Biotech Showcase 2019 Investment Trends Survey

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Anthony Griffin
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1 Demy-Colton and EBD Group Biotech Showcase 2019 Investment Trends Survey December 7, 2018

2 Survey Overview Survey included 10 questions on biotech industry investment trends for 2019 Survey was sent to the 2018 list of registered Biotech Showcase attendees 80 people provided responses

3 QuesBon 1: Which of the following best describes your professional role? Venture capitalist Corporate investor Investment banker/banker Private investor Buy side/sell side research analyst Executive or upper management of biotech or pharma company Research and development executive Government official Professional service provider Press and media

4 Survey Responder Demographics - Chart Professional Press and media, 3.75% service provider, 1 Buy side/sell side research analyst Corporate Investor Government official, Investors, 33.75% 5.00% 7.50% 16.25% Investment Banker Private Investor Venture Capitalist Executives and Upper Management, 48.75% Based on 80 responses to survey

5 Survey Responder Demographics - Table RESPONDER OCCUPATION # OF RESPONDERS PERCENT OF TOTAL INVESTOR (Total of subcategories below) % Venture capitalist % Corporate investor 2 Investment banker/banker % Private investor % Buy side/sell side research analyst 2 EXECUTIVE/UPPER MANAGEMENT (Total of subcategories below) % Executive or upper management of biotech or pharma company % Research and development executive % Government official 2 Professional service provider 9 1 Press and media % Total Responders 80

6 Question 2: Overall, you expect to see in life science investments in 2019 compared to Increase Decrease No change

7 The majority of life science investors and executives expect to see an increase in investment during % 60% 50% 7.50% Investors Executives Media, Services, Gov 40% 37.50% 30% 20% 6.25% 10% 0% 20.00% 3.75% 8.75% 6.25% 7.50% Increase Decrease No Change

8 Sixty percent of life science investors expect to see an increase in investment in % 60% 50% 40% 30% 20% 10% 0% Increase Decrease No Change

9 Question 3: Of the following areas, which do you think is poised to have the biggest nearterm breakthrough? Alzheimer s and CNS diseases Cell and gene therapy Immuno-oncology NASH RNA therapeutics Rare and orphan disease Digital medicine Other (please specify)

10 Of the major therapeutic areas, biotech leaders think cell and gene therapy is poised to have biggest breakthrough in % 30% 3.75% 25% 20% % 15% 10% 5% 0% Cell and gene therapy % 7.50% 5.00% 6.25% 3.75% Immuno-oncology Rare and orphan disease Digital medicine Alzheimer s and CNS 5.00% NASH RNA therapeutics 3.75% Other

11 Question 4: Of the factors listed below, what is the biggest challenge biotech companies face in securing funds in the coming year? Crowded market or sector Economic volatility Inexperienced management team Lack of achieved milestones Inability to manage pipeline progression or clinical trials Other (please specify)

12 Biggest challenges for securing funds in the coming year are crowded markets, economic volatility, and inexperienced management 25% 20% 15% 10% 5% 0% Crowded market or sector Economic volatility Inexperienced management team Lack of achieved milestones Inability to manage pipeline progression or clinical trials Other

13 US Outlook

14 Question 5: Do you expect the recent stock market volatility to affect overall biotech investment in 2019? Yes No Unsure

15 Most biotech leaders expect the stock market volatility to have an overall effect on 2019 investments 70% 60% 50% 1 40% 27.50% 30% 20% 3.75% 10% 20.00% % 0% 7.50% 6.25% Yes No Unsure

16 Question 6: What US city/region will see the biggest percent increase in investment dollars in the biotechnology industry in 2019? Boston Los Angeles New York Philadelphia Raleigh-Durham San Diego San Francisco Seattle Other (please specify)

17 Boston holds #1 seat for predicted influx of investment dollars among the major U.S. cities 35% 30% 25% 10.00% 20% 15% 1 10% 5% 0% 8.75% 3.75% % 5.00% 8.75% 7.50% 5.00% 3.75% 3.75% 3.75% Boston San Diego San Francisco New York Other* Los Angeles Philadelphia Raleigh-Durham Seattle *Texas (3), New Jersey, Maryland

18 Investors think New York is the next city, after Boston and San Francisco, to see an influx of investment dollars in % 9% 8% 7% 6% 5% 4% 8.75% 7.50% 3% 2% 1% 0% Boston San Francisco 5.00% New York 3.75% 3.75% Other* Philadelphia San Diego Los Angeles Raleigh-Durham Seattle *Texas (3), New Jersey, Maryland

19 Global Outlook

20 Ques%on 7: Which region outside the United States will see the biggest percent increase in investment dollars in the biotechnology industry in 2019? China UK Germany Benelux Japan France Spain Scandinavia South Korea Other*

21 China predicted to see the biggest percent increase in 2019 biotech investment dollars when compared to other global biotech hot spots 50% 45% 40% 7.50% 35% 30% 25% 25.00% 20% 15% 10% 5% 0% 5.00% % 5.00% 5.00% 6.25% 3.75% China UK Germany Benelux Japan France Spain Scandinavia S. Korea Other* *Israel (3), Singapore, Unspecified

22 Question 8 & 9: What impact will US/China trade war have on strategy for investment, partnerships, or expansion in China? Negative Impact No Impact Will this trade war have a long-term impact on biotech investments originating from China? Yes No Unsure

23 While life science leaders do not expect the U.S./China trade war to have an impact on their regional strategies, they do expect it will have long-term impact on investments coming from that region Investor and Executive Responses 60% 50% 40% % 20% 33.33% 7.58% 18.18% Negative Impact No Impact More than half of biotech leaders think the trade war with China will have no impact on their strategy for partnerships, investments, or expansion in this region 10% 0% 15.15% 13.64% 12.12% Yes No Unsure Investors Executives One third of biotech execuaves think the trade war will have a long term impact on investments originaang from China

24 Question 10: What impact will the UK exit from the EU in March 2019 have on investment in the regions below? United Kingdom, North America, European Union, Other Global Markets Increase Decrease No change

25 When the UK exits from the EU in March, investors expect to see a decrease in investments in the UK while other markets will see an increase or remain unchanged United Kingdom North America European Union Other Global Markets 10% 15% 76% 61% 34% 5% 30% 30% 41% 75% 19% 6% Increase Decrease No Change

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Employment Trends & Salary Survey 2017-18 in partnership with www.sciproglobal.com Contents Introduction to SciPro...3 Executive Summary...4 Section 1 Demographics...5-10 Section 2 Hiring Trends...11-18