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Barr, B; Taylor-Robinson, D; Scott-Samuel, A; McKee, M; Stuckler, D (2012) Suicides associated with the 2008-10 economic recession in England: time trend analysis. BMJ (Clinical research ed), 345. ISSN 0959-8138 DOI: https://doi.org/10.1136/bmj.e5142 Downloaded from: http://researchonline.lshtm.ac.uk/251167/ DOI: 10.1136/bmj.e5142 Usage Guidelines Please refer to usage guidelines at http://researchonline.lshtm.ac.uk/policies.html or alternatively contact researchonline@lshtm.ac.uk. Available under license: Creative Commons Attribution Non-commercial http://creativecommons.org/licenses/by-nc/3.0/

Web appendix: Supplementary material Web Appendix 1. Descriptive Statistics Web Appendix 2. Unadjusted Associations per and post recession Web Appendix 3. Modeling lead and lagged effects Web Appendix 4. Replication of table 1 for longest available time-series (1993-2010), years of falling unemployment (1993-2005) and years of rising unemployment (2006-2010), with and without controls for time-trends Web Appendix 5. Replication of table 2, excluding undetermined injuries

Web Appendix 1. Descriptive Statistics, 2000-2010 Variable Male suicides Female suicides Male Female Male suicide change Female suicide change Number of Local Area- Years 1017 Mean Min Max Source 35.24 (24.82) 11.89 (9.36) 6528.07 (6720.90) 2396.55 (2734.65) 0.05 (0.42) 0.16 (0.81) 2 139 0 55 928 53287 377 27130-0.81 4.5-1 9 The Office for National Statistics (ONS) NOMIS The Office for National Statistics (ONS) NOMIS

Web Appendix 2. Unadjusted associations, pre- and post-recession The figure below shows the unadjusted association of the increase in unemployment in each area before (years 2005-2007) and after (2008-2010) the onset of recession with the change in suicides. While a significant association is observed for both men (r = 0.29, p=0.005) and women (r = 0.25, p=0.014), this unadjusted correlation may over estimate the association as compared to the fixed effects model. Figure: Unadjusted association of the percentage increase in the number of unemployed men and women with the percentage increase in the number of suicides, before- and after- the 2008 recession, by sex Notes: Each dot represents a local area (classified based on NUTS3 areas of county Councils and groups of unitary authorities); points shading representing weighting for the number of suicides in 2005-2007.

Web Appendix 3. Modelling lead and lagged effects, 1993-2010 Table 3a. Lags Current Previous Year s Previous Two Year s Male Suicide 1.8% ** [0.7,2.9] -0.8% [-1.9,0.3] 0.6% [-0.9,2.1] Female Suicide -1.5% [-6.9,4.6] 0.6% [-1.4,2.6] -0.8% [-2.9,4.5] Number of local areayears 1395 1385 R 2 0.037 0.038 95% confidence intervals in brackets * p< 0.05, ** p< 0.01, *** p< 0.001 Since unemployment is a lagging indicator of the economy, it has been speculated that the anticipation of unemployment may create fear and anxiety, corresponding to elevated risks of suicides. As shown below, such effects were not observed in our model. Table 3b. Leads Male Suicide -0.1% [-1.4,1.1] 0.6% [-0.2,1.4] 2.2% ** [0.051,0.39] Female Suicide -1.8 [-3.7,0.1] -1.2 [-0.7,3.0] -0.9 [-3.8,2.0] 1395 1386 Two Year s Prior to Year Prior to Current Number of local areayears R 2 0.040 0.045 95% confidence intervals in brackets * p< 0.05, ** p< 0.01, *** p< 0.001

Web Appendix 4. Replication of table 1 for longest available time-series (1993-2010), years of falling unemployment (1993-2005) and years of rising unemployment (2006-2010), with and without controls for time-trends. Controlling for time-trends Men number Women Percentage in Suicide Rates All years 1993-2005 (years of falling 2006-2010 (years of rising 1.6 ** [0.9,2.4] 2.5 * [0.4,4.5] 1.5 ** [0.5,2.4] number 0.80 [-1.1,2.7] -0.9 [-4.1,2.4] 1.0 [-1.7,3.7] Notes: 95% confidence intervals in brackets based on robust standard errors clustered by local area to reflect non-independence of sampling. Model based on equation 1. Number of local area years is 1581 for all years,1116 for 1993-2005 and 465 for 2006-2010. * p< 0.01, ** p< 0.001. Test for effect heterogeneity between time periods, for male model, p=0.35, Seemingly Unrelated Estimation (SUEST) Test Without Controlling for time-trends Men number Women Percentage in Suicide Rates All years 1993-2005 (years of falling 2006-2010 (years of rising 1.2 *** [0.7,1.8] 1.4 * [0.1,2.8] 0.15 *** [0.6,2.3] 0.7-0.05 1.6 number [-0.5,0.2] [-2.2,2.1] [-0.6,3.8] Notes: 95% confidence intervals in brackets based on robust standard errors clustered by local area to reflect non-independence of sampling. Model based on equation 1 but without controls for time-trends. Number of local area years is 1581 for all years,1116 for 1993-2005 and 465 for 2006-2010. * p< 0.01, ** p< 0.001 Model equation: Equation 1: Suicide i,t = β Unemp i,t + μ i + μ i x t + t + ε i,t Where i is the English area (based on the NUTS3 area classification) and t is the year. is the first-year difference of log suicides and, expressed as the percentage change; β is the coefficient describing the percentage increase in suicides associated with each percentage increase in the number of unemployed. μ is a set of region dummy variables, and t is a time-trend.

Web Appendix 5. Replication of table 2, excluding undetermined injuries. 10% rise in the number of male 10% rise in the number female Male Suicide Rates 1.3% * [95% CI: 0.35% to 2.3%] Female Suicide Rates -0.2% [95% CI: -3.2% to 2.8%] Notes: 95% confidence intervals in brackets. Model based on equation 1. Number of local area years is 1022 among men and 990 among women. * p< 0.001