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1 Form 604 Corporations Law Section 671B Notice of change of interests of substantial holder To Company Name/Scheme SIRTEX MEDICAL LIMITED ACN/ARSN Details of substantial holder (1) Name PERPETUAL LIMITED and subsidiaries ACN (if applicable) There was a change in the interests of the Substantial holder on The previous notice was given to the company on The previous notice was dated _22_ /_08_ /_ _ /_06_ /_ _ /_06_ /_ Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Class of securities (4) Previous notice Present notice Person s votes Voting power (5) Person s votes Voting power (5) Ordinary 4,117, % 4,732, % 3. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give substantial holding notice to the company or scheme are as follows: Date of change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) Class and number of securities affected Person s votes affected Refer annexure 3 4. Present relevant interests Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Holder of relevant interest Registered holder of securities Person entitled to be registered as holder (8) Nature of relevant interest (6) Class and number of securities Person s votes Refer annexure 1 & 2

2 5. Changes in association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN (if applicable) Refer to Annexure 1 Nature of association 6. Addresses The addresses of persons named in this form are as follows: Name Refer to Annexure 1 Address Signature Print name GLENDA CHARLES Capacity DEPUTY COMPANY SECRETARY

3 ANNEXURE 1 - Perpetual Investments Account Codes & Details Perpetual Investments Management Limited (PIML), subsidiary of Perpetual Limited, as Responsible Entity for: INTERNAL CODE ACCOUNT DETAILS REGISTRATION DETAILS ALL 'PC' CODES ACF: PIML (Select Investments) RBC Dexia Investor Services Australia Pty Limited RBC Investor Services Australia Nominees Pty Limited <PISELECT> GPO Box 5430, Sydney NSW 2001 PCEF ACF: Perpetual's Wholesale Concentrated Equity Fund Account Code: PICEF PIBIAS ACF: Perpetual Pure Value Share Fund Account Code: PIBIAS PIDGPF ACF: Perpetual Dynamic Global Property Fund Account Code: PIDGPF RBC Investor Services Australia Nominees Pty Limited <PICREDIT> PIGPVF ACF: Perpetual's Pure Value 2 Share Fund Account Code: PIGPVF PIGSFP ACF: Perpetual's Australian Share Fund Account Code: PIGSFP PIICAP ACF: WealthFocus Investment Advantage Perpetual Australian Share Fund Account Code: PIICAP RBC Investor Services Australia Nominees Pty Limited <PIIC A/C> PMISF ACF: Perpetual's Industrial Share Fund Account Code: PMISF PIRAF ACF: Perpetual Resources Fund Account code: PIRAF PISINP ACF: WealthFocus Investment Advantage Perpetual Industrial Share Fund Account Code: PISINP RBC Investor Services Australia Nominees Pty Limited <PIIC A/C> PISMA1 ACF: SMA Equity Imputation Portfolio Account Code: PISMA1 PISMA2 ACF: SMA Capital Accumulation Portfolio Account Code: PISMA2 PIWGAP UBS Nominee Pty Ltd ACF: Perpetual Wholesale Geared Australian Share Fund Account code: A C/- UBS Nominee Pty Ltd Level 16 Chifley Tower 2 Chifley Square PIWCPF UBS Nominee Pty Ltd ACF: PI Protected Aust Share Fund A Account code: A C/- UBS Nominee Pty Ltd Level 16, Chifley Tower 2 Chifley Square This is Annexure 1 Page 1 of 6 referred to in Form 604

