Second Quarter and First Half 2018 Results. Supporting healthcare professionals for over 150 years

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Second Quarter and First Half 2018 Results Supporting healthcare professionals for over 150 years 1

Forward looking statements and non-ifrs measures This document may contain forward-looking statements that may or may not prove accurate. For example, statements regarding expected revenue growth and trading margins, market trends and our product pipeline are forward-looking statements. Phrases such as "aim", "plan", "intend", "anticipate", "well-placed", "believe", "estimate", "expect", "target", "consider" and similar expressions are generally intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from what is expressed or implied by the statements. For Smith & Nephew, these factors include: economic and financial conditions in the markets we serve, especially those affecting health care providers, payers and customers; price levels for established and innovative medical devices; developments in medical technology; regulatory approvals, reimbursement decisions or other government actions; product defects or recalls or other problems with quality management systems or failure to comply with related regulations; litigation relating to patent or other claims; legal compliance risks and related investigative, remedial or enforcement actions; disruption to our supply chain or operations or those of our suppliers; competition for qualified personnel; strategic actions, including acquisitions and dispositions, our success in performing due diligence, valuing and integrating acquired businesses; disruption that may result from transactions or other changes we make in our business plans or organisation to adapt to market developments; and numerous other matters that affect us or our markets, including those of a political, economic, business, competitive or reputational nature. Please refer to the documents that Smith & Nephew has filed with the U.S. Securities and Exchange Commission under the U.S. Securities Exchange Act of 1934, as amended, including Smith & Nephew's most recent annual report on Form 20-F, for a discussion of certain of these factors. Any forward-looking statement is based on information available to Smith & Nephew as of the date of the statement. All written or oral forward-looking statements attributable to Smith & Nephew are qualified by this caution. Smith & Nephew does not undertake any obligation to update or revise any forward-looking statement to reflect any change in circumstances or in Smith & Nephew's expectations. Certain items included in trading results, such as trading profit, trading profit margin, tax rate on trading results, trading cash flow, trading profit to cash conversion ratio, EPSA and underlying growth are non-ifrs financial measures. The non-ifrs financial measures in this announcement are explained and reconciled to the most directly comparable financial measure prepared in accordance with IFRS in our Second Quarter and First Half 2018 Results announcement dated 26 July 2018. 2

Namal Nawana Chief Executive Officer 3

Initial thoughts: A portfolio medical device company AWB 6% AWD 4% 14% Sports Medicine Joint Repair H1 2018 revenue split AWC 15% 13% Arthroscopic Enabling Technologies Hips 13% 10% 4% Trauma and Extremities 21% Other Surgical Businesses Knees Second Quarter and First Half 2018 Results 4

Initial thoughts: Our leading medical technologies Emerging REGENETEN NAVIO REDAPT WEREWOLF JOURNEY II BCS ALLEVYN LIFE INTERTAN POLARSTEM PICO 7 5

Initial thoughts: Improving how we do business Commercial model Operating model Focus more on lead products Provide leadership in each category A more customer centric approach Faster, more streamlined decision making First steps taken to new leadership structure Take complexity and costs out deliver on APEX Creating a purpose-driven culture 6

Q2 revenue of $1,245m; 4% reported growth, 2% underlying Geographical growth Revenue split Product franchise growth Sports Medicine Joint Repair 8% 1% US Arthroscopic Enabling Tech Trauma & Extremities Other surgical -5% -1% 8% Knees 3% 1% Other Est Hips 1% 2% 6% Emerging AWC AWB AWD -6% 9% 0% 5% 10% -10% 0% 10% Other Est is Australia, Canada, Europe, Japan and New Zealand Other Surgical includes ENT and robotics sales (excluding implant sales) All revenue growth rates in the presentation are on an underlying basis and without adjustment for number of selling days, unless otherwise stated 7

Sports Medicine, Trauma & OSB Q2 revenue performance Sports Medicine Joint Repair +8% ($173m) Arthroscopic Enabling Technologies (AET) -1% ($153m) Trauma & Extremities -5% ($122m) Other Surgical Businesses* +8% ($54m) Commentary REGENETEN (Rotation Medical) performing strongly in shoulder repair AET improving, focus on driving WEREWOLF COBLATION Trauma decline reflects Middle East tender order in Q2 2017 EVOS SMALL Plating System * Other Surgical Businesses includes ENT and robotics sales (excluding implant sales) 8

Reconstruction Q2 revenue performance Knees: global +3%, US +1%, OUS +6% ($258m) Hips: global +1%, US +4%, OUS -1% ($156m) Commentary Knees growth driven by JOURNEY II, LEGION and ANTHEM systems Renewed focus on POLAR3 total hip solution and leading survivorship data POLAR3 Total Hip Solution 9

Advanced Wound Management Q2 revenue performance Advanced Wound Care +2% ($187m) Advanced Wound Bioactives -6% ($87m) Advanced Wound Devices +9% ($55m) Commentary AWC growing overall, but still soft in Europe SANTYL improved sequentially NICE issued Medtech Innovation Briefing on prophylactic use of PICO in prevention of Surgical Site Complications a first in NPWT PICO 7 Single Use Negative Pressure Wound Therapy System 10

Ian Melling SVP Group Finance 11

H1 trading income statement Half Year 2018 $m 2017 $m Revenue 2,440 2,336 Cost of goods sold (651) (603) Gross profit 1,789 1,733 Gross profit margin 73.3% 74.2% Selling, general and admin (1,168) (1,133) Research and development (114) (107) Trading profit 507 493 Trading profit margin 20.8% 21.1% 1% underlying growth 30bps decline 12

