u o o 1 723%, 721%, 714%, 737%, 743%, 750%, 740%, 752% 907% o u (oo ), o (uu bu), bb (Oou uuu), Bo (Bo uu), B (oou uuu), (u ou), ou(u uuu), o (uu ), Zb (o o), o b 2 ooo o u u u - o (, U) (u 6) u o u o 1 o o bb (714%) o o (9070%) 4 uo + /uo oo () b o x ou 5 o x bubo b o ox oou ubu o (Zo, 2005) 1 b o + -uo oo, o o o ou uo o b oo bo uo u (Zo, 2005; Zou, 2003) 1 o 2 + o uo (íz-o Bo, 2010 ; bo-, 2010) u, 1 o z o, ubu u o ob o ou o + -uo oo ://ub/ 207 j@o

5 Jou, 2011;8(2) ://o ://ub/ 208 b 2 o 1 o u b o o Zb ou B Bo o u b 100% Zb 907% 100% 752% 750% 100% ou 740% 751% 726% 100% 750% 760% 735% 958% 100% B 743% 740% 721% 899% 900% 100% Bo 737% 743% 728% 880% 869% 893% 100% o 721% 718% 715% 869% 865% 894% 866% 100% u 723% 728% 710% 880% 877% 881% 858% 872% 100% b 714% 721% 715% 860% 863% 866% 850% 846% 846% 100% o: o 1 o u o u o (), Zb (Zb), o (), u (u), o (o), ou (ou), bb (b), Bo (Bo), B (B) () Zb 84 ou u B o Bo b ou Zb 168 ou u B o Bo b ou Zb 252 ou u B o 248 Bo b ou Zb 336 ou u B o 332 Bo b ou Zb

6 Jou, 2011;8(2) ://o ://ub/ 209 u 6 o u o u o 1 ubu o u o (), Zb (Zb), o (), u (u), o (o), ou (ou), bb (b), Bo (Bo), B (B) () o u u u o o o o b bou, 75% o o bou 50% o o bou o, b o o b o o, o b o b o o o 1 ubu o o o Zb, ooou o o O o, o ou u 40 ( 7) uo u o 1 o o o jo ou 1 ubu o o u o o ou 1 ubu o o, Zb o u o o ou ooo o 1 b o Zb jo b o 1 b uu o u (, 1987; jo, 1992; o, 1992; o, 1993) o u (, 1989), (, 1994; o, 1997), ou (bb, 2001), bb (, 1987; oo, 1991), bo (Zo, 1999), zb, u o oo o Zb 420 ou u B o Bo b ou Zb 504 ou u B o 500 Bo b ou Zb 587 ou 587 u B o 582 Bo b ou Zb ou u 662 B 662 o 658 Bo 662 b ou

7 Jou, 2011;8(2) ://o ou o -x o o b o 4 uu o o o 5 ( ) u uo b bou o o, + -b b o o o 2 9 u o u u o ou-b o-b b (, 2008) u 7 o o o 1 ooou ou o o 1 b o o o u b 4 o ub o u oo: u, oo (60320); o, uu bu ( ); b, Oou uuu (39040); Bo, Bo uu (34274); B, oou uuu (68880),, u ou (B03676); ou, u uuu (17249);, uu (J75582), Zb, o o (956975) oooou u o o o 90% o o 70% (b ) o 1 o u o - xo ( 1) oo o o 14 (, 1998) oo o o b b o- o o ou-o o bo ou () (z, 1994) o, o bou u o o b o 11~15 u b o () - ooo o o o o (u, 1997) o u, o 13 -u o o o b - u o o uu o, uu o o o + o (, 2008) 3- o o u b o o o o -O ( 8) o o o oo u u o o b u, o o uu u u 8 3- uu o 1 o u o, uu o 1 b B, uu o 1 o u o: u uo b o & oo oo U o o ( ) oo uo: uox o o o U Xx, , -: x@u 1 z J, z, J uo u o ou/ou o Bo Bo, 1994;1197(2): , B Oouo o ou o o o Bu ub: obuo o - B- o oo ou oboo, 1998;29(1): , ou,, o,, Bo, bo-, B, o, o o zo o u o obu o o u o oou uu o u, 1998;66(2): Zu,, oo,, oo o b + -uo oo 1 o u B ://ub/ 210 j@o

8 Jou, 2011;8(2) ://o bb Jou o oo, 2001;531: B, oo, o o o ooo o + /uo oo J Bo, 1997;4: , oo,, O,, o o + / - o J Bo, 1997;43: , bb, o J, Ju b o uu o + /o o o o Bo, 2000;39: , u, oo,, + /uo oo ( 1 ) uo u uo-o boo u 1996;12(2): , o oo, Bu, u u o + /uo oo: 5 oo (B) 2004;19: , u ou/uo oo 5 u, 2004;447(5): u, b ooo o oo J b Bo, 1997;159(1): B, juboj, Bj, Bz, Z, o, bo uoozo o + --uo oo 1 o o bo J o o, 2008;295(2): J, oo xo boo b uo 1 bu bu-bo b J Bo, 1998;273(23): ,, o J, B,, zo o + /uo oo o o bb J b Bo, 1989;110(1): u,, u,, o-oz oju -b u b uo boo ou + /uo oo ( 1 ) J oo, 2008;125(1): bo-, o, -, Ooo,, o U, + /uo oo: o o Bz J 2010;43, u o, u, Juo o, o o ou o, o o ou-uo oo 1 o b o J o oo b 2009;297, , b, b o B, uo o, x, Bu,, J bo uu o ou o o o + /u o 2008;321, Zo, B,, B o, - Z o xo o Bo ou/uo oo 2 J 2005;88, ub Zou,,, Bo, Bu o, u oo x o + /uo oo 1 ( 1 ) Jou o u Bo 2003;90, íz-o Bo u b u + o oo ou ou/uo oo 3B J Bo 2010; 22, o J,, xo o u o + /uo o-o u, 1987;330: jo, o uo xo o + /uo oo b o J Bo, 1992;267: o, u, U, o, -z, Bu B, J o o o + /o-oo oo, o o J Bo, 1992;267(9): o,, J o xo o + /o oo u o + /uo oo J Bo, 1993;268(3): , u, ooo o u + /uo o + /o oo o U, 1989;86(15): ,,, + /uo oo uo o uo buo o xo J Bo, 1994;269(16): ://ub/ 211 j@o

9 Jou, 2011;8(2) ://o 28 o, oo, z J, u o + /uo oo o jjuu Bo Boo Bo, 1997;61(6): bb, Bu,, uo o ou ou- o b u oxoo oo, 2001;177(3): oo, oo-,, ö B, u oo o ou--uo oo bb Bo Bo 1991;1089(1): Zo, O, J J uo o xo bo J 1999;77, /3/2011 ://ub/ 212 j@o

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