COUNTRIES IN EUROPE/RUSSIA, 2008 AND 2013 (MILLIONS)... 21

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1 CHAPTER ONE: INTRODUCTION... 1 STUDY GOALS AND OBJECTIVES... 1 REASONS FOR DOING THE STUDY... 1 SCOPE OF REPORT... 1 METHODOLOGY... 1 ANALYST CREDENTIALS... 2 RELATED BCC STUDIES... 2 BCC RESEARCH ONLINE SERVICES... 2 DISCLAIMER... 3 CHAPTER TWO: SUMMARY... 4 COSMETIC SURGERY MARKETS: MAJOR MARKETS SUMMARY... 4 LEADING PRODUCTS AND MANUFACTURERS... 4 SUMMARY TABLE GLOBAL COSMETIC SURGERY MARKET ANALYSIS BY SEGMENT, THROUGH 2013 ($ MILLIONS)... 5 SUMMARY FIGURE TOTAL GLOBAL COSMETIC SURGERY MARKET ANALYSIS BY SEGMENT, ($ MILLIONS)... 5 CHAPTER THREE: INDUSTRY OVERVIEW... 6 REGIONAL OVERVIEW... 6 UNITED STATES... 6 TABLE 1 LEADING COSMETIC PROCEDURES FOR MEN AND WOMEN, 2007 (THOUSANDS)... 6 TABLE 2 NUMBER OF U.S. COSMETIC PROCEDURES BY AGE, FIGURE 1 NUMBER OF U.S. COSMETIC PROCEDURES BY AGE, TABLE 3 COSMETIC PROCEDURES BY U.S. REGION, 2007 (%)... 8 FIGURE 2 COSMETIC PROCEDURES BY U.S. REGION, 2007 (%)... 8 UNITED KINGDOM... 9 TABLE 4 LEADING COSMETIC PROCEDURES FOR MEN AND WOMEN IN THE U.K., 2008 (%)... 9 CANADA... 9 REGULATORY STUCTURE... 9 UNITED STATES TABLE 5 MEDICAL SPECIALTIES (PARTS OF 21 CFR) EUROPEAN MEDICAL DEVICE APPROVALS JAPAN Japan (Continued) POPULATION AND GENDER DEMOGRAPHICS NORTHERN AMERICA AND GREENLAND TABLE 6 POPULATION AND AGE FIGURES FOR THE TWO MOST POPULATED COUNTRIES IN NORTHERN AMERICA/GREENLAND, 2008 (MILLIONS)... 16

2 TABLE 7 POPULATION AND AGE FIGURES FOR THE TWO MOST POPULATED COUNTRIES IN NORTHERN AMERICA/GREENLAND, 2013 (MILLIONS) FIGURE 3 POPULATIONS FOR THE TWO MOST POPULATED COUNTRIES IN NORTHERN AMERICA/GREENLAND, 2008 AND 2013 (MILLIONS) North America Gender Figures and Projections TABLE 8 GENDER FIGURES FOR THE TWO MOST POPULATED COUNTRIES IN NORTHERN AMERICA, 2008 AND 2013 (MILLIONS) EUROPE AND RUSSIA TABLE 9 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN EUROPE/RUSSIA, 2008 (MILLIONS) TABLE 10 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN EUROPE/RUSSIA, 2013 (MILLIONS) FIGURE 4 POPULATIONS FOR THE FIVE MOST-POPULATED COUNTRIES IN EUROPE/RUSSIA, 2008 AND 2013 (MILLIONS) European Gender Figures and Projections TABLE 11 GENDER FIGURES FOR THE FIVE MOST-POPULATED COUNTRIES IN EUROPE/RUSSIA, 2008 AND 2013 (MILLIONS) ASIA TABLE 12 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN ASIA, 2008 (MILLIONS) TABLE 13 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN ASIA, 2013 (MILLIONS) FIGURE 5 POPULATIONS FOR THE FIVE MOST POPULATED COUNTRIES IN ASIA, 2008 AND 2013 (MILLIONS) Asia Gender Figures and Projections TABLE 14 GENDER FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN ASIA-PACIFIC, 2008 AND 2013 (MILLIONS) LATIN AMERICA AND THE CARIBBEAN TABLE 15 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN LATIN AMERICA AND THE CARIBBEAN, 2008 (MILLIONS) TABLE 16 POPULATION AND AGE FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN LATIN AMERICA AND THE CARIBBEAN, 2013 (MILLIONS) FIGURE 6 POPULATIONS FOR THE FIVE MOST POPULATED COUNTRIES IN LATIN AMERICA AND THE CARIBBEAN, 2008 AND 2013 (MILLIONS) Latin America and the Caribbean Gender Figures and Projections... 26

