UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C Schedule 13G/A (Amendment No. 2)* Under the Securities Exchange Act of 1934

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1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washingtn, D.C Schedule 13G/A (Amendment N. 2)* Under the Securities Exchange Act f 1934 Synthetic Bilgics Inc. (Name f Issuer) Cmmn Stck (Title f Class f Securities) 87164U12 (CUSIP Number) December 31, 215 (Date f Event which Requires Filing f this Statement) Check the apprpriate bx t designate the rule pursuant t which this Schedule is filed: x Rule 13d-1(b) Rule 13d-1(c) Rule 13d-1(d) *The remainder f this cver page shall be filled ut fr a reprting persn s initial filing n this frm with respect t the subject class f securities, and fr any subsequent amendment cntaining infrmatin which wuld alter the disclsures prvided in a prir cver page. The infrmatin required in the remainder f this cver page shall nt be deemed t be filed fr the purpse f Sectin 18 f the Securities Exchange Act f 1934 ( Act ) r therwise subject t the liabilities f that sectin f the Act but shall be subject t all ther prvisins f the Act (hwever, see the Ntes). Persns wh respnd t the cllectin f infrmatin cntained in this frm are nt required t respnd unless the frm displays a currently valid OMB cntrl number.

2 CUSIP N U12 13G/A Page 2 f 9 Pages 1. NAMES OF REPORTING PERSONS Great Pint Partners, LLC I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) (b) 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION USA NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5. SOLE VOTING POWER 6. SHARED VOTING POWER 7. SOLE DISPOSITIVE POWER 8. SHARED DISPOSITIVE POWER 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructins) 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 3.8% TYPE OF REPORTING PERSON (See Instructins) IA 1 Cnsists f warrants t purchase an aggregate f 3,589,4 shares underlying warrants, wned by Bimedical Value Fund, LP, Bimedical Offshre Value Fund, Ltd., Bimedical Institutinal Value Fund, LP, GEF-SMA, LP and Class D Series f GEF-PS, LP. 2 Based n a ttal f 9,81,86 shares f Cmmn Stck utstanding, as reprted by the Issuer n a Frm 1-Q filed with the SEC n Nvember 5, 215.

3 CUSIP N U12 13G/A Page 3 f 9 Pages 1. NAMES OF REPORTING PERSONS Dr. Jeffrey R. Jay, M.D. I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) (b) 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION USA NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5. SOLE VOTING POWER 6. SHARED VOTING POWER 7. SOLE DISPOSITIVE POWER 8. SHARED DISPOSITIVE POWER 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructins) 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 3.8% TYPE OF REPORTING PERSON (See Instructins) IN

4 CUSIP N U12 13G/A Page 4 f 9 Pages 1. NAMES OF REPORTING PERSONS Mr. David Krin I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY): 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a) (b) 3. SEC USE ONLY 4. CITIZENSHIP OR PLACE OF ORGANIZATION USA NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5. SOLE VOTING POWER 6. SHARED VOTING POWER 7. SOLE DISPOSITIVE POWER 8. SHARED DISPOSITIVE POWER 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See Instructins) 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 3.8% TYPE OF REPORTING PERSON (See Instructins) IN

5 CUSIP N U12 13G/A Page 5 f 9 Pages Item 1. (a) Name f Issuer Synthetic Bilgics Inc. (b) Address f Issuer s Principal Executive Offices 965 Medical Center Drive, Suite 27 Rckville, MD Item 2. (a) Name f Persn Filing Great Pint Partners, LLC Dr. Jeffrey R. Jay, M.D. Mr. David Krin The Reprting Persns have entered int a Jint Filing Agreement, dated February 16, 216, a cpy f which is filed with this Schedule 13G/A as Exhibit A, pursuant t which the Reprting Persns have agreed t file this statement jintly in accrdance with the prvisins f Rule 13d-1(k)(1) under the Act. (b) Address f Principal Business Office, r if nne, Residence The address f the principal business ffice f each f the Reprting Persns is 165 Masn Street, 3rd Flr Greenwich, CT 683 (c) Citizenship Great Pint Partners, LLC is a limited liability cmpany rganized under the laws f the State f Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen f the United States. Mr. David Krin is a citizen f the United States. (d) Title f Class f Securities Cmmn Stck (e) CUSIP Number 87164U12 Item 3. If this statement is filed pursuant t 24.13d-1(b) r 24.13d.2(b) r (c), check whether the persn filing is a: Nt Applicable. (a) Brker r dealer registered under Sectin 15 f the Act (15 U.S.C. 78) (b) (c) (d) Bank as defined in Sectin 3(a)(6) f the Act (15 U.S.C. 78c). Insurance cmpany as defined in Sectin 3(a)(19) f the Act (15. U.S.C. 78c). Investment Cmpany registered under Sectin 8 f the Investment Cmpany Act f 194 (15 U.S.C. 8a-8).

