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American Funds Insurance Series Prospectus Class 1 shares May 1, 2017 Bond Fund Table contents Bond Fund 1 Investment objectives, strategies risks 5 Management organization 8 Purchases redemptions shares 12 Plan distribution 13 Fund expenses 13 Investment results 13 Distributions taxes 13 Financial highlights 14 The U.S. Securities Exchange Commission has not approved or disapproved these securities. Further, it has not determined that this prospectus is accurate or complete. Any representation to the contrary is a criminal fense.

Bo n d F u nd Investment objective The fund s objective is to provide as high a level current as is consistent with the preservation capital. Fees expenses the fund This table describes the fees expenses that you may pay if you buy hold an interest in Class 1 shares the fund. It does not reflect insurance contract fees expenses. If insurance contract fees expenses were reflected, expenses shown would be higher. Annual fund operating expenses (expenses that you pay each year as a percentage the value your ) Class 1 Management fee 0.36% Other expenses 0.02 annual fund operating expenses 0.38 Example This example is intended to help you compare the cost investing in Class 1 shares the fund with the cost investing in other mutual funds. The example assumes that you invest $10,000 in the fund for the time s indicated then redeem all your shares at the those s. The example also assumes that your has a 5% return each year that the fund s operating expenses remain the same. The example does not reflect insurance contract expenses. If insurance contract expenses were reflected, expenses shown would be higher. Although your actual costs may be higher or lower, based on these assumptions your costs would be: 1 year 3 years 5 years 10 years Class 1 $39 $122 $213 $480 Portfolio turnover The fund pays transaction costs, such as commissions, when it buys sells securities (or turns over its portfolio). A higher portfolio turnover rate may indicate higher transaction costs. These costs, which are not reflected in annual fund operating expenses or in the example, affect the fund s results. During the most recent fiscal year, the fund s portfolio turnover rate was 375% the average value its portfolio. Principal strategies The fund seeks to maximize your level current preserve your capital by investing primarily in bonds. Normally, the fund invests at least 80% its s in bonds other debt securities, which may be represented by other instruments, including derivatives. The fund invests at least 65% its s in -grade debt securities (rated Baa3 or better or BBB or better by Nationally Recognized Statistical Rating Organizations, or NRSROs, designated by the fund s adviser or unrated but determined to be equivalent quality by the fund s adviser), including cash cash equivalents, securities issued guaranteed by the U.S. other governments, securities backed by mortgages other s. The fund may invest up to 35% its s in debt securities rated Ba1 or below BB+ or below by NRSROs designated by the fund s adviser or unrated but determined by the fund s adviser to be equivalent quality. Such securities are sometimes referred to as junk bonds. The fund may invest in debt securities issuers domiciled outside the United States, including in emerging markets. The fund may also invest up to 20% its s in preferred stocks, including convertible nonconvertible preferred stocks. In addition, the fund may invest, subject to the restrictions above, in contracts for future delivery mortgage-backed securities, such as to-be-announced contracts mortgage rolls. These contracts are normally short duration may be replaced by another contract prior to maturity. Each such transaction is reflected as turnover in the fund s portfolio, resulting in a higher portfolio turnover rate than funds that do not employ this strategy. The fund is designed for investors seeking more price stability than stocks, capital preservation over the long term. The fund may invest in certain derivative instruments, such as futures contracts swaps. A derivative is a financial contract, the value which is based on the value an underlying financial (such as a stock, bond or currency), a reference rate or a market index. The fund may invest in a derivative only if, in the opinion the adviser, the expected risks rewards the proposed are consistent with the objective strategies the fund as disclosed in this prospectus in the fund s statement additional information. The adviser uses a system multiple portfolio managers in managing the fund s s. Under this approach, the portfolio the fund is divided into segments managed by individual managers who decide how their respective segments will be invested. The fund relies on the pressional judgment its adviser to make decisions about the fund s portfolio s. The basic philosophy the adviser is to seek to invest in attractively priced securities that, in its opinion, represent good, long-term opportunities. The adviser believes that an important way to accomplish this is through fundamental research, which may include analysis credit quality, general economic conditions various quantitative measures, in the case corporate obligations, meeting with company executives employees, suppliers, customers competitors. Securities may be sold when the adviser believes that they no longer represent relatively attractive opportunities. 1 American Funds Insurance Series / Prospectus

Principal risks This section describes the principal risks associated with the fund s principal strategies. You may lose money by investing in the fund. The likelihood loss may be greater if you invest for a shorter time. Market conditions The prices, the generated by, the bonds other securities held by the fund may decline sometimes rapidly or unpredictably due to various factors, including events or conditions affecting the general economy or particular industries; overall market changes; local, regional or global political, social or economic instability; governmental or governmental agency responses to economic conditions; currency exchange rate, interest rate commodity price fluctuations. Issuer risks The prices, the generated by, securities held by the fund may decline in response to various factors directly related to the issuers such securities, including reduced dem for an issuer s goods or services, poor management performance strategic initiatives such as mergers, acquisitions or dispositions the market response to any such initiatives. Investing in debt instruments The prices, the generated by, bonds other debt