4 PIWJPI ACF: Perpetual JF Wholesale Prop Income Fund Account Code: PIWJPI PIWMCX ACF: Perpetual Pure Microcap Pool Account Code: PIWMCX PIWEYX ACF: Perpetual Pure Equity Yield Pool Account Code: PIWEYX PIWARX UBS Nominee Pty Ltd ACF: Perpetual Pure Equity Alpha Pool Account code: A /A UBS Nominees Pty Ltd Level 16 Chifley Tower 2 Chifley Square PIWSPP UBS Nominee Pty Ltd ACF: Perpetual Wholesale Share Plus Fund Account code: A UBS Nominees Pty Ltd Level 16 Chifley Tower 2 Chifley Square PIWSRP ACF: Perpetual Wholesael Ethical Fund Account Code: PIWSRP PMWSC ACF: Perpetual Wholesale Smaller Company Fund Account Code: PIWSCS PPSF ACF: Perpetual Wholesale Property Securities Fund Account Code: PPSF PISTIF ACF: Perpetual Pure Credit Alpha Fund Account Code: PISTIF PIPAEQ ACF: Trust Company Australian Share Fund Account Code: PIPAEQ PIIMPF ACF: Trust Company Share Imputation Fund Account Code: PIIMPF PIPICF ACF: Trust Company Income Fund Account Code: PIPICF PIDVPF ACF: Trust Company Diversified Property Fund Account Code: PIDVPF Perpetual Investments Management Limited (PIML), subsidiary of Perpetual Limited, as Trustee for: ALL 'SS' CODES ACF: PIML (Select Super) RBC Dexia Investor Services Australia Pty Limited ACF: PIML (Select Super) RBC Dexia Investor Services Australia Pty Limited This is Annexure 1 Page 2 of 6 referred to in Form 604

5 Perpetual Investments Management Limited (PIML), subsidiary of Perpetual Limited, under Investment Management Agreements with: INTERNAL CODE ACCOUNT DETAILS REGISTRATION DETAILS PEPIC ACF: Perpetual Equity Investment Company Ltd Account Code: PEPIC <BKCUST A/C> CBAISF Citicorp Nominees Pty Ltd. ACF: Commonwealth Aust Shares Fund 4 Account Code: Citicorp Nominees Pty Ltd GPO Box 764G PICISP Citicorp Nominees Pty Ltd. ACF: Commonwealth Aust Shares Fund 4 Account Code: Citicorp Nominees Pty Ltd GPO Box 764G NSWTC BNP Paribas Noms Pty Ltd ACF: NSW Treasury Corporation Account Code: D BNP Paribas Noms Pty Ltd P.O. Box R209 Royal Exchange Sydney PIACT Northern Trust ACF: Australian Capital Territory Treasury Account Code:ASPA10 HSBC Custody Nominees (Australia) Limited GPO Box 5302 Sydney NSW 2001 PIAVIV ACF: NAVIGATOR AUSTRALIA LIMITED Account Code: M4NIPA PIACSR BNP Paribas Noms Pty Ltd ACF: Australian Catholic Superannuation & Retirement Fund Account code: T PIAVSU BNP Paribas Noms Pty Ltd ACF: AvSuper Pty Ltd Account code: Z PICHRS State Street Australia Limited ACF: CHRISTIAN SUPER Account code: CSEH HSBC Custody Nominees (Australia) Limited Level George St PICLUB National Nominees Ltd ACF: Club Plus Superannuation Account Code: C8PTAE PICSRI Northern Trust ACF: Commonwealth Australian Shares Fund 34 Account Code: CASF01 HSBC Custody Nominees (Australia) Limited GPO Box 5302 Sydney NSW 2001 PIEFM6 ACF: EFM Australian Share Fund 6 Account Code: S PIFIRS National Nominees Ltd ACF: FIRST SUPER MANDATE AUSTRALIA Account Code: TIPTAE PIGESB Northern Trust ACF: Government Employees Superannuation Board Account Code:GJ330 HSBC Custody Nominees (Australia) Limited GPO Box 5302 Sydney NSW 2001 PIHEST ACF: HEST Australia Limited Account Code: This is Annexure 1 Page 3 of 6 referred to in Form 604

