Merck KGaA. Germany, Chemicals/Pharmaceuticals. Merck KGaA Germany, Chemicals/Pharmaceuticals. Corporate profile. Key metrics.

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19 October 2017 Corporates Merck KGaA Merck KGaA Corporate profile Merck KGaA is a diversified chemicals/pharmaceuticals group that was founded in 1668 with the opening of a Merck pharmacy in Darmstadt, Germany, where the group is still based. The Merck family holds 70% of the voting rights with the remainder in public ownership. After several acquisitions and divestments, the group now consists of three divisions: Healthcare (pharmaceuticals and consumer healthcare), Life Science and Performance Materials (centred on its global market leadership in liquid crystals). In 2015, Merck acquired the US-based life science company Sigma Aldrich for a price of USD 17bn and became one of the consolidators in that industry. In pharmaceuticals, it is a specialised, mid-sized producer of drugs, relying on two blockbuster products, Erbitux and Rebif, but has developed a new focus on immunooncological products, mainly represented by its antibody avelumab. At the end of 2014, US-based big pharma company Pfizer acquired partial ownership of the molecule as well as US distribution rights for USD 850m. Key metrics Scope estimates Scope credit ratios 2016 2017F 2018F 2019F EBITDA/interest cover (x) 13.0x 15.4x 18.3x 21.9x SaD/EBITDA 2.9x 2.5x 1.8x 1.5x Ratings & Outlook Corporate Ratings Short Term Rating Analysts Olaf Tölke +49 69 6677389 11 o.toelke@scoperatings.com Sebastian Zank, CFA +49 30 27891 225 s.zank@scoperatings.com Related methodology European Pharmaceuticals, January 2017 A-/Stable S-1/Stable Scope-adjusted FFO/SaD 25% 32% 44% 53% FOCF/SaD 21% 22% 28% 29% Rating rationale Scope Ratings affirms its issuer rating of A- to Germany-based Merck KGaA (Merck). The short-term rating is S-1. The rating Outlook is Stable. The rating affirmation reflects Scope Ratings view of Merck s credit-supportive business risk profile, consisting of the mostly stable and cash-generative business models of its three critically-sized divisions. In addition, Scope sees the group s diversified structure as reflecting the owning family s strategy of achieving balanced cyclicality exposure. Merck s Healthcare division still hinges on its mature product portfolio and is only gradually moving towards a broader pharmaceuticals portfolio by way of expansion into immunooncology. The group s other divisions could, however, offset potentially weaker profitability in pharmaceuticals thanks to their stable cash flows. The ratings also reflect Scope s perception of Merck s conservative financial policy, which has focused on organic growth and deleveraging since the debt-funded acquisition of Sigma Aldrich in 2015. Credit metrics are presently sub-par for the ratings because of the acquisition s immediate impact; financial policy was, however, supportive of rapid deleveraging following the Serono and Millipore acquisitions. Scope continues to assess Merck s business risk profile as A+. This is based on a weighted approach with regard to the three divisions industry risk and competitive positioning to form the group s business risk profile. In Scope s view, Merck s exposure to the relatively stable, high-margin liquid crystals and life science industries continues to support the ratings. Scope Ratings AG Neue Mainzer Straße 66-68 60311 Frankfurt am Main Tel. + 49 69 6677389 0 Headquarters Lennéstraße 5 10785 Berlin Tel. +49 30 27891 0 Fax +49 30 27891 100 info@scoperatings.com www.scoperatings.com Bloomberg: SCOP 19 October 2017 1/10

