NuVasive, Inc. 34 th Annual J.P. Morgan Healthcare Conference

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NuVasive, Inc. 34 th Annual J.P. Morgan Healthcare Conference January 12, 2016 Greg Lucier Chairman and Chief Executive Officer

Safe Harbor Statements Forward-looking information and non-gaap measures NuVasive, Inc. ( NuVasive, NUVA or the Company ) cautions you that statements included in this presentation that are not a description of historical facts are forward-looking statements that involve risks, uncertainties, assumptions and other factors which, if they do not materialize or prove correct, could cause the Company's results to differ materially from historical results or those expressed or implied by such forwardlooking statements. Forward-looking statements include, but are not limited to, statements regarding the Company s expected financial results for 2015, its financial projections for 2016 and expectations for longerterm financial and business goals, including its growth plans to drive to $1 billion in revenue and beyond, statements about the planned acquisition of Ellipse Technologies, the timing and funding of the anticipated acquisition, the potential benefits, synergies and cost savings of the anticipated acquisition, including the expected impact on future financial and operating results, and post-acquisition plans and intentions. The Company s estimated quarterly and annual financial results for 2015 are preliminary and subject to adjustment in the ongoing review and audit procedures by the Company s external auditors. In addition, NuVasive s projections for 2016 represent the Company s initial estimates, and are subject to the risk of being inaccurate because of the preliminary nature of the forecasts, the risk of further adjustment, or unanticipated difficulty in selling products or generating expected profitability. The Company s planned acquisition of Ellipse Technologies is subject to closing conditions, including regulatory approvals, and the expected benefits and synergies may not be realized. Potential risks and uncertainties that could cause actual results, growth and/or future performance to differ materially include, but are not limited to: the risk of further adjustment to financial results or future financial expectations; the risk that revenue or earnings projections may turn out to be inaccurate because of the preliminary nature of the forecasts; unanticipated difficulty in selling products, generating revenue or producing expected profitability; the risk that the required regulatory approvals for the planned acquisition are not obtained, are delayed or are subject to unanticipated conditions that could adversely affect the combined company or the expected benefits of the acquisition; and those other risks and uncertainties more fully described in the Company s news releases and periodic filings with the Securities and Exchange Commission. NuVasive's public filings with the Securities and Exchange Commission are available at www.sec.gov. NuVasive assumes no obligation to update any forward-looking statement to reflect events or circumstances arising after the date on which it was made. 2

NuVasive Today Leading scale, innovative technology, strong partner relationships #3 player in the $9 billion global spine market Clinical and economic value partners Pioneered lateral access spine surgery- XLIF - 2003 * *Spinemarket worldwide spinal market estimates The leading provider of integrated MAS procedural systems Expert in minimally invasive (MIS) maximum access surgery (MAS ) 3

Comprehensive Spine Portfolio Procedural solutions spanning lumbar, thoracic and cervical applications Anterior/Lateral Cervical ACDF ACR Posterior/Lateral Cervical Posterior Cervical Fusion Laminoplasty PCM Cervical Disc Thoracolumbar XLIF XLIF Corpectomy ALIF Thoracolumbar MAS TLIF MAS PLIF MAS ILIF Open PLIF Open TLIF Posterior Fixation Incredible breadth of solutions up and down the spine to address global market 4

NuVasive s Purpose and Mission Guiding principals driving the business forward Transforming Spine Surgery. Changing Lives. First be the Best. Then be the First. 5

Strong History of Growth and Increasing Profitability Disciplined execution of strategy delivers exceptional results $850 $800 Global Revenue (In Millions) ~$811.0 15% Non-GAAP Operating Profit Margin >15.2% $762.4 13% $750 11.4% 11% $700 $685.2 9% 9.2% $650 7% $600 2013 2014 2015* 5% 2013 2014 2015* *Reflects preliminary financial results announced January 12, 2016; ^On a constant currency basis 6

2015 Operational and Financial Highlights Consistently delivering on commitments Innovation Launched Integrated Global Alignment (iga ) platform to help address proper alignment Introduced more than 10 new products and line extensions Strengthened lumbar performance Gained traction with new cervical offerings Operational Excellence Optimized organizational structure to become even more efficient and responsive Established world-class leadership team to drive next phase of growth and success Building out facility in West Carrollton, OH to support ~100% self-manufacturing goal Removed overhang of OIG investigation and NMP litigation Profitable Growth Delivering ~8% constant currency full year 2015 revenue growth* Delivering full year 2015 non-gaap operating profit margin >15.2%* *Reflects preliminary financial results announced January 12, 2016 7

