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1 LAIDLAW & COMPANY London New York San Francisco Boston EQUITY RESEARCH Company Report October 19, 2018 EyePoint Pharmaceuticals (EYPT - $2.95) With Early Yutiq Approval, All Eyes on Upcoming Launches We spent time with EYPT s senior management and come away incrementally more positive as they recently received earlier than anticipated approval of Yutiq (fluocinolone acetonide intravitreal implant) for posterior segment uveitis. While a positive PDUFA outcome was de-risked since the technology has been on the market for years; we are particularly encouraged that the approval happened 24 days ahead of expectations and just before the American Academy of Ophthalmology (AAO) meeting. As EYPT prepares for the launch of two ophthalmic products in 1H19, we view CEO Nancy Lurker s extensive commercial expertise as a significant value driver. With Yutiq preparations underway, we remind investors that uveitis is a quite different disease state than DME for which Yutiq s technology is already being used. DME is caused by angiogenesis and requires anti-vegf for first line therapy while uveitis is purely inflammatory and thus treated with steroids. We view their recently acquired Dexycu (dexamethasone intraocular suspension 9%) for postoperative inflammation as the main value driver. As the medical community would prefer to completely exclude drops from surgical procedures and ~4.4M cataract surgeries are performed annually, we believe EYPT may fulfill a significant unmet medical need. We believe understanding how to navigate their pass-through C-code is critical because the current status only lasts 3 years. We expect reimbursement status to last at least another two years as other drugs such, as Omeros (OMER) Omidria and Pacira s (PCRX) Exparel have received extensions. Due to the C-code, we are particularly encouraged by EYPT s strategy to target the ~2.6M patients under Medicare Part B fee for service undergoing cataract surgeries. With a price of ~$500, and potentially fulfilling a clear unmet medical need, we believe Dexycu can reach ~$137M in sales in its first three years. We have adjusted our launch to reflect EYPT s targeted strategy and see the story as relatively de-risked following Yutiq s approval. We are reiterating our Buy rating and increasing our PT from $6 to $8. Yutiq s early approval should help buzz at AAO. While we saw their PDUFA as relatively de-risked, we see Yutiq s early approval as a real positive ahead of AAO (10/27-10/30). Dexycu s targeted launch strategy could fulfill significant unmet medical need. As the medical community continues to strive for drop-less surgery, we believe Dexycu s targeted launch has significant market potential. Reiterating our Buy rating and raising our price target from to $6 to $8. Our price target is based on Yutiq US and royalties at $2/share, Dexycu US at $5.5/share and $0.50/share for cash and tech. Earnings Estimates: (per share) (Jun) 1Q 2Q 3Q 4Q FY P/E FY19E (0.22) (0.22) (0.21) (0.21) (0.86) NA FY18A (0.15) (0.13) (0.10) (0.19) (0.58) NA FY17A (0.21) (0.00) (0.15) (0.16) (0.52) NA FY16A NA NA NA NA (0.68) NA Source: estimates Healthcare / Biotechnology Ticker: EYPT Rating: Buy Price Target: higher $8.00 Trading Data: Last Price (10/18/2018) $ Week High (05/28/2018) $ Week Low (02/09/2018) $0.93 Market Cap. (MM) $219.8 Shares Out. (MM) 74.5 Analyst Francois Brisebois, MSc/ Specialty Pharma & Biotech (857) FOR ANALYST CERTIFICATION AND DISCLOSURES, PLEASE SEE DISCLOSURES SECTION AT THE END OF THIS REPORT. This report has been prepared by Laidlaw & Co (UK), Ltd. Investors should be aware that the firm may have a conflict of interest that could affect the objectivity of this report. Investors should consider this report as only a single factor in making their investment decision. All prices are those current at the end of the previous trading session unless otherwise indicated. Prices and consensus estimates are sourced from a reliable market source

2 Figure 1: Sum-of-the-Parts Analysis Sum-of-the-parts valuation Segment Valuation Per share (000's) value Yutiq US $110,887 $1.50 Yutiq royalties $56,566 $0.50 Dexycu US sales $449,586 $5.50 Cash (end '18) & tech value $30,618 $0.50 $647,658 $ fully diluted shares out (000) 81,162 Source: Company Reports; Laidlaw and Company estimates Eyepoint Pharmaceuticals, Inc. Page 2 of 9 Francois Brisebois

