Meeting the Health Care Challenges of Tomorrow. Jon Roberts Executive Vice President & President, CVS Caremark

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Meeting the Health Care Challenges of Tomorrow Jon Roberts Executive Vice President & President, CVS Caremark

Agenda PBMs: Needed Now More Than Ever Performance Highlights How We Address Payors #1 Priority: Reducing Cost Integrated Where It Matters Innovating for the Future 2

Challenged by Evolving Market Dynamics, Payors Look for More From a PBM Rising Drug Costs Increasing Consumerism Movement to Value-Based Care Evolving Role of Government Drug price inflation and high launch prices continue to drive trend and spend Size and scale remain key for negotiating strength Higher cost share for consumers Complex drug regimens are engagement challenges Incentives for quality driving change Focus on quantifiable improvement of outcomes Growing enrollment in government programs Challenging regulatory environment Increased focus on clinical outcomes 3

The Most Extensive Suite of Leading Assets Retail Clinics Long-Term Care Retail Cost Management Tools Mail Specialty Clinical Programs Infusion Digital Payors Patients Providers Medical Claims Editing enabling us to deliver superior outcomes at a lower cost 4

Our Integrated Model Positions Us as the PBM of Choice Integrated PBM / Health Plan Standalone PBM Purchasing Scale Actionable Clinical Information Integrated Where It Matters Consumer Touchpoints 5

Agenda PBMs: Needed Now More Than Ever Performance Highlights How We Address Payors #1 Priority: Reducing Cost Integrated Where It Matters Innovating for the Future 6

Continued Strong PBM Performance Net Revenue ($, billions) Operating Profit ($, billions) 14.7% CAGR 12.1% CAGR 76 88 100 120 132 3.1 3.5 4.0 4.6 4.9 2013 2014 2015 2016E 2017E 2013 2014 2015 2016E 2017E Refer to endnotes for additional information. 7

2017: Another Outstanding Selling Season LEADING THE MARKET IN SALES CVS Health won >50% of revenue from clients changing PBMs CVS Health achieved ~97% client retention Refer to endnotes for additional information. 8

2017: Another Outstanding Selling Season Employer $7.8 Billion Health Plan $1.4 Government & Union $1.3 $5.1 Sales (billions) Net new business of $4.3 billion Refer to endnotes for additional information. 9

New Business Provides Platform to Grow Enterprise Dispensing Last 3 Years New business $31B Enterprise Rx Volume (Rx dispensed, millions) 29.1 29.9 +20.7 +14.2 +7.3 15.7 19.4 26.7 Rxs for enterprise 42M 8.4 Class of 2015 Class of 2016 Class of 2017 Pre PBM Projected 2017 The longer we serve a client, the more we grow enterprise dispensing Refer to endnotes for additional information. 10

Our Record of Success in Building Prescription Volume With Health Plans New Health Plan Client Multi-Year Health Plan Client +3.4 3.3 6.7 Enterprise Rx Volume (Rx dispensed, millions) +3.5 7.8 11.3 +6.9 11.1 18.0 Enterprise Rx Volume (Rx dispensed, millions) +6.9 4.4 4.6 5.3 Medicaid Medicare D Total Total Pre PBM Post PBM 2014 2015 2016E Refer to endnotes for additional information. 11

Leading in Medicare by Delivering Service and Quality Largest PDPs by Enrollment (lives, millions) Star Rating Medicare Lives Served by PBMs (lives, millions) % of Lives in 4 or 5 Star Plan CVS Health SilverScript Humana Insurance Company United Healthcare Plan #1 3.0 4.7 5.6 4 3 3.5 United Healthcare CVS Caremark Humana Express Scripts 5.3 7.8 12.3 12.0 46% 80% 4% 77% Express Scripts Medicare 2.6 4 Prime 1.2 75% United Healthcare Plan #2 1.3 3 MedImpact 0.9 70% Aetna Plan #1 Cigna-Health Spring Rx 1.2 1.0 3.5 3 Other Envision Argus 0.7 0.7 0.5 63% 8% 44% Aetna Plan #2 (First Health) 0.9 3.5 Captive Non-Captive Refer to endnotes for additional information. 12

