Background Distribution and Safety Issues in the United States Consumer Advertising/Promotion World Health and Life Expectancy

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1 CHAPTER ONE: EXECUTIVE SUMMARY Background Scope and Methodology Size and Growth of the Market Key Issues and Trends Affecting Market Leading Competitors CHAPTER TWO: INTRODUCTION Background Distribution and Safety Issues in the United States Consumer Advertising/Promotion World Health and Life Expectancy o Life Expectancy o Birth Rates o Tobacco Use o Obesity Declining Growth of the World Population Prescription vs. Over-the-Counter Industry o Rx-to-OTC Switch Industry o Rx-to-OTC Switch Forecast in the United States Economic Trends o Purchasing Power Trends o U.S. Healthcare Market o U.S. Healthcare Challenges Health Insurance Issues and Trends o Healthcare Flexible Spending Accounts and OTC Medicines Consumer Issues and Trends o U.S Consumers o Consumers Around the World Access to Professional Medical Services and the Link to Self-Medication o Online Resources for Health Information Regulatory Environment o Revisions to Pharmaceutical Affairs Law (PAL) in Japan o Russian Beneficiary Drug Provision Program o A Third Class of Drugs in the United States CHAPTER THREE: OTC MARKETS IN ASIA-PACIFIC AND AFRICA

2 CHAPTER FOUR: OTC MARKETS IN EUROPE CHAPTER FIVE: OTC MARKETS IN NORTH AMERICA CHAPTER SIX: OTC MARKETS IN SOUTH AMERICA CHAPTER SEVEN: SUMMARY OF WORLD OTC MARKETS CHAPTER EIGHT: LEADING OTC MANUFACTURERS Competitor Analysis Significant Agreements, Mergers and Acquisitions o Procter & Gamble and Teva Pharmaceutical Industries o Sanofi and Chattem Consumer o Schering-Plough and Merck & Co. o Wyeth and Pfizer o Reckitt Benckiser and Adams Respiratory Therapeutics o Bristol-Myers Squibb and Novartis AG o Johnson & Johnson and Pfizer o Reckitt Benckiser and Boots Healthcare

3 o Bayer and Roche Leading Corporate Profiles o Bayer Healthcare Ag o Boehringer Ingelheim Gmbh o Glaxosmithkline o Mc Neil Consumer o (A Johnson & Johnson Company) o Merck o Novartis Consumer o Pfizer o Procter & Gamble o Reckitt Benckiser o Sanofi o Taisho Pharmaceutical APPENDIX: LIST OF MAJOR COMPANIES LIST OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY Table 1-1 5: Total World OTC, Figure 1-1 : Total World OTC : CHAPTER TWO: INTRODUCTION Table 2-1 : Average Life Expectancy in Years by Country 1980, 2004 and 2011 Figure 2-1 : Average Life Expectancy in Years by Country 1980 and 2011 Table 2-2 : Crude Birth Rate per 1,000 Persons 2000, 2005 and Projected 2012 and 2020 Table 2-3 : Percent of Smokers by Country Figure 2-2 : Average Percent of Smokers Worldwide in Developed Regions Table 2-4 : Percent of Obese* Population, 2008 Table 2-5 : World Population 1980 to 2050 Figure 2-3 : World Population 1980 to 2050 Table 2-6 : Total Pharmaceutical Markets, Prescription vs. Non-Prescription by Country, 2011 Figure 2-4 : Total Pharmaceutical Markets, Prescription vs. Non-Prescription by Country, 2011 Table 2-7 : Leading FDA Approved Rx-to-OTC Switches, Figure 2-5 : Number of New Rx-to-OTC Switches in the United States, per Year Table 2-8 Table 2-9 : Potential Rx-to-OTC Switches, Table 2-9 : P otential Rx-to-OTC Switches, Table 2-10 : Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000 and 2009

