Facts from IQVIA M Copyright 2017 IQVIA. All rights reserved.

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1 Facts from IQVIA M07 0 Copyright 07 IQVIA. All rights reserved.

2 Russia pharma market growth in January-July 0 Market grew by,% in value and decreased by,4% in volume VALUE, BLN RUB VOLUME, BLN PACKS +,% 0 3,00 -,4%, , 49-0% 93 -% M07/YTD 7 M07/YTD Retail Public (EXCL. DLO AND RLO) Reimbursement.55-0,.54-9,4% -4,0% Regional Reimbursement 0.3 +,5% 0.3 M07/YTD 7 M07/YTD Indicator RUB USD EUR PACKS Value M07/YTD 0, Bln. 0,3, 3,0 Growth M07/YTD,% +,% -0,4% -0% -,4% Source: IQVIA databases. Retail, Public, DLO, RLO (excluding food supplements and diagnostic agents), TRD Prices

3 Russia pharma market growth in January-July 0 Retail Sell-Out: Market grew by 5,% in value and by,% in volume VALUE, BLN RUB VOLUME, BLN PACKS 47 +5,% 503 +,% YoY growth, % YoY growth, %,50,54 5 5% +,0% % 7% -0,04% 47% 49% +% ,% M07/YTD 7 M07/YTD M07/YTD 7 M07/YTD OTC RX Source: Pharmatrend (excluding food supplements and diagnostic agents), FIN Prices

4 Russia retail market structure in January-July 0 Retail Sell-In: Share of Pharmacy chains is 7% in value and in volume VALUE, BLN RUB VOLUME, BLN PACKS 49,5 35 (7%), () 53 () M07/YTD 0,5 (%) M07/YTD Pharmacy Chains Individual pharmacies Source: Retail Audit (excluding food supplements and diagnostic agents), TRD Prices Pharmacy chain 5 or more pharmacies operating under one brand or ownership 3

5 Sell-In vs Sell-Out, OTC registered drugs Month-Over-Month Growth Rates, volume % 7,% ,%,7% 0,0% 0,9% 5,7% 4,0%,4% ,4% -.0% -3,% -, -5.9% -0, -4,0% -4,0% -5,9% -3,7% -,% -4.% % -7.% -0 07/07 07/0-7.4% 07/09 07/0 07/ 07/ 0/0 0/0 0/03 0/04 0/05 0/0 0/07 Sell-In Sell-Out Source: Retail Audit and Pharmatrend. OTC registered drugs 4

6 TOP-5 corporations on Russian market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -% SANOFI-AVENTIS 4,% BAYER HEALTHCARE 4,0% % -5% 3 JOHNSON & JOHNSON 3,0% 5% 4 TEVA,% % 5 SERVIER,% -% PFIZER, 4% -4% 7 SANDOZ, NOVARTIS, 0% 5% 9 OTCPHARM, % 0 GLAXOSMITHKLINE,% % 0% ABBOTT,0% % 5% MENARINI,9% - 3 NYCOMED/TAKEDA,9% 5% 4 ASTRAZENECA,9% 4% 5 KRKA,9% % 4% Source: IQVIA databases. Retail, Public, DLO, RLO (excluding food supplements and diagnostic agents), TRD Prices 5

7 TOP-5 brands on Russian market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -% REVLIMIDE,% 37% SOLIRIS 0,% % 3 XARELTO 0,% 39% 3 4 DETRALEX 7% - 5 TOUJEO SOLOSTAR 9% % ACTOVEGIN -% - 7 MEXIDOL % % NATRIUM CHLORIDUM -% -% 9 PREVENAR 3 0,4% -5% -7% 0 INGAVIRIN 0,4% % 5% CARDIOMAGNYL 0,4% ACELLBIA 0,4% -37% -3% 3 KAGOCEL 0,4% % % 4 ESSENTIALE N 0,4% -0% - 5 MIRAMISTIN 0,4% 9% Source: IQVIA databases. Retail, Public, DLO, RLO (excluding food supplements and diagnostic agents), TRD Prices

8 TOP-0 products by growth in advertisement investments in January-July 0 Total sales Bln RUB Advertisement cost, Growth Y-to-Y Sales, Growth Y-to-Y TRIMEDAT VALENTA 0,99.000% 5 NOVO PASSIT 0,7.000% 5% IBUCLIN 0,79.000% 4% MILDRONAT,35 % KETONAL,5 0% -% DONA 0,7 75% % SMECTA 0,70 % - FENISTIL,7 5 9% PHOSPHOGLIV,34 5% PENTALGIN,99 4 The rank in calculated among TOP-00 Brands by sales with advertising cost greater than 50 mln RUB Source: IQVIA databases. Pharmatrend, Mediascope data, FIN Prices 7

