TISSUEMED LIMITED REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2017

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Company Registration No. 01902503 (England and Wales) TISSUEMED LIMITED REPORT AND FINANCIAL STATEMENTS FOR THE YEAR ENDED 31 MARCH 2017

COMPANY INFORMATION Directors Secretary Paul L. Banner Jeremy D. Sampson David J. Mandley Judith Whitworth Company number 01902503 Registered office Auditor 5 Killingbeck Drive Leeds West Yorkshire LS146UF RSM UK Audit LLP Chartered Accountants 2 Whitehall Quay Leeds LS14HG

DIRECTORS' REPORT The directors present their annual report and financial statements for the year ended 31 March 2017. Principal activities The principal activity of the company is the design, development, manufacture and sale of innovative adhesive medical devices for use in internal surgical procedures. The devices are based on the company's proprietary TissueBond bioadhesive technology and through its family of TissuePatch TIA products are designed to improve clinical outcomes and provide cost benefits lo hospitals. Directors The directors who held office during the year and up to the date of signature of the financial statements were as follows: Paul L. Banner Jeremy D. Sampson David J. Mandley Auditor RSM UK Audit LLP have indicated their willingness to be reappointed for another term and appropriate arrangements have been put in place for them to be deemed reappointed as auditors in the absence of an Annual General Meeting. Statement of disclosure to auditor So far as the directors are aware, there is no relevant audit information of which the company's auditor is unaware. Additionally, the directors have taken all the necessary steps that they ought to have taken as directors in order to make themselves aware of all relevant audit information and to establish that the company's auditor is aware of that information. i report has been prepared in accordance with the provisions applicable to companies entitled to the small m anies exemption. \ bebaif of the board - 1 -

DIRECTORS' RESPONSIBILITIES STATEMENT The directors are responsible for preparing the Directors' Report and the financial statements in accordance with applicable law and regulations. Company law requires the directors to prepare financial statements for each financial year. Under that law the directors have elected to prepare the financial statements in accordance with United Kingdom Generally Accepted Accounting Praclice (United Kingdom Accounting Standards and applicable law). Under company law the directors must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the company and of the profit or loss of the company for that period. In preparing these financial statements, the directors are required to: select suitable accounting policies and then apply them consistently; make judgements and accounting estimates that are reasonable and prudent; prepare the financial statements on the going concern basis unless it is inappropriate to presume that the company will continue in business. The directors are responsible for keeping adequate accounting records that are sufficient to show and explain the company's transactions and disclose with reasonable accuracy at any time the financial position of the company and enable them to ensure that the financial statements comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the company and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities. - 2 -

INDEPENDENT AUDITOR'S REPORT TO THE MEMBERS OF TISSUEMED LIMITED Opinion on financial statements We have audited the financial statements on pages 4 to 11. The financial reporting framework that has been applied in their preparation is applicable law and United Kingdom Accounting Standards (United Kingdom Generally Accepted Accounting Practice), including FRS 102 "The Financial Reporting Standard applicable in the UK and Republic of Ireland". In our opinion the financial statements: give a true and fair view of the state of the company's affairs as at 31 March 2017 and of its profit for the year then ended; have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice; and have been prepared in accordance with the requirements of the Companies Act 2006. Scope of the audit of the financial statements A description of the scope of an audit of financial statements is provided on the Financial Reporting Council's website at http://www.frc.org.uklauditscopeukprivate Opinion on other matter prescribed by the Companies Act 2006 In our opinion the information given in the Directors' Report for the financial year for which the financial statements are prepared is consistent with the financial statements and, based on the work undertaken in the course of our audit, the Directors' Report has been prepared in accordance with applicable legal requirements. Matters on which we are required to report by exception In the light of the knowledge and understanding of the company and its environment obtained in the course of the audit, we have not identified material misstatements in the Directors' Report. We have nothing to report in respect of the following matters where the Companies Act 2006 requires us to report to you if, in our opinion: adequate accounting records have not been kept, or returns adequate for our audit have not been received from branches not visited by us; or the financial statements are not in agreement with the accounting records and returns; or certain disclosures of directors' remuneration specified by law are not made; or we have not received all the information and explanations we require for our audit; or the directors were not entitled to prepare the financial statements in accordance with the small companies regime and take advantage of the small companies' exemption from the requirement to prepare a strategic report or in preparing the directors' report. Respective responsibilities of directors and auditor As more fully explained in the Directors' Responsibilities Statement set out on page 2, the directors are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view. Our responsibility is to audit and express an opinion on the financial statements in accordanoe with applicable law and International Standards on Auditing (UK and Ireland). Those standards require us to comply with the Auditing Practices Board's (APB's) Ethical Standards for Auditors. This report is made solely to the company's members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the company's members those matters we are required to state to them in an auditor's report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the company and the company's members as a body, for our audit work, for this report, or for the opinions we have formed. Daniel Varley (Senior Statutory Auditor) For and on behalf of RSM UK Audit LLP, Statutory Auditor Chartered Accountants 2 Whitehall Quay Leeds LS14HG -t 7.. l.<f... ~~ 201-3-

