First Quarter 2017 Earnings Results

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First Quarter 2017 Earnings Results Performance Summary May 3, 2017

Legal Disclaimer The facts and figures contained in this report that do not refer to historical data are future projections and assumptions. Words and expressions such as believe, hope, anticipate, predict, expect, intend, should, will seek to achieve, it is estimated, future and similar expressions, in so far as they relate to the Grifols group, are used to identify future projections and assumptions. These expressions reflect the assumptions, hypotheses, expectations and predictions of the management team at the time of writing this report, and these are subject to a number of factors that mean that the actual results may be materially different. The future results of the Grifols group could be affected by events relating to its own activities, such as a shortage of supplies of raw materials for the manufacture of its products, the appearance of competitor products on the market, or changes to the regulatory framework of the markets in which it operates, among others. At the date of compiling this report, the Grifols group has adopted the necessary measures to mitigate the potential impact of these events. Grifols, S.A. does not accept any obligation to publicly report, revise or update future projections or assumptions to adapt them to events or circumstances subsequent to the date of writing this report, except where expressly required by the applicable legislation. This document does not constitute an offer or invitation to buy or subscribe shares in accordance with the provisions of the following Spanish legislation: Royal Legislative Decree 4/2015, of 23 October, approving recast text of Securities Market Law; Royal Decree Law 5/2005, of 11 March and/or Royal Decree 1310/2005, of 4 November, and any regulations developing this legislation. In addition, this document does not constitute an offer of purchase, sale or exchange, or a request for an offer of purchase, sale or exchange of securities, or a request for any vote or approval in any other jurisdiction. The information included in this document has not been verified nor reviewed by the external auditors of the Grifols Group. 2 1Q 2017 EARNINGS RESULTS GRIFOLS

Operational and Financial Highlights - 1Q 2017 Grifols market positioning amid a solid demand for the main plasma proteins leads to an outstanding 15.1% (11.9% cc 1 ) increase in sales of its Bioscience Division to Euros 853.6 million. The Diagnostic Division increases revenues by 6.0% (3.3% cc), driven by the evolution of the NAT (Nucleic Acid Testing) technology business in its main markets. The adjusted EBITDA 2 grows to Euros 322.9 million (a 14.3% increase) and the adjusted EBITDA margin is 30.4%. Net profits rise by 7.0% to Euros 134.0 million. The adjusted net profit 3 increases by 17.1% to reach Euros 164.2 million. Grifols is the world-leading company with nearly 180 plasma donation centers in the U.S. The group s investment plan aims to expand this network to 225. Grifols promotes the vertical integration of its Diagnostic Division with the acquisition of the Hologic's share of the NAT donor screening unit for USD 1,850 million in January 2017. Grifols successfully completes the refinancing of its debt by USD 7.300 million, notably improving all existing conditions: the average cost of debt drops by 120 basis points and falls below 3%. The average maturity exceeds 7 years. 3 1Q 2017 EARNINGS RESULTS GRIFOLS

Operational and Financial Highlights - 1Q 2017 Total net investments in R&D+i increase by 22.9% to Euros 62.6 million, including resources allocated to both internal and external projects. Euros 1,200 million 2016-2020 Capital Investment Plan on track with Euros 62.5 million invested during the quarter. 1. cc: at constant currency rates. 2. Excludes the non-recurring costs related to the acquisition of Hologic's share of the NAT donor-screening unit. 3. Excludes non-recurring costs and costs related to recent acquisitions, depreciation of deferred financial expenses associated with the refinancing process and depreciation of intangibles associated with acquisitions. 4 1Q 2017 EARNINGS RESULTS GRIFOLS

Key financial metrics - 1Q 2017 In millions of euros except % and EPS 1Q 2017 1Q 2016 % Var NET REVENUE (NR) 1,061.7 958.9 10.7% GROSS MARGIN 51.0% 49.4% EBITDA 306.0 282.5 8.3% % NR 28.8% 29.5% ADJUSTED EBITDA (1) 322.9 282.5 14.3% % NR 30.4% 29.5% EBIT 252.7 231.5 9.2% % NR 23.8% 24.1% GROUP PROFIT 134.0 125.2 7.0% % NR 12.6% 13.1% ADJUSTED (2) GROUP PROFIT 164.2 140.2 17.1% % NR 15.5% 14.6% CAPEX 62.5 57.5 8.7% R&D NET INVESTMENT 62.6 51.0 22.9% EARNINGS PER SHARE (EPS) 0.20 0.18 7.0% March 2017 December 2016 % Var TOTAL ASSETS 11,708.4 10,129.8 15.6% TOTAL EQUITY 3,816.8 3,728.0 2.4% CASH & CASH EQUIVALENTS 737.3 895.0 (17.6%) LEVERAGE RATIO 4.45/(4.51cc) (3) 3.55/(3.45cc) (3) (1) (2) Excludes non-recurring costs and associated with recent acquisitions, amortization of deferred expenses associated to the refinancing and amortization of intangible assets related to acquisitions (3) Excludes non-recurring costs and associated with recent acquisitions Constant currency (cc) excludes the impact of exchange rate movements 5 1Q 2017 EARNINGS RESULTS GRIFOLS