9 TOP-0 products by decline in advertisement investments in January-July 0 Total sales Bln RUB Advertisement cost, Growth Y-to-Y Sales, Growth Y-to-Y IMUDON 0,7 -% -% RINOSTOP,37 -% SUPRASTIN,07-5% 4% PHOSPHALUGEL 0,9-5% 9% MAGNE B,3-5% -4% MAXILAC 0, -50% 9% OCILLOCOCCINUM 0, -45% - XYMELIN 0,7-45% 4% HYLAK FORTE 0,7-40% -7% DE NOL, -37% 5% The rank in calculated among TOP-00 Brands by sales with advertising cost greater than 50 mln RUB Source: IQVIA databases. Pharmatrend, Mediascope data, FIN Prices

10 Most of the largest pharmacy chains showed an increase in sales in H 0 Top-0 of the largest pharmacy chains and associations based on drug sales in H 0 Company name ASNA Rigla Erkapharm Pharmacy chain 3, 3 Planeta Zdorovya 4 Melodia Zdorovya 5 Neo-Pharm IRIS April Pharmland Market share of the pharmacy chain 7, % 5,% 5, 4,0% 3,% 3,% 3,0%,5%,5%,% 3, Number of shops as of July, 0, units.,0,,34 5,50,,344,0,05,4 Average spending by consumer, rub Relative sales value Sales growth 9 50% 7% 5% -% 7% 3% 5% 40% % - including О3, Givika и DOMpharma; including Ozerki, Doctor Stoletov, Raduga; 3 - including AVE Group; Gorzdrav; A5 Group; 4 - Expert review; 5 - including5 partners pharmacies; - including Fakmakoleika, Fakmakoleika 4, Helmi, Tvoi Doctor, Zdes Apteka, Farmani, Aptechestvo, Stavorapolskie gorodskie apteki; 7 - share of the pharmacy network in the retail commercial market of drugs in the Q-Q 0; relative to the leading audited company; 9 sales growth in the Q-Q 0/Q 07 Source: IQVIA analysis 9

11 Most of the largest distributers showed an increase in direct sales in Q-Q 0 Top-0 of the largest distributors in the market of direct drug sales in H 0 Distributer Protek,9% Katren Puls Pharmkomplect R-Pharm Grand Capital BSS Profitmed IRVIN Avesta Pharmacy Share in the market of direct drug sales,% 4,7% 4,5% 4, 4,0% 3,5%,0%,%, 5,% Increase in direct sales of drugs, H 0/ H 07-4,9% -0, -,5% 7,4% 0,4%,,%,%,% 9, Presence of own pharmacy network «Rigla» «Melodia Zdorovya» «Apteka Forte» «Farmani» «Serdse Rossii» «Aloe» Geographical coverage (number of FD) 7 Source: IQVIA analysis 0

12 Kazakhstan pharma market growth in January-July 0 Market decreased by,5% in value and by,5% in volume VALUE, BLN KZT VOLUME, BLN PACKS -,5% -,5% ,35 0, ,9% 5 Retail 0,9-0, 0, % 54 3 Hospital Free & Co-Payment 0, % 0,04 M07/YTD 7 M07/YTD M07/YTD 7 M07/YTD Indicator KZT USD EUR PACKS Value M07/YTD 0, Bln. 43 0,7 0, 0,35 Growth M07/YTD,% -,5% -9, -7% -,5% Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices

13 TOP-5 corporations on Kazakhstan market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -% - SANTO,% % SANOFI-AVENTIS,0% -% -7% 3 NOBEL-AFF 4, % 4 TEVA 3,5% % 0% 5 BAYER HEALTHCARE 3, -4% 0% JOHNSON & JOHNSON 3,0% -5% 5% 7 NYCOMED/TAKEDA,% -5% -9% GLAXOSMITHKLINE,5% -4% -% 9 PFIZER,5% - 0 SANDOZ GROUP,4% 9% - ABBOTT, - -% ROCHE, -0% - 3 GEDEON RICHTER, -% -% 4 SERVIER, -7% -4% 5 MENARINI,% 9% -9% Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices

14 TOP-5 brands on Kazakhstan market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -% - PREVENAR 3,% 7 % HEXAXIM,7% 5% -5% 3 HERCEPTIN,0% 9% 4 IMMUTIN 0,% -7% -% 5 ACTOVEGIN 0,7% 0% AVASTIN 0,% 3% 4% 7 SPIRITUS AETHYLIC 0,% 7% 4% CEFAZOLIN 0,% -9% -9% 9 HYLAK FORTE 5% 0 CANEPHRON N ELAPRASE -34% - VIFERON -9% -0% 3 CORONIM 0 00% 0% 4 OCTANATE -0% -9% 5 NATRIUM CHLORIDUM % Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices 3