INCOME STATEMENT Turnover Cost of sales 2017 Notes 1,070,285 (125,891) 2016 772,543 (87,847) Gross profit 944,394 684,696 Research and development expenses Administrative expenses Other operating income (279,246) (690,432) 38,997 (305,864) (639,616) 82,640 Operating profiu(loss) 13,713 (178,144) Interest receivable and similar income ProfiU(loss) before taxation Taxation ProfiU(loss) for the financial year 4,066 17,779 41,747 59,526 5,656 (172,488) 66,192 (106,296) - 4-

Company Registration No. 01902503 STATEMENT OF FINANCIAL POSITION AS AT 31 MARCH 2017 Notes Fixed assets Tangible assets 4 35,468 13,069 Current assets Stocks Debtors Cash at bank and in hand 5 110,783 63,167 215,555 304,530 1,547,101 1,449,926 Creditors: amounts falling due within one year 6 Net current assets Total assets less current liabilities 1,873,439 1,817,623 (164,127) (145,438) 1,709,312 1,672,185 1,744,780 1,685,254 Capital and reserves Called up share capital Share premium account Profit and loss reserves 7 11,290,744 8,274,086 (17,820,050) 11,290,744 8,274,086 (17,879,576) Total equity 1,744,780 1,685,254 These financial statements have been prepared in accordance with the provisions applicable to companies subject to the small companies' regime. T a fi ancial statements were approved by the board of directors and authorised for issue on... l..b\.. &:I.. tl r signed on its behalf by: -5-

NOTES TO THE FINANCIAL STATEMENTS 1 Accounting policies Company information Tissuemed Limited is a private company limited by shares incorporated in England and Wales. registered office is 5 Killingbeck Drive, Leeds, West Yorkshire, LS14 6UF. The Accounting convention These financial statements have been prepared in accordance with FRS 102 "The Financial Reporting Standard applicable in the UK and Republic of Ireland" ("FRS 102") and the requirements of the Companies Act 2006 as applicable to companies subject to the small companies regime. The disclosure requirements of section 1A of FRS 102 have been applied other than where additional disclosure is required to show a true and fair view. The financial statements are prepared in sterling, which is the functional currency of the company. Monetary amounts in these financial statements are rounded to the nearest. The financial statements have been prepared under the historical cost convention. accounting policies adopted are set out below. The principal First time adoption of FRS 102 These financial statements are the first financial statements of Tissuemed Limited prepared in accordance with Financial Reporting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of Ireland' (FRS 102). The financial statements of Tissuemed Limited for the year ended 31 March 2016 were prepared in accordance withthe Financial Reporting Standard for Smaller Entities (effective January 2015) (UFRSSE"). Some of the FRS 102 recognition, measurement, presentation and disclosure requirements and accounting policy choices differ from the FRSSE. Consequently, the directors have amended certain accounting policies to comply with FRS 102. The directors have also taken advantage of certain exemptions from the requirements of FRS 102 permitted by FRS 102 Chapter 35 'Transition to this FRS', including the exemption from applying the requirements of Section 26 Share-based Payment to equity instruments granted before the date of transition to FRS 102. The reported financial position and financial performance for the previous period are not affected by the transition to FRS 102. Going concern The directors have considered the company's financial position. The company has net current assets of 1,709,312 (2016-1,672,185), and budgeted projections show that the company will be able to meet its liabilities as they fall due for a period of at least 12 months from the date of approval of the financial statements. Therefore the directors consider it appropriate to prepare the financial statements on a going concern basis. Turnover The turnover shown in the profit and loss account represents the value of all goods sold during the period, less returns received, at selling price exclusive of Value Added Tax. Sales are recognised at the point at which the company has fulfilled its contractual obligations and the risks and rewards attaching to the product, such as obsolescence, have been transferred to the customer. The risks and rewards attached to products are deemed to be transferred at the point of despatch. Research and development expenditure Expenditure on research and development incurred in the year is charged against profit. - 6-