6 PIMEDA ACF: MEDIA SUPER SMALLER COMPANIES FUND Account code: B PINGSS State Street Australia Limited ACF: NGS SUPER PTY LTD Account code: SDA7 HSBC Custody Nominees (Australia) Limited Level George St PIRAEO State Street Australia Limited ACF: RUSSELL AUSTRALIAN OPPORTUNITIES FUND Account code: BT7B HSBC Custody Nominees (Australia) Limited Level George St PITWUS ACF: TWU SUPERANNUATION Account Code: TWUAEP PIVEAF National Nominees Ltd ACF: Pooled Super Pty Ltd Account Code: VTETAE C/- RBC Dexia Investor Services Australia Nominees Pty Limited PIVISI National Nominees Ltd ACF: Pooled Super Pty Ltd Account Code: VTPTSC C/- RBC Dexia Investor Services Australia Nominees Pty Limited PMCBUS ACF: Construction and Building Union Superannuation Fund Account Code: AEQ76 PMCGSF Citicorp Nominees Pty Ltd ACF: Commonwealth Aust Shares Fund 11 Account Code: Citicorp Nominees Pty Ltd GPO Box 764G PMCPSF Citicorp Nominees Pty Ltd ACF:Commonwealth Property Fund 3 Account Code: Citicorp Nominees Pty Ltd GPO Box 764G PIAUST ACF: Australian Super Ethical SRI Fund Account Code: PIASSA ACF: Australian Super Ethical SRI Fund Account Code: PMSTA ACF: Super Trust of Australia Account Code:40909 PIMSLC ACF: Media Super Concentrated Equity Fund Account code: PISPCP T2 Perpetual Trustee Company Limited (Private Client Division) Perpetual Trustee Company Limited GPO Box 4172 Sydney NSW 2001 T3 The Trust Company Limited (Personal Client Services) The Trust Company Limited GPO Box 4270 Sydney NSW 2001 This is Annexure 1 Page 4 of 6 referred to in Form 604

7 T4 Perpetual Trustees Queensland Limited (Private Client Division) Perpetual Trustee Company Limited GPO Box 4172 Sydney NSW 2001 T6 Perpetual Trustees WA Limited (Private Client Division) Perpetual Trustee Company Limited GPO Box 4172 Sydney NSW 2001 T7 Perpetual Trustee Company Canberra Limited (Private Client Division) Perpetual Trustee Company Limited GPO Box 4172 Sydney NSW 2001 TEL ACF: Telstra Superannuation Pty Limited Account Code: EAV84 C/- RBC Investor Services Australia nominees Pty Limited PIVICS ACF: Vic Super Pty Limited Account Code: VSPSAS C/- RBC Investor Services Australia nominees Pty Limited PICATH ACF: CATHOLIC SUPER FUND PTY LTD Account Code: CDPRDE PIHEAL ACF: HEALTH SUPER PTY LTD Account Code: PIHEAL PILGSS ACF: HEST Australia Limited Account Code: GPO Box 5430 Sydney NSW 2002 PILUCR ACF: LUCRF PTY LTD MANDATE Account code: PILUCR PIPAEQ National Australia Bank Ltd via Asset Servicing ACF: The Trust Company Australian Share Fund Account Code : TCPAEQ C/- RBC Investor & Treasury Services Australia Nominees Pty Limited PIIMPF National Australia Bank Ltd via Asset Servicing ACF: The Trust Company Share Imputation Fund Account Code : TCIMPF C/- RBC Investor & Treasury Services Australia Nominees Pty Limited PIPICF National Australia Bank Ltd via Asset Servicing ACF: The Trust Company Income Fund Account Code : TCPICF C/- RBC Investor & Treasury Services Australia Nominees Pty Limited PIDVPF National Australia Bank Ltd via Asset Servicing ACF: The Trust Company Diversified Property Fund Account Code : TCDVPF C/- RBC Investor & Treasury Services Australia Nominees Pty Limited PISTCF ACF: SAS Trustee Corporation Account code: C/- RBC Dexia Investor Services Australia Nominees Pty Limited PMHOST ACF: Host - Plus Pty Ltd Account Code: PIHOST C/- RBC Dexia Investor Services Australia Nominees Pty Limited This is Annexure 1 Page 5 of 6 referred to in Form 604