Helping Our Health Plan Clients Grow Their Medicare Business 7.6% CAGR 2013-2016 4.8% CAGR 2013-2016 CMS-REPORTED TOTAL MARKET GROWTH GROWTH OF PLANS ADMINISTERED BY Refer to endnotes for additional information. 13

Specialty Growth Continues to Outpace the Market CVS Specialty Dispensed Revenue ($, billions) 27 32 37 29% CVS Specialty CAGR 14 20 19% Industry CAGR 2013 2014 2015 2016E 2017E Refer to endnotes for additional information. 14

Delivering High Levels of Client and Member Service Continuously Top 2 Box Satisfaction Scores 2016 Client Satisfaction 2016 Member Satisfaction 96% 94% Client and member online surveys Tracking performance to drive continuous improvement Client and member call analytics 9.1 million members across 275 clients successfully implemented 1/1/2016 Refer to endnotes for additional information. 15

Agenda PBMs: Needed Now More Than Ever Performance Highlights How We Address Payors #1 Priority: Reducing Cost Integrated Where It Matters Innovating for the Future 16

Despite Market Forces, We Helped Our Clients Cut Trend TREND CONTRIBUTORS JAN-SEP 2016 11.8% 9.0% 0.5% 2.3% -2.1% -6.4% Intelligent Purchasing Surveillance & Management Cost Management 3.3% JAN-SEP 2016 UNMANAGED TREND BRAND INFLATION GENERIC INFLATION UTILIZATION HEPATITIS C PBM MANAGEMENT JAN-SEP 2016 TREND Refer to endnotes for additional information. 17

Brand Price Inflation Drives Trend Average Wholesale Price (AWP) Inflation 12.5% 13.4% 14.4% 14.9% 12.8% 2.7% 2.6% 3.8% 2.9% 2.2% 2012 2013 2014 2015 Jan-Sep 2016 Brand Generic Refer to endnotes for additional information. 18

Brand Price Inflation Drives Trend Average Wholesale Price (AWP) Inflation 12.5% 13.4% BRAND INFLATION ADDED $21.1B 14.4% 14.9% 12.8% 3.8% 2.7% 2.6% Brand Generic GENERIC INFLATION 2.9% ADDED $1.9B 2.2% 2012 2013 2014 2015 Jan-Sep 2016 Refer to endnotes for additional information. 19

Higher Launch Prices Contribute to Rising Specialty Spend 200 Annual Price ($, thousands) 160 120 80 40 0 1997 1998 2002 2004 2006 2007 2008 2011 2013 2013 2014 2014 2015 2016 Refer to endnotes for additional information. 20

Aging Population, New Drugs Lead to Increased Utilization in Specialty Aging Population New Drugs Utilization Trend Rx per million plan members per month 9,226 6,621 10,000 Americans will turn 65 every day until 2030 > 200 new drugs expected to launch between 2016-2018 2011 2012 2013 2014 2015 By 2020, specialty drugs are expected to account for 55% of drug spend Refer to endnotes for additional information. 21

Winning With Payors: Our Differentiated Three- Pronged Approach to Reducing Costs Intelligent purchasing Thoughtful and strategic purchasing Real-time surveillance and dynamic management Identify trend drivers and rapidly provide solutions Versatile cost management strategies Provide flexibility to meet client priorities Differentiated approach to helping deliver lowest net cost 22

I N T E L L I G E N T P U R C H A S I N G Intelligent Purchasing: Foundational to Helping Deliver Lowest Net Cost Strategic Assessment Actions Pipeline Market Competition Right opportunities Negotiate from strength Low-cost generics through Red Oak Sourcing venture #1 generic sourcing entity in the U.S. Unmatched Negotiation Capabilities Brand inflation addressed by price protection Across more than 90% of our contracts Significant reduction in pharmacy spend (2012-2017) $9 Billion client savings driven by managed formularies 23

Intelligent Purchasing Dramatically Reduces Impact of Utilization and Drug Price Inflation I N T E L L I G E N T P U R C H A S I N G 14.2% 11.8% Unmanaged Inflation and Utilization Impact 12.4% 11.8% 5.0% Post-Rebate Trend 3.3% 2014 2015 2016 (Jan Sep) Refer to endnotes for additional information. 24