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) 1 Accounting policies (Continued) Tangible fixed assets Tangible fixed assets are initially measured at cost and subsequently measured at cost or valuation, net of depreciation and any impairment losses. Depreciation is recognised so as to write off the cost or valuation of assets less their residual values over their useful lives on the following bases: Fixtures and fittings Equipment 20% - 33% straight line basis 20% straight line basis The gain or loss arising on the disposal of an asset is determined as the difference between the sale proceeds and the carrying value of the asset, and is credited or charged to profit or loss. Impairment of fixed assets At each reporting period end date, the company reviews the carrying amounts of its tangible assets to determine whether there is any indication that those assets have suffered an impairment loss. If any such indication exists, the recoverable amount of the asset is estimated in order to determine the extent of the impairment loss (if any). Recoverable amount is the higher of fair value less costs to sell and value in use. In assessing value in use, the estimated future cash flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of money and the risks specific to the asset for which the estimates of future cash flows have not been adjusted. If the recoverable amount of an asset (or cash-generating unit) is estimated to be less than its carrying amount, the carrying amount of the asset (or cash-generating unit) is reduced to its recoverable amount. An impairment loss is recognised immediately in profit or loss, unless the relevant asset is carried at a revalued amount, in which case the impairment loss is treated as a revaluation decrease. Stocks Stocks are stated at the lower of cost and estimated selling price less costs to complete and sell. Cost comprises direct materials and, where applicable, direct labour costs and those overheads that have been incurred in bringing the stocks to their present location and condition. At each reporting date, an assessment is made for impairment. Any excess of the carrying amount of stocks over its estimated selling price less costs to complete and sell is recognised as an impairment loss in profit or loss. Reversals of impairment losses are also recognised in profit or loss. Cash and cash equivalents Cash and cash equivalents are basic financial instruments and include cash in hand, deposits held at call with banks, other short-term liquid investments with original maturities of three months or less, and bank overdrafts. - 7-

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) 1 Accounting policies (Continued) Financial instruments The company has elected to apply the provisions of Section 11 'Basic Financial Instruments' and Section 12 'Other Financial Instruments Issues' of FRS 102 to all of its financial instruments. Financial instruments are recognised when the company becomes party to the contractual provisions of the instrument. Financial assets and liabilities are offset, with the net amounts presented in the financial statements, when there is a legally enforceable right to set off the recognised amounts and there is an intention to settle on a net basis or to realise the asset and settle the liability simultaneously. Basic financial assets Basic financial assets, which include trade and other debtors and cash and bank balances, are initially measured at transaction price including transaction costs and are subsequently carried at amortised cost using the effective interest method unless the arrangement constitutes a financing transaction, where the financial asset is measured at the present value of the future receipts discounted at a market rate of interest. Classification of financiallíabilities Financial liabilities and equity instruments are classified according to the substance of the contractual arrangements entered into. An equity instrument is any contract that evidences a residual interest in the assets of the company after deducting all of its liabilities. Basic financial liabilities Basic financial liabilities, including trade and other creditors are initially recognised at transaction price unless the arrangement constitutes a financing transaction, where the debt instrument is measured at the present value of the future payments discounted at a market rate of interest. Debt instruments are subsequently carried at amortised cost, using the effective interest rate method. Equity instruments Equity instruments issued by the company are recorded at the fair value of proceeds received, net of direct issue costs. Dividends payable on equity instruments are recognised as liabilities once they are no longer at the discretion of the company. Taxation The tax expense represents the sum of the current tax expense and deferred tax expense. Current tax assets are recognised when tax paid exceeds the tax payable. Current and deferred tax is charged or credited to profit or loss, except when it relates to items charged or credited to other comprehensive income or equity, when tile tax follows the transaction or event it relates to and is also charged or credited to other comprehensive income, or equity. Current tax assets and current tax liabilities and deferred tax assets and deferred tax liabilities are offset, if and only if, there is a legally enforceable right to set off the amounts and the entity intends either to settle on the net basis or to realise the asset and settle the liability simultaneously. Current tax is based on taxable profit for the year. Current tax assets and liabilities are measured using tax rates that have been enacted or substantively enacted by the reporting period. - 8-

