Putting All of the Registry Data Together: What Does This Tell Us
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1 Putting All of the Registry Data Together: What Does This Tell Us ISAKOS Congress Shanghai China 6/7/17 Gregory B. Maletis, MD Kaiser Permanente ACL Registry NATIONAL IMPLANT REGISTRIES
2 I have no disclosures
3 Registry Demographics Yr Started Volume Mean Age Male Female Norway % 43% Sweden , % 42% Denmark , % 40% Kaiser Permanente United Kingdom , % 37% % 26% Luxembourg % 30% 3
4 Sports Am football Basketball Handball Skiing Soccer 10 0 Norway Sweden Denmark Kaiser Luxembourg June 4, Kaiser Foundation Health Plan, Inc. For internal use only. 4
5 Age at surgery 5
6 Grafts Utilized HS PT Allo Other 0 6
7 3 yr and 5 yr Revision Rates yr 5yr 1 0 Kaiser Sweden Denmark 7
8 Allograft HS BPTB 8 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
9 Hamstring vs BPTB KP 1.8 X higher risk Norway 2.3 X higher risk Denmark 1.4 X higher risk Scandinavia 1.4X higher risk 9
10 Does One Size Fit All June 4, Kaiser Foundation Health Plan, Inc. For internal use only. 10
11 Hamstring Diameter Makes a Difference KP 17% risk of revision for 0.5mm diameter Sweden 14% risk of revision for 0.5mm diameter June 4, Kaiser Foundation Health Plan, Inc. For internal use only. 11
12 Age Makes a Difference June 4, Kaiser Foundation Health Plan, Inc. For internal use only. 12
13 Age-Related Risk Factors 5 year cumulative revision probability < 21 years 9.0% years 5.5 % years 2.8% > 40 years 1.9% 5 year cumulative revision probability < 20 years 8.7% > 20 years 2.8% Age years 5.3X higher risk than years KP Denmark Sweden
14 Age Related Risk Factors KP Age <21 7.8X higher risk than > 40 Denmark Age <20 3.5X higher risk age >20 Sweden Age <16 5.3X higher risk than age >35 Sweden < 20 and soccer 3X higher risk of revision 14
15 Graft Survival Compared to CACL Survival Sweden 5-year survival CACLR 95.8% ACLR: 95.1% Younger age, females, lower BMI Younger age, females
16 Graft Fixation Norway KP Extratunnel 1.7X higher risk than Intratunnel Extrachannel X higher risk than Interference and Crosspin fixation 16 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
17 Change in Technique Move to AM portal Drilling 17 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
18 Drilling Method Denmark 4 yr revision rate AM 5.2% vs TT 3.2% After adjusting for covariates 2X higher risk with AM portal KP 5 yr risk of revision AM 6.4% vs TT 5.0% After adjusting for covariates including fixation No difference 18 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
19 Swedish Registry Drilling method TT had a decreased risk of revision compared to TP HR 0.7 TP anatomic had a 1.3 X higher risk than TP reference No Difference in KOOS based on drilling technique 19 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
20 Double Bundle 20 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
21 Trends in Graft Utilization KP Norway Percent of Graft Type, Program-Wide by Year Allograft (all) BPTB Autograft Other Hamstring Autograft Missing 27% decrease in Allograft use 68% decrease in < 21 year olds 21 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
22 Unique Outcomes
23 23 Revision Risk: 16 year old soccer player
24 24 Revision Risk: 40 year old non athlete
25 The Kaiser Permanente ACL Risk Calculator (KPARC) can be found at: 25
26 Danish Registry Influence of anticonception hormone treatment 26 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
27 Effect of Focal Cartilage Lesion on Patient Reported Outcome Norwegian registry Effect of Meniscal Repair or Resection on Patient Reported Outcomes at 2 years No difference in KOOS with Meniscal resection or LM repair compared to isolated ACLR MM Repair had worse QOL and Other symptoms 27.
28 Swedish Registry KOOS Early and Late Responders Reconstructed and Non Reconstructed ACLs 28 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
29 Patient Reported Outcomes ( Norwegian and Swedish Registries) Functional recovery = 19.7% Treatment Failure = 28.9% Acceptable = 66% Not acceptable = 34% Failure = 12%
30 What can we take away? Many similarities between the Kaiser (US) and European Registries. Understanding the similarities and differences should improve crosscultural acceptance of results. Outcomes that are consistent across Registries should be able to be relied upon. Different registries may be uniquely positioned to tackle different problems. There are still many unanswered questions. 30 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
31 Registries are one piece of the puzzle in trying to answer those important questions regarding ACL Reconstructions RCT Cohort Registries 31 June 4, Kaiser Foundation Health Plan, Inc. For internal use only.
32 Thank you
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