R E A L - T I M E S U R V E I L L A N C E Real-Time Surveillance & Dynamic Management: to Stay Ahead of Market Volatility Interactive RxInsights 25

R E A L - T I M E S U R V E I L L A N C E Real-Time Surveillance & Dynamic Management: to Stay Ahead of Market Volatility Aims to mitigate impact of manufacturer price increase Price Increases Utilization Increases Identify increases at category, class and drug levels Ensure thorough new-to-market assessment Drug Pipeline Fraud, Waste & Abuse Audit activity at pharmacy, prescriber and member levels 26

R E A L - T I M E S U R V E I L L A N C E Case Study: Dynamic Management Solution Cut Lidocaine Spend Dramatically in Weeks 1.46 1.50 Spend Per Member Per Month ($) 1.64 1.88 Solution Implemented 1.15 Trend Identified Developed solutions Client evaluation of options 0.21 0.01 0.01 0.00 January February March April May June July August September 27

Core Safety and Monitoring Programs Save Clients $100 Million R E A L - T I M E S U R V E I L L A N C E How the PBM Fights Prescription Drug Abuse $100 Million Savings $74M Claims review to identify suspect behavior such as use of multiple pharmacies or prescribers + + + System generates risk score, which is reviewed by pharmacist Intervene directly with prescriber and member when appropriate Collaborate with law enforcement = Unnecessary Pharmacy Spend $26M Medical Costs Avoided Refer to endnotes for additional information. 28

V E R S A T I L E C O S T M A N A G E M E N T Versatile Cost Management Strategies Address Client Priorities Across All Lines of Business Network Optimization incremental savings Targeted Strategies to identify specific trend drivers Foundational Approaches promote utilization of lower-cost therapy up to 4% savings up to 13% savings up to 8% savings Refer to endnotes for additional information. 29

Continuing to Lead the Market in Formulary Innovation V E R S A T I L E C O S T M A N A G E M E N T 2012 2015 2016 Formulary Removals New-To-Market Evaluations Specialty Class Review Our managed formulary options help drive lower PMPM costs Client-Managed $107.30 Standard $89.74 Advanced Control $87.44 Value $80.51 2017 Biosimilar Preference Hyperinflation Management Indication-Based Formulary Refer to endnotes for additional information. 30

Product Adoption and Runway V E R S A T I L E C O S T M A N A G E M E N T Current Lives Total Lives Opportunity Savings MAINTENANCE CHOICE 25 million 46 million Up to 4% TOTAL NETWORK STRATEGIES 37 million 86 million Up to 4% FORMULARY STRATEGIES 27 million 55 million Up to 8% EXCLUSIVE SPECIALTY 41 million 60 million Up to 10% SPECIALTY MEDICAL MANAGEMENT 14 million 51 million Up to 13% Refer to endnotes for additional information. 31

In Rapidly Evolving Market, Cost Management Demands More From a PBM Intelligent purchasing Real-time surveillance and dynamic management Versatile cost management strategies DIFFERENTIATED APPROACH TO HELPING DELIVER LOWEST NET COST 32

Agenda PBMs: Needed Now More Than Ever Performance Highlights How We Address Payors #1 Priority: Reducing Cost Integrated Where It Matters Innovating for the Future 33

The Complex Challenges of Population Health Managing specialty conditions 3 out of 4 SENIORS HAVE TWO OR MORE CHRONIC CONDITIONS Managing her own and her family s health 5% OF POPULATION ACCOUNTS FOR MORE THAN ONE-THIRD OF ALL HEALTH CARE COSTS Managing diabetes and high blood pressure $300 Billion ANNUAL COST OF NON-ADHERENCE Refer to endnotes for additional information. 34