NuVasive s Formula for Success Relentless focus on driving shareholder value Industry disruptor adding value and addressing unmet needs Driving organic growth with numerous inorganic opportunities Operational excellence delivering significant margin expansion Profitability 8

Positioned as Industry Disruptor Game-changing innovation designed to improve surgical outcomes Core focus on differentiated, less invasive treatments Providing clear clinical and economic value Innovation and differentiation drive premium pricing and greater mix of products used in procedure 9

Increasing R&D Investment to Fuel Growth Committed to leading innovation with incremental investment 8% 7% 6% 5% 4% 3% 2% R&D Investment Growing to ~7% of Revenue* ~4.5% ~6.0% ~7.0% Investing in solutions for unmet clinical needs Focused on driving procedural evolution Constantly adding sophistication and value to competitively elevate offering Goal of launching 10+ new products per year Today At $1 Billion in Revenue Beyond $1 Billion in Revenue *NuVasive estimates 10

Category-Winning Innovation with iga Reshaping spine market with game-changing technology Integrated Global Alignment platform addresses next frontier in spine surgery ALIGNMENT Utilized in both minimally invasive and traditional approaches 11

Key Opinion Leaders Driving iga Adoption Strong early momentum at leading academic institutions 12

The Future of Spine Combining innovation know-how with select technology solutions Data and information driven operative decisions Robotics Navigated guidance 3-D imaging and additive manufacturing Image recognition 13

Driving Multi-Faceted Growth Strong organic growth with numerous inorganic growth opportunities ORGANIC Disruptive Technology: Category leader innovating at a generation above competitors Commercial Success: Compel hospitals and surgeons to use more NuVasive technology and services Globalization: Develop the scale to the grow International business to nearly double revenue contribution INORGANIC Strategic, Disciplined M&A: Pursue acquisitions and strategic partnerships that focus on clear criteria: Support strategy Geographic expansion Add technological capabilities Complementary to portfolio Financial impact Proper return 14

Taking Share Through Commercial Success Driving organic growth with multi-pronged go-to-market approach Commercial Success Surgeon Conversion Service Line Partnership Service Integration and Expansion 15

Focused on Strategic Hiring NuVasive is a preferred destination for sale representatives Strength of competitive offering attracting talented, experienced sales representatives Implementing clinical associate model to allow for increased competitive conversion and drive sales force efficiencies Expanding sales force in line with business needs, but focused on key geographies NuVasive s War Room 16

Enhanced Approach to U.S. Market Growth Shift focus in major markets for scalable growth and efficiencies Identified multiple large, underpenetrated major metropolitan markets Going deep in market and winning with differentiated offering Strategically investing in people and resources Dramatically increasing market share Driving revenue growth of 2x-3x greater than Company total Inherent operating efficiencies with scaling market 17

NuVasive International Presence Today ~4% International market share leaves significant runway for growth International Revenue (In Millions) $120 $100 $103 $80 $73 $60 $55 $40 $20 $0 2012 2013 2014 *On a constant currency basis 18

Accelerating International Growth Plans to drive near doubling of International revenue Replicate success in markets like Japan, Italy and Australia Lead with competitive XLIF and iga technology Focus on differentiated procedural sell to drive positive momentum Seek inorganic expansion in key markets, like China 19

Acquiring Ellipse Technologies Reinforces focus on transformative spine solutions Adds fast-growing, highly regarded complex deformity franchise Significant opportunity to integrate disruptive technology platform with NuVasive product offerings MAGEC SPINAL BRACING AND DISTRACTION SYSTEM Expands International presence immediately with opportunities for greater penetration globally Accelerates revenue and earnings growth while supporting ROIC goal $380 million upfront payment with potential $30 million milestone financed with cash on hand FY16 revenue of ~$60 million Before PRECICE LIMB LENGTHENING TECHNOLOGY After The Company entered into an agreement to acquire Ellipse Technologies, Inc. on January 4, 2016. The transaction is expected to close by the end of February 2016, subject to customary closing conditions and regulatory approvals. 20

Ellipse Technologies Significantly Adds to Portfolio Comprehensive approach to fast-growing complex deformity market 2 product families PRECICE LIMB LENGTHENING TECHNOLOGY intramedullary nail used for limb lengthening of the femur and tibia with a remote control to non-invasively lengthen the implant. MAGEC SPINAL BRACING AND DISTRACTION SYSTEM adjustable growing rod that utilizes innovative magnet technology and a remote control to non-invasively lengthen the device 5,000 patients treated worldwide 21

