MANUFACTURING PROBLEMS AS OF 12th October 2017

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1 MANUFACTURING PROBLEMS AS OF 12th October 2017 If you know of any stock Issues that are not on this list please get in touch at Dumfries and Galloway on the date displayed and may not apply to other regions. Drug Manufacturer Brand Name Comments Adalat La 20mg Bayer plc Audavate Rd 0.025% w/w Cream Actavis Out of stock - No Date Suggested Alternatives Date of first reported issue as yet 15/06/2017 Out of stock - Expected April 2018 betnovate RD Cream Alphaderm Cream 30g & 100g Alliance Pharma Out of Stock - No date as yet Alzain 25mg, 75mg & 150mg capsule Dr Reddys Avaxim Injection Sanofi Ambrix Vaccine 1 PFS gsk Amoxil Paed Suspension 20ml GSK Bactroban Cream 15g GSK Out of stock - 25mg expected w/c 18/10/17-75mg expected w/c 28/11/17-150mg expected w/c 11/11/17 All other strengths are available - Axalid is a brand of pregabalin and available from AAH, Alliance & Pheonix 17/07/2017 Out of Stock - Hopefully be back available by end of November /08/2017 Out of stock - Expected Quarter Ointment is available

2 Co - amilofruse 5/40mg tablets Aurobindo Colestyramine sachets x 50 Teva Duac Once Daily Gel 3% 60g GSK Out of stock - In quality Control hopefully released within 2-4 weeks 27/07/2017 Out of stock - Quality Issue - Until July/September 2018 October 2017 Conotrane Cream 100g Leo Pharma Limited stock available Cyclimorph 10mg & 15mg Injection 1ml x 5 Concordia Out of stock - 10mg Expected end of October mg No date as yet Questran Sachets available (formulary choice) Diamox SR 250mg capsules Concordia Out of stock -Expected November / Decewmber 2017 no direct alternative Diloxanide 500mg tablets Concordia Temporary Discontinued - No date as yet to re-instate Dilzem Sr 60mg Cap Teva Out of Stock - Expected January/ March 2018 use other brand Diprosone Cream MSD Out of Stock - 30g expected Mid 12/10/2017 November 2017 Dirosone Lotion MSD Out of Stock - No date as yet 12/10/2017 Ceanel Shampoo 150ml & Alliance Pharma Out of stock - No date as yet 500ml 12/10/2017 Distamine 250mg Tablets Alliance Pharma Discontinued Entresto Novartis Pharma Erythormycin 2% Solution x 50ml New product - Limited Stock - Novartis can make urgent supplies directly to contractors within 24 hours GSK Stiemycin Discontinued 125mg Tablets available

3 Estradot 50microgram Patch Novartis Pharma Long term Manufacturing problem - Novartis can supply for Rx one month at a time after account set up Fucibet Cream 30g Leo Pharma Limited stock available Fucidin Cream 15g & 30g Leo Pharma Limited stock available Evorel 50microgram Patch Alliance Fucidin Ointment 15g & 30g Leo Pharma Engerix B Paed PFS non fixed needle 0.5ml GSK Engerix B Vial 1 & 10 GSK 15g Limited Supply Available - 30g out of stock no date as yet Alliance Intermittent supply - Expected Quarter /08/2017 Intermittent supply - Expected Q /06/2017 Engerix B x 1 PFS NFN GSK Out of Stock - Expected Q /06/2017 Engerix PF Syringe Adult 1 x 10 GSK Out of stock - expected Q dose 16/06/2017 Havrix Monodose PFS 1 & 10'S GSK Out of stock - expected Q /06/2017 Havrix Monodose PFS 1 & 10'S Junior GSK Out of stock - packs of 1 expected Late October packs of 10 expected Q Azargo Eye Drops Alcon Limited stock available - Being managed by Alcon - No date 12/10/2017 Isopto Alkaline eye drop 10ml Alcon Discontinued by supplier 17/07/2017 Hepatyrix 1 & 10's PFS GSK Out of Stock - Expected /08/2017 Isotrex Gel x 30g GSK Discontinued