The group has extremely large global market shares and operating margins in the former, with the latter offering growth potential and comparatively high profitability. However, Scope continues to believe that the Healthcare division, in its present transitional state, somewhat weakens the group s business risk profile, despite the initial success attained with drug approvals for Bavencio and Mavenclad. Emerging margin pressure in Performance Materials as a consequence of stronger competitive forces in the liquid crystals area do not have a negative bearing on Scope s business risk assessment for the division yet, as the division s operating profit margins are still expected to reach close to 40% in 2017 overall. Scope s assessment of Merck s financial risk profile continues to reflect its expectation that the group is both able and willing to reduce debt continuously in the coming years. The group has already cut gross financial debt by EUR 1.2bn since the end of 2015. However, Merck s growth strategy involves budgeted rises in R&D, marketing and capital expenditures, and, as most of these increases will be incurred in 2017 and 2018, credit metrics are likely to improve more slowly than expected in the current year. Potential profit weakness in Performance Materials is also a consideration. However, the group s management has decided to assess strategic options for its Consumer Health activities during 2018 which might generate disposal proceeds north of EUR 2bn if sold, in our view. Depending on the timing of the transaction, credit metrics for 2018 are likely to be very favourably affected, balancing out the negative factors mentioned above by far. For 2017, Scope expects the FFO/Scope-adjusted-debt (SaD) ratio to recover to about 30% and the adjusted EBITDA/SaD ratio to fall to about 2.5x. Outlook The Stable Outlook reflects Scope s expectations that Merck should improve its financial risk profile in 2018 to levels of about 2.5x with regard to SaD/EBITDA. Scope views credit metrics of SaD/EBITDA of 2.5x and FFO/SaD of 30-35% as indicative for the current rating and outlook and reflective of a financial risk profile assessment in the BBB category. A higher rating could be triggered by both an improved business risk assessment, if the Healthcare division performs well in the future, and a sustainable enhancement of credit metrics above the aforementioned levels. A negative rating action could result in the event of a more aggressive financial policy (which Scope does not anticipate) or a sustained negative deviation from the ratio levels commensurate with the present ratings (SaD/EBITDA of above 2.5x and FFO/SaD of below 30%). 19 October 2017 2/10

Rating drivers Positive rating drivers Diversified group structure with positive effects on internal risk balancing World market leader by far in liquid crystal production Potential pharma blockbuster in development Significant and consistent free cash generation Acquisition of Sigma Aldrich has led to group becoming a life science consolidator Conservative financial policy with good track record Negative rating drivers Healthcare division in transition Margin pressure in liquid crystals Credit metrics currently at sub-par levels for the rating Rating-change drivers Positive rating-change drivers Considerable, uninterrupted improvement in credit metrics Significant turnaround in Healthcare division, for example through the approval of new antibody avelumab Negative rating-change drivers Inability to deleverage quickly, resulting in no significant improvement in credit metrics Change to more aggressive financial policy 19 October 2017 3/10

Financial overview Scope estimates Scope credit ratios 2016 2017F 2018F 2019F EBITDA/interest cover (x) 13.0x 15.4x 18.3x 21.9x SaD/EBITDA 2.9x 2.5x 1.8x 1.5x Scope-adjusted FFO/SaD 25% 32% 44% 53% FOCF/SaD 21% 22% 28% 29% Scope-adjusted EBITDA in EUR m 2016 2017F 2018F 2019F EBITDA 4,086 4,281 4,103 4,279 Operating lease payment in respective year 98 97 104 97 Other 0 0 0 0 Scope-adjusted EBITDA 4,184 4,378 4,207 4,376 Scope funds from operations in EUR m 2016 2017F 2018F 2019F EBITDA 4,086 4,281 4,103 4,279 less: (net) cash interest as per cash flow statement -305-235 -170-140 less: cash tax paid as per cash flow statement -788-500 -570-670 add: depreciation component operating leases 98 97 104 97 Scope funds from operations 3,091 3,643 3,470 3,570 Scope-adjusted debt in EUR m 2016 2017F 2018F 2019F Reported gross financial debt 12,597 11,209 8,687 6,987 Hybrid bond -744-744 -744-744 deduct: cash, cash equivalents -1,084-918 -1,808-1,073 Cash not accessible 300 300 300 300 add: pension adjustment 969 850 902 950 add: operating lease obligation 293 293 293 293 Other -128-150 -150-150 Scope-adjusted debt 12,203 10,840 7,480 6,564 19 October 2017 4/10