8 PIWQLS UBS Nominees Pty Ltd ACF: Perpetual QI Long Short Fund Account code: A C/- RBC Dexia Investor Services Australia Nominees Pty Limited UBS Nominees Pty Ltd Level 16 Chifley Tower 2 Chifley Square QITE2 ACF: Quantitative Investments TE 2 Equity Fund Account Code: PIQTE2 Perpetual Limited GPO BOX 4172 Sydney NSW 2001 This is Annexure 1 Page 6 of 6 referred to in Form 604

9 ANNEXURE 2 PRESENT RELEVANT INTERESTS ASXCode Portfolio Holding SRX PIASSA 288,661 SRX PIAVIV 12,198 SRX PICHRS 101,733 SRX PICISP 264,542 SRX PICSRI 6,772 SRX PIEFM6 155,275 SRX PIGSFP 431,609 SRX PIICAP 77,150 SRX PIIMPF 12,883 SRX PIPAEQ 11,945 SRX PISINP 146,119 SRX PIVEAF 498,032 SRX PIWGAP 326,290 SRX PIWSRP 1,583,462 SRX PMCGSF 116,236 SRX PMISF 700,055 This is annexure 2 Page 1 of 1 referred to in Form 604 Title: Notice of change of interests of substantial holder

10 ANNEXURE 3 CHANGES IN RELEVANT INTERESTS Account Security Volume Value Price AsAtDate PMCGSF SRX - 7,341 $ 228, $ /07/2016 PMCGSF SRX $ 3, $ /07/2016 PMCGSF SRX 7,584 $ 192, $ /06/2016 PMCGSF SRX 8,637 $ 227, $ /06/2016 PIICAP SRX 529 $ 16, $ /07/2016 PIICAP SRX 5,099 $ 158, $ /07/2016 PIVEAF SRX 696 $ 21, $ /07/2016 PIVEAF SRX 6,714 $ 208, $ /07/2016 PMCGSF SRX 4,044 $ 107, $ /06/2016 PIICAP SRX 1,920 $ 59, $ /07/2016 PIVEAF SRX 3,400 $ 105, $ /07/2016 PIWSRP SRX 7,161 $ 190, $ /06/2016 PIIMPF SRX 306 $ 8, $ /06/2016 PIVEAF SRX - 7,000 $ 218, $ /07/2016 PIICAP SRX - 5,046 $ 157, $ /07/2016 PIVEAF SRX - 2,561 $ 76, $ /07/2016 PIICAP SRX - 1,377 $ 41, $ /07/2016 PIVEAF SRX 7,000 $ 177, $ /06/2016 PIVEAF SRX 6,681 $ 175, $ /06/2016 PIVEAF SRX 2,274 $ 60, $ /06/2016 PIICAP SRX 5,054 $ 128, $ /06/2016 PIICAP SRX 5,938 $ 156, $ /06/2016 PIICAP SRX 1,612 $ 42, $ /06/2016 PICSRI SRX 11 $ $ /07/2016 PIEFM6 SRX 1,813 $ 56, $ /08/2016 PICSRI SRX 103 $ 3, $ /07/2016 PISINP SRX 2,603 $ 80, $ /08/2016 PICSRI SRX 61 $ 1, $ /07/2016 PIEFM6 SRX 254 $ 7, $ /08/2016 PICSRI SRX 117 $ 3, $ /06/2016 PISINP SRX 402 $ 12, $ /08/2016 PIEFM6 SRX - 5,533 $ 159, $ /07/2016 PICISP SRX 9,720 $ 301, $ /08/2016 PIEFM6 SRX $ 16, $ /07/2016 PIEFM6 SRX 1,299 $ 32, $ /07/2016 PIEFM6 SRX 3,054 $ 76, $ /07/2016 PICISP SRX 311 $ 9, $ /08/2016 PIEFM6 SRX 450 $ 11, $ /06/2016 PIEFM6 SRX 6,051 $ 157, $ /06/2016 PICHRS SRX 1,733 $ 53, $ /08/2016 PIEFM6 SRX 7,322 $ 194, $ /06/2016 PIEFM6 SRX 1,462 $ 38, $ /06/2016 PIPAEQ SRX 758 $ 23, $ /08/2016 PISINP SRX - 7,208 $ 208, $ /07/2016 PIAVIV SRX 622 $ 19, $ /08/2016 PISINP SRX $ 15, $ /07/2016 PISINP SRX 1,237 $ 31, $ /07/2016 This is annexure 3 Page 1 of 3 referred to in Form 604 Title: Notice of change of interests of substantial holder

