Exiqon A/S (NASDAQ OMX Copenhagen: EXQ ) today announced results for the first three months of 2015:

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Interim report for the quarter 1 January 31 March 2015 Announcement No. 5/2015 To NASDAQ OMX Copenhagen A/S 7 May 2015 Exiqon A/S Skelstedet 16 2950 Vedbæk Denmark CVR nr. 18 98 44 31 Phone: +45 4566 0888 Fax: +45 4566 1888 exiqon@exiqon.com www.exiqon.com Q1 2015 WAS THE BEST QUARTER EVER FOR EXIQON Exiqon A/S (NASDAQ OMX Copenhagen: EXQ ) today announced results for the first three months of 2015: Summarized results (DKK million) Q1 2015 Q1 2014 Change Total revenue 39.0 32.5 + 20% Gross profit 25.9 22.0 + 18% EBITDA 2.7 1.6 + 63% EBIT 0.9 0.5 +101% Net profit 0.0 0.8 N/A Cash flows from operating activities 1.2-2.3 N/A Revenue highlights RNA research services and product sales (excluding OEM) are key drivers for Exiqon s growth; and sales increased 24% to DKK 31.0 million (DKK 24.9 million) in the first quarter: o RNA services sales increased 70% to DKK 6.6 million (DKK 3.8 million) and initially drives Exiqon s strategy towards becoming the leading provider of flexible solutions for RNA analysis, offering high growth potential and paving the way for new proprietary products. o Product sales increased 16% to a record DKK 24.4 million (DKK 21.0 million) as Exiqon continues to leverage existing capabilities to capture new markets for RNA sequencing and RNA functional analysis with significant growth potential. Other income, including license and contract research income, increased 16% to DKK 4.4 million (DKK 3.8 million) in the first quarter, reflective of a continued interest for Exiqon s proprietary technologies, and the ongoing development of novel diagnostics within prostate and colorectal cancer with long-term potential of transforming current healthcare practices and improve patient care. Operational highlights On 31 March 2015 Exiqon launched Next Generation Sequencing services for micrornas present in blood serum and plasma, marking the latest addition to a growing portfolio of RNA sequencing analysis services with high growth potential. In July, 2015 Exiqon plans to launch a new cloud to provide leading flexible solutions for RNA analysis to customers in an easy-to-order process by integrating the company s proprietary bioinformatics tools and customizable LNA enhanced products for RNA analysis. In a comment CEO Lars Kongsbak said: A great quarter for Exiqon. We delivered on key financial objectives. First quarter results are a function of the successful repositioning of our business to capture new markets, targeting double digit growth in our products and services sales. Exiqon reiterates its full year guidance of revenues between DKK 150-160 million and EBITDA of DKK 5-10 million based on an average USD/DKK exchange rate of DKK 6.50.

KEY FIGURES AND RATIOS EXIQON GROUP (UNAUDITED) (DKK 000 except key figures and ratios) Income statement Revenue 39,022 32,471 132,392 Production costs -13,094-10,425-47,193 Gross profit 25,928 22,046 85,199 Research and development costs -8,319-6,669-26,283 Sales and marketing costs -12,180-10,391-43,087 Administrative costs -4,480-4,515-18,911 EBITDA *) 2,681 1,646 3,107 Operating profit/(loss) (EBIT) 949 471-3,082 Profit/(loss) for the period 29 793-2,780 Total Comprehensive profit/(loss) for the period 1,205 749-2,058 Balance sheet Assets Intangible assets 59,966 60,880 60,433 Property, plant and equipment 11,360 5,454 12,023 Non-current assets 74,267 69,806 75,211 Cash and cash equivalents 20,931 25,516 20,084 Current assets 64,560 59,824 62,451 Total assets 138,827 129,630 137,662 Equity and liabilities Equity 79,899 77,897 78,015 Non-current liabilities 2,602 15,744 18,155 Current liabilities 56,326 35,989 41,492 Total liabilities 58,928 51,733 59,647 Total equity and liabilities 138,827 129,630 137,662 Cash flow statement Depreciation, amortization and impairment 1,734 1,174 6,197 Cash flows from operating activities 1,213-2,312-2,434 Acquisition of intangible assets and property, plant and equipment -579-982 -4,977 Cash flows from investing activities -579-982 -4,831 Cash flows from financing activities -586-356 -2,859 Cash and cash equivalents at the end of period 20,931 25,516 20,084 Key figures and ratios Number of shares, average 36,874,082 36,874,082 36,874,082 Basic EPS (DKK) 0.00 0.02-0.08 Diluted EPS (DKK) 0.00 0.02-0.08 Gross margin 66.4% 67.9% 64.4% Assets/Equity (gearing) 1.74 1.66 1.76 Average number of employees 91 83 87 Market price per share (DKK) 8.8 8.8 7.0 Market capitalisation (DKK million) 322.6 322.6 258.1 Price / net asset value 4.04 4.14 3.31 Net interest bearing debt / Equity 0.11 0.01 0.13 Net interest bearing debt / EBITDA 3.40 0.52 3.39 Interest coverage 2.96 3.02 1.44 Basic and diluted EPS have been calculated in accordance with IAS 33 Earnings per share. Other ratios have been calculated in accordance with Recommendations & Financial Ratios 2010 issued by the Danish Society of Financial Analysts, dated June 2010. (*) EBITDA (defined as Earnings Before Special Items, Interest, Tax, Depreciation and Amortization) includes non-cash costs of sharebased payment in the first three months of 2015 with tdkk 679. Page 2 of 8