6 CUSIP N U12 13G/A Page 6 f 9 Pages (e) An investment adviser in accrdance with 24.13d-1(b)(1)(ii)(E). (f) An emplyee benefit plan r endwment fund in accrdance with 24.13d-1(b)(1)(ii)(F). (g) A parent hlding cmpany r cntrl persn in accrdance with 24.13d-1(b)(1)(ii)(G). (h) A savings assciatins as defined in Sectin 3(b) f the Federal Depsit Insurance Act (12 U.S.C. 1813). (i) A church plan that is excluded frm the definitin f an investment cmpany under Sectin 3(c)(14) f the Investment Cmpany Act f 194 (15 U.S.C. 8a-3). (j) Grup, in accrdance with 24.13d-1(b)(1)(ii)(J). Item 4. Ownership Bimedical Value Fund, L.P. ( BVF ) is the recrd wner f warrants t purchase 1,3,72 shares f Cmmn Stck (the BVF Warrant Shares ). Great Pint Partners, LLC ( Great Pint ) is the investment manager f BVF, and by virtue f such status may be deemed t be the beneficial wner f the BVF Warrant Shares. Each f Dr. Jeffrey R. Jay, M.D. ( Dr. Jay ), as senir managing member f Great Pint, and Mr. David Krin ( Mr. Krin ), as special managing member f Great Pint, has vting and investment pwer with respect t the BVF Warrant Shares, and therefre may be deemed t be the beneficial wner f the BVF Warrant Shares. Bimedical Offshre Value Fund, Ltd. ( BOVF ) is the recrd wner f warrants t purchase 1,63,3 shares f Cmmn Stck (the BOVF Warrant Shares ). Great Pint is the investment manager f BOVF, and by virtue f such status may be deemed t be the beneficial wner f the BOVF Warrant Shares. Each f Dr. Jay, as senir managing member f Great Pint, and Mr. Krin, as special managing member f Great Pint, has vting and investment pwer with respect t the BOVF Warrant Shares, and therefre may be deemed t be the beneficial wner f the BOVF Warrant Shares. Bimedical Institutinal Value Fund, L.P. ( BIVF ) is the recrd wner f warrants t purchase 232,597 shares f Cmmn Stck (the BIVF Warrant Shares ). Great Pint is the investment manager f BIVF, and by virtue f such status may be deemed t be the beneficial wner f the BIVF Warrant Shares. Each f Dr. Jay, as senir managing member f Great Pint, and Mr. Krin, as special managing member f Great Pint, has vting and investment pwer with respect t the BIVF Warrant Shares, and therefre may be deemed t be the beneficial wner f the BIVF Warrant Shares. GEF-SMA, LP ( GEF-SMA ) is the recrd wner f warrants t purchase 996,844 shares f Cmmn Stck (the GEF- SMA Warrant Shares ). Great Pint is the investment manager f GEF-SMA, and by virtue f such status may be deemed t be the beneficial wner f the GEF-SMA Warrant Shares. Each f Dr. Jay, as senir managing member f Great Pint, and Mr. Krin, as special managing member f Great Pint, has vting and investment pwer with respect t the GEF- SMA Warrant Shares, and therefre may be deemed t be the beneficial wner f the GEF-SMA Warrant Shares.