securities held by the fund may be affected by changing interest rates by changes in the effective maturities credit ratings these securities. Rising interest rates will generally cause the prices bonds other debt securities to fall. Falling interest rates may cause an issuer to redeem, call or refinance a debt security before its stated maturity, which may result in the fund having to reinvest the proceeds in lower yielding securities. Longer maturity debt securities generally have greater sensitivity to changes in interest rates may be subject to greater price fluctuations than shorter maturity debt securities. Bonds other debt securities are also subject to credit risk, which is the possibility that the credit strength an issuer will weaken /or an issuer a debt security will fail to make timely payments principal or interest the security will go into default. Lower quality debt securities generally have higher rates interest may be subject to greater price fluctuations than higher quality debt securities. Credit risk is gauged, in part, by the credit ratings the debt securities in which the fund invests. However, ratings are only the opinions the rating agencies issuing them are not guarantees as to credit quality or an evaluation market risk. The fund s adviser relies on its own credit analysts to research issuers issues in seeking to mitigate various credit default risks. Investing in lower rated debt instruments Lower rated bonds other lower rated debt securities generally have higher rates interest involve greater risk default or price declines due to changes in the issuer s creditworthiness than those higher quality debt securities. The market prices these securities may fluctuate more than the prices higher quality debt securities may decline significantly in s general economic difficulty. These risks may be increased with respect to s in junk bonds. Investing in mortgage-related other -backed securities Mortgage-related securities, such as mortgage-backed securities, other -backed securities, include debt obligations that represent interests in pools mortgages or other -bearing s, such as consumer loans or receivables. Such securities ten involve risks that are different from or more acute than the risks associated with investing in other types debt securities. Mortgage-backed other -backed securities are subject to changes in the payment patterns borrowers the underlying debt. When interest rates fall, borrowers are more likely to refinance or prepay their debt before its stated maturity. This may result in the fund having to reinvest the proceeds in lower yielding securities, effectively reducing the fund s. Conversely, if interest rates rise borrowers repay their debt more slowly than expected, the time in which the mortgagebacked other -backed securities are paid f could be extended, reducing the fund s cash available for re in higher yielding securities. American Funds Insurance Series / Prospectus 2

Investing in future delivery contracts The fund may enter into contracts, such as to-be-announced contracts mortgage dollar rolls, that involve the fund selling mortgage-related securities simultaneously contracting to repurchase similar securities for delivery at a future date at a predetermined price. This can increase the fund s market exposure, the market price the securities that the fund contracts to repurchase could drop below their purchase price. While the fund can preserve generate capital through the use such contracts by, for example, realizing the difference between the sale price the future purchase price, the generated by the fund may be reduced by engaging in such transactions. In addition, these transactions may increase the turnover rate the fund. Investing in securities backed by the U.S. government Securities backed by the U.S. Treasury or the full faith credit the U.S. government are guaranteed only as to the timely payment interest principal when held to maturity. Accordingly, the current market values for these securities will fluctuate with changes in interest rates. Securities issued by government-sponsored entities federal agencies instrumentalities that are not backed by the full faith credit the U.S. government are neither issued nor guaranteed by the U.S. government. Investing in inflation linked bonds The values inflation linked bonds generally fluctuate in response to changes in real interest rates i.e., rates interest after factoring in inflation. A rise in real interest rates may cause the prices inflation linked securities to fall, while a decline in real interest rates may cause the prices to increase. Inflation linked bonds may experience greater losses than other debt securities with similar durations when real interest rates rise faster than nominal interest rates. There can be no assurance that the value an inflation linked security will be directly correlated to changes in interest rates; for example, if interest rates rise for reasons other than inflation, the increase may not be reflected in the security s inflation measure. Investing in inflation linked bonds may also reduce the fund s distributable during s extreme deflation. If prices for goods services decline throughout the economy, the principal on inflation linked securities may decline result in losses to the fund. Investing outside the United States Securities issuers domiciled outside the United States, or with significant operations or revenues outside the United States, may lose value because adverse political, social, economic or market developments (including social instability, regional conflicts, terrorism war) in the countries or regions in which the issuers operate or generate revenue. These securities may also lose value due to changes in foreign currency exchange rates against the U.S. dollar /or currencies other countries. Issuers these securities may be more susceptible to actions foreign governments, such as the imposition price controls or punitive taxes, that could adversely impact the value these securities. Securities markets in certain countries may be more volatile /or less liquid than those in the United States. Investments outside the United States may also be subject to different accounting practices different regulatory, legal reporting stards practices, may be more difficult to than those in the United States. In addition, the value s outside the United States may be reduced by foreign taxes, including foreign withholding taxes on interest dividends. Further, there may be increased risks delayed settlement securities purchased or sold by the fund. The risks investing outside the United States