MANAGEMENT REPORT Reported figures are for the full reporting period. Figures for the comparable reporting period in the previous year are stated in parenthesis. In the first three months of 2015 the average USD/DKK exchange rate applied to translate revenue and expenses was DKK 6.72 (DKK 5.45). Revenue Research product sales and services increased 24% to DKK 31.0 million (DKK 24.9 million) when excluding OEM sales to licensees of DKK 3.6 million (DKK 3.8 million). Services sales remain the primary initial growth driver, in line with the company s strategy to address new markets for RNA sequencing analysis and RNA functional analysis. New products are planned for launch H2 2015 to support the growth in products sales in the new markets mid-term. In Europe research product sales and services (excluding OEM) increased 29% to DKK 14.4 million (DKK 11.2 million). North America research product sales and services (excluding OEM) increased 33% to DKK 11.9 million (DKK 8.9 million) benefitting from an improved competitive pricing situation following the recent increase in the USD/DKK exchange rate. Rest of World sales decreased 2% to DKK 4.7 million (DKK 4.8 million), markets are proving difficult due to price sensitivity. Royalty and license income accounted for DKK 2.9 million (DKK 2.3 million) and revenue from consortium grants reported separately as contract research income totaled DKK 1.5 million (DKK 1.5 million). Total revenue increased 20% to DKK 39.0 million (DKK 32.5 million) in line with expectations. Gross profit and margins Gross profit increased 18% to DKK 25.9 million (DKK 22.0 million) as a result of higher sales volumes. Shortterm margins are affected negatively by the increase in Services, relative to product sales, however, improved economies of scale and automated solutions will allow us to continue improving margins in the mid and long term. Operating costs Operating costs excluding production costs increased 16% to DKK 25.0 million (DKK 21.6 million) in line with the company s strategy to maximize investment in R&D and S&M without compromising EBITDA profitability. EBITDA/EBIT and Net profit EBITDA improved to DKK 2.7 million (DKK 1.6 million) whereas EBIT was affected by higher depreciations following recent increase in investments and improved to DKK 0.9 million (DKK 0.5 million). Net profit of DKK 0.03 million (DKK 0.79 million) was negatively affected by a lower provision for tax refund in 2015. Summarized financial numbers compared to full year outlook In the table below, the company's realized performance for the first three months of 2015 has been summarized and compared to the outlook for the full year; including an adjustment of the realized numbers to the exchange rate used as basis for the full year outlook (USD/DKK 6.50): (DKK million) Realized 2015 (USD/DKK 6.72) Realized 2015 adjusted to USD/DKK 6.50 Outlook 2015 (USD/DKK 6.50) Revenue 39.0 38.4 150-160 EBITDA 2.7 2.4 5-10 Cash flows Cash flows from operating activities were DKK 1.2 million (DKK -2.3 million) primarily reflective of cash flows from primary activities of DKK 2.6 million (DKK -2.7 million), net interest and value gains of DKK -1.3 million (DKK 0.4 million) and high end period sales leading to high trade receivables of DKK 22.4 million (15.6 million). Equity and capital resources Equity increased to DKK 79.9 million (DKK 77.9 million). On 31 March 2015 cash and cash equivalents totalled DKK 20.9 (DKK 25.5 million) including a credit of DKK 10 million that is subject to repayment by 10 January 2016 and proceeds of DKK 15 million from the company's corporate bond that is subject to repayment by 1 March 2016. We expect that the company s future capital needs are covered by these existing arrangements. Any requirement for additional capital in the future, we will seek to cover by continuing the existing arrangements beyond their current terms, replacing them with new arrangements on similar terms, or increasing the current share capital under existing authorizations to the Supervisory Board. Page 3 of 8

