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Morgan Stanley Institutional Liquidity Funds Institutional Class Portfolios Prime Portfolio Money Market Portfolio Government Portfolio Government Securities Portfolio Treasury Portfolio Treasury Securities Portfolio Tax-Exempt Portfolio Prospectus February 28, 2018 Fund Ticker Symbol Prime Portfolio MPFXX Money Market Portfolio MPUXX Government Portfolio MVRXX Government Securities Portfolio MUIXX Treasury Portfolio MISXX Treasury Securities Portfolio MSUXX Tax-Exempt Portfolio MTXXX e-delivery: Go Paperless. It s faster, easier and greener. Sign up today at: www.icsdelivery.com May not be available for all accounts. The Securities and Exchange Commission ( SEC ) has not approved or disapproved these securities or passed upon the adequacy of this Prospectus. Any representation to the contrary is a criminal offense. LFICPRO 2/18

Table of Contents Page Fund Summary 1 Prime Portfolio 1 Money Market Portfolio 4 Government Portfolio 7 Government Securities Portfolio 9 Treasury Portfolio 11 Treasury Securities Portfolio 13 Tax-Exempt Portfolio 15 Details of the Funds 17 Prime Portfolio 17 Money Market Portfolio 18 Government Portfolio 19 Government Securities Portfolio 21 Treasury Portfolio 22 Treasury Securities Portfolio 23 Tax-Exempt Portfolio 24 Additional Information About the Funds Investment Strategies and Related Risks 26 Shareholder Information 30 Fund Management 38 Financial Highlights 39

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Prime Portfolio Objective The Prime Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.08% Total Annual Fund Operating Expenses 1 0.23% Fee Waiver and/or Expense Reimbursement 1 0.03% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $71 $126 $290 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. Principal Investment Strategies The Fund invests in liquid, high quality U.S. dollardenominated money market instruments of U.S. and foreign financial corporations and U.S. non-financial corporations. The Fund also invests in obligations issued or guaranteed by the U.S. Government and its agencies and instrumentalities. The Fund s money market investments may include commercial paper, corporate debt obligations, debt obligations (including certificates of deposit and promissory notes) of U.S. banks or foreign banks, or of U.S. branches or subsidiaries of foreign banks, or foreign branches of U.S. banks (such as Yankee obligations), certificates of deposit of savings banks and savings and loan organizations, asset-backed securities, repurchase agreements and municipal obligations. The Fund may also invest in U.S. dollar-denominated foreign securities and money market instruments. The Fund operates as an institutional money market fund, which is neither a government money market fund nor retail money market fund as such terms are defined or interpreted under Rule 2a-7 under the Investment Company Act of 1940, as amended (the 1940 Act ). As such, the Fund is required to price and transact in its shares at a net asset value per share ( NAV ) reflecting market-based values of its portfolio holdings (i.e., at a floating NAV), rounded to a minimum of the fourth decimal place. Like other money market funds of its type, the Fund is subject to the possible imposition of liquidity fees and/ or redemption gates. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Because the share price of the Fund will fluctuate, when you sell your shares they may be worth more or less than what you originally paid for them. The Fund may impose a fee upon the sale of your shares or may temporarily suspend your ability to sell shares if the Fund s liquidity falls below required minimums because of market conditions or other factors. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. Bank Obligations. The activities of U.S. and most foreign banks are subject to comprehensive regulations. The enactment of new legislation or regulations, as well as changes in interpretation and enforcement of current laws, may affect the manner of operations and profitability of domestic and foreign banks. In addition, banks may be particularly susceptible to certain economic factors. U.S. Government Securities. The U.S. government securities in which the Fund invests can be subject to two types of risk: credit risk and interest rate risk. When the general level of 1