Net revenue by division - 1Q 2017 In thousands of euros 1Q 2017 % of Net Revenues 1Q 2016 ** % of Net Revenues % Var % Var cc* BIOSCIENCE 853,639 80.4% 741,859 77.4% 15.1% 11.9% DIAGNOSTIC 170,643 16.1% 161,040 16.8% 6.0% 3.3% HOSPITAL 22,964 2.2% 22,838 2.4% 0.6% (0.3%) BIO SUPPLIES 14,401 1.3% 17,635 1.8% (18.3%) (20.5%) OTHERS 33 0.0% 15,561 1.6% (99.8%) (99.3%) TOTAL 1,061,680 100.0% 958,933 100.0% 10.7% 7.7% * Constant currency (cc) excludes the impact of exchange rate movements ** Comparable net revenues considering the reclassification of the biological products for non-therapeutic use sales that since January of 2017 are reported in the Bio Supplies Division 6 1Q 2017 EARNINGS RESULTS GRIFOLS

Net revenue by region - 1Q 2017 In thousands of euros 1Q 2017 % of Net Revenues 1Q 2016 ** % of Net Revenues % Var % Var cc* US + CANADA 728,570 68.6% 634,972 66.2% 14.7% 11.1% EU 161,747 15.3% 162,708 17.0% (0.6%) 0.3% ROW 171,363 16.1% 161,253 16.8% 6.3% 2.1% TOTAL 1,061,680 100.0% 958,933 100.0% 10.7% 7.7% * Constant currency (cc) excludes the impact of exchange rate movements ** Comparable net revenues considering the reclassification of the biological products for non-therapeutic use sales that since January of 2017 are reported in the Bio Supplies Division 7 1Q 2017 EARNINGS RESULTS GRIFOLS

Profit & Loss account - 1Q 2017 In thousands of euros 1Q 2017 1Q 2016 % Var NET REVENUE (NR) 1,061,680 958,933 10.7% COST OF SALES (519,783) (484,754) 7.2% GROSS MARGIN 541,897 474,179 14.3% % NR 51.0% 49.4% R&D (59,171) (47,665) 24.1% SG&A (230,014) (195,061) 17.9% OPERATING EXPENSES (289,185) (242,726) 19.1% OPERATING RESULT (EBIT) 252,712 231,453 9.2% % NR 23.8% 24.1% FINANCIAL RESULT (66,225) (68,565) (3.4%) SHARE OF RESULTS OF EQUITY ACCOUNTED INVESTEES (3,288) 1,351 (343.4%) PROFIT BEFORE TAX 183,199 164,239 11.5% % NR 17.3% 17.1% INCOME TAX EXPENSE (49,464) (39,417) 25.5% % OF PRE-TAX INCOME 27.0% 24.0% CONSOLIDATED PROFIT FOR THE YEAR 133,735 124,822 7.1% RESULT ATTRIBUTABLE TO NON-CONTROLLING INTERESTS (258) (424) (39.2%) GROUP PROFIT FOR THE PERIOD 133,993 125,246 7.0% % NR 12.6% 13.1% 8 1Q 2017 EARNINGS RESULTS GRIFOLS

Balance sheet (Assets) - 1Q 2017 In thousands of euros March December 2017 2016 NON-CURRENT ASSETS 8,756,188 7,007,258 GOODWILL AND OTHER INTANGIBLE ASSETS 6,529,475 4,839,297 PROPERTY PLANT & EQUIPMENT 1,841,190 1,809,852 INVESTMENTS IN EQUITY ACCOUNTED INVESTEES 243,341 201,345 NON-CURRENT FINANCIAL ASSETS 64,600 89,545 OTHER NON-CURRENT ASSETS 77,582 67,219 CURRENT ASSETS 2,952,170 3,122,514 INVENTORIES 1,685,606 1,642,931 TRADE AND OTHER RECEIVABLES 485,251 533,668 OTHER CURRENT FINANCIAL ASSETS 12,541 2,582 OTHER CURRENT ASSETS 31,481 48,324 CASH AND CASH EQUIVALENTS 737,291 895,009 TOTAL ASSETS 11,708,358 10,129,772 9 1Q 2017 EARNINGS RESULTS GRIFOLS