FINANCIAL OUTLOOK 2015 Exiqon expects revenues between DKK 150-160 million and EBITDA of DKK 5-10 million in 2015. The outlook for 2015 is based on an average USD/DKK exchange rate of DKK 6.50. In addition to exchange rates, the outlook depends primarily on organic growth in Exiqon s services and product sales, excluding OEM sales to licensees. Exiqon continues to pursue license and partnering opportunities during 2015. No significant one-time costs are included in the outlook for 2015, nor are any expected. Any costs related to new warrant grants are not included in the guidance for 2015. STATEMENT BY THE EXECUTIVE BOARD AND SUPERVISORY BOARD ON THE INTERIM REPORT The Supervisory Board and the Executive Board have today considered and approved the interim report of Exiqon A/S for the period 1 January 31 March 2015. The interim report has been prepared in accordance with IAS 34 and additional Danish disclosure requirements for the presentation of financial statements by listed companies. The interim report is unaudited. We consider the accounting policies to be appropriate, the accounting estimates made to be reasonable and the overall presentation of the interim report to be adequate, so that the interim report, in our opinion, gives a true and fair view of the assets, liabilities, financial position and results of operations and cash flows of the group for the period 1 January 31 March 2015. We consider the Management s report to give a true and fair description of the development in the Group s activities and economic situation, the results of operations and the Group s financial position as a whole and a description of the significant risks and uncertainty factors, which the Group faces. Vedbaek, 7 May 2015 Executive Board Lars Kongsbak, CEO Hans Henrik Chrois Christensen, CFO Supervisory Board Erik Walldén, chairman Thorleif Krarup, deputy chairman Michael Nobel Per Wold-Olsen Rodney Turner Additional information Lars Kongsbak, CEO, phone +45 4566 0888 (cell: +45 4090 2101) Hans Henrik Chrois Christensen, CFO, phone +45 4566 0888 (cell: +45 4090 2131) Forward-looking statements Certain parts of this release contain forward-looking information with respect to the plans, projections and future performance of the company, each of which involves significant uncertainties. The company s actual results may differ materially from the information set forth in these statements. Timelines relating to collaborative diagnostic programs should be considered approximate. Page 4 of 8

CONSOLIDATED STATEMENT OF COMPREHENSIVE INCOME (UNAUDITED) Note Revenue 2,3 39,022 32,471 132,392 Production costs -13,094-10,425-47,193 Gross profit 25,928 22,046 85,199 Research and development costs -8,319-6,669-26,283 Sales and marketing costs -12,180-10,391-43,087 Administrative costs -4,480-4,515-18,911 Operating profit/(loss) (EBIT) 949 471-3,082 Financial income 2,128 360 2,210 Financial expenses -3,325-907 -5,111 Profit/(loss) before tax -248-76 -5,983 Tax on profit/(loss) for the period 277 869 3,203 Profit/(loss) for the period 29 793-2,780 Other comprehensive income Items that may be reclassified subsequently to profit or loss: Exchange adjustments relating to foreign subsidiaries 1,176-44 722 Total comprehensive income for the period 1,205 749-2,058 Earnings per share Earnings per share 0.00 0.02-0.08 Diluted earnings per share 0.00 0.02-0.08 Page 5 of 8

CONSOLIDATED STATEMENT OF FINANCIAL POSITION (UNAUDITED) Note 31 Mar. 2015 31 Mar. 2014 31 Dec. 2014 Goodwill 49,368 49,368 49,368 Acquired patent rights 4,625 5,674 4,887 Acquired software licenses 5,500 5,470 5,932 Intangible assets under construction 473 368 246 Intangible assets 59,966 60,880 60,433 Leasehold improvements 621 671 663 Production and laboratory equipment 8,893 3,943 9,474 Fixtures and fittings, tools and equipment 1,820 615 1,777 Tangible assets under construction 26 225 109 Property, plant and equipment 11,360 5,454 12,023 Deferred tax assets 1,576 1,788 1,430 Deposits 1,365 1,684 1,325 Financial assets 2,941 3,472 2,755 Non-current assets 74,267 69,806 75,211 Inventories 12,950 13,579 13,963 Trade receivables 22,416 15,588 22,147 Other receivables 2,007 1,094 1,200 Refund from Tax Authorities 3,877 2,250 3,690 Prepayments 2,379 1,797 1,367 Receivables 30,679 20,729 28,404 Cash and cash equivalents 20,931 25,516 20,084 Current assets 64,560 59,824 62,451 Total assets 138,827 129,630 137,662 Share capital 36,874 36,874 36,874 Reserves 43,025 41,023 41,141 Equity 79,899 77,897 78,015 Corporate Bonds 0 15,000 15,000 Financial lease liabilities 2,602 744 3,155 Non-current liabilities 2,602 15,744 18,155 Corporate Bonds 15,000 0 0 Financial lease liabilities 2,442 603 2,439 Trade payables 11,427 11,203 10,505 Short term bank loan 10,006 10,020 10,018 Other payables 9,810 7,343 10,394 Deferred revenue 7,641 6,820 8,136 Current liabilities 56,326 35,989 41,492 Total liabilities 58,928 51,733 59,647 Total equity and liabilities 138,827 129,630 137,662 Page 6 of 8