3 TABLE 17 GENDER FIGURES FOR THE FIVE MOST POPULATED COUNTRIES IN LATIN AMERICA AND THE CARIBBEAN, 2008 AND 2013 (MILLIONS) STATISTICS OF COMMON CONDITIONS NORTHERN AMERICA/GREENLAND TABLE 18 NORTHERN AMERICAN INCIDENCE/PREVALENCE OF CONDITION/DISEASE, 2008 AND 2013 (MILLIONS) TABLE 19 NORTHERN AMERICAN/GREENLAND POPULATIONS SEEKING SELECTED SERVICE/PRODUCTS, 2008 AND 2013 (MILLIONS) EUROPE/RUSSIA TABLE 20 EUROPEAN/RUSSIAN INCIDENCE/PREVALENCE OF CONDITION/DISEASE, 2008 AND 2013 (MILLIONS) TABLE 21 EUROPEAN/RUSSIAN POPULATIONS SEEKING SELECTED SERVICE/PRODUCTS, 2008 AND 2013 (MILLIONS) ASIA PACIFIC TABLE 22 ASIA PACIFIC INCIDENCE/PREVALENCE OF CONDITION/DISEASE, 2008 AND 2013 (MILLIONS) TABLE 23 ASIA PACIFIC POPULATIONS SEEKING SELECTED SERVICE/PRODUCTS, 2008 AND 2013 (MILLIONS) LATIN AMERICA TABLE 24 LATIN AMERICAN INCIDENCE/PREVALENCE OF CONDITION/DISEASE, 2008 AND 2013 (MILLIONS) TABLE 25 LATIN AMERICAN POPULATIONS SEEKING SELECTED SERVICE/PRODUCTS, 2008 AND 2013 (MILLIONS) CHAPTER FOUR: ISSUES AFFECTING THE MARKET CONSUMER TRENDS IN RESPONSE TO U.S. ECONOMIC DOWNTURN SAFETY ISSUES SILICONE BREAST IMPLANT ISSUES IN THE U.S Silicone Breast Implant (Continued) COMPLICATIONS TABLE 26 COSMETIC SURGERY COMPLICATIONS WOUND HEALING COMPLICATIONS OF SURGERY Scarring Adhesions Dehiscence Evisceration Infection Hemorrhage Fistulas COSMETIC FILLER COMPLICATIONS TABLE 27 NUMBER OF ADVERSE EVENTS ASSOCIATED WITH DERMAL FILLERS REPORTED TO THE FDA,

4 FIGURE 7 NUMBER OF ADVERSE EVENTS ASSOCIATED WITH DERMAL FILLERS REPORTED TO THE FDA, TABLE 28 COUNTRY OF ORIGIN FOR ADVERSE EVENTS ASSOCIATED WITH DERMAL FILLERS AS REPORTED TO THE FDA, TABLE 29 DERMAL FILLER ADVERSE EVENTS BY INJECTION SITE TABLE 30 FREQUENCY OF ADVERSE EVENTS ASSOCIATED WITH DERMAL FILLERS FIGURE 8 FREQUENCY OF ADVERSE EVENTS ASSOCIATED WITH DERMAL FILLERS WOUND CLOSURE TRENDS AND SURGICAL SEALANTS PRODUCT EXAMPLES MEDICAL TOURISM AND COSMETIC SURGERY TABLE 31 COST OF COSMETIC PROCEDURES IN THE U.S. AND INTERNATIONAL COUNTRIES ($) SPA INDUSTRY TABLE 32 U.S. SPA VISITATION STATISTICS AND GENERATED REVENUES, TABLE 33 NUMBER OF SPAS BY TYPE, MEDICAL SPAS TABLE 34 REVENUES BY SPA TYPE, 2005 AND 2006 ($ MILLIONS) NEW DEVELOPMENTS IN INJECTABLES COMPANY ACQUISITIONS, COLLABORATIONS, AND ALLIANCES MEDICIS PHARMACEUTICALS AND LIPOSONIX BIOFORM MEDICAL AND ADVANCED COSMETIC INTERVENTION MENTOR CORP. AND PEROUSE PLASTIE SAS ALLERGAN AND COVIDIEN, LTD BIOFORM MEDICAL AND CHEMISCHE FABRIK KREUSSLER & CO ALLERGAN AND ENDOART S.A ALLERGAN AND GROUPE CORNÉAL LABORATORIES BIOFORM MEDICAL AND CRYOLIFE ALLERGAN AND INAMED CORP PALOMAR MEDICAL TECHNOLOGIES AND JOHNSON & JOHNSON CONSUMER COMPANIES INTERNATIONAL MARKET TRENDS CHINA INDIA BRAZIL ARGENTINA UNITED KINGDOM JAPAN... 53

