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Claim #25 Date Filed: 5/6/2018 Fill in this information to identify the case: Orexigen Therapeutics, Inc. Debtor Bankruptcy Court for the: District of Delaware (State) Case number 18-10518 Official Form 410 Proof of Claim 04/16 Read the instructions before filling out this form. This form is for making a claim for payment in a bankruptcy case. Do not use this form to make a request for payment of an administrative expense. Make such a request according to 11 U.S.C. 503. Filers must leave out or redact information that is entitled to privacy on this form or on any attached documents. Attach redacted copies or any documents that support the claim, such as promissory notes, purchase orders, invoices, itemized statements of running accounts, contracts, judgments, mortgages, and security agreements. Do not send original documents; they may be destroyed after scanning. If the documents are not available, explain in an attachment. A person who files a fraudulent claim could be fined up to 500,000, imprisoned for up to 5 years, or both. 18 U.S.C. 152, 157, and 3571. Fill in all the information about the claim as of the date the case was filed. That date is on the notice of bankruptcy (Form 309) that you received. Part 1: Identify the Claim 1. Who is the current creditor? Google LLC f/k/a Google Inc. Name of the current creditor (the person or entity to be paid for this claim) Other names the creditor used with the debtor 2. Has this claim been acquired from someone else? 3. Where should notices and payments to the creditor be sent? Where should notices to the creditor be sent? Federal Rule of Bankruptcy Procedure (FRBP) 2002(g) Yes. From whom? Google LLC f/k/a Google Inc. David Curtin Name 1600 Amphitheatre Parkway Mountain View, CA 94043, USA Google LLC f/k/a Google Inc. Steven E. Ostrow Name White and Williams LLP 7 Times Square, Suite 2900 Number Street New York, NY 10036-6524, USA City State Contact phone Contact email Where should payments to the creditor be sent? (if different) Number ZIP Code 212-714-3068 ostrows@whiteandwilliams.com Street City State Contact phone Contact email ZIP Code 650-253-7752 davidcurtin@google.com Uniform claim identifier for electronic payments in chapter 13 (if you use one): 4. Does this claim amend one already filed? Yes. Claim number on court claims registry (if known) Filed on MM 5. Do you know if anyone else has filed a proof of claim for this claim? Official Form 410 / DD / YYYY Yes. Who made the earlier filing? Proof of Claim 1 q%22%&!t«1810518180506000000000001 page 1

Part 2: Give Information About the Claim as of the Date the Case Was Filed 6. Do you have any number you use to identify the debtor? Yes. Last 4 digits of the debtor s account or any number you use to identify the debtor: 6059 7. How much is the claim? 1,098,062.08. Does this amount include interest or other charges? Yes. Attach statement itemizing interest, fees, expenses, or other charges required by Bankruptcy Rule 3001(c)(2)(A). 8. What is the basis of the claim? Examples: Goods sold, money loaned, lease, services performed, personal injury or wrongful death, or credit card. Attach redacted copies of any documents supporting the claim required by Bankruptcy Rule 3001(c). Limit disclosing information that is entitled to privacy, such as health care information. Services Provided 9. Is all or part of the claim secured? Yes. The claim is secured by a lien on property. Nature or property: Real estate: If the claim is secured by the debtor s principle residence, file a Mortgage Proof of Claim Attachment (Official Form 410-A) with this Proof of Claim. Motor vehicle Other. Describe: Basis for perfection: Attach redacted copies of documents, if any, that show evidence of perfection of a security interest (for example, a mortgage, lien, certificate of title, financing statement, or other document that shows the lien has been filed or recorded.) Value of property: Amount of the claim that is secured: Amount of the claim that is unsecured: (The sum of the secured and unsecured amount should match the amount in line 7.) Amount necessary to cure any default as of the date of the petition: Annual Interest Rate (when case was filed) % Fixed Variable 10. Is this claim based on a lease? Yes. Amount necessary to cure any default as of the date of the petition. 11. Is this claim subject to a right of setoff? Yes. Identify the property: Official Form 410 Proof of Claim page 2