Balance sheet (Equity & Liabilities) - 1Q 2017 In thousands of euros March December 2017 2016 EQUITY 3,816,765 3,727,978 CAPITAL 119,604 119,604 SHARE PREMIUM 910,728 910,728 RESERVES 2,240,347 1,694,245 TREASURY STOCK (68,710) (68,710) INTERIM DIVIDENDS (122,908) (122,908) CURRENT YEAR EARNINGS 133,993 545,456 OTHER COMPREHENSIVE INCOME 597,378 643,066 NON-CONTROLLING INTERESTS 6,333 6,497 NON-CURRENT LIABILITIES 6,946,755 5,330,031 NON-CURRENT FINANCIAL LIABILITIES 6,333,049 4,712,071 OTHER NON-CURRENT LIABILITIES 613,706 617,960 CURRENT LIABILITIES 944,838 1,071,763 CURRENT FINANCIAL LIABILITIES 158,813 230,065 OTHER CURRENT LIABILITIES 786,025 841,698 TOTAL EQUITY AND LIABILITIES 11,708,358 10,129,772 10 1Q 2017 EARNINGS RESULTS GRIFOLS

Cash flow - 1Q 2017 In thousands of euros 1Q 2017 1Q 2016 GROUP PROFIT 133,993 125,246 DEPRECIATION AND AMORTIZATION 53,314 51,068 NET PROVISIONS (272) (92) OTHER ADJUSTMENTS AND OTHER CHANGES IN WORKING CAPITAL (21,103) (2,837) CHANGES IN INVENTORIES (59,885) (70,455) CHANGES IN TRADE RECEIVABLES 57,252 (39,660) CHANGES IN TRADE PAYABLES (17,915) (4,935) CHANGE IN OPERATING WORKING CAPITAL (20,548) (115,050) NET CASH FLOW FROM OPERATING ACTIVITIES 145,384 58,335 BUSINESS COMBINATIONS AND INVESTMENTS IN GROUP COMPANIES (1,812,688) (27,270) CAPEX (62,523) (57,537) R&D/OTHER INTANGIBLE ASSETS (3,810) (4,803) OTHER CASH INFLOW / (OUTFLOW) 20,614 (2,881) NET CASH FLOW FROM INVESTING ACTIVITIES (1,858,407) (92,491) FREE CASH FLOW (1,713,023) (34,156) ISSUE / (REPAYMENT) OF DEBT 1,663,125 (24,376) OTHER CASH FLOWS FROM/(USED IN) FINANCING ACTIVITIES (97,198) (29,761) NET CASH FLOW FROM FINANCING ACTIVITIES 1,565,927 (54,137) TOTAL CASH FLOW (147,096) (88,293) CASH AND CASH EQUIVALENTS AT THE BEGINNING OF THE YEAR 895,009 1,142,500 EFFECT OF EXCHANGE RATE CHANGES IN CASH AND CASH EQUIVALENTS (10,622) (46,630) CASH AND CASH EQUIVALENTS AT THE END OF THE PERIOD 737,291 1,007,577 11 1Q 2017 EARNINGS RESULTS GRIFOLS

Group profit reconciliation - 1Q 2017 In millions of euros 1Q 2017 1Q 2016 % Var GROUP NET PROFIT 134.0 125.2 7.0% % NR 12.6% 13.1% Amortization of deferred financial expenses 15.0 10.2 47.1% Amortization of intangible assets acquired in business combinations 9.4 9.5 (1.1%) Non-recurring costs and costs associated with recent acquisitions 16.9 - Tax impacts of adjustments (11.1) (4.7) 136.2% ADJUSTED GROUP NET PROFIT 164.2 140.2 17.1% % NR 15.5% 14.6% 12 1Q 2017 EARNINGS RESULTS GRIFOLS

Share performance - 1Q 2017 GRIFOLS DAILY SHARE PRICE, CLASS A & CLASS B vs IBEX 35 BASE 100: from December 31, 2016 to March 31, 2017 Source: Infobolsa 130 Class A: +21.8% Class B: +15.8% 120 110 IBEX-35: +11.9% 100 90 Dec-16 Jan-17 Feb-17 Mar-17 13 1Q 2017 EARNINGS RESULTS GRIFOLS