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Prime Portfolio (Cont d) interest rates goes up, the prices of most fixed-income securities go down. When the general level of interest rates goes down, the prices of most fixed-income securities go up. With respect to U.S. government securities that are not backed by the full faith and credit of the United States, there is the risk that the U.S. Government will not provide financial support to such U.S. government agencies, instrumentalities or sponsored enterprises if it is not obligated to do so by law. Asset-Backed Securities. Asset-backed securities involve the risk that various federal and state consumer laws and other legal and economic factors may result in the collateral backing the securities being insufficient to support payment on the securities. Some asset-backed securities entail prepayment risk, which may vary depending on the type of asset. Repurchase Agreements. Repurchase agreements are subject to risks associated with the possibility of default by the seller at a time when the collateral has declined in value, or insolvency of the seller, which may affect the Fund s right to control the collateral and result in certain costs and delays. Repurchase agreements may involve a greater degree of credit risk than investments in U.S. government securities. Foreign Money Market Securities. Investing in money market securities of foreign issuers involves some additional risks, including the possibility of adverse political, economic or other developments affecting the issuers of these securities. Municipal Obligations. To the extent the Fund invests in municipal obligations issued by state and local governments and their agencies, the Fund may be susceptible to political, economic, regulatory or other factors affecting issuers of these municipal obligations. To the extent that Fund invests in municipal obligations of issuers in the same economic sector, it could be more sensitive to economic, business or political developments that affect such sector. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the Fund s Institutional Class shares for the one, five and 10 year periods. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. Annual Total Returns Calendar Years 3.0% 2.5% 2.0% 1.5% 1.0% 0.5% 0.0% 2.74 0.26 0.16 0.11 0.16 0.08 0.05 0.09 0.48 1.13 2008 '09 '10 '11 '12 '13 '14 '15 '16 '17 High Quarter 03/31/08 1.00% Low Quarter 09/30/14 0.01% Average Annual Total Returns (for the Periods Ended December 31, 2017) Past One Year Past Five Years Past Ten Years Prime Portfolio 1.13% 0.36% 0.52% You may obtain the Fund s 7-day current yield by calling 1-888-378-1630. Fund Management Adviser. Morgan Stanley Investment Management Inc. Purchase and Sale of Fund Shares Institutional Class shares of the Fund are available to investors who at the time of initial purchase make a minimum investment of $10,000,000. You may not be subject to the minimum investment requirement under certain circumstances. For more information, please refer to the section of this Prospectus entitled Shareholder Information Minimum Investment Amount. Shares of the Fund may be purchased or sold on any day the New York Stock Exchange ( NYSE ) is open for business (except when the following federal holidays are observed: Columbus Day and Veterans Day) directly from the Fund by mail (c/o DST Asset Manager Solutions, Inc., P.O. Box 219804, Kansas City, MO 64121-9804), by telephone (1-888- 378-1630) or by contacting an authorized third-party, such as a broker-dealer or other financial intermediary that has entered into a selling agreement with the Fund s Distributor, Morgan Stanley Distribution, Inc. (each a Financial Intermediary ). You may purchase and redeem shares online through Morgan Stanley s Treasury Investment Portal service at www.morganstanley.com/liquidity, provided you have a preestablished Internet trading account. For more information, please refer to the sections of this Prospectus entitled Shareholder Information How to Purchase Shares and Shareholder Information How to Redeem Shares. Selected accounts that utilize the Fund as their sweep vehicle will be reviewed on each business day and shares will automatically be purchased or sold to cover any credits or debits incurred that day. 2

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Prime Portfolio (Cont d) Tax Information The Fund intends to make distributions that may be taxed as ordinary income or capital gains. Payments to Broker-Dealers and Other Financial Intermediaries If you purchase shares of the Fund through a Financial Intermediary (such as a bank), the Adviser and/or the Distributor may pay the Financial Intermediary for the sale of Fund shares and related services. These payments, which may be significant in amount, may create a conflict of interest by influencing the Financial Intermediary and your salesperson to recommend the Fund over another investment. Ask your salesperson or visit your Financial Intermediary s web site for more information. 3