12. Is all or part of the claim entitled to priority under 11 U.S.C. 507(a)? Yes. Check all that apply: Amount entitled to priority A claim may be partly priority and partly nonpriority. For example, in some categories, the law limits the amount entitled to priority. Domestic support obligations (including alimony and child support) under 11 U.S.C. 507(a)(1)(A) or (a)(1)(b). Up to 2,850* of deposits toward purchase, lease, or rental of property or services for personal, family, or household use. 11 U.S.C. 507(a)(7). Wages, salaries, or commissions (up to 12,850*) earned within 180 days before the bankruptcy petition is filed or the debtor s business ends, whichever is earlier. 11 U.S.C. 507(a)(4). Taxes or penalties owed to governmental units. 11 U.S.C. 507(a)(8). Contributions to an employee benefit plan. 11 U.S.C. 507(a)(5). Other. Specify subsection of 11 U.S.C. 507(a)( ) that applies. 13. Is all or part of the claim pursuant to 11 U.S.C. 503(b)(9)? * Amounts are subject to adjustment on 4/01/19 and every 3 years after that for cases begun on or after the date of adjustment. Yes. Indicate the amount of your claim arising from the value of any goods received by the debtor within 20 days before the date of commencement of the above case, in which the goods have been sold to the Debtor in the ordinary course of such Debtor s business. Attach documentation supporting such claim. Part 3: Sign Below The person completing this proof of claim must sign and date it. FRBP 9011(b). If you file this claim electronically, FRBP 5005(a)(2) authorizes courts to establish local rules specifying what a signature is. A person who files a fraudulent claim could be fined up to 500,000, imprisoned for up to 5 years, or both. 18 U.S.C. 152, 157, and 3571. Check the appropriate box: I am the creditor. I am the creditor s attorney or authorized agent. I am the trustee, or the debtor, or their authorized agent. Bankruptcy Rule 3004. I am a guarantor, surety, endorser, or other codebtor. Bankruptcy Rule 3005. I understand that an authorized signature on this Proof of Claim serves as an acknowledgement that when calculating the amount of the claim, the creditor gave the debtor credit for any payments received toward the debt. I have examined the information in this Proof of Claim and have reasonable belief that the information is true and correct. I declare under penalty of perjury that the foregoing is true and correct. Executed on date 05/06/2018 MM / DD / YYYY /s/amy E. Vulpio Signature Print the name of the person who is completing and signing this claim: Name Amy E. Vulpio First name Middle name Last name Title Company Address Counsel for Google LLC f/k/a Google Inc. White and Williams LLP Identify the corporate servicer as the company if the authorized agent is a servicer. 1650 Market Street, 18th Floor, Philadelphia, PA, 19103, USA Number Street City State ZIP Code Contact phone 215-864-6250 Email vulpioa@whiteandwilliams.co Official Form 410 Proof of Claim page 3

Debtor: 18-10518 - Orexigen Therapeutics, Inc. District: District of Delaware Creditor: Google LLC f/k/a Google Inc. Steven E. Ostrow White and Williams LLP 7 Times Square, Suite 2900 New York, NY, 10036-6524 USA Phone: 212-714-3068 Phone 2: Has Supporting Documentation: Yes, supporting documentation successfully uploaded Related Document Statement: Has Related Claim: Related Claim Filed By: Filing Party: Authorized agent Fax: Email: ostrows@whiteandwilliams.com Disbursement/tice Parties: Google LLC f/k/a Google Inc. David Curtin 1600 Amphitheatre Parkway Mountain View, CA, 94043 USA Phone: 650-253-7752 Phone 2: Fax: E-mail: davidcurtin@google.com DISBURSEMENT ADDRESS Other Names Used with Debtor: Basis of Claim: Services Provided Total Amount of Claim: 1,098,062.08 Has Priority Claim: Has Secured Claim: Amount of 503(b)(9): Based on Lease: Subject to Right of Setoff: Submitted By: Amy E. Vulpio on 06-May-2018 12:26:24 p.m. Eastern Time Title: Counsel for Google LLC f/k/a Google Inc. Company: White and Williams LLP Amends Claim: Acquired Claim: Last 4 Digits: Uniform Claim Identifier: Yes - 6059 Includes Interest or Charges: Priority Under: Nature of Secured Amount: Value of Property: Annual Interest Rate: Arrearage Amount: Basis for Perfection: Amount Unsecured:

Optional Signature Address: Amy E. Vulpio 1650 Market Street, 18th Floor Philadelphia, PA, 19103 USA Telephone Number: 215-864-6250 Email: vulpioa@whiteandwilliams.com

Orexigen Therapeutics, Inc. - Account Statement Chapter 11 Bankruptcy Filing - March 12,2018 Orexigen Therapeutics. Inc. 4852-4820-5113-4628 0007-5749-6059 US tihc3q WELIS-USA-US-USD-IN- 4/4/2018 USD 1160.000.00) (2.330.98) 12.330.98) Google LLCf/k/a Google Inc. Google AdWords Orexieen Therapeutics, Inc. 4852-4820-5113-4628 0007-5749-60S9 US 3427306995 2/28/2018 USD 4S8.243.06 458.243.06 Google LLC f A/a Google Inc. Google AdWords Orexieen Therapeutics. Inc. 4852482051134628-3 3/30/2018 458.243.06 Orexisen Therapeutics. Inc. 4852-4820-5113-4628 0007-5749-6059 US 48S24820S1134628-4 3439537381 3/31/2018 4/30/2018 USD 480.087.65 172.418.63 172.418.63 Google UCf/k/a Google Inc. Google AdWords Orexigen Therapeutics, Inc. Orexigen Therapeutics, Inc. 4852-4820-5113-4628 0007-5749-6059 US 4852482051134628-2 3415897206 1/31/2018 3/2/2018 USD 467,400.39 467.400.39 467.400.39 Google LLCf/k/aGooirle Inc. Goocle AdWords,095,731.10 1,098,062.08 T (2,330.98)1