Integrated Where It Matters: Health Engagement Engine Transforms Data Into Actionable Interventions Pharmacy claims from plan members CVS Health Research Institute Insights Pharmacy customer data HEALTH ENGAGEMENT ENGINE Nurse Provider Hospital Pharmacist Health Plan Medical claims from health plan Registered web user data Email Phone Insights from clinical collaborations Medical visit records at MinuteClinic Data from EHR Text Bag tag Mail Utilizing member insights to deliver personalized interventions 35

Meet Sarah HEALTH ENGAGEMENT ENGINE Specialty Connect ScriptSync Pharmacy claims EHR Data 43 years old, multiple sclerosis Pre-diabetic Relies on support from her CareTeam, struggling to manage her MS Is not optimally adherent to her cholesterol medication Medical claims from health plan Pharmacy customer data MinuteClinic visit data Specialty CareTeam Digital Tools MinuteClinic support Refer to endnotes for additional information. 36

Our Unique Model and Capabilities Deliver Better Clinical Results Wellness and Preventative Care Adherence Support Addressing Gaps in Care Specialty Patient Support Transitions in Care 34% Higher vaccination rate with HealthTag 9.9% Adherence increase with Pharmacy Advisor 7.5% Reduction in gaps in care with pharmacist counseling 23% Fewer hospitalizations with embedded rare disease nurse 48% Reduction in hospital readmissions Refer to endnotes for additional information. 37

Agenda PBMs: Needed Now More Than Ever Performance Highlights How We Address Payors #1 Priority: Reducing Cost Integrated Where It Matters Innovating for the Future 38

AFFORDABLE We Continue to Innovate to Anticipate and Address Unmet Needs for Clients and Members Value Formulary Formulary Exclusions Advanced Control Formulary Price Protection Dynamic Trend Manager Value-Based Contracting ACCESSIBLE EFFECTIVE Health System Affiliations Pharmacy Advisor Savings Strategy EHR Connectivity Specialty Embedded Nurse Specialty Connect ScriptSync Infusion Suites at MinuteClinic Inside Target stores Pharmacy Advisor 2.0 Care 1-on-1 Transform Care Programs Maintenance Choice 3.0 Current 2017 39

Value-Based Contracting With Pharma Manufacturers Principles Of Value-Based Contracting Further aligns incentives on outcomes and cost Price linked explicitly to the defined value metrics Indication-Based Rebates A differentiated rebate structure based on indication or diagnosis Builds upon preferred drug strategy Indication-Based Pricing Payors and manufacturers agree on different prices for different indications Potential to impact plan design/copay and physician reimbursement Outcomes-Based Contracting Manufacturers pay retrospective rebates based on clinical outcomes Improves negotiating strength given the growing number of indications for many specialty drugs 40

Value-Based Retail Networks Help Deliver Savings and Improved Performance Network Composition Value-based networks up to ~50,000 pharmacies Stringent performance criteria Network Design Provide a high level of member access Pay-for-performance component Performance Metrics Adherence in specific disease states; closing gaps in care Formulary compliance Client savings up to 3% Refer to endnotes for additional information. 41

Staggering Cost of Diabetes 1 in 3 Members will be diagnosed with diabetes in their lifetime By the Numbers $10K Higher annual medical costs for people with Type 2 diabetes A Challenging Care Plan Medication therapies Monitoring of blood glucose levels multiple times per day Ongoing provider follow-ups and exams Regular A1c checks Lifestyle modifications; diet and exercise Refer to endnotes for additional information. 42

Target Transform Care Programs Improve Clinical Outcomes and Reduce Costs Influence Stratify Employ advanced analytics to segment the population by disease complexity Personalized outreach based on robust member targeting Delivered exclusively through CVS-Only Diabetes Network IMPROVING OUTCOMES Enhanced A1c control with connected glucometer Live diabetes coaching 1:1 pharmacist adherence counseling MinuteClinic diabetes care visit Medication management solutions CONTROLLING COST Single-digit trend guarantee Diabetes network Formulary alignment 43

CVS Health Transform Diabetes Care in Action Paul Newly prescribed antidiabetic medication Counseled. Connected. Monitored. Supported. Paul s Care Journey to Effective Diabetes Control Transform Diabetes Management Savings for client with 100,000 lives: up to $36 million per year Refer to endnotes for additional information. 44