11 PISINP SRX 2,515 $ 63, $ /07/2016 PIAVIV SRX 62 $ 1, $ /07/2016 PIAVIV SRX 593 $ 18, $ /07/2016 PICISP SRX - 9,424 $ 272, $ /07/2016 PICISP SRX - 1,048 $ 29, $ /07/2016 PICISP SRX 1,840 $ 46, $ /07/2016 PICISP SRX 4,692 $ 118, $ /07/2016 PIAVIV SRX $ 25, $ /07/2016 PIAVIV SRX $ 3, $ /07/2016 PIAVIV SRX 824 $ 20, $ /06/2016 PIAVIV SRX 917 $ 24, $ /06/2016 PICISP SRX 10,200 $ 265, $ /06/2016 PIAVIV SRX 228 $ 6, $ /06/2016 PICISP SRX 12,356 $ 328, $ /06/2016 PICISP SRX 2,483 $ 65, $ /06/2016 PISINP SRX 304 $ 7, $ /06/2016 PISINP SRX 5,704 $ 148, $ /06/2016 PISINP SRX 6,952 $ 184, $ /06/2016 PISINP SRX 1,381 $ 36, $ /06/2016 PMISF SRX 10,864 $ 336, $ /08/2016 PMISF SRX 1,230 $ 38, $ /08/2016 PMISF SRX 1,100 $ 34, $ /08/2016 PMISF SRX 9,859 $ 306, $ /08/2016 PIAVIV SRX 774 $ 23, $ /08/2016 PIASSA SRX 2,791 $ 86, $ /08/2016 PIASSA SRX 7,985 $ 246, $ /08/2016 PMISF SRX - 23,869 $ 689, $ /07/2016 PMISF SRX - 38,137 $ 1,062, $ /07/2016 PIASSA SRX 533 $ 16, $ /07/2016 PMISF SRX 6,082 $ 153, $ /07/2016 PIASSA SRX 5,134 $ 159, $ /07/2016 PIASSA SRX 2,600 $ 81, $ /07/2016 PMISF SRX 12,263 $ 308, $ /07/2016 PIIMPF SRX 809 $ 24, $ /08/2016 PIWGAP SRX 11,823 $ 365, $ /08/2016 PMISF SRX 1,705 $ 43, $ /06/2016 PIASSA SRX - 5,000 $ 155, $ /07/2016 PIASSA SRX - 3,106 $ 93, $ /07/2016 PMISF SRX 28,045 $ 728, $ /06/2016 PIASSA SRX 5,000 $ 126, $ /06/2016 PMISF SRX 34,070 $ 904, $ /06/2016 PIASSA SRX 5,048 $ 132, $ /06/2016 PIASSA SRX 1,697 $ 45, $ /06/2016 PMISF SRX 6,598 $ 175, $ /06/2016 PIWGAP SRX 2,218 $ 68, $ /07/2016 PIWGAP SRX 21,385 $ 663, $ /07/2016 PIWGAP SRX 12,369 $ 385, $ /07/2016 PIWGAP SRX 5,860 $ 186, $ /07/2016 PIWGAP SRX - 21,046 $ 656, $ /07/2016 PIWGAP SRX - 4,861 $ 145, $ /07/2016 PICHRS SRX 100,000 $ 3,096, $ /08/2016 PIWGAP SRX 22,821 $ 579, $ /06/2016 PIWGAP SRX 14,689 $ 386, $ /06/2016 This is annexure 3 Page 2 of 3 referred to in Form 604 Title: Notice of change of interests of substantial holder