may be heightened in connection with s in emerging markets. Investing in derivatives The use derivatives involves a variety risks, which may be different from, or greater than, the risks associated with investing in traditional cash securities, such as stocks bonds. Changes in the value a derivative may not correlate perfectly with, may be more sensitive to market events than, the underlying, rate or index, a derivative instrument may expose the fund to losses in excess its initial. Derivatives may be difficult for the fund to buy or sell at an opportune time or price may be difficult to terminate or otherwise fset. The fund s use derivatives may result in losses to the fund, investing in derivatives may reduce the fund s returns increase the fund s price volatility. The fund s counterparty to a derivative transaction (including, if applicable, the fund s clearing broker, the derivatives exchange or the clearinghouse) may be unable or unwilling to honor its financial obligations in respect the transaction. A description the derivative instruments in which the fund may invest the various risks associated with those derivatives is included in the fund s statement additional information under Description certain securities, techniques risks. Liquidity risk Certain fund holdings may be deemed to be less liquid or illiquid because they cannot be readily sold without significantly impacting the value the holdings. Liquidity risk may result from the lack an active market for a holding, legal or contractual restrictions on resale, or the reduced number capacity market participants to make a market in such holding. Market prices for less liquid or illiquid holdings may be volatile, reduced liquidity may have an adverse impact on the market price such holdings. Additionally, the sale less liquid or illiquid holdings may involve substantial delays (including delays in settlement) additional costs the fund may be unable to sell such holdings when necessary to meet its liquidity needs. Management The adviser to the fund actively manages the fund s s. Consequently, the fund is subject to the risk that the methods analyses employed by the adviser in this process may not produce the desired results. This could cause the fund to lose value or its results to lag relevant benchmarks or other funds with similar objectives. Your in the fund is not a bank deposit is not insured or guaranteed by the Federal Deposit Insurance Corporation or any other governmental agency, entity or person. You should consider how this fund fits into your overall program. 3 American Funds Insurance Series / Prospectus

Investment results The following bar chart shows how the results the Class 1 shares the fund have varied from year to year, the following table shows how the fund s average annual total returns for various s compare with a broad measure securities market results other applicable measures market results. This information provides some indication the risks investing in the fund. The Lipper Core Bond Funds Average includes mutual funds that disclose objectives /or strategies reasonably comparable to those the fund. Past results (before after taxes) are not predictive future results. Figures shown reflect fees expenses associated with an in the fund, but do not reflect insurance contract fees expenses. If insurance contract fees expenses were included, results would have been lower. Updated information on the fund s results can be obtained by visiting americanfunds.com/afis. Calendar year total returns (%) 15 10 5 0 5 10 15 12.83 6.73 6.41 5.58 5.59 3.66 3.27 0.45 1.89 9.16 07 08 09 10 11 12 13 14 15 16 Highest/Lowest quarterly results during this were: Highest 6.05% (quarter ended June 30, 2009) Lowest 5.47% (quarter ended September 30, 2008) Average annual total returns For the s ended December 31, 2016: 1 year 5 years 10 years Lifetime Fund (inception date 1/2/96) 3.27% 2.56% 3.19% 4.78% Bloomberg Barclays U.S. Aggregate Index (reflects no deduction for sales charges, account fees, expenses or 2.65 2.23 4.34 5.21 U.S. federal taxes) Lipper Core Bond Funds Average (reflects no deduction for sales charges, account fees or U.S. federal taxes) 3.00 2.41 3.94 4.71 Management Investment adviser Capital Research Management Company SM Portfolio managers The individuals primarily responsible for the portfolio management the fund are: Portfolio manager/ Series title (if applicable) Portfolio manager experience in this fund Primary title with adviser Pramod Atluri 1 year Vice President Capital Fixed Income Investors David A. Hoag 10 years Partner Capital Fixed Income Investors Tax information See your variable insurance contract prospectus for information regarding the federal tax treatment your variable insurance contract related distributions. Payments to broker-dealers other financial intermediaries If you purchase shares the fund through a broker-dealer or other financial intermediary (such as an insurance company), the fund the fund s distributor or its affiliates may pay the intermediary for the sale fund shares related services. These payments may create a conflict interest by influencing the broker-dealer or other intermediary your individual financial advisor to recommend the fund over another. Ask your individual financial advisor or visit your financial intermediary s website for more information. The fund is not sold directly to the general public but instead is fered as an underlying option for variable insurance contracts. In addition to payments described above, the fund its related companies may make payments to the sponsoring insurance company (or its affiliates) for distribution /or other services. These payments may be a factor that the insurance company considers in including the fund as an underlying option in the variable insurance contract. The prospectus (or other fering document) for your variable insurance contract may contain additional information about these payments. American Funds Insurance Series / Prospectus 4