Go gie Invoice Invoice number: 3427306995 Google LLC 1600 Amphitheatre Pkwy Mountain View, CA 94043 Bill to Irvin Carlin Orexigen Therapeutics, Inc. 3344 N. Torrey Pines Court Suite 200 La Jolla, CA 92037 Details Invoice number... 3427306995 Invoice date... Feb 28,2018 Payment terms... Net 30 Billing ID...0007-5749-6059 Account ID...708-157-6227 Google AdWords Total amount due in USD 458,243.06 Due Mar 30, 2018 Summary for Feb 1,2018 - Feb 28, 2018 Pay in USD: Subtotal in USD Tax (0%) Total amount due in USD 458,243.06 0.00 458,243.06 Remittance instructions: To ensure we correctly match your payment, always reference invoice numbers when making your payment. If paying for multiple invoices, send an email to collections@google.com with your company name and total payment amount in the subject line and list the invoice numbers & respective amounts in the email. Please send your payments only to the bank account listed below on this official Google invoice. To pay by wire transfer, send to: Account holder name: Google LLC Bank: Wells Fargo Bank, Palo Alto, CA 94321-0150 SWIFT BIC: WFBIUS6S ABA #: 121000248 Account #: I To pay by check, mail to: Google LLC Dept. 33654 P.O. Box 39000 San Francisco, CA 94139 For questions about this invoice please email collections@google.com Page 1 of 2

Google Invoice Invoice number: 3427306995 Account: Contrave Search Account ID: 708-157-6227 Account budget: Orexigen Therapeutics, Inc. - v 27, 2017 Feb 1,2018-Feb 28, 2018 Description Quantity Units Amount() BrandedJJS 78413 Clicks 172,023.94 Conquesting_Exact_US 33628 Clicks 64,888.34 Category_Exact_US 27297 Clicks 60,204.46 Category_Broad_US 31912 Clicks 58,788.12 Conquesting_Broad_US 15144 Clicks 35,527.59 CategoryAppetite_Exact_US 6252 Clicks 15,200.00 CategoryPrescription_Broad_US 5054 Clicks 13,198.32 CategoryAppetite_Broad_US 4871 Clicks 9,541.18 CategoryPrescriptionJExactJJS 3498 Clicks 9,115.84 BrandedJJSJow 4056 Clicks 8,553.70 Branded_Purchase lntent_us 5332 Clicks 7,612.04 CategoryCoMorbidities_Broad_US 776 Clicks 2,298.87 nbrand_chemical Name 743 Clicks 705.82 CategoryCoMorbidity_Exact_US 127 Clicks 315.24 CategoryCravings_Broad_US 147 Clicks 269.19 CategoryCravings_Exact_US 21 Clicks 43.15 Invalid activity -42.74 Subtotal in USD 458,243.06 Tax (0%) 0.00 Total in USD 458,243.06 For questions about this invoice please email collections@google.com Page 2 of 2

Go ale Invoice Invoice number: 3439537381 Google LLC 1600 Amphitheatre Pkwy Mountain View, CA 94043 Bill to Irvin Carlin Orexigen Therapeutics, Inc. 3344 N. Torrey Pines Court Suite 200 La Jolla, CA 92037 Details Invoice number Invoice date... Payment terms Billing ID... Account ID....3439537381.Mar 31, 2018 Net 30.0007-5749-6059.708-157-6227 Google AdWords Total amount due in USD 480,087.65 Due Apr 30, 2018; Summary for Mar 1.2018 - Mar 31, 2018 Pay in USD: Subtotal in USD Tax (0%) Total amount due in USD 480,087.65 0.00 480,087.65 Remittance instructions: To ensure we correctly match your payment, always reference invoice numbers when making your payment. If paying for multiple invoices, send an email to collections@google.com with your company name and total payment amount in the subject line and list the invoice numbers & respective amounts in the email. Please send your payments only to the bank account listed below on this official Google invoice. To pay by wire transfer, send to: Account holder name: Google LLC Bank: Wells Fargo Bank, Palo Alto, CA 94321-0150 SWIFT BIC: WFBIUS6S ABA #: 121000248 Account #: < To pay by check, mail to: Google LLC Dept. 33654 P.O. Box 39000 San Francisco, CA 94139 For questions about this invoice please email collections@google.com Page 1 of 2