5 CHAPTER FIVE: BODY CONTOURING AND SKIN REJUVENATION PROCEDURES DESCRIPTION OF PROCEDURES ABDOMINOPLASTY BREAST IMPLANTS, AUGMENTATION, MASTOPEXY, AND REDUCTION LIPOSUCTION OTHER PROCEDURES PRODUCT DESCRIPTIONS EQUIPMENT AND INSTRUMENTS Cynosure Medicis Pharmaceuticals Mentor Corp Palomar Syneron IMPLANTS Allergan Allied Biomedical Mentor Corp Nagor, Ltd Polytech Health and Aesthetics GmbH Sientra OTHER DEVICES Allergan MARKET ANALYSIS PRODUCT MARKET SIZE AND GROWTH Equipment and Instruments TABLE 35 GLOBAL BODY CONTOURING PRODUCT REVENUES BY EQUIPMENT TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 9 GLOBAL BODY CONTOURING PRODUCT REVENUES BY EQUIPMENT TYPE, ($ MILLIONS) Body Implants and Other Implantable Devices TABLE 36 GLOBAL BODY CONTOURING PRODUCT REVENUES BY IMPLANT TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 10 GLOBAL BODY CONTOURING PRODUCT REVENUES BY IMPLANT TYPE, ($ MILLIONS) SERVICE MARKET SIZE AND GROWTH TABLE 37 GLOBAL BODY CONTOURING SERVICE REVENUES BY TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 11 GLOBAL BODY CONTOURING SERVICE REVENUES BY TYPE, ($ MILLIONS) TABLE 38 GLOBAL BODY CONTOURING SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, THROUGH 2013 ($ MILLIONS)... 64

6 FIGURE 12 GLOBAL BODY CONTOURING SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, ($ MILLIONS) GLOBAL MARKET ANALYSIS Northern America Europe Asia Pacific Latin America COMPETITIVE STRUCTURE AND MARKET SHARE TABLE 39 COMPETITIVE SUMMARY FOR BODY CONTOURING PRODUCTS BY COMPETITOR REVENUE, 2008 ($ MILLIONS) FIGURE 13 COMPETITIVE SUMMARY FOR BODY CONTOURING PRODUCTS BY COMPETITOR REVENUE, 2008 (%) CHAPTER SIX: FACIAL RECONSTRUCTION AND REJUVENATION PROCEDURES DESCRIPTION OF PROCEDURES BLEPHAROPLASTY (EYELID SURGERY) RHINOPLASTY (NOSE SURGERY) FACELIFT FOREHEAD/BROW LIFT BOTOX HA DERMABRASION/MICRODERMABRASION CHEMICAL PEELS OTHER INJECTABLE PROCEDURES OTHER PROCEDURES PRODUCT DESCRIPTIONS EQUIPMENT AND INSTRUMENTS Laser and Light-Based Technology Candela Corp Cutera Cynosure Iridex Lumenis Palomar Medical Technologies Syneron Medical Radiofrequency Technology Solta Medical IMPLANTS Nagor, Ltd Polytech Health and Aesthetics GmbH Surgiform SurgiSil, LLP INJECTABLE MATERIALS... 77