Three critically sized divisions Internal risk balancing Solid business risk profile Credit-supportive mix of industries Business risk profile Based on its long-term commitment to diversified pharmaceuticals/chemicals exposure, Merck has built its group structure around three sizeable divisions holding, in part, significant market shares. The acquisition of US-based Sigma Aldrich for the group s Life Science division in 2015, positioned it among the top three producers of laboratory equipment and related products globally. While its liquid crystals business (as part of its Performance Materials division) continues to enjoy global supremacy, Merck s pharmaceutical subdivision is a mid-sized drug producer which has only recently been able to gain approval for novel pipeline projects ending a period of years without innovation. Scope believes Merck s group structure can effectively shield group cash generation from recessions and a potential downturn in pharmaceuticals. This is based on our view of both the life science and liquid crystals industries comparatively low cyclicality and high cash flow generation. While the pharmaceutical industry is generally less exposed to macroeconomic downturns, cyclicality risk is of a more long-term nature, defined by product lifecycles and the pipeline replacement of patent-expired products. In accordance with its corporate ratings methodology, Scope assesses each of the group divisions business risk profile separately, taking into account the divisions different characteristics. By applying weights related to the divisions individual profit contribution to the group (see Figure 1), we determined Merck s group business risk profile as falling within the A category. Scope views the mix of industries which Merck is exposed to as very credit-supportive. It is our belief that all underlying industries are only very faintly exposed to macroeconomic downturns. The Life Science and Healthcare divisions are driven by ageing societies and unhealthy lifestyles, as well as innovation. The Performance Materials division generally supplies speciality products for a large number of industrial applications, making a sharply negative cyclical impact less likely for the overall division. We also believe that barriers to entry are high in pharmaceuticals (R&D, marketing expertise) and liquid crystals (technical expertise and a high degree of concentration in the industry). While we consider that the group s other performance material activities (pigments and electronics) shift the divisional entry barrier risk down slightly, we view the life science industry, which deals with medical equipment, as well protected by medium-risk barriers to entry due to its focus on speciality products and increasing network requirements. Figure 3: Profit breakdown by division, 2017E Figure 4: Stable long-term trends, in EUR m Performance Materials 24% Healthcare 41% 16,000 14,000 12,000 Sales EBITDA 10,000 8,000 6,000 4,000 Life Science 35% 2,000 0 Source: Scope estimates Source: Scope estimates 19 October 2017 5/10

Group s competitive position weighed down by healthcare Performance Materials: dominated by liquid crystals Life Science: enhanced competitive position Merck s pharmaceutical activities suffer from an aged and comparatively small product portfolio. While its two mature blockbusters Erbitux (oncology) and Rebif (multiple sclerosis), are already past patent expiry in major markets, both are still holding up sales extremely well, which is important in the present transitional phase of the overall division. While first indication approvals of Bavencio (avelumab), Merck s prospective anti-pdl-1 blockbuster, and Mavenclad, its oral multiple sclerosis treatment, are positive, they do not yet change our assessment of the group s competitive position in healthcare overall, as sales generation is still outstanding. High margins and good pipeline prospects are also credit-supportive, despite the heavy focus on avelumab. However, the rating is held back by the group s small market shares and high product concentration rates, with the top three healthcare products generating 46% of pharmaceutical revenues in the first half of 2017 (compared with 36% at Bayer, for example). Scope regards the competitive position of Merck s Performance Materials division as very comfortable from a ratings point of view. This is particularly due to its liquid crystals exposure, which we estimate as generating more than half of divisional profit. The group s liquid crystals business is extremely strong both in terms of market share and EBITDA margin, despite having come under pressure from intense price competition. Merck s pigments and electronics activities (integrated circuit materials, OLEDs) diminish this strength somewhat from a rating perspective, but nevertheless have good market shares and margins, attesting to the highly specialised nature of the products. With the inclusion of Sigma Aldrich, Merck s Life Science division now ranks among the top three suppliers worldwide. All major product categories are covered (except for diagnostic instruments) and market shares are significant. We therefore regard diversification as key to our assessment of the division s competitive position. Furthermore, Sigma Aldrich s industry-leading EBITDA margin of 32% (2015) and strong cash generation are likely to propel Merck s divisional profitability going forward. In the first six months of 2017, divisional EBITDA margins improved to more than 28%, up from 26% in the same period in 2016. In addition, the division looks set to benefit from growth levels that are expected to be well above that of GDP in the mid-term. From a geographic perspective, the Sigma Aldrich acquisition will significantly strengthen the division s US exposure within an already global structure. On a combined basis, the division is well represented in Europe and North America, which are home to about 80% of the life science industry. Financial risk profile Improving credit metrics Merck s key credit metrics came close to a net cash position in 2014, based on continuous deleveraging after 2011, the year of the EUR 5bn Millipore takeover. The Sigma Aldrich transaction in 2015 led to a steep increase in gross financial debt by about EUR 8bn compared with the year before, and was responsible for adjusted leverage rising above 3x, its highest historical level. We continue to expect a strong rise in operating cash flows, up from a low base in 2015, as already demonstrated by a 15% increase in reported operating cash flow in 2016 to allow for continuous deleveraging. While Merck s management has recently dampened excessively high profit expectations for 2017 and 2018, anticipated divestiture proceeds for its consumer healthcare activities are likely to boost deleveraging tremendously. This is despite the planned increase in R&D and marketing expenses as well as higher capital expenditures in the coming years, coupled with lower expected liquid crystals profits. Financial debt has already been reduced by more than EUR 1bn since the end of 2015, in line with the management strategy of prioritising deleveraging in 2017 and 2018. 19 October 2017 6/10