Investment objectives, strategies risks Bond Fund The fund s objective is to provide as high a level current as is consistent with the preservation capital. While it has no present intention to do so, the fund s board may change the fund s objective without shareholder approval upon 60 days written notice to shareholders. The fund seeks to maximize your level current preserve your capital by investing primarily in bonds. Normally, the fund invests at least 80% its s in bonds other debt securities, which may be represented by other instruments, including derivatives. This policy is subject to change only upon 60 days written notice to shareholders. The fund invests at least 65% its s in -grade debt securities (rated Baa3 or better or BBB or better by Nationally Recognized Statistical Rating Organizations, or NRSROs, designated by the fund s adviser or unrated but determined to be equivalent quality by the fund s adviser), including cash cash equivalents, securities issued guaranteed by the U.S. other governments, securities backed by mortgages other s. The fund may invest up to 35% its s in debt securities rated Ba1 or below BB+ or below by NRSROs designated by the fund s adviser or unrated but determined by the fund s adviser to be equivalent quality. Such securities are sometimes referred to as junk bonds. The fund may invest in debt securities issuers domiciled outside the United States, including in emerging markets. The fund may also invest up to 20% its s in preferred stocks, including convertible nonconvertible preferred stocks. In addition, the fund may invest, subject to the restrictions above, in contracts for future delivery mortgage-backed securities, such as tobe-announced contracts mortgage rolls. Although the fund may generally invest in debt securities any maturity or duration, such contracts are normally short duration may be replaced by another contract prior to maturity. Each such transaction is reflected as turnover in the fund s portfolio, resulting in a higher portfolio turnover rate than funds that do not employ this strategy. The fund is designed for investors seeking more price stability than stocks, capital preservation over the long term. The fund may invest in certain derivative instruments. A derivative is a financial contract, the value which is based on the value an underlying financial (such as a stock, bond or currency), a reference rate or a market index. The fund may invest in a derivative only if, in the opinion the adviser, the expected risks rewards the proposed are consistent with the objective strategies the fund as disclosed in this prospectus in the fund s statement additional information. Among other derivative instrument types, the fund may invest in futures contracts interest rate swaps in order to seek to manage the fund s sensitivity to interest rates, in credit default swap indices, or CDX, in order to assume exposure to a diversified portfolio credits or to hedge against existing credit risks. A futures contract is a stardized exchange-traded agreement to buy or sell a specific quantity an underlying, rate or index at an agreed-upon price at a stipulated future date. An interest rate swap is an agreement between two parties to exchange or swap payments based on changes in one or more interest rates, one which is typically fixed the other which is typically a floating rate based on a designated short-term interest rate, such as the London Interbank Offered Rate, prime rate or other benchmark. A CDX is based on a portfolio credit default swaps with similar characteristics, such as credit default swaps on high-yield bonds. In a typical CDX transaction, one party the protection buyer is obligated to pay the other party the protection seller a stream ic payments over the term the contract, provided generally that no credit event on an underlying reference obligation has occurred. If such a credit event has occurred, the protection seller must pay the protection buyer the loss on those credits. The fund may also enter into currency transactions to provide for the purchase or sale a currency needed to purchase a security denominated in that currency. In addition, the fund may enter into forward currency contracts to protect against changes in currency exchange rates. The fund may also enter into forward currency contracts to seek to increase total return. A forward currency contract is an agreement to purchase or sell a specific currency at a future date at a fixed price. The fund may also hold cash or money market instruments, including commercial paper short-term securities issued by the U.S. government, its agencies instrumentalities. The percentage the fund invested in such holdings varies depends on various factors, including market conditions purchases redemptions fund shares. The adviser may determine that it is appropriate to invest a substantial portion the fund s s in such instruments in response to certain circumstances, such as s market turmoil. In addition, for temporary defensive purposes, the fund may invest without limitation in such instruments. A larger amount such holdings could moderate a fund s results in a rising market prices. Alternatively, a larger percentage such holdings could reduce the magnitude a fund s loss in a falling market prices provide liquidity to make additional s or to meet redemptions. The following are principal risks associated with the fund s strategies. Market conditions The prices, the generated by, the bonds other securities held by the fund may decline sometimes rapidly or unpredictably due to various factors, including events or conditions affecting the general economy or particular industries; overall market changes; local, regional or global political, social or economic instability; governmental or governmental agency responses to economic conditions; currency exchange rate, interest rate commodity price fluctuations. Issuer risks The prices, the generated by, securities held by the fund may decline in response to various factors directly related to the issuers such securities, including reduced dem for an issuer s goods or services, poor management performance strategic initiatives such as mergers, acquisitions or dispositions the market response to any such initiatives. Investing in debt instruments The prices, the generated by, bonds other debt securities held by the fund may be affected by changing interest rates by changes in the effective maturities credit ratings these securities. Rising interest rates will generally cause the prices bonds other debt securities to fall. Falling interest rates may cause an issuer to redeem, call or refinance a debt security before its stated maturity, which may result in the fund having to reinvest the proceeds in lower 5 American Funds Insurance Series / Prospectus