7 CUSIP N U12 13G/A Page 7 f 9 Pages Class D Series f GEF-PS, LP ( GEF-PS ) is the recrd wner f warrants t purchase 266,587 shares f Cmmn Stck (the GEF-PS Warrant Shares ). Great Pint is the investment manager f GEF-PS, and by virtue f such status may be deemed t be the beneficial wner f the GEF-PS Warrant Shares. Each f Dr. Jay, as senir managing member f Great Pint, and Mr. Krin, as special managing member f Great Pint, has vting and investment pwer with respect t the GEF-PS Warrant Shares, and therefre may be deemed t be the beneficial wner f the GEF-PS Warrant Shares. Ntwithstanding the abve, Great Pint, Dr. Jay and Mr. Krin disclaim beneficial wnership f the BVF Warrant Shares, the BOVF Warrant Shares, the BIVF Warrant Shares, the GEF-SMA Warrant Shares, and the GEF-PS Warrant Shares. 1. Great Pint Partners, LLC (a) Amunt beneficially wned: 3,589,4 3 (b) Percent f class: 3.8% 4 (c) Number f shares as t which the persn has: (i) Sle pwer t vte r t direct the vte:. (ii) Shared pwer t vte r t direct the vte: 3,589,4 3 (iii) Sle pwer t dispse r t direct the dispsitin f:. (iv) Shared pwer t dispse r t direct the dispsitin f: 3,589, Dr. Jeffrey R. Jay, M.D. (a) Amunt beneficially wned: 3,589,4 3 (b) Percent f class: 3.8% 4 (c) Number f shares as t which the persn has: (i) Sle pwer t vte r t direct the vte:. (ii) Shared pwer t vte r t direct the vte: 3,589,4 3 (iii) Sle pwer t dispse r t direct the dispsitin f:. (iv) Shared pwer t dispse r t direct the dispsitin f: 3,589, Mr. David Krin (a) Amunt beneficially wned: 3,589,4 3 (b) Percent f class: 3.8% 4 3 Cnsists f warrants t purchase an aggregate f 3,589,4 shares underlying warrants, wned by Bimedical Value Fund, LP, Bimedical Offshre Value Fund, Ltd., Bimedical Institutinal Value Fund, LP, GEF-SMA, LP and Class D Series f GEF-PS, LP. 4 Based n a ttal f 9,81,86 shares f Cmmn Stck utstanding, as reprted by the Issuer n a Frm 1-Q filed with the SEC n Nvember 5, 215.

8 CUSIP N U12 13G/A Page 8 f 9 Pages (c) Number f shares as t which the persn has: (i) Sle pwer t vte r t direct the vte:. (ii) Shared pwer t vte r t direct the vte: 3,589,4 3 (iii) Sle pwer t dispse r t direct the dispsitin f:. (iv) Shared pwer t dispse r t direct the dispsitin f: 3,589,4 3 Item 5. Ownership f Five Percent r Less f a Class If this statement is being filed t reprt the fact that as f the date heref each f the Reprting Persns has ceased t be the beneficial wner f mre than five percent f the class f securities, check the fllwing x. Item 6. Ownership f Mre than Five Percent n Behalf f Anther Persn: See Item 4. Item 7. Identificatin and Classificatin f the Subsidiary Which Acquired the Security Being Reprted n by the Parent Hlding Cmpany Nt Applicable. Item 8. Identificatin and Classificatin f Members f the Grup Nt Applicable. Item 9. Ntice f Disslutin f Grup Nt Applicable. Item 1. Certificatin By signing belw I certify that, t the best f my knwledge and belief, the securities referred t abve were nt acquired and are nt held fr the purpse f r with the effect f changing r influencing the cntrl f the issuer f the securities and were nt acquired and are nt held in cnnectin with r as participant in any transactin having that purpse r effect.

9 CUSIP N U12 13G/A Page 9 f 9 Pages SIGNATURE After reasnable inquiry and t the best f my knwledge and belief, I certify that the infrmatin set frth in this statement is true, cmplete and crrect. Date: February 16, 216 GREAT POINT PARTNERS, LLC By: /s/ Dr. Jeffrey R. Jay, M.D. Dr. Jeffrey R. Jay, M.D., as senir managing member /s/ Dr. Jeffrey R. Jay, M.D. DR. JEFFREY R. JAY, M.D. /s/ Mr. David Krin Mr. David Krin

10 Exhibit A The undersigned hereby agree as fllws: AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G/A (i) Each f them is individually eligible t use the Schedule 13G/A t which this Exhibit is attached, and such Schedule 13G/A is filed n behalf f each f them; and (ii) Each f them is respnsible fr the timely filing f such Schedule 13G/A and any amendments theret, and fr the cmpleteness and accuracy f the infrmatin cncerning such persn cntained therein; but nne f them is respnsible fr the cmpleteness r accuracy f the infrmatin cncerning the ther persns making the filing, unless such persn knws r has reasn t believe that such infrmatin is inaccurate. Date: February 16, 216 GREAT POINT PARTNERS, LLC By: /s/ Dr. Jeffrey R. Jay, M.D. Dr. Jeffrey R. Jay, M.D., as senir managing member /s/ Dr. Jeffrey R. Jay, M.D. DR. JEFFREY R. JAY, M.D. /s/ Mr. David Krin Mr. David Krin