Figure 3: Sigma boosts operating cash flow, in EUR m Figure 4: enabling continuous credit quality recovery SCOPE-adjusted-debt/EBITDA 3,500 4.0 SCOPE-adjusted FFO/SCOPE-adjusted debt 1000% 3,000 3.5 2,500 3.0 2,000 1,500 1,000 500 2.5 2.0 1.5 1.0 0.5 100% 0 2012 2013 2014 2015 2016 2017E 2018E 2019E 0.0 2012 2013 2014 2015 2016 2017F 2018F 2019F 10% Source: Scope estimates Source: Scope Committed financial policy Conservative liquidity management S-1 short-term rating Scope considers Merck s financial policy to be sound and committed, as underlined by the deleveraging trend following acquisitions in 2012 and 2015. After the Sigma Aldrich takeover, the group s management stated publicly that it would enter a phase of consolidation and organic growth with a focus on reducing debt quickly, not least motivated by the intention of keeping ratings stable. This strategy is very credible in our view, as supported by a positive track record in the cases of the Serono (2007) and Millipore (2010) acquisitions. It shows that the group is willing to deleverage, and its ability to do so is underscored by a projected increase in annual operating cash flows including Sigma (see Figure 3). After dividends to outside shareholders and the Merck family, a free cash flow level of over EUR 1bn is likely on an annual basis. We continue to view Merck s liquidity management as conservative, based on the sustained excess cash that acts as a cushion on the balance sheet. While we have determined about EUR 200m in cash as the minimum level necessary to run the business from a technical perspective, Merck has historically kept balance sheet liquidity at more than EUR 1bn. Short-term maturities at the end of June 2017 were still at a high EUR 4.2bn, which is about EUR 2bn greater than the historical average. This reflects the funding of Sigma Aldrich through the partial use of Merck s EUR 2bn commercial paper programme, as well as additional bank lines, which are effectively rolled over but which technically constitute short-term debt. We expect the group s short-term debt to fall rapidly in the coming quarters, as the bilateral bank lines should be paid back first. The continued availability of EUR 2bn in committed back-up facilities and the group s increasing free cash generation were further factors contributing to our analysis. Based on our positive assessment of liquidity as well as Merck s solid investment grade rating, Scope has assigned a short-term rating of S-1. This rating also reflects our perception of the group s sustainable cash-generative business model which continues to improve thanks to the Sigma Aldrich acquisition. Including all internal and external sources of liquidity, coverage of short-term debt is projected at 2x, a level we deem commensurate with the rating. 19 October 2017 7/10

Outlook The Stable Outlook reflects Scope s expectations that Merck should improve its financial risk profile in 2018 to levels of about 2.5x with regard to SaD/EBITDA. Scope views credit metrics of SaD/EBITDA of 2.5x and an FFO/SaD ratio of 30-35% as indicative for the current rating and outlook, and reflective of a financial risk profile assessment in the BBB category. A higher rating could be triggered by both an improved business risk assessment, if the Healthcare division performs well in future, and a sustainable enhancement of credit metrics above the aforementioned levels. A negative rating action could result in the event of a more aggressive financial policy (which we do not anticipate) or a sustained negative deviation from the ratio levels commensurate with present ratings (SaD/EBITDA of above 2.5x and FFO/SaD of below 30%). 19 October 2017 8/10