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Money Market Portfolio Objective The Money Market Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.17% Total Annual Fund Operating Expenses 1 0.32% Fee Waiver and/or Expense Reimbursement 1 0.12% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $91 $168 $394 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. Principal Investment Strategies The Fund invests in liquid, high quality U.S. dollardenominated money market instruments of U.S. and foreign financial and non-financial corporations. The Fund also invests in obligations of foreign governments and in obligations issued or guaranteed by the U.S. Government and its agencies and instrumentalities. The Fund s money market investments may include commercial paper, corporate debt obligations, debt obligations (including certificates of deposit and promissory notes) of U.S. banks or foreign banks, or of U.S. branches or subsidiaries of foreign banks, or foreign branches of U.S. banks (such as Yankee obligations), certificates of deposit of savings banks and savings and loan organizations, asset-backed securities, repurchase agreements and municipal obligations. The Fund may also invest in U.S. dollar-denominated foreign securities and money market instruments. The Fund operates as an institutional money market fund, which is neither a government money market fund nor retail money market fund as such terms are defined or interpreted under Rule 2a-7 under the Investment Company Act of 1940, as amended (the 1940 Act ). As such, the Fund is required to price and transact in its shares at a net asset value per share ( NAV ) reflecting market-based values of its portfolio holdings (i.e., at a floating NAV), rounded to a minimum of the fourth decimal place. Like other money market funds of its type, the Fund is subject to the possible imposition of liquidity fees and/ or redemption gates. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Because the share price of the Fund will fluctuate, when you sell your shares they may be worth more or less than what you originally paid for them. The Fund may impose a fee upon the sale of your shares or may temporarily suspend your ability to sell shares if the Fund s liquidity falls below required minimums because of market conditions or other factors. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. Bank Obligations. The activities of U.S. and most foreign banks are subject to comprehensive regulations. The enactment of new legislation or regulations, as well as changes in interpretation and enforcement of current laws, may affect the manner of operations and profitability of domestic and foreign banks. In addition, banks may be particularly susceptible to certain economic factors. U.S. Government Securities. The U.S. government securities in which the Fund invests can be subject to two types of risk: credit risk and interest rate risk. When the general level of 4

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Money Market Portfolio (Cont d) interest rates goes up, the prices of most fixed-income securities go down. When the general level of interest rates goes down, the prices of most fixed-income securities go up. With respect to U.S. government securities that are not backed by the full faith and credit of the United States, there is the risk that the U.S. Government will not provide financial support to such U.S. government agencies, instrumentalities or sponsored enterprises if it is not obligated to do so by law. Asset-Backed Securities. Asset-backed securities involve the risk that various federal and state consumer laws and other legal and economic factors may result in the collateral backing the securities being insufficient to support payment on the securities. Some asset-backed securities entail prepayment risk, which may vary depending on the type of asset. Repurchase Agreements. Repurchase agreements are subject to risks associated with the possibility of default by the seller at a time when the collateral has declined in value, or insolvency of the seller, which may affect the Fund s right to control the collateral and result in certain costs and delays. Repurchase agreements may involve a greater degree of credit risk than investments in U.S. government securities. Foreign Money Market Securities. Investing in money market securities of foreign issuers involves some additional risks, including the possibility of adverse political, economic or other developments affecting the issuers of these securities. Municipal Obligations. To the extent the Fund invests in municipal obligations issued by state and local governments and their agencies, the Fund may be susceptible to political, economic, regulatory or other factors affecting issuers of these municipal obligations. To the extent that Fund invests in municipal obligations of issuers in the same economic sector, it could be more sensitive to economic, business or political developments that affect such sector. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the Fund s Institutional Class shares for the one, five and 10 year periods. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. Annual Total Returns Calendar Years 4.0% High Quarter 03/31/08 1.01% Low Quarter 03/31/14 0.01% Average Annual Total Returns (for the Periods Ended December 31, 2017) Past One Year Past Five Years Past Ten Years Money Market Portfolio 1.14% 0.39% 0.56% You may obtain the Fund s 7-day current yield by calling 1-888-378-1630. Fund Management Adviser. Morgan Stanley Investment Management Inc. Purchase and Sale of Fund Shares Institutional Class shares of the Fund are available to investors who at the time of initial purchase make a minimum purchase of $10,000,000. You may not be subject to these minimum investment requirement under certain circumstances. For more information, please refer to the section of this Prospectus entitled Shareholder Information Minimum Investment Amount. Shares of the Fund may be purchased or sold on any day the New York Stock Exchange ( NYSE ) is open for business (except when the following federal holidays are observed: Columbus Day and Veterans Day) directly from the Fund by mail (c/o DST Asset Manager Solutions, Inc., P.O. Box 219804, Kansas City, MO 64121-9804), by telephone (1-888- 378-1630) or by contacting an authorized third-party, such as a broker-dealer or other financial intermediary that has entered into a selling agreement with the Fund s Distributor, Morgan Stanley Distribution, Inc. (each a Financial Intermediary ). You may purchase and redeem shares online through Morgan Stanley s Treasury Investment Portal service at www.morganstanley.com/liquidity, provided you have a preestablished Internet trading account. For more information, please refer to the sections of this Prospectus entitled Shareholder Information How to Purchase Shares and Shareholder Information How to Redeem Shares. Selected accounts that utilize the Fund as their sweep vehicle will be reviewed on each business day and shares will automatically be purchased or sold to cover any credits or debits incurred that day. Tax Information The Fund intends to make distributions that may be taxed as ordinary income or capital gains. 3.0% 2.0% 1.0% 0.0% 2.88 1.14 0.52 0.30 0.18 0.13 0.18 0.09 0.17 0.06 2008 '09 '10 '11 '12 '13 '14 '15 '16 '17 Payments to Broker-Dealers and Other Financial Intermediaries If you purchase shares of the Fund through a Financial Intermediary (such as a bank), the Adviser and/or the Distributor may pay the Financial Intermediary for the sale of Fund shares and related services. These payments, which may be 5

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Money Market Portfolio (Cont d) significant in amount, may create a conflict of interest by influencing the Financial Intermediary and your salesperson to recommend the Fund over another investment. Ask your salesperson or visit your Financial Intermediary s web site for more information. 6

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Government Portfolio Objective The Government Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.06% Total Annual Fund Operating Expenses 1 0.21% Fee Waiver and/or Expense Reimbursement 1 0.01% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $67 $117 $267 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. Principal Investment Strategies The Fund has adopted a policy to invest exclusively in obligations issued or guaranteed by the U.S. Government and its agencies and instrumentalities and in repurchase agreements collateralized by such securities in order to qualify as a government money market fund under federal regulations. The Fund may also hold cash from time to time. A government money market fund is a money market fund that invests at least 99.5% of its total assets in cash, securities issued or guaranteed by the United States or certain U.S. government agencies or instrumentalities and/or repurchase agreements that are collateralized fully by the foregoing. A government money market fund is exempt from requirements that permit money market funds to impose a liquidity fee and/or a redemption gate that temporarily restricts redemptions. In selecting investments, the Adviser seeks to maintain the Fund s share price at $1.00. The share price remaining stable at $1.00 means that the Fund would preserve the principal value of your investment. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Although the Fund seeks to preserve the value of your investment at $1.00 per share, it cannot guarantee it will do so. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. U.S. Government Securities. The U.S. government securities in which the Fund invests can be subject to two types of risk: credit risk and interest rate risk. When the general level of interest rates goes up, the prices of most fixed-income securities go down. When the general level of interest rates goes down, the prices of most fixed-income securities go up. With respect to U.S. government securities that are not backed by the full faith and credit of the United States, there is the risk that the U.S. Government will not provide financial support to such U.S. government agencies, instrumentalities or sponsored enterprises if it is not obligated to do so by law. Repurchase Agreements. Repurchase agreements are subject to risks associated with the possibility of default by the seller at a time when the collateral has declined in value, or insolvency of the seller, which may affect the Fund s right to control the collateral and result in certain costs and delays. Repurchase agreements may involve a greater degree of credit risk than investments in U.S. government securities. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the 7