Expanding Member Options Maintenance Choice 3.0 FILL AT CVS HOME DELIVERY BY MAIL SAME-DAY HOME DELIVERY The next generation of prescription convenience Only for CVS Caremark Members 45

Helping Each Member Along Their Path to Better Health BILL 65 years old RICK 51 years old SUSAN 37 years old LOIS 58 years old COPD Does not live near CVS Diabetes High blood pressure High cholesterol 3 children; manages her family s prescriptions as well Multiple Sclerosis Connects digitally Needs Rx and aspirin fast HOME DELIVERY VIA MAIL AT THE PHARMACY COUNTER CVS EXPRESS CURBSIDE PICKUP SAME-DAY HOME DELIVERY Convenience and accessibility; putting care within easy reach Refer to endnotes for additional information. 46

Today s Key Takeaways Driving More Affordable, Accessible and Effective Care Driving Outcomes and Savings Providing the Front Door and the Last Mile Best Partner for PBMs and Health Plans Integrated Pharmacy Care Positioned for L-T Enterprise Growth Evolving market demands more from a PBM; next-generation pharmacy management essential for payors, members and providers Delivering better outcomes by supporting members throughout therapy, whenever and wherever they utilize prescriptions Better coordination with providers and health systems; expanded member engagement helps to improve outcomes and lower costs Truly integrated assets help us optimize the member s experience at all of our touchpoints and make every interaction more effective New business provides platform to build enterprise share; service and quality drive Medicare growth Meeting the Health Care Challenges of Tomorrow 47

Endnotes Slide 7 1. 2016E & 2017E values represent the midpoint of the guidance ranges. Slide 8 1. Revenue from clients changing PBMs: CVS Health internal data analysis. 2. Client retention rate: 1 less (estimated 2017 lost revenues from any known terminations plus annualization of any midyear 2016 terminations, divided by estimated 2017 PBM revenues) expressed as a percentage. Both terminations and PBM revenues exclude the Medicare Part D SilverScript individual PDP business. Slide 9 1. Gross and net new business revenue exclude Medicare Part D SilverScript individual products. Slide 10 1. Enterprise Rxs represents all Rx volume dispensed through a CVS Health enterprise channel (Mail, Specialty, Retail, Long-Term Care). All dispensed CVS retail and mail prescriptions include the adjustment to convert 90-day prescriptions to the equivalent of three 30-day prescriptions. This adjustment reflects the fact that these prescriptions include approximately three times the amount of product days supplied compared to a normal 30-day prescription. Slide 11 1. Enterprise Rxs represents all Rx volume dispensed through a CVS Health enterprise channel (Mail, Specialty, Retail, Long-Term Care). All dispensed CVS retail and mail prescriptions include the adjustment to convert 90-day prescriptions to the equivalent of three 30-day prescriptions. This adjustment reflects the fact that these prescriptions include approximately three times the amount of product days supplied compared to a normal 30-day prescription. 48

Endnotes Slide 12 1. Largest PDPs by enrollment: Reflects the estimated Captive/non-Captive lives by PBM for 2016 plan year. Membership based on October 2016 Medicare Part D CMS enrollment and estimation of current contracts under PBM management. PBM health plan client relationship is sourced from public announcements by PBM and health plan organizations; only relationships that are publicly announced are included in this analysis. 2. Medicare lives served by PBM: Reflects the Captive/non-Captive lives by PBM for 2016 plan year. Membership based on October 2016 Medicare Part D CMS enrollment published by CMS and grouped by CMS contract number managed by related PBM. 3. STARS ratings: Stars performance is derived using Part D Stars Ratings for contracts under PBM management during the 2017 Stars measurement period (2015 plan year) and the CMS reported enrollment at the time of 2017 Star Ratings release (September 2016 enrollment). Slide 13 1. Source: Growth of Plans Administered by CVS Health is based on non-silverscript PBM clients for the continuous period 2013 2016. 2. Source: CMS Growth Rate based on covered lives reported in the CMS Monthly Report Summary. Slide 14 1. Source: CVS Health internal data analysis. Industry CAGR calculated 2013-2016 via Milliman report: http://www.phrma.org/sites/default/files/pdf/milliman-specialty-drug-forecasts.pdf Slide 15 1. Client satisfaction source: PBMI 2016 Pharmacy Benefit Management Customer Satisfaction Report. 2. Member satisfaction source: 2016 Member Experience survey. 3. 275 clients includes new and reinstallation of existing clients with significant plan design changes. 49