4 Isotrexin Gel x 30g GSK Out of stock- Expected Quarter Adalat Retard 10mg Tablet Bayer plc Kwells 150microgram Bayer plc Out of stock - Expected end of 300microgram back in stock Locoid Cream 30g & 100g Leo Pharma Limited stock available Maxidex Eye Drops 10ml Alcon Navispare Tablet Amco / Mercury Limited stock available - Being managed by Alcon - No date Temporary Discontinued - Unsure at present if will be manufactured again 5ml Available 17/07/2017 use alternative similar diuretic combination diuretics not recommended in the formulary For mental health switch Orphenadrine 50mg Tablets Teva Teva have Discontinued - to Procyclidine or back up Trihexiphenidyl -Advise do not stop abruptly BD OR TDS as you get Cholinergic rebound Occlusol Wart Solution 10ml Alliance Pharma Out of Stock - Expected Late Pavacol D Alliance Pharma Discontinued- Both 300ml & 600ml Actavis brand is in stock Mirtazepine Orodispersible Concordia Out of stock - No date as yet and supplied to both AAH tablets all strengths & Alliance 12/10/2017

5 Phenindione 50mg Tablet Concordia Discontinued Potassium Chloride 600mg SR Tablets Alliance Pharma Slow K Discontinued by Alliance Pharma Cytotec Tablets x 60's Pfizer Detrusitol 2mg Tablet Pfizer Premarin 1.25mg tablets Pfizer Constella 290microgram Capsule Allergan FML Eye Drops 5ml Allergan Pred Forte eye drops Allergan Out of stock - 10ml will not be available all mg & 25mg are available - check with PST regarding cost?? 17/07/2017 Out of Stock - Expected Monday 16/10/17 12/10/2017 Out of Stock - Expected w/e 20/10/17 12/10/2017 In Quality Control - no date as yet of being released 17/07/2017 Out of Stock - Expected w/c 16/10/17 Out of Stock - Expected December ml available 5ml in stock at present although low stock levels - next order due 11th September 2017 Prednisolone 2.5mg & 5mg ec tablets Alliance Pharma Deltacortril Discontinued by manufacturers - Alliance Pharma do a generic Predniolone ec tablet 2.5mg & 5mg in packs of 30's now - Both in stock Premique tablets 0.625mg/5mg Pfizer Discontinued Prempak-C 0.625mg Pfizer Discontinued both strengths Protopic Ointment 60g Leo Pharma N/A Limited supply available Pneumococcal Vaccine MSD Out of Stock - Expected start of November 2017

6 Provera 10mg x 10 & 100's Pfizer Quinaderm 5% cream x 50g Alliance Pharma N/A Quinaderm 10% cream 25g & 50g Alliance Pharma Out of Stock - Expected early November /10/2017 Raw material problem - Not expecetd untill Mid 2018 Raw material problem - Not expected untill Mid 2018 Respontin Nebules 1ml & 2ml GSK Discontinued Rabies Vaccine BP Sanofi Out of Stock - No date as yet 12/10/2017 Revaxis Injection Sanofi Out of Stock - No date as yet 12/10/2017 Synflorix vaccine 1PFS GSK Out of stock - Expected /06/2017 Teoptic 1% Eye Drops Thea Pharmaceuticals N/A Discontinued 2% still currently Manufactured 01/06/2017 Traxam Pain Relief 3% gel 100g Concordia Out of stock - Technical Issue - non formulary use expected Quarter ibuprofen gel Traxam 3% gel 30g concordia Out of stock - Technical Issue - non formulary use expected Quarter ibuprofen gel Trimovate Cream 30g GSK N/A Out of Stock - Expected Quarter /06/2017 Twinrix PFS 1 & 10'S GSK N/A Expected Quarter Twinrix Paediatric 1 Dose GSK Intermittent supply - Expected Quarter /08/2017 Typherix Vaccine 1 & 10 PFS GSK Out of Stock - Expected /08/2017 Vaqta Adult & Paediatric Out of Stock - Expected start of MSD Injection November /08/2017 Varilrix Vial & Dil GSK N/A Out of stock - Expected Mid October 2017 Viatim Injection Sanofi Out of Stock- Expected end of NoVEMBER 07/08/2017 Zantac Tablets 150mg & 300mg GSK Out of Stock - Expected Quarter Switch to generic Zorac Gel 0.1% Gel Out of Stock - Expected w/c Allergan 16/10/17

7 Viagra 50mg x 4's Pfizer Out of Stock - In Quality control - No date of being released - Pack size 8's available or Generic 12/10/2017