yielding securities. Longer maturity debt securities generally have greater sensitivity to changes in interest rates may be subject to greater price fluctuations than shorter maturity debt securities. Bonds other debt securities are also subject to credit risk, which is the possibility that the credit strength an issuer will weaken /or an issuer a debt security will fail to make timely payments principal or interest the security will go into default. Lower quality debt securities generally have higher rates interest may be subject to greater price fluctuations than higher quality debt securities. Credit risk is gauged, in part, by the credit ratings the debt securities in which the fund invests. However, ratings are only the opinions the rating agencies issuing them are not guarantees as to credit quality or an evaluation market risk. The fund s adviser relies on its own credit analysts to research issuers issues in seeking to mitigate various credit default risks. Investing in lower rated debt instruments Lower rated bonds other lower rated debt securities generally have higher rates interest involve greater risk default or price declines due to changes in the issuer s creditworthiness than those higher quality debt securities. The market prices these securities may fluctuate more than the prices higher quality debt securities may decline significantly in s general economic difficulty. These risks may be increased with respect to s in junk bonds. Investing in mortgage-related other -backed securities Mortgage-related securities, such as mortgage-backed securities, other -backed securities, include debt obligations that represent interests in pools mortgages or other -bearing s, such as consumer loans or receivables. Such securities ten involve risks that are different from or more acute than the risks associated with investing in other types debt securities. Mortgage-backed other -backed securities are subject to changes in the payment patterns borrowers the underlying debt. When interest rates fall, borrowers are more likely to refinance or prepay their debt before its stated maturity. This may result in the fund having to reinvest the proceeds in lower yielding securities, effectively reducing the fund s. Conversely, if interest rates rise borrowers repay their debt more slowly than expected, the time in which the mortgagebacked other -backed securities are paid f could be extended, reducing the fund s cash available for re in higher yielding securities. Investing in future delivery contracts The fund may enter into contracts, such as to-be-announced contracts mortgage dollar rolls, that involve the fund selling mortgage-related securities simultaneously contracting to repurchase similar securities for delivery at a future date at a predetermined price. This can increase the fund s market exposure, the market price the securities that the fund contracts to repurchase could drop below their purchase price. While the fund can preserve generate capital through the use such contracts by, for example, realizing the difference between the sale price the future purchase price, the generated by the fund may be reduced by engaging in such transactions. In addition, these transactions may increase the turnover rate the fund. Investing in securities backed by the U.S. government Securities backed by the U.S. Treasury or the full faith credit the U.S. government are guaranteed only as to the timely payment interest principal when held to maturity. Accordingly, the current market values for these securities will fluctuate with changes in interest rates. Securities issued by government-sponsored entities federal agencies instrumentalities that are not backed by the full faith credit the U.S. government are neither issued nor guaranteed by the U.S. government. Investing in inflation linked bonds The values inflation linked bonds generally fluctuate in response to changes in real interest rates i.e., rates interest after factoring in inflation. A rise in real interest rates may cause the prices inflation linked securities to fall, while a decline in real interest rates may cause the prices to increase. Inflation linked bonds may experience greater losses than other debt securities with similar durations when real interest rates rise faster than nominal interest rates. There can be no assurance that the value an inflation linked security will be directly correlated to changes in interest rates; for example, if interest rates rise for reasons other than inflation, the increase may not be reflected in the security s inflation measure. Investing in inflation linked bonds may also reduce the fund s distributable during s extreme deflation. If prices for goods services decline throughout the economy, the principal on inflation linked securities may decline result in losses to the fund. Investing outside the United States Securities issuers domiciled outside the United States, or with significant operations or revenues outside the United States, may lose value because adverse political, social, economic or market developments (including social instability, regional conflicts, terrorism war) in the countries or regions in which the issuers operate or generate revenue. These securities may also lose value due to changes in foreign currency exchange rates against the U.S. dollar /or currencies other countries. Issuers these securities may be more susceptible to actions foreign governments, such as the imposition price controls or punitive taxes, that could adversely impact the value these securities. Securities markets in certain countries may be more volatile /or less liquid than those in the United States. Investments outside the United States may also be subject to different accounting practices different regulatory, legal reporting stards practices, may be more difficult to than those in the United States. In addition, the value s outside the United States may be reduced by foreign taxes, including foreign withholding taxes on interest dividends. Further, there may be increased risks delayed settlement securities purchased or sold by the fund. The risks investing outside the United States may be heightened in connection with s in emerging markets. Investing in derivatives The use derivatives involves a variety risks, which may be different from, or greater than, the risks associated with investing in traditional cash securities, such as stocks bonds. Changes in the value a derivative may not correlate perfectly with, may be more sensitive to market events than, the underlying, rate or index, a derivative instrument may expose the fund to losses in excess its initial. Derivatives may be difficult for the fund to buy or sell at an opportune time or price may be difficult to terminate or otherwise fset. The fund s use derivatives may result in losses to the fund, investing in derivatives may reduce the fund s returns increase the fund s price volatility. The fund s counterparty to a derivative transaction (including, if applicable, the fund s clearing broker, the derivatives exchange or the clearinghouse) may be unable or unwilling to honor its financial obligations in respect the transaction. A description the derivative instruments in which the fund may invest the various risks American Funds Insurance Series / Prospectus 6