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Government Portfolio (Cont d) performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the Fund s Institutional Class shares for the one, five and 10 year periods. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. Annual Total Returns Calendar Years 3.0% 2.5% 2.37 Shareholder Information How to Purchase Shares and Shareholder Information How to Redeem Shares. Selected accounts that utilize the Fund as their sweep vehicle will be reviewed on each business day and shares will automatically be purchased or sold to cover any credits or debits incurred that day. Tax Information The Fund intends to make distributions that may be taxed as ordinary income or capital gains. 2.0% 1.5% 1.0% 0.5% 0.0% 0.17 0.06 0.02 0.05 0.05 0.04 0.05 0.27 0.77 2008 '09 '10 '11 '12 '13 '14 '15 '16 '17 High Quarter 03/31/08 0.90% Low Quarter 09/30/11 0.00% Average Annual Total Returns (for the Periods Ended December 31, 2017) Past One Year Past Five Years Past Ten Years Government Portfolio 0.77% 0.23% 0.38% Payments to Broker-Dealers and Other Financial Intermediaries If you purchase shares of the Fund through a Financial Intermediary (such as a bank), the Adviser and/or the Distributor may pay the Financial Intermediary for the sale of Fund shares and related services. These payments, which may be significant in amount, may create a conflict of interest by influencing the Financial Intermediary and your salesperson to recommend the Fund over another investment. Ask your salesperson or visit your Financial Intermediary s web site for more information. You may obtain the Fund s 7-day current yield by calling 1-888-378-1630. Fund Management Adviser. Morgan Stanley Investment Management Inc. Purchase and Sale of Fund Shares Institutional Class shares of the Fund are available to investors who at the time of initial purchase make a minimum investment of $10,000,000. You may not be subject to the minimum investment requirement under certain circumstances. For more information, please refer to the section of this Prospectus entitled Shareholder Information Minimum Investment Amount. Shares of the Fund may be purchased or sold on any day the New York Stock Exchange ( NYSE ) is open for business (except when the following federal holidays are observed: Columbus Day and Veterans Day) directly from the Fund by mail (c/o DST Asset Manager Solutions, Inc., P.O. Box 219804, Kansas City, MO 64121-9804), by telephone (1-888- 378-1630) or by contacting an authorized third-party, such as a broker-dealer or other financial intermediary that has entered into a selling agreement with the Fund s Distributor, Morgan Stanley Distribution, Inc. (each a Financial Intermediary ). You may purchase and redeem shares online through Morgan Stanley s Treasury Investment Portal service at www.morganstanley.com/liquidity, provided you have a preestablished Internet trading account. For more information, please refer to the sections of this Prospectus entitled 8

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Government Securities Portfolio Objective The Government Securities Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.07% Total Annual Fund Operating Expenses 1 0.22% Fee Waiver and/or Expense Reimbursement 1 0.02% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $69 $122 $278 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. Principal Investment Strategies The Fund has adopted a policy to invest substantially all of its assets in U.S. Treasury obligations and certain U.S. government securities, the interest from which is generally exempt from state income taxation, in order to qualify as a government money market fund under federal regulations. The Fund may also hold cash from time to time. A government money market fund is a money market fund that invests at least 99.5% of its total assets in cash, securities issued or guaranteed by the United States or certain U.S. government agencies or instrumentalities and/or repurchase agreements that are collateralized fully by the foregoing. A government money market fund is exempt from requirements that permit money market funds to impose a liquidity fee and/or a redemption gate that temporarily restricts redemptions. In selecting investments, the Adviser seeks to maintain the Fund s share price at $1.00. The share price remaining stable at $1.00 means that the Fund would preserve the principal value of your investment. The U.S. government securities that the Fund may purchase include those issued or guaranteed either by the U.S. Treasury or certain agencies, authorities or instrumentalities of the U.S. Government. The Fund may also invest in repurchase agreements with the Federal Reserve Bank of New York. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Although the Fund seeks to preserve the value of your investment at $1.00 per share, it cannot guarantee it will do so. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. U.S. Government Securities. The U.S. government securities in which the Fund invests can be subject to two types of risk: credit risk and interest rate risk. When the general level of interest rates goes up, the prices of most fixed-income securities go down. When the general level of interest rates goes down, the prices of most fixed-income securities go up. With respect to U.S. government securities that are not backed by the full faith and credit of the United States, there is the risk that the U.S. Government will not provide financial support to such U.S. government agencies, instrumentalities or sponsored enterprises if it is not obligated to do so by law. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the 9

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Government Securities Portfolio (Cont d) Fund s Institutional Class shares for the one and five year periods and since inception. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. Annual Total Returns Calendar Years 0.8% 0.6% 0.4% 0.2% 0.0% 0.08 0.03 0.01 0.01 0.01 0.01 0.01 0.18 0.72 2009 '10 '11 '12 '13 '14 '15 '16 '17 High Quarter 12/31/17 0.24% Low Quarter 03/31/15 0.00% Average Annual Total Returns (for the Periods Ended December 31, 2017) Past One Year Past Five Years Since Inception 03/19/08 Government Securities Portfolio 0.72% 0.19% 0.24% Shareholder Information How to Purchase Shares and Shareholder Information How to Redeem Shares. Selected accounts that utilize the Fund as their sweep vehicle will be reviewed on each business day and shares will automatically be purchased or sold to cover any credits or debits incurred that day. Tax Information The Fund intends to make distributions that may be taxed as ordinary income or capital gains. Payments to Broker-Dealers and Other Financial Intermediaries If you purchase shares of the Fund through a Financial Intermediary (such as a bank), the Adviser and/or the Distributor may pay the Financial Intermediary for the sale of Fund shares and related services. These payments, which may be significant in amount, may create a conflict of interest by influencing the Financial Intermediary and your salesperson to recommend the Fund over another investment. Ask your salesperson or visit your Financial Intermediary s web site for more information. You may obtain the Fund s 7-day current yield by calling 1-888-378-1630. Fund Management Adviser. Morgan Stanley Investment Management Inc. Purchase and Sale of Fund Shares Institutional Class shares of the Fund are available to investors who at the time of initial purchase make a minimum investment of $10,000,000. You may not be subject to the minimum investment requirement under certain circumstances. For more information, please refer to the section of this Prospectus entitled Shareholder Information Minimum Investment Amount. Shares of the Fund may be purchased or sold on any day the New York Stock Exchange ( NYSE ) is open for business (except when the following federal holidays are observed: Columbus Day and Veterans Day) directly from the Fund by mail (c/o DST Asset Manager Solutions, Inc., P.O. Box 219804, Kansas City, MO 64121-9804), by telephone (1-888- 378-1630) or by contacting an authorized third-party, such as a broker-dealer or other financial intermediary that has entered into a selling agreement with the Fund s Distributor, Morgan Stanley Distribution, Inc. (each a Financial Intermediary ). You may purchase and redeem shares online through Morgan Stanley s Treasury Investment Portal service at www.morganstanley.com/liquidity, provided you have a preestablished Internet trading account. For more information, please refer to the sections of this Prospectus entitled 10