7 Botulinium Toxin Allergan Galderma Medicis Collagen Allergan Ortho Dermatologics HA Allergan Anika Therapeutics Medicis Pharmaceuticals Mentor Corp Other Injectables BioForm Medical MARKET ANALYSIS PRODUCT MARKET SIZE AND GROWTH Equipment and Instruments TABLE 40 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY EQUIPMENT TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 14 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY EQUIPMENT TYPE, ($ MILLIONS) Facial Implants TABLE 41 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY IMPLANT TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 15 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY IMPLANT TYPE, THROUGH 2013 ($ MILLIONS) Injectable Materials TABLE 42 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY INJECTABLE MATERIAL, THROUGH 2013 ($ MILLIONS) FIGURE 16 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION PRODUCT REVENUES BY INJECTABLE MATERIAL, ($ MILLIONS) SERVICE MARKET SIZE AND GROWTH TABLE 43 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION SERVICE REVENUES BY TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 17 FACIAL RECONSTRUCTION AND REJUVENATION SERVICE REVENUES BY TYPE, THROUGH 2013 ($ MILLIONS)... 87

8 TABLE 44 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, THROUGH 2013 ($ MILLIONS) FIGURE 18 GLOBAL FACIAL RECONSTRUCTION AND REJUVENATION SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, ($ MILLIONS) GLOBAL MARKET ANALYSIS Northern America Europe Asia Pacific Latin America COMPETITIVE STRUCTURE AND MARKET SHARE TABLE 45 GLOBAL COMPETITIVE SUMMARY FOR FACIAL RECONSTRUCTION AND REJUVENATION PRODUCTS BY COMPETITOR REVENUE, 2008 ($ MILLIONS) FIGURE 19 GLOBAL COMPETITIVE SUMMARY FOR FACIAL RECONSTRUCTION AND REJUVENATION PRODUCTS BY COMPETITOR REVENUE, 2008 (%) CHAPTER SEVEN: OTHER COSMETIC PROCDURES DESCRIPTIONS OF PROCEDURES SCLEROTHERAPY LASER HAIR REMOVAL HAIR TRANSPLANT/RESTORATION PRODUCT DESCRIPTION EQUIPMENT AND INSTRUMENTS Laser and Light-based Technology Candela Corp Cutera Cynosure Iridex Lumenis Palomar Medical Technologies Syneron Medical OTHER PRODUCTS Implants Polytech Health and Aesthetics GmbH Sientra Miscellaneous Products Chemische Fabrik Kreussler & Co MARKET ANALYSIS PRODUCT MARKET SIZE AND GROWTH Equipment and Instruments TABLE 46 GLOBAL OTHER COSMETIC PROCEDURE PRODUCT REVENUES BY TYPE, THROUGH 2013 ($ MILLIONS)... 99

9 FIGURE 20 GLOBAL OTHER COSMETIC PROCEDURE PRODUCT REVENUES BY EQUIPMENT TYPE, THROUGH 2013 ($ MILLIONS) SERVICE MARKET SIZE AND GROWTH TABLE 47 GLOBAL OTHER COSMETIC PROCEDURE SERVICE REVENUES BY TYPE, THROUGH 2013 ($ MILLIONS) FIGURE 21 GLOBAL OTHER COSMETIC PROCEDURE SERVICE REVENUES BY TYPE, ($ MILLIONS) TABLE 48 GLOBAL OTHER COSMETIC PROCEDURE SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, THROUGH 2013 ($ MILLIONS) FIGURE 22 GLOBAL OTHER COSMETIC PROCEDURE SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, ($ MILLIONS) GLOBAL MARKETS ANALYSIS Northern America Europe Asia Pacific Latin America COMPETITIVE STRUCTURE AND MARKET SHARE TABLE 49 GLOBAL COMPETITIVE SUMMARY FOR OTHER COSMETIC PROCEDURE PRODUCTS BY COMPETITOR REVENUE, 2008 ($ MILLIONS) FIGURE 23 GLOBAL COMPETITIVE SUMMARY FOR OTHER COSMETIC PROCEDURE PRODUCTS BY COMPETITOR REVENUE, 2008 (%) CHAPTER EIGHT: MARKET SUMMARY TOTAL MARKET FOR COSMETIC SURGERY PRODUCTS TABLE 50 TOTAL GLOBAL MARKET FOR COSMETIC SURGERY BY PRODUCT SEGMENT, THROUGH 2013 ($ MILLIONS) FIGURE 24 TOTAL GLOBAL MARKET FOR COSMETIC SURGERY BY PRODUCT SEGMENT, ($ MILLIONS) TOTAL WORLD MARKET FOR COSMETIC SURGERY SERVICES TABLE 51 TOTAL GLOBAL MARKET FOR COSMETIC SURGERY SERVICE BY SERVICE AREA, THROUGH 2013 ($ MILLIONS) FIGURE 25 TOTAL GLOBAL MARKET FOR COSMETIC SURGERY SERVICES BY SERVICE AREA, ($ MILLIONS) TABLE 52 GLOBAL COSMETIC PROCEDURE SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, THROUGH 2013 ($ MILLIONS) FIGURE 26 GLOBAL COSMETIC PROCEDURE SERVICE REVENUES BY INVASIVE AND NONINVASIVE REVENUES, ($ MILLIONS) CHAPTER NINE: TECHNOLOGY

