Deutsche Bank German, Swiss & Austrian Conference. Matthias Zachert Chief Financial Officer

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1 Deutsche Bank German, Swiss & Austrian Conference Matthias Zachert Chief Financial Officer Frankfurt, 16 May, 2012

2 Disclaimer Remarks All comparative figures relate to the corresponding last year s period. Important information This presentation does not constitute an offer of securities for sale or a solicitation of an offer to purchase securities in the United States. The shares referred to herein have not been and will not be registered under the U.S. Securities Act of 1933, as amended (the Securities Act ), and may not be offered or sold in the United States absent registration under the Securities Act or an available exemption from such registration. Note regarding forward-looking statements The information in this document may contain forward-looking statements. Forward-looking statements may be identified by words such as expects, anticipates, intends, plans, believes, seeks, estimates, will or words of similar meaning and include, but are not limited to, statements about the expected future business of Merck KGaA resulting from the proposed transaction. These statements are based on the current expectations of management of Merck KGaA and E. Merck KG, and are inherently subject to uncertainties and changes in circumstances. Among the factors that could cause actual results to differ materially from those described in the forward-looking statements are factors relating to satisfaction of the conditions to the proposed transaction, and changes in global, political, economic, business, competitive, market and regulatory forces. Merck KGaA and E. Merck KG do not undertake any obligation to update the content of this presentation and forward-looking statements to reflect actual results, or any change in events, conditions, assumptions or other factors.

3 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 3

4 Merck Group Q Q Summary Key Highlights Reasonable operational performance despite difficult year-over-year comparison Merck Serono and Merck Millipore drive all of the organic revenue growth Performance Materials declines after a strong start in Q Cost containment continued Efficiency program launched and first planned initiatives announced Q Financials Sales ( bn) % 2.56 Q Q EBITDA pre ( m) % 675 Q Q

5 Merck Group Q Operating performance meets expectations m Q Q Δ Total Revenues Net Sales Royalty income Gross Profit as % of net sales 2,645 2, , ,564 2, , % 4% -6% -2% Marketing &Selling % Royalty and Comm. Exp % Administration % Other Expenses / Income % R&D % Amortization % EBIT % Comments: Sales growth of 4% reflects 1% organic growth, 2% impact from currency, and 1% from acquisitions Gross profit down due to Higher start-up costs (LSB) Lack of positive manufacturing variances Negative FX effect (CHF) Marketing & Selling down due to successful cost containment Other Expenses / Income Q1 12 incl. 30m of one-time costs, Q1 11 incl. 158m gain Amortization lower due to 50m cladribine impairment in Q1 11 EBITDA pre as % of net sales % 5

6 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 6

7 Merck Group We have added scale while strengthening the attractiveness of assets in our portfolio 2002 Revenues 7.5 bn Transaction volume 2011 Revenues 10.3 bn Laboratory Distribution Divestments Millipore Merck Millipore Life Science Products Analytics & Reagents Electronic Chemicals Pigments Liquid Crystals CropBioscience 7 bn 16 bn Performance Materials Consumer Health Consumer Health 20% Generics Acquisitions Serono Merck Serono Ethicals Theramex divested merged acquired 7

8 Merck Group Our stronger portfolio has enabled us to fundamentally improve our profitability Merck Group total revenues and adjusted EBIT margin* m 10,000 Acquisition of Serono Divestment of Generics Acquisition of Millipore 9,291 10,276 adj. EBIT margin* 8,000 7,473 7,202 7,057 7,558 7,747 30% 6,000 5,859 5,870 6, % 23.1% 22.6% 22.3% 20% 4,000 2, % 11.8% 14.5% 15.0% 17.7% 16.7% 10% % * adj. EBIT margin = adj. EBIT** divided by total revenues ** adj. EBIT = EBIT less costs related to acquisitions (amortization and impairments of intangible assets, and integration costs) and less exceptionals 8

9 Merck Group Portfolio evolution improved our profitability structure, but further potential remains ^ Assessment of long-term financial performance relative to peers Sales growth Gross margin SG&A R&D productivity Merck Serono Consumer Health Performance Materials Merck Millipore above peers in-line with peers below peers 9

10 Merck Group We now focus on efficiency Transformation process Efficiency De-complex organization Optimize cost structure Increase R&D productivity Organic growth Exploit leading market positions Execute selected bolt-on acquisitions Portfolio No portfolio divestments until 2014 No transformational deals before 2014 Cultural change Fill key positions with best managers Foster performance culture 10

11 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 11

12 Merck Serono Catching up with industry standards % of sales (FY 2011) Industry Average * Merck Serono 45% high mean 22% 28.2% SG&A spend R&D spend EBITDA* margin Eliminate duplications between headquarters in Darmstadt and Geneva Focus investments on markets and products with highest return profiles Centralize businesses Eliminate duplications between headquarters and local R&D operations Faster decision making Increase efficiency and output Source: sell-side analyst research * EBITDA pre one-time items 12