associated with those derivatives is included in the fund s statement additional information under Description certain securities, techniques risks. Liquidity risk Certain fund holdings may be deemed to be less liquid or illiquid because they cannot be readily sold without significantly impacting the value the holdings. Liquidity risk may result from the lack an active market for a holding, legal or contractual restrictions on resale, or the reduced number capacity market participants to make a market in such holding. Market prices for less liquid or illiquid holdings may be volatile, reduced liquidity may have an adverse impact on the market price such holdings. Additionally, the sale less liquid or illiquid holdings may involve substantial delays (including delays in settlement) additional costs the fund may be unable to sell such holdings when necessary to meet its liquidity needs. Management The adviser to the fund actively manages the fund s s. Consequently, the fund is subject to the risk that the methods analyses employed by the adviser in this process may not produce the desired results. This could cause the fund to lose value or its results to lag relevant benchmarks or other funds with similar objectives. The following are certain additional risks associated with the fund s strategies. Interest rate risk The values liquidity the securities held by the fund may be affected by changing interest rates. For example, the values these securities may decline when interest rates rise increase when interest rates fall. Longer maturity debt securities generally have greater sensitivity to changes in interest rates may be subject to greater price fluctuations than shorter maturity debt securities. The fund may invest in variable floating rate securities. Although the values such securities are generally less sensitive to interest rate changes than those other debt securities, the value variable floating rate securities may decline if their interest rates do not rise as quickly, or as much, as general interest rates. Conversely, floating rate securities will not generally increase in value if interest rates decline. During s extremely low short-term interest rates, the fund may not be able to maintain a positive yield, given the current historically low interest rate environment, risks associated with rising rates are currently heightened. Investing in futures contracts In addition to the risks generally associated with investing in derivative instruments, futures contracts are subject to the creditworthiness the clearing organizations, exchanges futures commission merchants with which the fund transacts. Additionally, although futures require only a small initial in the form a deposit initial margin, the amount a potential loss on a futures contract could greatly exceed the initial amount invested. While futures contracts are generally liquid instruments, under certain market conditions futures may be deemed to be illiquid. For example, the fund may be temporarily prohibited from closing out its position in a futures contract if intraday price change limits or limits on trading volume imposed by the applicable futures exchange are triggered. If the fund is unable to close out a position on a futures contract, the fund would remain subject to the risk adverse price movements until the fund is able to close out the futures position. The ability the fund to successfully utilize futures contracts may depend in part upon the ability the fund s adviser to accurately forecast interest rates other economic factors to assess predict the impact such economic factors on the futures in which the fund invests. If the adviser incorrectly forecasts economic developments or incorrectly predicts the impact such developments on the futures in which it invests, the fund could be exposed to the risk loss. Investing in swaps Swaps, including interest rate swaps credit default swap indices, or CDX, are subject to many the risks generally associated with investing in derivative instruments. Additionally, although swaps require no or only a small initial in the form a deposit initial margin, the amount a potential loss on a swap contract could greatly exceed the initial amount invested. The use swaps involves the risk that the adviser will not accurately predict anticipated changes in interest rates or other economic factors, which may result in losses to the fund. To the extent the fund enters into a bilaterally negotiated swap transaction, there is a possibility that the counterparty will fail to perform in accordance with the terms the swap agreement. If a counterparty defaults on its obligations under a swap agreement, the fund may lose any amount it expected to receive from the counterparty, potentially including amounts in excess the fund s initial. Certain swap transactions are subject to matory central clearing or may be eligible for voluntary central clearing. Although clearing interposes a central clearinghouse as the ultimate counterparty to each participant s swap, central clearing will not eliminate (but may decrease) counterparty risk relative to uncleared bilateral swaps. Some swaps, such as CDX, may be dependent on both the individual credit the fund s counterparty on the credit one or more issuers any underlying s. If the fund does not correctly evaluate the creditworthiness its counterparty, where applicable, issuers any underlying reference s, the fund s in a swap may result in losses to the fund. Currency transactions In addition to the risks generally associated with investing in derivative instruments, the use forward currency contracts involves the risk that currency movements will not be accurately predicted by the adviser, which could result in losses to the fund. While entering into forward currency contracts could minimize the risk loss due to a decline in the value the hedged currency, it could also limit any potential gain that may result from an increase in the value the currency. Additionally, the adviser may use forward currency contracts to increase exposure to a certain currency or to shift exposure to currency fluctuations from one country to another. Forward currency contracts may expose the fund to potential gains losses in excess the initial amount invested. Exposure to country, region, industry or sector Subject to the fund s limitations, the fund may have significant exposure to a particular country, region, industry or sector. Such exposure may cause the fund to be more impacted by risks relating to the country, region, industry or sector than a fund without such levels exposure. For example, if the fund has significant exposure in a particular country, then social, economic, regulatory or other issues that negatively affect that country may have a greater impact on the fund than on a fund that is more geographically diversified. In addition to the principal strategies described above, the fund has other practices that are described in the statement additional information, which includes a description other risks related to the fund s principal strategies other practices. The fund s results will depend on the ability the fund s adviser to navigate the risks discussed above as well as those described in the statement additional information. 7 American Funds Insurance Series / Prospectus