3 Figure 2: Potential Clinical Trial Timeline EyePoint Pharmaceuticals Potential clinical trial timeline estimates Durasert three-year uveitis Posterior segment uveitis Phase 3 (Study 001) p3 data 2016A 2017A 2018E 2019E 2020E 2021E 2022E sept-15 dec-15 mar-16 jun-16 sept-16 dec-16 mar-17 jun-17 sept-17 dec-17 mar-18 jun-18 sept-18 dec-18 mar-19 jun-19 sept-19 dec-19 mar-20 jun-20 sept-20 dec-20 mar-21 jun-21 sept-21 dec-21 mar-22 jun-22 1QA 2QA 3QA 4QA 1QA 2QA 3QA 4QA 1QE 2QE 3QE 4QE 1QE 2QE 3QE 4QE 1QE 2QE 3QE 4QE 1QE 2QE 3QE 4QE 1QE 2QE 3QE 4QE Phase 3 (Study 005) phase 3 data NDA filing, FDA approval, launch NDA FDA LAUNCH - US EMEA filing, approval, launch by partner ALIM MAA partner EMA LAUNCH - EU Durasert short-acting snda filing, FDA approval, launch snda FDA LAUNCH - US/EU EMEA filing, approval, launch by partner MAA partner EMA LAUNCH - EU Source: Company Reports; estimates Eyepoint Pharmaceuticals, Inc. Page 3 of 9 Francois Brisebois

4 Figure 3: Quarterly Income Statement EyePoint Pharmaceuticals Quarterly income statement sept-17 dec-17 mar-18 jun-18 jun-18 sept-18 dec-18 mar-19 jun-19 jun-19 ($000 except per share) 1QA 2QA 3QA 4QA Year 1QE 2QE 3QE 4QE Year Revenues 2018A Collaborative R&D , ,200 Royalty income , ,583 Durasert 3 year US 1,224 1,836 3,060 Durasert 3 year royalty uveitis EMEA Dexycu US 3,348 3,348 Total Revenues $385 $933 $928 $715 $2,961 $674 $685 $2,435 $6,438 $10,232 Expenses: COGS (% of US Revenue) ,369 2,038 Gross Margin , ,072 5,069 8,194 Research and development 3,819 4,269 3,325 4,765 16,178 4,750 4,750 5,000 5,000 19,500 Sales and Marketing 1,512 1,512 1,750 2,000 2,250 2,500 8,500 General and administrative 2,572 2,472 2,281 4,220 11,545 6,000 7,500 8,000 11,000 32,500 Total operating expenses 6,391 6,741 5,606 10,497 29,235 12,500 14,250 15,250 18,500 60,500 Operating Income/ (loss) (6,006) (5,808) (4,678) (9,782) (26,274) (11,995) (13,702) (13,178) (13,431) (52,306) Interest and other income (693) (619) (125) (125) (125) (125) (500) (Loss) income before inc.taxes (5,983) (5,782) (4,653) (10,475) (26,893) (12,120) (13,827) (13,303) (13,556) (52,806) income tax benefit (exp) Adj. Ni/(loss) as reported (5,983) (5,782) (4,653) (10,475) (26,893) (12,120) (13,827) (13,303) (13,556) (52,806) 2018A 2019E 2019E 1X and non-cash (2,325) (23,953) (26,278) NI/(loss) as reported (5,983) (5,782) (6,978) (34,428) (53,171) (12,120) (13,827) (13,303) (13,556) (52,806) Earning per Share (EPS) ($0.15) ($0.13) ($0.15) ($0.62) ($1.15) Adj EPS ex-1x & non-cash ($0.15) ($0.13) ($0.10) ($0.19) ($0.58) ($0.22) ($0.22) ($0.21) ($0.21) ($0.86) Weighted avg. shares (000) 39,430 44,530 45,644 55,387 46,226 55,687 62,687 62,987 63,287 61,162 Fully diluted shares (000) 48,430 53,530 54,644 74,500 57,776 75,687 82,687 82,987 83,287 81,162 Source: Company Reports; estimates Eyepoint Pharmaceuticals, Inc. Page 4 of 9 Francois Brisebois