Endnotes Slide 17 1. Source: CVS Health internal data analysis, utilization trend based on commercial cohort (Health Plans and Employers). 2. Trend is reported net of rebates. Slide 18, 19 1. Source: CVS Health internal data analysis, client cohort excludes SilverScript PDP and EGWP clients. Slide 20 1. Drug launch price reflects the Average Wholesale Price (AWP). Values are annual with the exception of short-term treatments (Incivek, Sovaldi, Viekira & Harvoni) where the value listed is for the duration of the treatment. Slide 21 1. Number of Americans turning 65 source: PEW Research Center. 2. Source: Projections by Pipeline Services, data 2016 through 2018, as of November 1, 2016. This slide contains references to brand-name prescription drugs that are trademarks or registered trademarks of pharmaceutical manufacturers not affiliated with CVS Health. 3. Utilization trend based on an internal case study of a large national client. 4. 2020 specialty spend projections based on National Health Expenditure data. Slide 24 1. Source: CVS Health internal data analysis, Commercial cohort (Health Plans and Employers). Slide 28 1. Source: Safety and Monitoring internal case study; reporting period 1/1/2015 12/31/2015. 2. Medical savings: estimate based on medical literature describing the prevention of additional medical costs such as physicians visits, emergency room visits and unnecessary laboratory fees. 50

Endnotes Slide 29 1. Savings results will vary based on a variety of factors including demographics, plan design and other programs implemented by the client. Slide 30 1. Source: CVS Health internal data analysis, 2016. All cohorts used for analysis are age-adjusted to commercial means. The Client-Managed cohort includes commercial employers and health plans who determine their own formulary structure. CVS Health managed formulary cohorts (Standard, Advanced Control, and Value) include employers and health plans. Calculated cost includes both client and member share, and includes discounts from rebates. Slide 31 1. Current Lives includes 2017 known enrollments less terminations. 2. Total lives opportunity includes current lives plus runway. 3. Exclusive Specialty Savings: Specialty spend under the pharmacy benefit. 4. Specialty Medical Management: Total lives Opportunity based on Health Plan lives in PBM book of business; savings apply to specialty spend under the medical benefit. 5. Savings results will vary based on a variety of factors including demographics, plan design and other programs implemented by the client. Slide 34 1. Source: CVS Health internal data analysis of 2015 Blue Health Intelligence Commercial Specialty Drug Database. 2. Source: http://www.cdc.gov/chronicdisease/about/multiple-chronic.htm. 3. Source: NEHI http://www.nehi.net/bendthecurve/sup/documents/medication_adherence_brief.pdf. Slides 36/44/46 1. While the member stories and profiles depicted are fictional, the information is representative of clinical profiles and health care experiences encountered on a regular basis. 51

Endnotes Slide 37 1. Wellness and Preventative: CVS Health internal data analysis 2015. 2. Adherence Support: Increase based on oral diabetes medications. 3. Addressing Gaps in Care: CVS Health internal data analysis, 2013 data. 4. Specialty Patient Support : CVS Health internal data analysis, 2013 data. 5. Hospital Readmissions: CVS Health internal data analysis, 2014 data. 6. Savings results will vary based on a variety of factors including demographics, plan design and other programs implemented by the client. Slide 41 1. Client Savings: CVS Health internal data analysis. 2. Savings results will vary based on a variety of factors including demographics, plan design and other programs implemented by the client. Slide 42 1. Source: Gilmer et al., Diabetes Care, 2005; Shetty J Manag Care Pharm, 2005. Slide 44 1. Estimated client savings based on internal study on the Diabetes Program, looking at improvement opportunities for a 100K life diabetic population relative to A1c, Blood Pressure and Cholesterol metrics, along with their American Diabetes Association clinical targets. 52