4 Figure 2-6 : Total Healthcare Expenditures as a Percent of GDP by Country 1990, 2000, and 2006 Table 2-11 : Gross National Income Comparison by Country Figure 2-7 : Gross National Income Growth by Country Table 2-12 : National Healthcare Expenditures in the United States Figure 2-8 : Healthcare Spending as a Percent of GDP in the United States Table 2-13 : Health Insurance Trends in the United States Table 2-14 : Practicing Physicians per 1,000 Population by Country, Figure 2-9 : Internet Users per 100 Inhabitants, 2010 Figure 2-10 : Typical Pharmacist-Consumer OTC Drug Counseling Session CHAPTER THREE: OTC MARKETS IN ASIA-PACIFIC AND AFRICA Table 3-1 : Total Midyear Population by the Five Most Populated Countries in Asia- Pacific, Figure 3-1 : Total Midyear Population by the Five Most Populated Countries in Asia- Pacific, 2005, 2015, and 2025 Table 3-2 : Total Midyear Population in Africa by Region, Figure 3-2 : Total Midyear Population for Africa by Region, 2005, 2015, and 2025 Table 3-3 : Examples of Marketed OTC Products in Asia-Pacific and Africa (Product Name by Type and Marketer) Table 3-4 : Asia-Pacific/Africa OTC Market as a Percentage of World Market, 2007, 2011 and 2015 Figure 3-3 : Asia-Pacific/Africa OTC Market as a Percentage of World Market, 2011 Figure 3-4 : Asia-Pacific/Africa OTC Market as a Percentage of World Market, 2015 Table 3-5 : Asia-Pacific/Africa OTC, Figure 3-5 : Asia-Pacific/Africa OTC : Table 3-6 : Asia-Pacific/Africa OTC by Product Segment, Figure 3-6 : Asia-Pacific/Africa OTC by Product Segment, Figure 3-7 : Asia-Pacific/Africa OTC by Product Segment, 2011 Table 3-7 : Asia-Pacific/Africa OTC by Selected Country, 2011 Figure 3-8 : Asia-Pacific/Africa OTC by Selected Country, 2011 CHAPTER FOUR: OTC MARKETS IN EUROPE Table 4-1 : Total Midyear Population by the Five Most Populated Countries in Europe, Figure 4-1 : Total Midyear Population by the Five Most Populated Countries in Europe, 2005, 2015, and 2025 Table 4-2 : Examples of Marketed OTC Products in Europe (Product Name by Type and Marketer) Table 4-3 : European OTC Market as a Percentage of World Market, 2007, 2011 and 2015 Figure 4-2 : European OTC Market as a Percentage of World Market, 2011 Figure 4-3 : European OTC Market as a Percentage of World Market, 2015 Table 4-4 : European OTC,

5 Figure 4-4 : European OTC : Table 4-5 : European OTC, Markets by Product Segment, Figure 4-5 : European OTC, Markets by Product Segment, Figure 4-6 : European OTC by Product Segment, 2011 Table 4-6 : European OTC by Selected Country, 2011 Figure 4-7 : European OTC by Selected Country, 2011 CHAPTER FIVE: OTC MARKETS IN NORTH AMERICA Table 5-1 : Total Midyear Population by the Five Most Populated Countries in North America, Figure 5-1 : Total Midyear Population by the Five Most Populated Countries in North America, 2005, 2015, and 2025 Table 5-2 : Examples of Marketed OTC Products in North America (Product Name by Type and Marketer) Table 5-3 : North American OTC Market as a Percentage of World Market, 2007, 2011 and 2015 Figure 5-2 : North American OTC Market as a Percentage of World Market, 2011 Figure 5-3 : North American OTC Market as a Percentage of World Market, 2015 Table 5-4 : North American OTC, Figure 5-4 : North American OTC : Table 5-5 : North American OTC by Product Segment, Figure 5-5 : North American OTC by Product Segment, Figure 5-6 : North American OTC by Product Segment, 2011 Table 5-6 : North American OTC by Selected Country, 2011 Figure 5-7 : North American OTC by Selected Country, 2011 CHAPTER SIX: OTC MARKETS IN SOUTH AMERICA Table 6-1 : Total Midyear Population by the Five Most Populated Countries in South America, Figure 6-1 : Total Midyear Population by the Five Most Populated Countries in South America, 2005, 2015, and 2025 Table 6-2 : Examples of Marketed OTC Products in South America (Product Name by Type and Marketer) Table 6-3 : South American OTC Market as a Percentage of World Market, 2007, 2011 and 2015 Figure 6-2 : South American OTC Market as a Percentage of World Market, 2011 Figure 6-3 : South American OTC Market as a Percentage of World Market, 2015 Table 6-4 : South American OTC, Figure 6-4 : South American OTC : Table 6-5 : South American OTC by Product Segment, Figure 6-5 : South American OTC by Product Segment, Figure 6-6 : South American OTC by Product Segment, 2011 Table 6-6 : South American OTC by Selected Country, 2011 Figure 6-7 South American OTC by Selected Country, 2011

6 CHAPTER SEVEN: SUMMARY OF WORLD OTC MARKETS Table 7-1 : Total World OTC, Figure 7-1 : Total World OTC : Table 7-2 : Total World OTC, Markets by Product Segment, Figure 7-2 : Total World OTC, Markets by Product Segment, Figure 7-3 : Total World OTC by Product Segment, 2011 Figure 7-4 : Total World OTC by Product Segment, 2015 Table 7-3 : Top Ten World OTC Markets by Country, 2011 Figure 7-5 : Top Ten World OTC Markets by Country, 2011 CHAPTER EIGHT: LEADING OTC MANUFACTURERS Table 8-1 : Leading Suppliers Shares of the OTC Market by Estimated Revenues 2009, 2010 and 2011 Figure 8-1 : Leading Suppliers Shares of the OTC Market, 2009 Figure 8-2 : Leading Suppliers Shares of the OTC Market, 2010 Figure 8-3 : Leading Suppliers Shares of the OTC Market, 2011

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