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Treasury Portfolio Objective The Treasury Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.06% Total Annual Fund Operating Expenses 1 0.21% Fee Waiver and/or Expense Reimbursement 1 0.01% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $67 $117 $267 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. Principal Investment Strategies The Fund has adopted a policy to invest exclusively in U.S. Treasury obligations, which are backed by the full faith and credit of the United States, and repurchase agreements collateralized by such securities in order to qualify as a government money market fund under federal regulations. The Fund may also hold cash from time to time. A government money market fund is a money market fund that invests at least 99.5% of its total assets in cash, securities issued or guaranteed by the United States or certain U.S. government agencies or instrumentalities and/or repurchase agreements that are collateralized fully by the foregoing. A government money market fund is exempt from requirements that permit money market funds to impose a liquidity fee and/or a redemption gate that temporarily restricts redemptions. In selecting investments, the Adviser seeks to maintain the Fund s share price at $1.00. The share price remaining stable at $1.00 means that the Fund would preserve the principal value of your investment. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Although the Fund seeks to preserve the value of your investment at $1.00 per share, it cannot guarantee it will do so. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. Repurchase Agreements. Repurchase agreements are subject to risks associated with the possibility of default by the seller at a time when the collateral has declined in value, or insolvency of the seller, which may affect the Fund s right to control the collateral and result in certain costs and delays. Repurchase agreements may involve a greater degree of credit risk than investments in U.S. government securities. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the Fund s Institutional Class shares for the one, five and 10 year periods. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. 11

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Treasury Portfolio (Cont d) Annual Total Returns Calendar Years 2.0% 1.5% 1.0% 0.5% 0.0% 1.60 0.07 0.04 0.01 0.03 0.03 0.03 0.04 0.23 0.76 2008 '09 '10 '11 '12 '13 '14 '15 '16 '17 High Quarter 03/31/08 0.62% Low Quarter 12/31/11 0.00% Average Annual Total Returns (for the Periods Ended December 31, 2017) Past One Year Past Five Years Past Ten Years Treasury Portfolio 0.76% 0.22% 0.28% Tax Information The Fund intends to make distributions that may be taxed as ordinary income or capital gains. Payments to Broker-Dealers and Other Financial Intermediaries If you purchase shares of the Fund through a Financial Intermediary (such as a bank), the Adviser and/or the Distributor may pay the Financial Intermediary for the sale of Fund shares and related services. These payments, which may be significant in amount, may create a conflict of interest by influencing the Financial Intermediary and your salesperson to recommend the Fund over another investment. Ask your salesperson or visit your Financial Intermediary s web site for more information. You may obtain the Fund s 7-day current yield by calling 1-888-378-1630. Fund Management Adviser. Morgan Stanley Investment Management Inc. Purchase and Sale of Fund Shares Institutional Class shares of the Fund are available to investors who at the time of initial purchase make a minimum investment of $10,000,000. You may not be subject to the minimum investment requirement under certain circumstances. For more information, please refer to the section of this Prospectus entitled Shareholder Information Minimum Investment Amount. Shares of the Fund may be purchased or sold on any day the New York Stock Exchange ( NYSE ) is open for business (except when the following federal holidays are observed: Columbus Day and Veterans Day) directly from the Fund by mail (c/o DST Asset Manager Solutions, Inc., P.O. Box 219804, Kansas City, MO 64121-9804), by telephone (1-888- 378-1630) or by contacting an authorized third-party, such as a broker-dealer or other financial intermediary that has entered into a selling agreement with the Fund s Distributor, Morgan Stanley Distribution, Inc. (each a Financial Intermediary ). You may purchase and redeem shares online through Morgan Stanley s Treasury Investment Portal service at www.morganstanley.com/liquidity, provided you have a preestablished Internet trading account. For more information, please refer to the sections of this Prospectus entitled Shareholder Information How to Purchase Shares and Shareholder Information How to Redeem Shares. Selected accounts that utilize the Fund as their sweep vehicle will be reviewed on each business day and shares will automatically be purchased or sold to cover any credits or debits incurred that day. 12

