UBS Global Healthcare Conference AngioDynamics Investor Presentation. May 21, 2018

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UBS Global Healthcare Conference AngioDynamics Investor Presentation May 21, 2018 1

Forward-Looking Statement Notice Regarding Forward-Looking Statements This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements regarding AngioDynamics expected future financial position, results of operations, cash flows, business strategy, budgets, projected costs, capital expenditures, products, competitive positions, growth opportunities, plans and objectives of management for future operations, as well as statements that include the words such as expects, reaffirms, intends, anticipates, plans, believes, seeks, estimates, optimistic, or variations of such words and similar expressions, are forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties. Investors are cautioned that actual events or results may differ from AngioDynamics expectations. Factors that may affect the actual results achieved by AngioDynamics include, without limitation, the ability of AngioDynamics to develop its existing and new products, technological advances and patents attained by competitors, infringement of AngioDynamics technology or assertions that AngioDynamics technology infringes the technology of third parties, the ability of AngioDynamics to effectively compete against competitors that have substantially greater resources, future actions by the FDA or other regulatory agencies, domestic and foreign health care reforms and government regulations, results of pending or future clinical trials, overall economic conditions, the results of on-going litigation, challenges with respect to third-party distributors or joint venture partners or collaborators, the results of sales efforts, the effects of product recalls and product liability claims, changes in key personnel, the ability of AngioDynamics to execute on strategic initiatives, the effects of economic, credit and capital market conditions, general market conditions, market acceptance, foreign currency exchange rate fluctuations, the effects on pricing from group purchasing organizations and competition, the ability of AngioDynamics to integrate purchased businesses, as well as the risk factors listed from time to time in AngioDynamics SEC filings, including but not limited to its Annual Report on Form 10-K for the year ended May 31, 2017 and its quarterly reports on Form 10-Q for the fiscal periods ended August 31, 2017 and November 30, 2017. AngioDynamics does not assume any obligation to publicly update or revise any forward-looking statements for any reason. In the United States, the NanoKnife System has received a 510(k) clearance by the Food and Drug Administration for use in the surgical ablation of soft tissue, and is similarly approved for commercialization in Canada, the European Union and Australia. The NanoKnife System has not been cleared for the treatment or therapy of a specific disease or condition. Notice Regarding Non-GAAP Financial Measures Management uses non-gaap measures to establish operational goals, and believes that non-gaap measures may assist investors in analyzing the underlying trends in AngioDynamics business over time. Investors should consider these non-gaap measures in addition to, not as a substitute for or as superior to, financial reporting measures prepared in accordance with GAAP. In this presentation, AngioDynamics has reported adjusted EBITDAS (income before interest, taxes, depreciation and amortization and stock-based compensation); free cash flow and adjusted earnings per share. Management uses these measures in its internal analysis and review of operational performance. Management believes that these measures provide investors with useful information in comparing AngioDynamics performance over different periods. By using these non-gaap measures, management believes that investors get a better picture of the performance of AngioDynamics underlying business. Management encourages investors to review AngioDynamics financial results prepared in accordance with GAAP to understand AngioDynamics performance taking into account all relevant factors, including those that may only occur from time to time but have a material impact on AngioDynamics financial results. Please see the tables that follow for a reconciliation of non-gaap measures to measures prepared in accordance with GAAP. Trademarks AngioDynamics, the AngioDynamics logo, BioFlo, the BioFlo logo, NanoKnife, the NanoKnife logo, VenaCureEVLT, the VenaCureEVLT logo, AngioVac, the AngioVac logo, Solero, the Solero logo, Uni-Fuse, the Uni-Fuse logo, NAMIC, and the NAMIC logo are trademarks and/or registered trademarks of AngioDynamics, Inc., an affiliate or subsidiary. Endexo is a trademark and/or registered trademark of Interface Biologics. Habib is a trademark and/or registered trademark of Emcision. ASCLERA is a registered trademark of Chemische Fabrik Kreussler & Co., GmbH. All other marks are property of their respective owner. 2

3

AngioDynamics Today 3 Focus Operating franchises in growing, strategic markets Patient Focus on serving undertreated patient populations, improving patient outcomes and offering economic value to healthcare providers Growth Strategy Industry Leader Leading provider of innovative medical devices used by physicians for treatment of cancer and peripheral vascular disease Growth strategy to optimize product portfolio, focus on operational efficiencies and expand internationally 4

2017: Strengthening Operations Commercial Improvements Defined and implemented a new corporate strategy Revised compensation structure to align to industry best practices More disciplined Product Development process 2018: Driving Transformation Expanding Growth Opportunities Commercial discipline Global Business Unit structure strengthens international reach Innovative technologies that serve patient needs Operational Improvements Strengthened balance sheet and financial operations Improved supply chain Simplified footprint Accelerating Performance Strategic capital allocation Operational excellence to drive efficiencies Strong cash flow generation to drive investment in growth products 5

AngioDynamics Framework For Growth Driving Efficiencies Delivering sustainable and improved margins Investing in Disruptive Technology Strengthening Global Platform Focused investments on growth and innovation Increased focus on highgrowth markets Driving Performance Strong cash flow generation 6

Three Global Business Units with Unique Growth Opportunities Peripheral Vascular Vascular Access Oncology/Surgery Categories Categories Categories Fluid Management Venous Insufficiency Thrombus Management Drainage Angiographic Catheters Key Growth Drivers PICCs Ports Dialysis Key Growth Drivers Non-Thermal Ablation Microwave Ablation Radiofrequency Ablation Surgical Resection Key Growth Drivers Invest where we can win 7

8 Financial Update

FY2018 Nine-Month Actuals and Full-Year Expectations FY2018 YTD Results FY2018 Expectations Revenue $256.0M $345M $350M GAAPEarnings Per Share Non-GAAP Adjusted EPS $0.38 $0.49 $0.45 $0.50 $0.64 $0.68 Gross Margin 50.6% ~52% Adjusted EBITDAS $41.4M $55M+ Free Cash Flow $15.9M $30M - $35M* Cash and Cash Equivalents $52.3M $50M+ Debt $93.75M $92.5M 9 * Excludes any amounts payable in connection to matters related to two DOJ subpoenas Adjusted EBITDAS is defined as Net Income (loss) before interest, taxes, depreciation, amortization and stock based compensation adjusted for any one time/unusual and non-cash items, as well as legal costs related to litigation that is not in the ordinary course of business. Adjusted EPS is defined as Net Income adjusted for amortization, contingent consideration adjustments, and any one time/unusual and non-cash items, as well as legal costs related to litigation that is not in the ordinary course of business

Significant Liquidity Drives Capital Allocation Strategy $ in millions $350 $300 $210-$220m $240-$260m $290-$315m Uses of Cash Priorities $250 1. Invest internally $200 $150 2. Opportunistically evaluate M&A $100 $50 3. Execute share buyback program authorized up to $25 million $0 FY2018 FY2019 FY2020 Cash and Investments Revolver Availability 10 Significant cash generation and available debt capital support range of allocation options to capitalize on growth opportunities

Our Vision for AngioDynamics 1 2 3 Be recognized as a consistent, highperforming MedTech company Partner with providers and caregivers to deliver superior care to patients Increase our value to each of our stakeholders 11