I. Regulatory disclosures - Important information Information pursuant to Regulation (EC) No 1060/2009 on credit rating agencies, as amended by Regulations (EU) No. 513/2011 and (EU) No. 462/2013 Responsibility The party responsible for the dissemination of the financial analysis is Scope Ratings AG, Berlin, District Court for Berlin (Charlottenburg) HRB 161306 B, Chief Executive Officer: Torsten Hinrichs, Dr Stefan Bund. Rating prepared by Olaf Tölke, Lead Analyst Rating committee responsible for approval of the rating Werner Stäblein, Committee Chair The rating outlook indicates the most likely direction of the rating if the rating were to change within the next 12 to 18 months. A rating change is, however, not automatically ensured. Information on interests and conflicts of interest The rating was prepared independently by Scope Ratings but for a fee based on a mandate of the rated entity. The issuer has participated in the rating process. As at the time of the analysis, neither Scope Ratings AG nor companies affiliated with it hold any interests in the rated entity or in companies directly or indirectly affiliated to it. Likewise, neither the rated entity nor companies directly or indirectly affiliated with it hold any interests in Scope Ratings AG or any companies affiliated to it. Neither the rating agency, the rating analysts who participated in this rating, nor any other persons who participated in the provision of the rating and/or its approval hold, either directly or indirectly, any shares in the rated entity or in third parties affiliated to it. Notwithstanding this, it is permitted for the above-mentioned persons to hold interests through shares in diversified undertakings for collective investment, including managed funds such as pension funds or life insurance companies, pursuant to EU Rating Regulation (EC) No 1060/2009. Neither Scope Ratings nor companies affiliated with it are involved in the brokering or distribution of capital investment products. In principle, there is a possibility that family relationships may exist between the personnel of Scope Ratings and that of the rated entity. However, no persons for whom a conflict of interests could exist due to family relationships or other close relationships will participate in the preparation or approval of a rating. Key sources of information for the rating Website of the rated entity Valuation reports, other opinions Current performance record Audited annual financial statements Detailed information provided on request Data provided by external data providers External market reports Press reports/other public information Scope Ratings considers the quality of the available information on the evaluated company to be satisfactory. Scope ensured as far as possible that the sources are reliable before drawing upon them, but did not verify each item of information specified in the sources independently. Methodology The methodologies applicable for this rating (Corporate Rating Methodology; Rating Methodology: European Pharmaceuticals) are available on www.scoperatings.com. The historical default rates of Scope Ratings can be viewed on the central platform (CEREP) of the European Securities and Markets Authority (ESMA): http://cerep.esma.europa.eu/cerep-web/statistics/defaults.xhtml. A comprehensive clarification of Scope s default rating, definitions of rating notations and further information on the analysis components of a rating can be found in the documents on methodologies on the rating agency s website. Examination of the rating by the rated entity prior to publication Prior to publication, the rated entity was given the opportunity to examine the rating and the rating drivers, including the principal grounds on which the credit rating or rating outlook is based. The rated entity was subsequently provided with at least one full working day, to point out any factual errors, or to appeal the rating decision and deliver additional material information. Following that examination, the rating was not modified. 19 October 2017 9/10

Conditions of use/exclusion of liability 2017 Scope SE & Co. KGaA and all its subsidiaries including Scope Ratings AG, Scope Analysis, Scope Investor Services GmbH (collectively, Scope). All rights reserved. The information and data supporting Scope s ratings, rating reports, rating opinions and related research and credit opinions originate from sources Scope considers to be reliable and accurate. Scope cannot, however, independently verify the reliability and accuracy of the information and data. Scope s ratings, rating reports, rating opinions, or related research and credit opinions are provided as is without any representation or warranty of any kind. In no circumstance shall Scope or its directors, officers, employees and other representatives be liable to any party for any direct, indirect, incidental or otherwise damages, expenses of any kind, or losses arising from any use of Scope s ratings, rating reports, rating opinions, related research or credit opinions. Ratings and other related credit opinions issued by Scope are, and have to be viewed by any party, as opinions on relative credit risk and not as a statement of fact or recommendation to purchase, hold or sell securities. Past performance does not necessarily predict future results. Any report issued by Scope is not a prospectus or similar document related to a debt security or issuing entity. Scope issues credit ratings and related research and opinions with the understanding and expectation that parties using them will assess independently the suitability of each security for investment or transaction purposes. Scope s credit ratings address relative credit risk, they do not address other risks such as market, liquidity, legal, or volatility. The information and data included herein is protected by copyright and other laws. To reproduce, transmit, transfer, disseminate, translate, resell, or store for subsequent use for any such purpose the information and data contained herein, contact Scope Ratings AG at Lennéstraße 5 D-10785 Berlin. Rating issued by Scope Ratings AG, Lennéstraße 5, 10785 Berlin 19 October 2017 10/10