5 Figure 4: Annual Income Statement EyePoint Pharmaceuticals Annual income statement ($000's except per share) 2016A 2017A 2018E 2019E 2020E Revenues Collaborative R&D $398 $6,569 $1,343 $1,200 $1,200 Royalty income $1,222 $970 $1,618 $2,583 $4,427 Durasert 3 year US $3,060 $11,798 Durasert 3 year OUS royalty $41 $524 Dexycu $3,348 $48,271 Total Revenues $1,620 $7,539 $2,961 $10,232 $66,221 COGS 2,038 15,874 Gross margin 1,620 7,539 2,961 8,194 50,347 R&D 14,381 14,880 16,178 19,500 21,500 SG&A 9,013 11,235 11,545 32,500 58,500 Operating income/(loss) (21,774) (18,576) (26,274) (52,306) (42,153) Interest expense (619) (500) (500) Total other loss Adj-Net income/(loss) (21,547) (18,485) (26,893) (52,806) (42,653) Series A convert premium NI/(loss) as reported (21,547) (18,485) (53,171) (52,806) (42,653) Adj-EPS ex-non-cash ($0.68) ($0.52) ($0.58) ($0.86) ($0.62) EPS as reported Shares out (000) 31,623 35,344 46,226 61,162 68,900 Fully diluted shares (000) 37,228 44,022 57,776 81,162 88,900 Source: Company Reports; estimates Eyepoint Pharmaceuticals, Inc. Page 5 of 9 Francois Brisebois

6 Major Risks Exogenous events could impact our outlook. We believe pharmaceutical companies have the least control over competitive, political, and regulatory risks. Although we have incorporated competitive assumptions into our forecasts, there may be other risks beyond the scope of our analysis. Changes in the drug reimbursement system, as well as any political or regulatory amendments, may significantly influence the earnings power of these companies. Actual clinical results and the FDA s conclusions may deviate from expectations. Many of our assumptions are based on a review of incomplete clinical trial data available in the public domain. Often, our conclusions are drawn from early stage data, which may not be reflected by pivotal studies. Furthermore, the FDA s conclusions may not coincide with our own, materially changing our revenue and earnings assumptions. Compliance issues, product recalls, and other mandates by regulatory authorities could materially change our expectations. Regulatory compliance issues, ranging from accounting irregularities to defective manufacturing practices, could materially change our assumptions and earnings outlook. Unanticipated product recalls and labeling changes could also have adverse consequences on our earnings assumptions. Legal risks could lead to additional liabilities and revenue loss. In addition to the expenses incurred by patent challenges, product liability and other legal suits could occur and lead to additional liabilities and revenue loss, which could substantially change our financial assumptions. Eyepoint Pharmaceuticals, Inc. Page 6 of 9 Francois Brisebois

7 DISCLOSURES: ANALYST CERTIFICATION The analyst responsible for the content of this report hereby certifies that the views expressed regarding the company or companies and their securities accurately represent his personal views and that no direct or indirect compensation is to be received by the analyst for any specific recommendation or views contained in this report. Neither the author of this report nor any member of his immediate family or household maintains a position in the securities mentioned in this report. EQUITY DISCLOSURES For the purpose of ratings distributions, regulatory rules require the firm to assign ratings to one of three rating categories (i.e. Strong Buy/Buy-Overweight, Hold, or Underweight/Sell) regardless of a firm's own rating categories. Although the firm s ratings of Buy/Overweight, Hold, or Underweight/Sell most closely correspond to Buy, Hold and Sell, respectively, the meanings are not the same because our ratings are determined on a relative basis against the analyst sector universe of stocks. An analyst's coverage sector is comprised of companies that are engaged in similar business or share similar operating characteristics as the subject company. The analysis sector universe is a sub-sector to the analyst's coverage sector, and is compiled to assist the analyst in determining relative valuations of subject companies. The composition of an analyst's sector universe is subject to change over time as various factors, including changing market conditions occur. Accordingly, the rating assigned to a particular stock represents solely the analyst's view of how that stock will perform over the next 12-months relative to the analyst's sector universe. Additional information available upon request. # Laidlaw & Co (UK) Ltd. has not provided any investment banking services for the company (ies) mentioned in this report over the last 12 months. RATINGS INFORMATION Rating and Price Target Change History 3 Year Rating Change History 3 Year Price Change History * Previous Close10/18/2018 Source: Created by: Blue-Compass.net Source: Created by: Blue-Compass.net Note: Company renamed Eyepoint Pharmaceuticals, Inc., ticker changed to EYPT on 04/02/2017 Rating System* Strong Buy (SB) Expected to significantly outperform the sector over 12 months. % of Companies Under Coverage With This Rating % of Companies for which has performed services for in the last 12 months Investment Banking Brokerage 0.00% 0.00% 0.00% Buy (B) Expected to outperform the sector average over 12 months % 22.81% 3.51% Eyepoint Pharmaceuticals, Inc. Page 7 of 9 Francois Brisebois