Morgan Stanley Institutional Liquidity Funds Prospectus Fund Summary Treasury Securities Portfolio Objective The Treasury Securities Portfolio (the Fund ) seeks preservation of capital, daily liquidity and maximum current income. Fees and Expenses The table below describes the expenses that you may pay if you buy and hold Institutional Class shares of the Fund. The Fund does not charge any sales loads or other fees when you purchase or redeem shares. Annual Fund Operating Expenses (expenses that you pay each year as a percentage of the value of your investment) Institutional Class Advisory Fee 0.15% Distribution and/or Shareholder Service (12b-1) Fee N/A Other Expenses 0.06% Total Annual Fund Operating Expenses 1 0.21% Fee Waiver and/or Expense Reimbursement 1 0.01% Total Annual Fund Operating Expenses After Fee Waiver and/or Expense Reimbursement 1 0.20% Example The example below is intended to help you compare the cost of investing in the Fund s Institutional Class with the cost of investing in other mutual funds. The example assumes that you invest $10,000 in the Fund s Institutional Class, your investment has a 5% return each year and that the Fund s operating expenses remain the same (except that the example incorporates the fee waiver and/ or expense reimbursement arrangement for only the first year). Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 Year 3 Years 5 Years 10 Years Institutional Class $20 $67 $117 $267 1 The Fund s Adviser and Administrator, Morgan Stanley Investment Management Inc., has agreed to reduce its advisory fee, its administration fee and/or reimburse the Fund s Institutional Class so that Total Annual Fund Operating Expenses, excluding certain investment related expenses, taxes, interest and other extraordinary expenses (including litigation), will not exceed 0.20%. The fee waivers and/or expense reimbursements will continue for at least one year or until such time as the Board of Trustees of Morgan Stanley Institutional Liquidity Funds (the Trust ) acts to discontinue all or a portion of such waivers and/or reimbursements when it deems such action is appropriate. and/or repurchase agreements that are collateralized fully by the foregoing. A government money market fund is exempt from requirements that permit money market funds to impose a liquidity fee and/or a redemption gate that temporarily restricts redemptions. In selecting investments, the Adviser seeks to maintain the Fund s share price at $1.00. The share price remaining stable at $1.00 means that the Fund would preserve the principal value of your investment. Principal Risks There can be no assurance that the Fund will achieve its investment objective. You could lose money by investing in the Fund. Although the Fund seeks to preserve the value of your investment at $1.00 per share, it cannot guarantee it will do so. An investment in the Fund is not insured or guaranteed by the Federal Deposit Insurance Corporation ( FDIC ) or any other government agency. The Fund s sponsor has no legal obligation to provide financial support to the Fund, and you should not expect that the sponsor will provide financial support to the Fund at any time. The principal risks of investing in the Fund include: Credit and Interest Rate Risk. Credit risk refers to the possibility that the issuer or guarantor of a security will be unable to make interest payments and/or repay the principal on its debt. Interest rate risk refers to fluctuations in the value of a debt security resulting from changes in the general level of interest rates. The historically low interest rate environment increases the risk associated with rising interest rates. The Fund may face a heightened level of risk, especially since the Federal Reserve Board has ended its quantitative easing program and has begun to raise rates. Performance Information The bar chart and table below provide some indication of the risks of investing in the Fund by showing changes in the performance of the Fund s Institutional Class shares from yearto-year and by showing the average annual returns of the Fund s Institutional Class shares for the one and five year periods and since inception. The Fund s past performance is not necessarily an indication of how the Fund will perform in the future. Updated performance information is available online at www.morganstanley.com/liquidity. Annual Total Returns Calendar Years 0.8% 0.72 Principal Investment Strategies The Fund has adopted a policy to invest exclusively in U.S. Treasury obligations, which are backed by the full faith and credit of the United States, in order to qualify as a government money market fund under federal regulations. The Fund may also hold cash from time to time. A government money market fund is a money market fund that invests at least 99.5% of its total assets in cash, securities issued or guaranteed by the United States or certain U.S. government agencies or instrumentalities 0.6% 0.4% 0.2% 0.0% 0.19 0.07 0.01 0.01 0.01 0.01 0.01 0.01 2009 '10 '11 '12 '13 '14 '15 '16 '17 13