12 PIWGAP SRX 6,830 $ 181, $ /06/2016 PIASSA SRX 4,333 $ 133, $ /08/2016 PIICAP SRX 4,733 $ 146, $ /08/2016 PIPAEQ SRX 474 $ 14, $ /08/2016 PIGSFP SRX 14,513 $ 448, $ /08/2016 PIPAEQ SRX 81 $ 2, $ /07/2016 PIPAEQ SRX 783 $ 24, $ /07/2016 PIPAEQ SRX 367 $ 11, $ /07/2016 PIGSFP SRX 2,932 $ 91, $ /07/2016 PIGSFP SRX 28,258 $ 877, $ /07/2016 PIPAEQ SRX $ 10, $ /07/2016 PIPAEQ SRX $ 23, $ /07/2016 PIPAEQ SRX $ 10, $ /07/2016 PIPAEQ SRX 788 $ 20, $ /06/2016 PIPAEQ SRX 951 $ 25, $ /06/2016 PMCGSF SRX 7,219 $ 223, $ /08/2016 PIPAEQ SRX 265 $ 7, $ /06/2016 PIWSRP SRX 19,067 $ 588, $ /08/2016 PIWSRP SRX 12,531 $ 387, $ /08/2016 PIGSFP SRX 14,216 $ 442, $ /07/2016 PIIMPF SRX 300 $ 9, $ /08/2016 PIWGAP SRX 20,259 $ 625, $ /08/2016 PIGSFP SRX - 29,113 $ 908, $ /07/2016 PIGSFP SRX - 17,177 $ 515, $ /07/2016 PMCGSF SRX 5,043 $ 155, $ /08/2016 PIIMPF SRX 90 $ 2, $ /07/2016 PIIMPF SRX 864 $ 26, $ /07/2016 PIGSFP SRX 29,034 $ 736, $ /06/2016 PIIMPF SRX 295 $ 9, $ /07/2016 PIWSRP SRX 2,304 $ 71, $ /07/2016 PIWSRP SRX 22,209 $ 689, $ /07/2016 PIIMPF SRX 429 $ 13, $ /07/2016 PIGSFP SRX 33,796 $ 888, $ /06/2016 PIGSFP SRX 9,521 $ 252, $ /06/2016 PIWSRP SRX 11,239 $ 350, $ /07/2016 PIWSRP SRX - 2,579 $ 82, $ /07/2016 PIGSFP SRX 26,982 $ 833, $ /08/2016 PMCGSF SRX 787 $ 24, $ /07/2016 PMCGSF SRX 7,585 $ 235, $ /07/2016 PIWSRP SRX - 23,000 $ 717, $ /07/2016 PIIMPF SRX $ 27, $ /07/2016 PIIMPF SRX $ 18, $ /07/2016 PIICAP SRX 2,794 $ 86, $ /08/2016 PIWSRP SRX - 8,525 $ 255, $ /07/2016 PMCGSF SRX 3,399 $ 105, $ /07/2016 PIIMPF SRX $ 10, $ /07/2016 PIVEAF SRX 3,831 $ 118, $ /08/2016 PIIMPF SRX 895 $ 22, $ /06/2016 PIWSRP SRX 21,000 $ 533, $ /06/2016 PIIMPF SRX 1,038 $ 27, $ /06/2016 PIWSRP SRX 21,163 $ 556, $ /06/2016 This is annexure 3 Page 3 of 3 referred to in Form 604 Title: Notice of change of interests of substantial holder