Google" Invoice Invoice number: 3439537381 Account: Contrave Search Account ID: 708-157-6227 Account budget: Orexigen Therapeutics, Inc. - v 27, 2017 Mar 1,2018-Mar 31, 2018 Description Quantity Units Amount() BrandedJJS 83502 Clicks 194,770.12 Category_Broad_US 33555 Clicks 64,488.12 Category_Exact_US 23249 Clicks 57,100.69 Conquesting_Exact_US 24796 Clicks 47,425.18 Conquesting_Broad_US 15241 Clicks 46,065.74 BrandedJJSJow 11281 Clicks 21,764.40 CategoryPrescription_Broad_US 3805 Clicks 16,138.08 Category Appetite_Exact_US 5036 Clicks 14,708.72 CategoryPrescription_Exact_US 2875 Clicks 8,470.68 CategoryAppetite_Broad_US 2731 Clicks 4,664.21 CategoryCoMorbidities_Broad_US 587 Clicks 1,985.86 Branded_Purchase lntent_us 742 Clicks 1,307.71 nbrand_chemical Name 658 Clicks 663.47 CategoryCravings_Broad_US 230 Clicks 386.59 CategoryCoMorbidity_Exact_US 42 Clicks 133.70 CategoryCravings_Exact_US 20 Clicks 30.58 Invalid activity -16.20 Subtotal in USD 480,087.65 Tax (0%) 0.00 Total in USD 480,087.65 For questions about this invoice please email collections@google.com Page 2 of 2

Go. me %gp Invoice Invoice number: 3415897206 Google LLC 1600 Amphitheatre Pkwy Mountain View, CA 94043 Federal Tax ID: 77-0493581 Bill to Irvin Carlin Orexigen Therapeutics, Inc. 3344 N. Torrey Pines Court Suite 200 La Jolla, CA 92037 Details Invoice number.........3415897206 Invoice date......jan 31, 2018 Payment terms.........net 30 Billing ID......0007-5749-6059 Account ID......708-157-6227 Google AdWords Total amount due in USD 467,400.39 Due Mar 2, 2018 Summary for Jan 1, 2018 - Jan 31, 2018 Pay in USD: Subtotal in USD Tax (0%) Total amount due in USD 467,400.39 0.00 467,400.39 Remittance instructions: To ensure we correctly match your payment, always reference invoice numbers when making your payment. If paying for multiple invoices, send an email to collections@google.com with your company name and total payment amount in the subject line and list the invoice numbers & respective amounts in the email. Please send your payments only to the bank account listed below on this official Google invoice. To pay by wire transfer, send to: Account holder name: Google LLC Bank: Wells Fargo Bank, Palo Alto, CA 94321-0150 SWIFT BIC: WFBIUS6S ABA #: 121000248 Account #:< To pay by check, mail to: Google LLC Dept. 33654 P.O. Box 39000 San Francisco, CA 94139 For questions about this invoice please email collections@google.com Page 1 of 2

Go -gfe Invoice invoice number: 3415897206 Account: Contrave Search Account ID: 708-157-6227 Account budget: Orexigen Therapeutics, Inc. - v 27, 2017 Jan 1,2018-Jan 31,2018 Description Quantity Units Amount() BrandedJJS 113107 Clicks 160,334.67 Conquesting_Exact_US 37899 Clicks 76,516.95 Conquesting_Broad_US 27827 Clicks 71,828.97 Category_Exact_US 25552 Clicks 52,730.41 Category_Broad_US 24990 Clicks 50,720.40 CategoryPrescription_Broad_US 4671 Clicks 11,334.24 Category Appetite_Exact_US 4936 Clicks 10,941.67 Branded_Purchase IntentJJS 8412 Clicks 9,243.38 CategoryPrescription_Exact_US 3691 Clicks 8,548.52 CategoryAppetite_Broad_US 3861 Clicks 7,616.84 CategoryCoMorbidities_Broad_US 1878 Clicks 6,061.22 nbrand_chemical Name 1075 Clicks 852.18 CategoryCoMorbidity_Exact_US 119 Clicks 324.13 CategoryCravings_Broad_US 165 Clicks 292.32 CategoryCravings_Exact_US 27 Clicks 59.07 Invalid activity -4.58 Subtotal in USD Tax (0%) 467,400.39 0.00 Total in USD 467,400.39 For questions about this invoice please email collections@google.com Page 2 of 2