Fund comparative indexes The Bloomberg Barclays U.S. Aggregate Index represents the U.S. -grade fixed-rate bond market. This index is unmanaged, its results include reinvested distributions but do not reflect the effect sales charges, commissions, account fees, expenses or U.S. federal taxes. The Lipper Core Bond Funds Average is composed funds that invest at least 85% their net s in domestic -grade debt issues (rated in the top four grades) with any remaining in nonbenchmark sectors such as high-yield, global emerging market debt. These funds maintain dollar-weighted average maturities five to ten years. The results the underlying funds in the average include the re dividends capital gain distributions, as well as brokerage commissions paid by the funds for portfolio transactions other fund expenses, but do not reflect the effect sales charges, account fees or U.S. federal taxes. Management organization Investment adviser Capital Research Management Company, an experienced management organization founded in 1931, serves as the adviser to the Series other mutual funds, including the American Funds. Capital Research Management Company is a wholly owned subsidiary The Capital Group Companies, Inc. is located at 333 South Hope Street, Los Angeles, California 90071. Capital Research Management Company manages the portfolios business affairs the Series. The total management fee paid by each fund to its adviser for the most recent fiscal year, in each case expressed as a percentage average net s that fund, appears in the Annual Fund Operating Expenses table for each fund. Please see the statement additional information for further details. A discussion regarding the basis for the approval the Series Investment Advisory Service Agreement by the Series board trustees is contained in the Series annual report to shareholders for the fiscal year ended December 31, 2016. Capital Research Management Company manages equity s through three equity divisions fixed- s through its fixed- division, Capital Fixed Income Investors. The three equity divisions Capital World Investors, Capital Research Global Investors Capital International Investors make decisions independently one another. The equity divisions may, in the future, be incorporated as wholly owned subsidiaries Capital Research Management Company. In that event, Capital Research Management Company would continue to be the adviser, day-to-day management equity s would continue to be carried out through one or more these subsidiaries. Although not currently contemplated, Capital Research Management Company could incorporate its fixed- division in the future engage it to provide day-to-day management fixed- s. Capital Research Management Company each the funds it advises have received an exemptive order from the U.S. Securities Exchange Commission that allows Capital Research Management Company to use, upon approval the funds boards, its management subsidiaries affiliates to provide day-to-day management services to the funds, including making changes to the management subsidiaries affiliates providing such services. The Series shareholders approved this arrangement; however, there is no assurance that Capital Research Management Company will incorporate its divisions or exercise any authority granted to it under the exemptive order. In addition, shareholders the Series approved a proposal to reorganize the Series into a Delaware statutory trust. However, the Series reserves the right to delay implementing the reorganization. Portfolio holdings A description the funds policies procedures regarding disclosure information about their portfolio holdings is available in the statement additional information. The Capital System SM Capital Research Management Company uses a system multiple portfolio managers in managing mutual fund s. Under this approach, the portfolio a fund is divided into segments managed by individual managers who decide how their respective segments will be invested. In addition to the portfolio managers below, Capital Research Management Company s analysts may make decisions with respect to a portion a fund s portfolio. Investment decisions are subject to a fund s objective(s), policies restrictions the oversight the appropriate -related committees Capital Research Management Company its divisions. Certain senior members Capital Fixed Income Investors, the adviser s fixed- division, serve on the Portfolio Strategy Group. The group utilizes a research-driven process with input from the adviser s analysts, portfolio managers economists to define themes on a range macroeconomic factors, including duration, yield curve sector allocation. Where applicable, the decisions made by a fund s fixed- portfolio managers are informed by the themes discussed by the group. American Funds Insurance Series / Prospectus 8