8 Hold (H) Sell (S) Expected returns to be in line with the sector average over 12 months. Returns expected to significantly underperform the sector average over 12 months. 3.51% 1.75% 0.00% 0.00% 0.00% 0.00% ADDITIONAL COMPANIES MENTIONED Omeros (OMER Not Rated) Pacira (PCRX Not Rated) ADDITIONAL DISCLOSURES As of the date of this report, neither the author of this report nor any member of his immediate family or household maintains an ownership position in the securities of the company (ies) mentioned in this report. This report does not provide individually tailored investment advice and has been prepared without regard to the individual financial circumstances and objectives of persons who receive it. Laidlaw & Co (UK), Ltd. recommends that investors independently evaluate particular investments and strategies, and encourages investors to seek the advice of a financial adviser. The appropriateness of a particular investment or strategy will depend on an investor's individual circumstances and objectives. The securities, instruments, or strategies discussed in this report may not be suitable for all investors, and certain investors may not be eligible to purchase or participate in some or all of them. This report is not an offer to buy or sell or the solicitation of an offer to buy or sell any security/instrument or to participate in any particular trading strategy. Associated persons of Laidlaw & Co (UK), Ltd not involved in the preparation of this report may have investments in securities/instruments or derivatives of securities/instruments of companies mentioned herein and may trade them in ways different from those discussed in this report. While Laidlaw & Co (UK), Ltd., prohibits analysts from receiving any compensation. Bonus or incentive based on specific recommendations for, or view of, a particular company, investors should be aware that any or all of the foregoing, among other things, may give rise to real or potential conflicts of interest. With the exception of information regarding Laidlaw & Co (UK), Ltd. this report is based on public information. Laidlaw & Co (UK), Ltd makes every effort to use reliable, comprehensive information, but we make no representation that it is accurate or complete and it should not be relied upon as such. Any opinions expressed are subject to change and Laidlaw & Co (UK), Ltd disclaims any obligation to advise you of changes in opinions or information or any discontinuation of coverage of a subject company. Facts and views presented in this report have not been reviewed by, and may not reflect information known to, professionals in other Laidlaw & Co (UK), Ltd business areas. Laidlaw & Co (UK), Ltd associated persons conduct site visits from time to time but are prohibited from accepting payment or reimbursement by the company of travel expenses for such visits. The value of and income from your investments may vary because of changes in interest rates, foreign exchange rates, default rates, prepayment rates, securities/instruments prices. market indexes, operational or financial conditions of companies or other factors. There may be time limitations on the exercise of options or other rights in securities/instruments transactions. Past performance is not necessarily a guide to future performance. Estimates of future performance are based on assumptions that may not be realized. If provided, and unless otherwise stated, the closing price on the cover page is that of the primary exchange for the subject company's securities/instruments. Any trademarks and service marks contained in this report are the property of their respective owners. Third-party data providers make no warranties or representations of any kind relating to the accuracy, completeness, or timeliness of the data they provide and shall not have liability for any damages of any kind relating to such data. This report or any portion thereof may not be reprinted, sold or redistributed without the written consent of Laidlaw & Co (UK), Ltd. This report is disseminated and available primarily electronically, and, in some cases, in printed form. The information and opinions in this report were prepared by Laidlaw & Co (UK), Ltd. For important disclosures, please see Laidlaw & Co (UK), Ltd. s disclosure website at or contact your investment representative or Laidlaw & Co (UK), Ltd at 521 Fifth Ave, 12th Floor, New York, NY USA Laidlaw & Co. (UK), Ltd. Eyepoint Pharmaceuticals, Inc. Page 8 of 9 Francois Brisebois

9 NOTES: Eyepoint Pharmaceuticals, Inc. Page 9 of 9 Francois Brisebois