H1 EPSA and EPS 2018 $m Half Year 2017 $m Growth Trading profit 507 493 3% Net interest payable (25) (25) Other finance costs (7) (4) Share of results from associate 2 - Adjusted profit before tax 477 464 3% Taxation on trading result (96) (88) Adjusted attributable profit 381 376 1% Weighted average number of shares (m) 873 874 Adjusted earnings per share ("EPSA") 43.7 43.0 2% Earnings per share ("EPS") 31.4 37.0 (15%) Tax rate (1) : 20.1% (H1 2017: 19.0%) Interim dividend: 14 cents (+14%) (1) Tax rate on trading result 13

H1 free cash flow Half Year 2018 $m 2017 $m Trading profit 507 493 Share based payment 18 15 Depreciation and amortisation 171 154 Capital expenditure (178) (178) Movements in working capital and other (131) (157) Trading cash flow 387 327 Trading cash conversion 76% 66% Restructuring, acquisition, legal & other (147) (67) Net interest paid (26) (25) Taxation paid (95) (62) Free cash flow 119 173 14

2018 Guidance Sales growth Underlying: 2% to 3% Reported (1) : around 3% to 4% Trading profit margin At or above 2017 levels Tax rate (2) : 20-21% (1) Based on exchange rates prevailing on 20 th July 2018 (2) Tax rate on trading result 15

Summary

Appendices 17

2018 technical guidance July 2018 Foreign exchange and other revenue impact Impact of translational FX* on revenue +1.1% Acquisition impact on revenue +0.3% Exceptional items Restructuring costs c. $100m Acquisition and integration costs c. $5m European Medical Device Regulation (MDR) compliance costs $20m-$30m Other Amortisation of acquisition intangibles c. $110m Income from associates c. $5m Net interest $51m - $55m Other finance costs c. $15m Tax rate on trading result 20-21% * Based on the foreign exchange rates prevailing on 20 th July 2018 18

H1 IFRS reconciliation 2018 $m Half year 2017 $m Growth Trading profit 507 493 3% Trading profit margin 20.8% 21.1% (30bps) Acquisition related costs (2) (2) Restructuring and rationalisation (58) - Amortisation of acquisition intangibles (57) (65) Legal and other items (18) (12) IFRS Operating profit 372 414 (10%) Operating profit margin 15.3% 17.7% (240bps) 19

Franchise revenue analysis Q1 Q2 Q3 Q4 2017 2018 Full Year Growth Growth Growth Growth Growth Growth Revenue Growth % % % % % % $m % Sports Medicine, Trauma & OSB 4 3 2 2 3 1 502 2 Sports Medicine Joint Repair 7 5 8 6 6 6 173 8 Arthroscopic Enabling Technologies (1) (4) (3) (3) (3) (5) 153 (1) Trauma & Extremities 5 7 (2) 5 4 (2) 122 (5) Other Surgical Businesses 7 11 6 4 7 9 54 8 Q1 Q2 Reconstruction 3 2 4 4 3 0 414 3 Knee Implants 5 4 6 6 5 2 258 3 Hip Implants 0 (1) 1 1 0 (2) 156 1 Advanced Wound Management 1 3 2 0 2 (2) 329 1 Advanced Wound Care 1 2 (1) (3) 0 0 187 2 Advanced Wound Bioactives (8) 0 7 0 0 (12) 87 (6) Advanced Wound Devices 16 14 8 14 13 2 55 9 Group 3 3 3 2 3 0 1,245 2 All revenue growth rates are on an underlying basis and without adjustment for number of selling days 20

Regional revenue analysis Q1 Q2 Q3 Q4 2017 2018 Full Year Growth Growth Growth Growth Growth Growth Revenue Growth % % % % % % $m % Q1 Q2 Geographic regions US 1 2 2 1 2 (2) 590 1 Other Established Markets 1 (1) 0 (1) 0 (2) 429 1 Established Markets 1 1 1 0 1 (2) 1,019 1 Emerging Markets 12 13 9 14 12 9 226 6 Group 3 3 3 2 3 0 1,245 2 Other Established Markets is Australia, Canada, Europe, Japan and New Zealand. All revenue growth rates are on an underlying basis and without adjustment for number of selling days 21

H1 revenue of $2,440m; 4% reported growth, 1% underlying Geographical growth Revenue split Product franchise growth -1% US Sports Medicine Joint Repair Arthroscopic Enabling Tech Trauma & Extremities Other surgical -3% -3% 7% 9% Knees 3% 0% Other Est Hips 0% 1% 8% -5% 0% 5% 10% Emerging AWC AWB AWD -8% 6% -10% 0% 10% Other Est is Australia, Canada, Europe, Japan and New Zealand Other Surgical includes ENT and robotics sales (excluding implant sales) All revenue growth rates in the presentation are on an underlying basis and without adjustment for number of selling days, unless otherwise stated 22

Trading days per quarter Q1 Q2 Q3 Q4 Full Year 2016 64 64 63 60 251 2017 64 63 63 60 250 2018 63 64 63 61 251 Year-on-year differences in the number of trading days typically impacts our surgical businesses in the Established Markets more than our wholesaler and distributor-supported businesses. We define trading days as week days adjusted for significant holidays in our principal countries. 23