15 Belarus pharma market growth in January-July 0 Market grew by in value and by 0,7% in volume VALUE, BLN BLR VOLUME, BLN PACKS + +0,7% 0,9, 0, 0, 0,7 +7,7% 0, Retail 0,7-0,% 0,7 Hospital 0, +7% 0,3 0,03 +4,% 0,03 M07/YTD 7 M07/YTD M07/YTD 7 M07/YTD Indicator BLR USD EUR PACKS Value M07/YTD 0, Bln.,0 0,53 0,44 0, Growth M07/YTD,% + +7, -3, +0,7% Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices 4

16 TOP-5 corporations on Belarus market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% % BELMEDPREPARATY RUE 0, 7% % BORISOV ZMP 7,4% 9% - 3 LEKPHARM JLLC 5,% -% 4 NOVARTIS 4,% % 5 PHARMLAND JV LTD 3, % BAYER HEALTHCARE,7% % -5% 7 SANOFI,% 4% - PHARMTECHNOLOGY LTD,% % -% 9 GEDEON RICHTER,5% % 0 GSK,4% 0% BERLIN-CH/MENARINI,4% % % NATIVITA JLLC, 97% 7% 3 MINSKINTERCAPS MRUE, % -5% 4 KRKA,0% 5% 3 5 NESVIZH PLANT RUE,7% 0% 0% Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices 5

17 TOP-5 brands on Belarus market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% % LINEZOLID,% 7% 40% SODIUM CHLORIDE,0% 9% 7% 3 T-MAB 0,9% 7% 7% 4 OCTANATE 0,% 9% 57% 5 R-MAB 0,7% 49% 3 GLICLAZIDE MR 0,% 7% 7% 7 LISINOPRIL 0,% - LENALIDOMIDE 0,% 9 PROTAMINE-INSULIN HS 0,% 7% 0 XARELTO 7 5 LOSARTAN 4% 4% CEREPRO % % 3 ATORVASTATIN 0,4% % 5% 4 MOXONIDINE-LF 0,4% -49% -% 5 ACTOVEGIN 0,4% - -9% Source: IQVIA databases. Retail, Hospital (excluding food supplements and diagnostic agents), TRD Prices

18 Moldova pharma market growth in January-July 0 Market decreased by 7,% in value and by,% in volume VALUE, MLN LEU VOLUME, MLN PACKS 03,4-7,% -5,% 7,33 Retail Reimbursement Public -,% 4, 4, 3.0 -,9% % % 97 M07/YTD 7 M07/YTD +,% ,% 4.4 M07/YTD 7 M07/YTD Indicator LEU USD EUR PACKS Value M07/YTD 0, Mln. 7,7 93, 4, Growth M07/YTD,% -7,% +,% -4,0% -,% Source: IQVIA databases. Retail, Hospital, Reimbursement (excluding food supplements and diagnostic agents), TRD Prices 7

19 TOP-5 corporations on Moldova market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -7% - KRKA 7,% -% GEDEON RICHTER 7,7% 0% 4% 3 BERLIN-CH/MENARINI, -% -% 4 GSK 4, 4% 9% 5 NOVARTIS 3,% -5% - TAKEDA,9% -% 3 7 SANOFI,% NOVO NORDISK,5% -9% 4% 9 WORLD MEDICINE, - 7% 0 EGIS, -0% ACINO PHARMA AG,0% -0% 9% BALKAN PHARMA,9% 7% % 3 GRINDEX,% 4% % 4 BILIM PHARMACEUTICALS,% -9% -% 5 ABBVIE,4% 4 50% 70 Source: IQVIA databases. Retail, Hospital, Reimbursement (excluding food supplements and diagnostic agents), TRD Prices

20 TOP-5 brands on Moldova market, January-July 0 Market share, M07/YTD Value growth / decline Volume growth / decline Total pharma market 00,0% -7% - CARDIOMAGNYL,5% % DIROTON,4% 0% % 3 PROTAPHANE HM, -7% - 4 AMPRIL, -5% 5 VYLVIO, RAWEL SR,% -0% % 7 LORISTA 0,9% 40% 4 SODIUM CHLORIDE 0,9% -% - 9 CONCOR 0,9% -4% 5% 0 GLUCOPHAGE 0,% -% IMIPENEM & CILASTATIN 0,% SENTOR 0,7% -% 0% 3 REBIF 0,7% % 4 IMPAMID SR 0,7% 0% 7% 5 ZINNAT 0,7% -7% Source: IQVIA databases. Retail, Hospital, Reimbursement (excluding food supplements and diagnostic agents), TRD Prices 9

21 Please Contact Us for More Information Svetlana Nikulina Senior Sales Manager Anton Kalyapin Senior Offering Manager Anton.Kalyapin@IQVIA.com Nadezhda Kalinich Client Service Representative Nadezhda.Kalinich@IQVIA.com