CONSOLIDATED STATEMENT OF CASH FLOWS (UNAUDITED) Operating profit/(loss) (EBIT) 949 471-3,082 Depreciation and amortization 1,734 1,174 6,197 Non-cash adjustments (warrants) 679 929 3,854 Change in working capital -803-5,284-9,403 Profit on sale of assets 0 0-146 Cash flows from primary activities 2,559-2,710-2,580 Net interest and value gains -1,478-559 -3,497 Current tax 132 957 3,643 Cash flows from operating activities 1,213-2,312-2,434 Acquisition of intangible assets -333-502 -2,382 Acquisition of property, plant and equipment -246-480 -2,595 Sale of assets 0 0 146 Cash flows from investing activities -579-982 -4,831 Repayment of lease debt -550-340 -3,215 Repayment of deposit and loans -23-23 351 Short term bank loan -13 7 5 Cash flows from financing activities -586-356 -2,859 Change in cash and cash equivalents 48-3,650-10,124 Unrealised currency gain/(loss) 799-24 1,018 Cash and cash equivalents at the beginning of the period 20,084 29,190 29,190 Cash and cash equivalents at the end of the period 20,931 25,516 20,084 CONSOLIDATED STATEMENT OF CHANGES IN EQUITY (UNAUDITED) Other reserves Reserve for Sharebased Number of Share exchange Retained shares capital adjustments payment profit Total Consolidated No. Equity at 1 January 2015 36,874,082 36,874 98 20,195 20,848 78,015 Profit/(loss) for the period 29 29 Exchange adjustments relating to foreign subsidiaries 1,176 1,176 Total comprehensive income 0 1,176 0 29 1,205 Share-based payment 679 679 Other transactions 0 0 0 679 0 679 Equity at 31 March 2015 36,874,082 36,874 1,274 20,874 20,877 79,899 Equity at 1 January 2014 36,874,082 36,874-624 16,341 23,628 76,219 Profit/(loss) for the period 793 793 Exchange adjustments relating to foreign subsidiaries -44-44 Total comprehensive income 0-44 0 793 749 Share-based payment 929 929 Other transactions 0 0 0 929 0 929 Equity at 31 March 2014 36,874,082 36,874-668 17,270 24,421 77,897 Page 7 of 8

NOTES TO THE INTERIM FINANCIAL STATEMENTS Note 1 Accounting policies The interim report of the Exiqon Group for the period 1 January 31 March 2015 is presented in accordance with IAS 34 and additional Danish disclosure requirements for the presentation of financial statements by listed companies. The interim condensed consolidated financial statements do not include all the information and disclosures required in the annual financial statements, and should be read in conjunction with the Group s annual financial statements as of 31 December 2014. The accounting policies adopted in the preparation of the interim condensed consolidated financial statements are consistent with those followed in preparation of the Group s annual consolidated financial statements for the year that ended 31 December 2014. Management has not made new significant accounting estimates and assumptions on topics besides those listed in the Annual Report for 2014. Note 2 Revenue Product sales 28,059 24,841 96,269 Services 6,557 3,846 20,507 License income 2,859 2,315 8,912 Contract research and grants income 1,547 1,469 6,704 39,022 32,471 132,392 Note 3 Segment information Exiqon s Management has organized the reporting in two reportable operating segments: Exiqon Life Sciences and Exiqon Diagnostics. The Group divides its revenue into three geographies: North America, Europe and Rest of World. The split is based on the registered offices of the customers. Management monitors the operating results of its business segments separately to decide the resource allocation and performance assessments. Segment performance is monitored on operating results (EBITDA/EBIT) as presented in the table below. Financial items and taxes are managed on a corporate level and not allocated to the operating segments. Revenue: Life Sciences 1) The item Other includes net non-operating items. Diagnostics Geography Revenue of the Exiqon Group is distributed on geographical segments as follows: --oo0oo-- Group eliminations Other 1) Consolidated External customers 38,175 847 0 0 39,022 Internal customers 8,053 0-8,053 0 0 Total revenue 46,228 847-8,053 0 39,022 EBITDA 7,013-4,332 0 0 2,681 Operating profit/(loss) (EBIT) 5,530-4,581 0 0 949 Net non-operating cost 0 0 0-1,197-1,197 Profit (loss) before tax 5,530-4,581 0-1,197-248 Assets 60,718 53,301 0 24,808 138,827 North America 14,250 11,479 45,576 Europe 19,694 15,831 72,000 Rest of World 5,078 5,161 14,816 39,022 32,471 132,392 Page 8 of 8