The primary individual portfolio managers for each the funds are: Portfolio manager for the Series/Title (if applicable) Donald D. O Neal Vice Chairman the Board Alan N. Berro President Carl M. Kawaja Vice President Sung Lee Vice President Primary title with adviser (or affiliate) experience Partner Capital Research Global Investors Investment pressional for 32 years, all with Capital Research Management Company or affiliate Investment pressional for 31 years in total; 26 years with Investment pressional for 30 years in total; 26 years with Partner Capital Research Global Investors Investment pressional for 23 years, all with Capital Research Management Company or affiliate Dylan Yolles Vice President Partner Capital International Investors Investment pressional for 20 years in total; 17 years with Hilda L. Applbaum Investment pressional for 30 years in total; 22 years with Pramod Atluri Vice President Capital Fixed Income Investors Investment pressional for 19 years in total; 1 year with David C. Barclay Partner Capital Fixed Income Investors Investment pressional for 36 years in total; 29 years with L. Alfonso Barroso Partner Capital Research Global Investors Investment pressional for 23 years, all with Capital Research Management Company or affiliate David J. Betanzos Partner Capital Fixed Income Investors Investment pressional for 17 years in total; 15 years with Mark A. Brett Partner Capital Fixed Income Investors Investment pressional for 38 years in total; 24 years with Christopher D. Buchbinder Partner Capital Research Global Investors Investment pressional for 22 years, all with Capital Research Management Company or affiliate J. David Carpenter Investment pressional for 23 years in total; 19 years with Mark L. Casey Investment pressional for 17 years, all with Capital Research Management Company or affiliate Thomas H. Chow Vice President Capital Fixed Income Investors Investment pressional for 28 years in total; 2 years with Patrice Collette Investment pressional for 23 years in total, 17 years with David A. Daigle Partner Capital Fixed Income Investors Investment pressional for 23 years, all with Capital Research Management Company or affiliate Isabelle de Wismes Gerald Du Manoir Investment pressional for 33 years in total; 24 years with Partner Capital International Investors Investment pressional for 27 years, all with Capital Research Management Company or affiliate Portfolio manager s role in management, experience in, the fund(s) Growth-Income Fund 12 years Asset Allocation Fund 17 years New World Fund 18 years International Fund 11 years International Growth Income Fund 9 years Growth-Income Fund 12 years (plus 5 years prior experience as an analyst for the fund) Serves as an equity/fixed- portfolio manager for: Global Balanced Fund 6 years Serves as a fixed- portfolio manager for: Bond Fund 1 year Serves as a fixed- portfolio manager for: High-Income Bond Fund 24 years International Fund 8 years Serves as a fixed- portfolio manager for: Capital Income Builder 3 years Mortgage Fund 3 years U.S. Government/AAA-Rated Securities Fund 2 years Serves as a fixed- portfolio manager for: Global Balanced Fund 6 years Global Bond Fund 2 years Blue Chip Income Growth Fund 10 years Asset Allocation Fund 4 years Growth Fund Less than 1 year (plus 11 years prior experience as an analyst for the fund) Serves as a fixed- portfolio manager for: High-Income Bond Fund 2 years Global Growth Fund 2 years (plus 14 years prior experience as an analyst for the fund) Serves as a fixed- portfolio manager for: Asset Allocation Fund 8 years Global Bond Fund 2 years High-Income Bond Fund 8 years (plus 9 years prior experience as an analyst for the fund) Global Growth Fund 5 years (plus 14 years prior experience as an analyst for the fund) Serves as a fixed- portfolio manager for: Capital Income Builder Less than 1 year 9 American Funds Insurance Series / Prospectus

Portfolio manager for the Series/Title (if applicable) Paul Flynn Primary title with adviser (or affiliate) experience Investment pressional for 21 years in total; 19 years with J. Blair Frank Partner Capital Research Global Investors Investment pressional for 24 years in total; 23 years with Bradford F. Freer Investment pressional for 25 years in total; 23 years with Nicholas J. Grace David A. Hoag Thomas H. Høgh Claudia P. Huntington Michael T. Kerr Jonathan Knowles Darcy Kopcho Lawrence Kymisis Harold H. La Jeffrey T. Lager James B. Lovelace Jesper Lyckeus Fergus N. MacDonald Ronald B. Morrow James R. Mulally Investment pressional for 27 years in total; 23 years with Partner Capital Fixed Income Investors Investment pressional for 29 years in total; 26 years with Partner Capital Fixed Income Investors Investment pressional for 30 years in total; 27 years with Partner Capital Research Global Investors Investment pressional for 44 years in total; 42 years with Investment pressional for 34 years in total; 32 years with Investment pressional for 25 years, all with Capital Research Management Company or affiliate Partner Capital International Investors Investment pressional for 37 years in total; 29 years with Partner Capital Research Global Investors Investment pressional for 22 years in total; 14 years with Partner Capital Research Global Investors Investment pressional for 19 years in total; 18 years with Investment pressional for 22 years in total; 21 years with Partner Capital Research Global Investors Investment pressional for 35 years, all with Capital Research Management Company or affiliate Partner Capital Research Global Investors Investment pressional for 22 years in total; 21 years with Partner Capital Fixed Income Investors Investment pressional for 25 years in total; 14 years with Investment pressional for 49 years in total; 20 years with Partner Capital Fixed Income Investors Investment pressional for 41 years in total; 37 years with Portfolio manager s role in management, experience in, the fund(s) Serves as an equity/fixed- portfolio manager for: Global Growth Fund Less than 1 year Global Balanced Fund 4 years Global Small Capitalization Fund 14 years Growth-Income Fund 11 years New World Fund Less than 1 year (plus 13 years prior experience as an analyst for the fund) Global Growth Income Fund 3 years (plus 6 years prior experience as an analyst for the fund) New World Fund 5 years (plus 8 years prior experience as an analyst for the fund) Global Growth Income Fund 1 year Serves as a fixed- portfolio manager for: Bond Fund 10 years Serves as a fixed- portfolio manager for: Global Bond Fund 11 years Global Small Capitalization Fund 4 years Growth-Income Fund 23 years (plus 5 years prior experience as an analyst for the fund) Growth Fund 12 years Global Growth Fund 4 years (plus 10 years prior experience as an analyst for the fund) Capital Income Builder 3 years Global Small Capitalization Fund 5 years Global Small Capitalization Fund 9 years (plus 4 years prior experience as an analyst for the fund) Asset Allocation Fund 10 years Blue Chip Income Growth Fund 10 years International Fund 10 years (plus 8 years prior experience as an analyst for the fund) International Growth Income Fund 9 years Serves as a fixed- portfolio manager for: Mortgage Fund 6 years U.S. Government/AAA-Rated Securities Fund 7 years Growth Fund 14 years (plus 5 years prior experience as an analyst for the fund) Serves as a fixed- portfolio manager for: Asset Allocation Fund 11 years Ultra-Short Bond Fund 1 year American Funds Insurance Series / Prospectus 10