13 Merck Serono Division represents the largest savings potential within the group Group SG&A in 2011 Group R&D in % 81% Merck Serono SG&A: 2,526m Merck Serono R&D: 1,225m Merck Serono Merck Millipore Performance Materials Consumer Health 13

14 Merck Serono Eliminate costs while ensuring R&D is located close to future growth opportunities Boston Hub Darmstadt Hub Beijing Hub Geneva Hub 14

15 Merck Serono Breakdown of Merck Serono net cost savings through E Net savings Merck Serono by cost type 300m 200m 120 R&D P&L line: R&D 90 50m Commercial operations P&L line: SG&A 2012E 2013E 2014E 300 m of net cost savings by

16 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 16

17 Merck Serono Rebif and Erbitux will continue to be important assets for the division Continue to defend Rebif Maximize performance of Erbitux Sales ( m) Organic growth Sales ( m) Organic growth 2012E ~1.691 flat 2012E ~ % ,4% ,5% ,4% % Rebif and Erbitux proving resilient in face of increasing competition 17

18 Merck Serono Over half of our portfolio is generating strong performance and will continue to grow 2011 Sales by business +3% organic growth +7% organic growth Key growth drivers ( m) Organic growth Gonal-f % Concor % 46% 54% Glucophage Endocrinology % +10% Rebif & Erbitux All other Merck Serono products We have good assets that will continue to grow 18

19 Merck Serono Emerging Markets is an increasing share of our sales and will drive attractive growth Sales by geography Emerging Markets All other regions 26% 29% 33% +15% organic growth 74% +16% organic growth 71% 67% > 5,600m Emerging Markets represented 75% of 2011 organic growth E 19

20 Merck Serono We have begun the process of rebuilding our pipeline in 2011 Phase I Phase II Phase III January 2011 Pimasertib (Cancer) c-met KI (Cancer) IFNbeta XR (MS) ATX-MS-1467 (MS) Sprifermin(OA) ARX 201(GHD) Erbitux (BC) IMO-2055 (SCCHN) DI17E6 (CRC) Cilengitide (NSCLC) Cilengitide (SCCHN) Sprifermin(CIR) Stimuvax (NSCLC) Cilengitide (GBM) Erbitux (acc) Erbitux (GC) Rebif (CIS) Cladribine (CIS) Safinamide (espd) Safinamide (lspd) Atacicept (SLE) Dominated by phase III projects, using up large parts of the resources Late-stage projects in non-core therapeutic areas Predominantly in-house projects Early-stage pipeline too light May 2012 MEK Inhibitor (cancer) NHS-IL 12 (cancer) c-met KI (cancer) Pimasertib (cancer) Pimasertib/PI3K (cancer) PI-2301 (MS) Fc-IFNbeta (MS) ARX 424 (MS) IFNbeta XR (MS) ATX-MS-1467 (MS) Sprifermin (OA) TH-302 (PC) Cilengitide (NSCLC) DI17E6 (CRC) DI17E6 (mcrpc) ONO-4641 (MS) Atacicept (SLE) Sprifermin(CIR) TH-302 (STS) Erbitux (GC) Stimuvax (NSCLC) Cilengitide (GBM) Kuvan (PKU ped.) Reasonable number of phase III projects in core therapeutic areas (e.g. oncology) Shared risk with partners, also in late-stage development (e.g. TH-302) Early-stage pipeline strengthened Pipeline has improved, but significant work remains 20

21 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 21

22 Merck Group New management in key positions and across the entire organization Divisions Merck Serono Corporate Head of Consumer Health Care Head of Merck Millipore Merck Serono Chief Operating Officer Head of Merck Serono Development Head of Corporate HR Head of Corporate Controlling Merck Group Changes within the top 30 positions: 34% since Jan 1, 2011, including three new board members New roles and new people to drive businesses forward 22

23 Merck Group We have aligned our compensation system to drive cultural change Old plan Annual Cash Bonus Individuals measured against many KPIs Limited upside for individual outperformance: 0-150% Bonus largely driven by collective group targets Stock Plan No incentives linked to stock New Plan Annual Cash Bonus Greater differentiation between over and underperformers Greater upside and downside: 0-200% Bonus based on individual and divisional performance Stock Plan Stock based plan Mandatory one-time co-invest of 10% annual gross salary 23

24 Merck Group Capturing savings will enable us to deliver attractive operating profitability Merck Serono net savings target 300m 2.73bn* 3bn 3.2bn* Merck Group EBITDA target 2014** 2011A 2014E * EBITDA pre one-time items ** does not reflect financial impact of new product launches in Merck Serono 24

25 Agenda 1. Update on Q Business portfolio strengthened 3. Delivering on efficiency 4. Exploiting opportunities for growth 5. Driving cultural change 6. Appendix 25