10 CURRENT USES OF TECHNOLOGY VASER LIPOSELECTION ULTRASHAPE TECHNOLOGY SUTURE LIFT NON-CUTTING DOUBLE EYELIDS NEW DEVELOPMENTS ALLERGAN MEDICIS PHARMACEUTICALS MENTOR CORP BIOFORM MEDICAL PATENT EVALUATION FOR LEADING SURGICAL PROCEDURES LIPOSUCTION PATENTS TABLE 53 U.S. LIPOSUCTION PATENTS, AUGUST 1987 THROUGH JUNE TABLE 53 (CONTINUED) FIGURE 27 NUMBER OF U.S. LIPOSUCTION PATENTS BY TYPE, AUGUST 1987 TO JUNE FIGURE 28 U.S. LIPOSUCTION PATENT INFORMATION BY COMPANY, AUGUST 1987 THROUGH JUNE BREAST IMPLANT AND BREAST AUGMENTATION TABLE 54 U.S. BREAST IMPLANT AND BREAST AUGMENTATION PATENTS TABLE 54 (CONTINUED) FIGURE 29 NUMBER OF U.S. BREAST IMPLANT AND BREAST AUGMENTATION PATENTS BY TYPE FIGURE 30 NUMBER OF U.S. BREAST IMPLANT AND BREAST AUGMENTATION PATENTS BY COMPANY RHINOPLASTY TABLE 55 U.S. RHINOPLASTY PATENTS BLEPHAROPLASTY TABLE 56 U.S. BLEPHAROPLASTY PATENTS ABDOMINOPLASTY TABLE 57 ABDOMINOPLASTY PATENTS LEADING COMPANIES IN COSMETIC SURGERY PATENTS CHAPTER TEN: COMPANY PROFILES ALLERGAN, INC FIGURE 31 ALLERGAN S COMPANY REVENUES, ($ MILLIONS) BIOFORM MEDICAL, INC FIGURE 32 BIOFORM S COMPANY REVENUES, ($ MILLIONS) CANDELA CORP CANDELA CORP. (CONTINUED)

11 FIGURE 33 CANDELA S COMPANY REVENUES, ($ MILLIONS) CUTERA, INC FIGURE 34 CUTERA S COMPANY REVENUES, ($ MILLIONS) CYNOSURE, INC FIGURE 35 CYNOSURE S COMPANY REVENUES, ($ MILLIONS) IRIDEX CORP FIGURE 36 IRIDEX S COMPANY REVENUES, ($ MILLIONS) LUMENIS, LTD LUMENIS, LTD. (CONTINUED) FIGURE 37 LUMENIS COMPANY REVENUES, ($ MILLIONS) MEDICIS PHARMACEUTICAL CORP FIGURE 38 MEDICIS COMPANY REVENUES, ($ MILLIONS) MENTOR CORP. (SUBSIDIARY OF JOHNSON & JOHNSON) FIGURE 39 MENTOR S COMPANY REVENUES, ($ MILLIONS) PALOMAR MEDICAL TECHNOLOGIES, INC FIGURE 40 PALOMAR S COMPANY REVENUES, ($ MILLIONS) FIGURE 40 (CONTINUED) SOLTA MEDICAL, INC. (FORMERLY THERMAGE) FIGURE 41 SOLTA S COMPANY REVENUES, ($ MILLIONS) SYNERON MEDICAL, LTD FIGURE 42 SYNERON S COMPANY REVENUES, ($ MILLIONS) FIGURE 42 (CONTINUED) APPENDIX I: PRODUCT SUPPLIERS PRODUCT SUPPLIERS PRODUCT SUPPLIERS (CONTINUED) PRODUCT SUPPLIERS (CONTINUED) PRODUCT SUPPLIERS (CONTINUED)