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) 1 Accounting polìcles (Continued) Employee benefits The costs of short-term employee benefits are recognised as a liability and an expense, unless those costs are required to be recognised as part of the cost of stock or fixed assets. The cost of any unused holiday entitlement is recognised in the period in which the employee's services are received. Termination benefits are recognised immediately as an expense when the company is demonstrably committed to terminate the employment of an employee or to provide termination benefits. Retirement benefits The company operates a defined contribution pension scheme and the pension charge represents the amounts payable by the company to the fund in respect of the year. The assets of the scheme are held separately from those of the company in an independently administered fund. Operating leases RenIais payable under operating leases, including any lease incentives received, on a straight line basis over the term of the relevant lease. are charged to income Government grants Government grants are credited to deferred revenue. Grants towards capital expenditure are released to the profit and loss account over the useful life of the assets. Grants towards revenue expenditure are released to the profit and loss account as the related expenditure is incurred. Foreign exchange TransacUons denominated in foreign currencies are recorded at the rates of exchange ruling at the dates of the transactions, or at an average rate for the period if the rates do not fluctuate significantly. Monetary assets and liabilities are translated at year end exchange raies or, where appropriate, at rates of exchange fixed under the terms of the relevant transaction. The resulting exchange rate differences are charged to the profit and loss account. 2 Employees The average monthly number of persons (including directors) employed by the company during the year was 15 (2016-15). 3 Directors' remuneration Remuneration paid to directors 166,510 168,509 Dividends totalling nil (2016 - nil) were paid in the year in respect of shares held by the company's directors. The number of directors for whom retirement benefits are accruing under defined contribution schemes amounted to 1 (2016-1). -9-

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) 4 Tangible fixed assets Fixtures and Equipment Total fittings Cost At 1 Aprii 2016 300,110 381,988 682,098 Additions 10,154 24,647 34,801 At 31 March 2017 310,264 406,635 716,899 Depreciation and impairment At 1 April 2016 293,403 375,626 669,029 Depreciation charged in the year 6,507 5,895 12,402 At 31 March 2017 299,910 381,521 681,431 Carrying amount At 31 March 2017 10,354 25,114 35,468 At 31 March 2016 6,707 6,362 13,069 5 Debtors Amounts falling due within one year: Trade debtors 143,127 176,912 Corporation tax recoverable 36,114 66,192 VAT recoverable 3,679 6,014 Other debtors 32,635 55,412 215,555 304,530 6 Creditors: amounts falling due within one year Trade creditors 50,277 83,496 Other taxation and social security 17,677 12,959 Other creditors 96,173 48,983 164,127 145,438 Ineluded within creditors at the year end is 2,564 (2016-2,504) of outstanding pension contributions. - 10 -

NOTES TO THE FINANCIAL STATEMENTS (CONTINUED) 7 Called up share capital Ordinary share capital Issued and fully paid 5,003,100 1 P Ordinary shares of 1 p each 911,460 SOp Ordinary shares of 50p each 36,296,600 25p Ordinary shares of 25p each 342,166,600 0.5p Ordinary shares of 0.5p each 50,031 50,031 455,730 455,730 9,074,150 9,074,150 1,710,833 1,710,833 11,290,744 11,290,744 The company's ordinary shares rank pari passu and carry no right to fixed income. Each ordinary share carries the right to one vote at general meetings of the company. 8 Share-based payment transactions The following share options, to subscribe for Ordinary shares of 0.5p each, existed during the period: Grant date Subscription price per share Vesting period Number of shares for which rights are exercisable 25-May-07 01-Aug-07 07-Dec-0? 25-Nov-14 0.020 0.045 0.045 0.005 10 years 10 years 10 years 10 years 2,610,827 5,500,000 2,575,714 10,000,000 2,610,827 5,500,000 2,575,714 10,000,000 9 Operating lease commitments At the reporting end date the company had outstanding commitments for future minimum lease payments under non-cancellable operating leases, which fall due as follows: Within one year 44,748 42,047 Between one and five years 139,511 15,285 184,259 5?,332-11 -