26 Merck Group Strong and healthy business with attractive gross margins compared to the industry 2011 Gross margins vs. industry average % of sales 100% Industry high Industry low 80% 60% 40% 20% 88% 69% 60% 58% 76% 0% Merck Serono Consumer Health Performance Materials Merck Millipore Merck Group Source: company analysis 26 Strong gross Strong profits and healthy reflect attractiveness business compared of products to peers and brands * GSK, Merck&Co, Sanofi-Aventis ** Bayer-CHC, Novartis-CHC, GSK-CHC

27 Merck Serono Restructuring Savings will predominantly ramp up in 2013 and 2014 Net 300m of savings Impact of savings by year m R&D Close down R&D hub Geneva Reduce fixed costs Trim HQ costs SG&A Reduce admin & marketing along with globalization of organization Ensure appropriate levels of customer facing contacts E 2013E 2014E Strong SG&A and healthy biggest business lever for compared improvement to peers * GSK, Merck&Co, Sanofi-Aventis ** Bayer-CHC, Novartis-CHC, GSK-CHC 27

28 Merck Serono Restructuring We will incur 600m in restructuring costs Timing of one-time costs Timing of cash outflows 400m 50% 25% R&D 25% 150m SG&A 50m SG&A 2012E 2013E 2014E 2012E 2013E 2014E Majority Strong of and one-time healthy costs business are cash-related compared to expenses peers * GSK, Merck&Co, Sanofi-Aventis ** Bayer-CHC, Novartis-CHC, GSK-CHC 28

29 Merck Group Merck strives for realistic Group targets Sales ( m) EBITDA pre ( m) EPS pre ( ) +4% - 8% +10% - 17% 10,350-10,700 3,000-3, % - 32% ,906 2, E E E * % of sales 27.5%* 29% 30%* Assumptions: Unchanged economic environment FX: EUR/USD = 1.35; EUR/CHF =

30 Merck Pharma Merck Serono mid-term financial targets Sales ( m) EBITDA pre ( m) +2% - 6% +15% - 21% 5,700-5,900 1,800-1, Assumptions: No new product launches Austerity measures will continue to put pressure on developed markets Emerging Markets will continue to fuel growth Royalty income to be expected to decrease to 180m 200m in 2014 * % of sales E E 28.2%* 31% 32%* Exploit Cost market savings potential will outside fundamentally Europe, especially improve in profitability Emerging Markets 30

31 Merck Pharma Consumer Health mid-term financial targets 494 Sales ( m) EBITDA pre ( m) +1% - 7% +27% - 53% Assumptions: Cost Containment, notably: Efficiencies on fixed cost structure Improvement on sales promotion activities Exit unprofitable products * % of sales E E 11.8%* ~15% 17%* Exploit Marketing market potential & selling outside savings Europe, drive especially profitability in Emerging improvement Markets 31

32 Merck Chemicals Performance Materials mid-term financial targets Sales ( m) EBITDA pre ( m) ~2% -9% - 0% , Assumptions: Slight margin erosion (volume up, price down) No new liquid crystal technologies launched * % of sales E E 46.6%* ~41% 45%* Exploit Performance market potential Materials outside remains Europe, especially an attractive in Emerging business Markets 32

33 Merck Chemicals Merck Millipore mid-term financial targets Sales ( m) EBITDA pre ( m) +11% - 15% % ~2,650-2,750 ~ Assumptions: Growth drivers predominantly: Asia Higher production of biologic drugs New products Bolt-on acquisitions High R&D maintained * % of sales E E 23.6%* ~23% 24%* Exploit market potential Solid outside growth Europe, business especially in Emerging Markets 33

34 Merck Group Ensure effective cash allocation 2012/2013 Deleveraging 03/2012: 500m bond (interest rate = 2.125%) 12/2012: 500m bond (interest rate = 3.75%) 09/2013: 750m bond (interest rate = 4.875%) Restructuring One-time costs : ~ 600m External Growth Bolt-on acquisitions 2012/2013 In-licensing deals in pharma No large, transformational transactions Dividend Stable dividend payment: 35-40% payout ratio (on adjusted net income, i.e. before one-time costs) 34

35 Merck Group Strengthened balance sheet through deleveraging bn Gross Financial Debt bn bn Interest savings Bond 03/12: 10m p.a. Bond 12/12: 20m p.a. Bond 09/13: 40m p.a Dec Dec Dec We will continue to reduce our gross and net debt 35

36 Merck Group Reliable dividend policy Dividend Payment Dividend Policy: Minimum Dividend : Target payout ratio: 35-40% of net income adjusted for onetime items (i.e. transformation costs) 1.00 Stable dividend will be assured over next three years despite one-time costs E 2013E 2014E Stable dividend payments ensure minimum return for shareholders 36

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