Pharmaceutical market structure

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2 Pharmaceutical market structure Russian pharmaceutical market volume in 2015 ~ billion, RUR* / 17,3 billion $* Consumer money State budget RETAIL 66,6 % 13,5 % Reimbursement 16% % 4% Retail 67% *Excluding biologically active additives (BAA) and additional assortment 17% Source: AlphaRM analytical database Hospital Reimbursement Target segment 13% 4% 66% % 3,9 % Hospitals Target segment** State procurement **Specially allocated funds

3 Russian market. General economic indicators Gross national product at current prices (nominal) ,2 % Gross national product in constant prices (in 2011 prices) ,9 % - 22,6 % Russian GDP, billion, RUR Russian GDP, billion, $ Russian GDP, billion, - 3,7 % ,3 % - 27,8 % Russian GDP, billion, RUR Russian GDP, billion, $ Russian GDP, billion,

4 Russian market. General economic indicators Inflation,% RUR ,9 11,36 6,1 6,58 6, Dynamics of the average salary % ,4 % ,1 % Average salary, RUR Average salary, $ Average salary,

5 Russian pharmaceutical market indicators Total market*, billion, RUR + 11,2 % + 13,2% Target segment Reimbursement Hospital Retail Total market*, billion, units - 2,2 % - 2 % ,2% - 26,5 % -12,6% Total market, RUR, billion Total market, $, billion Total market,, billion Source: AlphaRM analytical database *Excluding biologically active additive (BAA) and additional assortment

6 Russian pharmaceutical market. Pharmaceutical manufacturers rating 8 companies from TOP 10 grew up or stagnated in national currency in 2015 TOP 10 Other Company MS,% RUR, 2015 NOVARTIS (Switzerland) 5,24 PHARMSTANDART (Russia) 4,42 SANOFI (France) 4,01 TAKEDA (Japan) 3,03 BAYER (Germany) 2,86 Abbott (USA) 2,56 SERVIER (France) 2,55 Johnson & Johnson (USA) 2,37 STADA (Germany) 2,33 TEVA (Israel) 2,24 Source: AlphaRM analytical database

7 Retail. Pharmacies structure Pharmacy retail segment value ~ 927* billion rubles 1 st Q st Q 2016 Federal chains 22% 14% 17% 12% Regional chains Local chains 22% 15% 16% 14% Small local chains 35% Single pharmacies 33% TOTAL 50,6K +9,3 % TOTAL 55,3K *Including biologically active additives (BAA) and additional assortment Source: AlphaRM analytical database

8 Pharmacy chain Number of pharmacies Rigla (Moscow) (Moscow) A5 Group (Moscow) Planeta zdorovya (Perm) 901 Doctor Stoletov & Ozerki (Moscow) 292 Pervaya pomosch & Raduga (St. Petersburg) Imploziya (Samara) Pharmaimpex (Izhevsk) 589 Pharmland (Ufa) 585 Farmakopeyka & Tvoi doctor (Tula) 531 Pharmacy chain Retail. Pharmacies structure Pharmacy retail segment value ~ 927* billion rubles 1 st Q st Q 2016 *Including biologically active additives (BAA) and additional assortment Number of pharmacies MS, RUR Rigla (Moscow) , (Moscow) ,32 Planeta zdorovya (Perm) 950 2,53 Doctor Stoletov & Ozerki (Moscow) 312 2,51 Pervaya pomosch & Raduga (St. Petersburg) ,49 Imploziya (Samara) , 42 Pharmaimpex (Izhevsk) 592 1,61 Farmakopeyka & Tvoi doctor (Tula) 581 1,60 Neo-Pharm (Moscow) 240 1,53 Pharmland (Ufa) 625 1,53 Source: AlphaRM analytical database

9 Retail. Main indicators RX drugs grew more than OTC, share of imported drugs has not changed significantly RX OTC Other Essential drug list + 12,1 % 37,19% + 11,3% 36,90% 49,40% 48,93% + 14,1 % 50,60% 51,07% + 13,7% 62,81% 63,10% % 69% Import Local + 11,8 % + 16,1 % 32% 68%

10 Retail. Dynamics For the first three months of the year: growth in rubles ~ 1,1%, reduction in units ~ 8% RUR Units Billion, RUR Mln. - 5 % + 6,8% +2,8% JANUARY FEBRUARY MARCH - 7,2% - 3,7% - 14,7% JANUARY FEBRUARY MARCH Source: AlphaRM analytical database

11 State procurement. Structure State segment shows small but steady growth in national currency ,4 % Target segment Reimbursement Hospital Billion, RUR Hospitals Reimbursement Target segment (Specially allocated funds) > stationary hospital, > outpatient clinic High-cost nosology, ONLS program, Regional reimbursement Federal and regional target (special -purpose) program, Departmental and social institutions 47,8 % 40,4 % 11,8 %

12 State procurement. Main indicators RX OTC 5,09% 1,25% 2,69% 29,68% Essential drug list Other 20,92% 17,17% 94,91% 98,75% 97,31% 70,32% 79,08% 82,83% Hospital Reimbursement Target market Hospital Reimbursement Target market % 81% + 3 % Import + 27 % Local 22% 78%

13 Dynamics of state procurement market Completed tenders value Mln., RUR October November December January February March Source: AlphaRM analytical database

14 Russian pharmaceutical market. Dynamics ,3 239,7 251,9 325,2 235,7 Q1 2015/ Q ,2 % State segment Retail segment Billion, RUR Q Q Q32015 Q Q Source: AlphaRM analytical database

15 Russian total market general economic indicators. Forecast Inflation,% 11,36 12,9 8,78 6,45 6,1 6,58 7, F Russian GDP (nominal) % ,1 % ,6 % Russian GDP, billion, RUR Russian GDP, billion, $ F 1000 Russian GDP, billion,

16 Russian pharmaceutical market Forecast 2016 The pharmaceutical market will exceed billion rubles* in % /+ 10 % + 11,2 % Billion, RUR F - 2,2 % - 1 % / -6 % Target segment Reimbursement Hospital Retail Billion, Units F

17 Russian pharmaceutical market Forecast 2016 The pharmaceutical market will increase by 3% - 10% in rubles* in ,5 % + 6 % ,2 % - 2,8 % Total market, RUR, billion Total market, $, billion Total market,, billion ,6 % - 3,2 % F 14 *Excluding biologically active additive (BAA) and additional assortment

18 Main trends for the year 2016 Retail segment: growth of the pharmacy chains segment share; consolidation of wholesale (distribution) segment; market growth while reducing the purchasing power of consumers; reorientation of consumers to purchase more cheaper analogues or generics. State segment: decreasing of the share of imported medicines in the structure of purchases (in the framework of the program of "Import substitution", in particular the adoption of the so-called Odd man out" resolution); reduction in funding regional target and reimbursement programs; waiting for starting of pilot projects of the pharmaceutical insurance system.

19 Thank you for your attention!

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