Delivering Increasing Organic Profitability Focus on operational excellence enhances long-term margin expansion 30% Non-GAAP Operating Profit Margin* 25% ~25.0% 20% 15% 10% 11.4% >15.2% ~20.0% 5% 0% 2014 Actual 2015 Preliminary At $1 Billion in Revenue Beyond $1 Billion in Revenue *NuVasive financial performance guidance as of January 12, 2016 22

Core Operating Profit Margin Improvements Plans to capture ~1,500 basis points* of margin expansion 1,500 ~1,500 Basis Points 200 Sales Force Efficiencies tenure, coverage vs. quota carrying representatives, etc. 1,000 400 International Scalability International non-gaap operating profit margins moving to ~35% 500-400 500 In-Source Manufacturing % select implants and instruments in-sourced moving to 100% Asset Efficiencies freight, SKU rationalization, set configurations, E&O reduction, facilities, support functions, etc. *NuVasive non-gaap operating profit margin improvement expectations as Company reaches beyond $1 billion in revenues 23

New Manufacturing Facility in Ohio Build-out of new facility in West Carrollton, OH to support self-manufacturing of select implants and instruments Plan to Invest ~$45 million to construct and equip new facility with state-of-the art equipment Expect to employ ~300 full-time, high-tech positions Expect to add ~100 CNC machine tools and advanced inspection equipment, as well as cleanroom operations Further align R&D and product development teams to optimize and accelerate product launches Enhances manufacturing presence in U.S. Supports acceleration of non-gaap operating profit margins 24

Closing the Gap in Profitability Performance Driving effective tax rate improvements in line with peer group Effective Tax Rate* 60% 55% 50% 45% 40% 35% 30% 25% 20% 15% 10% 54% ~43%* ~33% ~30% Peer Group = ~32% 2014 2015 At $1 Billion in Revenue Beyond $1 Billion in Revenue *NuVasive financial performance guidance as of January 12, 2016 25

Significantly Improving Free Cash Flow Business optimization and prudent investment enhancing position Free Cash Flow Trend* ~25% CAGR* Operating profit margin expansion Reducing effective tax rate Improving inventory days on hand Greater asset efficiencies to reduce CapEx Today At $1 Billion in Revenue Beyond $1 Billion in Revenue *NuVasive financial performance guidance as of January 12, 2016 26

Multiple Value Creation Opportunities Three clear paths to creating greater shareholder value 1. Growing revenue at multiples of the market 2. Driving profitability profile to ~25% non-gaap operating profit margin 3. Significant reduction to effective tax rate Earnings growth of approximately 2x topline growth Significant gains in free cash flow 27

Preliminary 2015 Results and 2016 Guidance* Driving strong momentum within the business Preliminary full year 2015 revenue of ~$811 million, or ~8% growth over prior year on a constant currency basis Preliminary full year 2015 non-gaap operating profit margin anticipated to exceed guidance of 15.2% Reiterated full year 2016 revenue guidance of ~$870 million, excluding the impact of Ellipse Technologies acquisition Reiterated full year 2016 non-gaap operating profit margin expansion guidance of ~100 basis points vs. full year 2015, excluding the impact of Ellipse Technologies acquisition Ellipse Technologies acquisition drives acceleration of long-term stated revenue growth target to high single-digit; slightly accretive to non-gaap EPS in first 12 months and significantly thereafter *Reflects preliminary financial results announced January 12, 2016 28

Why Invest in NuVasive Relentless focus on driving shareholder value $9 Billion Global Spine Market Competitively positioned in large and growing global spine market with favorable transformative dynamics playing to NuVasive strengths Disruptive Technology Commercial Success Globalization Industry-leading innovation and integrated procedural solutions enables share-taking and premium pricing Drive surgeon conversion, increase service line partnerships and expand services integration Double International revenue contribution in coming years Grow revenues at multiples of market in mid to high single-digit range* Achieve ~25% long-term non- GAAP operating profit margin and ~32% adjusted EBITDA goals* Optimize tax structure to help drive EPS growth 2x the rate of revenue growth* Disciplined capital deployment for strategic M&A and partnerships Set to generate significant increases in free cash flow *NuVasive financial performance guidance as of January 12, 2016 on standalone basis; Company to update long-term performance goals following h completion of Ellipse Technologies acquisition 29

NuVasive, Inc. 34 th Annual J.P. Morgan Healthcare Conference January 12, 2016 Greg Lucier Chairman and Chief Executive Officer