Mesoblast (MSB) Major CHF catalyst next week, Time to get on board
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- Abigail Webster
- 5 years ago
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1 9 November 2018 Analyst Tanushree Jain Authorisation John Hester Recommendation Buy (unchanged) Price $2.18 Valuation $4.06 (previously $3.95) Risk Speculative GICS Sector Pharmaceuticals & Biotechnology Expected Return Capital growth 86.2% Dividend yield 0.0% Total expected return 86.2% Company Data & Ratios Enterprise value Market cap $1.03bn $1.08bn Issued capital m Free float 70.4% Avg. daily val. (52wk) $2.44m 12 month price range $1.19- $2.47 Price Performance (1m) (3m) (12m) Price (A$) Absolute (%) Rel market (%) Absolute Price $3.5 $3.0 $2.5 $2.0 $1.5 $1.0 $0.5 $0.0 Nov 16 SOURCE: IRESS Mar Jul 17 Nov Mar Jul MSB S&P 300 Rebased Mesoblast (MSB) Speculative See Key risks on Page 7 & Biotechnology Risk Warning on Page 9 Speculative securities may not be suitable for Retail clients Major CHF catalyst next week, Time to get on board Balance Sheet strengthened with strategic transactions MSB has successfully organised largely non-dilutive financing both through debt facility agreements with Hercules Capital and NovaQuest and through its strategic licensing agreement with Tasly pharmaceuticals for China. This has strengthened MSB s balance sheet ahead of key upcoming catalysts and should also support its ongoing partnering negotiations. Its current cash position on a proforma basis is US$95.1m (including US$55.1m cash at end of Sep 18 and US$40m received from Tasly in Oct 18). MSB is burning ~US$22m/qtr, implying over 12 months cash runway. MSB also has access to another US$50m through its existing financing agreements. Major CHF catalyst next week Top-line results from the NIH funded Phase 2B end stage CHF trial in LVAD patients with MPC-150-IM are due to be reported at the prestigious AHA conference in US on 11 th Nov. We are optimistic of a successful outcome based on a) positive results from the pilot trial which showed low dose MPCs strengthened the native heart function, lowered early mortality rate and reduced hospitalisations (especially due to GI bleeding) and b) results will be presented as a podium presentation in late breaking clinical trial session at the conference. This is significant as only 3 presentations are selected for this session and they tend to be that which the AHA considers to be important scientific research, a fact which guarantees extensive media coverage. Results are likely to assist MSB discussing a potential accelerated pathway under the RMAT designation with the FDA, and have a read through for larger advanced CHF trial and also provide impetus to ongoing partnering discussions. Valuation lifted to $4.06, Retain Buy (speculative) Following changes to our model, the net result is an increase in our Net loss forecasts for FY19 and FY20 by 17% and 9% respectively, driven by both higher interest expense forecasts and higher opex forecasts on adding selling expense related to direct sales of GvHD product in the US. The short term NPAT adjustments were offset by higher long term revenue forecasts and rolling forward of our DCF model, leading to a modest lift in our valuation for MSB to A$4.06/sh (was A$3.95/sh). Earnings Forecast Year end 30th June 2017A 2018A 2019E 2020E 2021E Sales (US$m) EBITDA (US$m) NPAT (reported) (US$m) NPAT (adjusted) (US$m) EPS (reported) (cps) EPS (adjusted) (cps) EPS growth (%) N/A N/A N/A N/A NM PER (x) N/A N/A N/A N/A N/A EV/EBITDA (x) Dividend ( ps) Yield (%) 0.0% 0.0% 0.0% 0.0% 0.0% Franking (%) N/A N/A N/A N/A N/A ROE (%) -17.5% -12.1% -16.2% -10.2% -16.5% Note: Revenue includes R&D tax incentive, commercial milestone and royalty revenue from launch of TEMCELL GvHD product in Japan, revenue from launch of GvHD and CHF in US and potential upfront and milestone from CLBP deal.source: BELL POTTER SECURITIES ESTIMATES BELL POTTER SECURITIES LIMITED ABN AFSL and DISCLAIMER: THIS REPORT MUST BE READ WITH THE DISCLAIMER ON PAGE 9 THAT FORM PART OF IT INCLUDING THE FOLLOWING DISCLOSURE. DISCLOSURE: BELL POTTER SECURITIES ACTED AS LEAD MANAGER AND UNDERWRITER IN THE MARCH AND SEPTEMBER 2017 PLACEMENTS AND RECEIVED FEES FOR THAT SERVICE. Page 1
2 Earnings and Valuation Changes We have revisited our assumptions for Mesoblast and made adjustments to our forecasts based on the FY18 results, 1QFY19 cash flow report and recent completion of financing with Novaquest and licensing agreement with Tasly, which have impacted earnings and valuation. Key assumption changes We have updated our model with the actual equity issued to Novaquest and Tasly under their debt and licensing agreements respectively. We now model direct risk adjusted sales and associated selling and marketing expenses for MSB s MSC-100-IV GvHD product for children. Previously we had modelled risk adjusted upfronts, milestones and royalties assumptions in our model on the assumption that MSB would have partnered this product. We assume peak sales (non-risk adjusted) in US alone at US$122m. We now assume a deal for MSB s CLBP (Chronic discogenic low back pain) product happens in FY20 and have moved the deal upfront and milestones accordingly. We have shifted our first sales from CLBP product to FY23 (was FY21) given likely delay in timing of initiation of a second Phase 3 trial which is dependent on a partnering outcome. We have also shifted our first sales from MPC-150-IM for Class II/III advanced CHF patients to FY22 (was FY20). Given that the trial is events driven the timeline for Top line results is fluid (BPe FY20) and the launch timeline would be dependent in the first instance on the timing of the Top line results. Similarly, we have shifted our launch times for Rheumatoid arthritis product to FY24 (was FY22) and Diabetic Kidney Disease to FY24 (was FY23). This change assumes a delay in initiation of these trials as MSB is prioritising existing Tier 1 late stage programs pending a partnering deal. We have included interest expense at 15% p.a. related to the Novaquest loan in our forecasts for FY19-FY26, which have impacted our earnings forecasts during the period. In FY18, MSB recorded US$3.6m as royalty revenue from GvHD product Temcell in Japan, which was slightly higher than our forecast. Accordingly, we have slightly increased our forward royalty revenue forecasts from Temcell. Additionally, the company also received a third sales milestone of US$0.5m from partner JCR in 2H18 which we did not expect, with a total of US$1.5m in milestones for the year. Accordingly, we have bought forward the milestones still receivable from JCR and now expect the balance of US$1m to be received in FY19, with none in FY20. Our opex forward forecasts have increased due to both higher manufacturing commercialisation expense and also due to incorporating selling and marketing expense related to the GvHD product. We now model only the US opportunity for MSB s MPC-150-IM in LVAD patients with end stage CHF. We have also revised our market model assumptions, assuming both a higher pricing as well as higher market penetration for this drug in the US where it would be an ultra-orphan indication. We have also increased the tiered royalty rate to 20% to 25% (was 15% to 25%). Similarly, we have also increased the pricing for the advanced CHF patients (Class II/III) given it s the same product that would be used for both the indications. We expect the end stage CHF pricing will come down once the Class II/III product gets launched. Page 2
3 We have revised our market model assumptions for CLBP and now assume a higher price point for the product, given the disease is very debilitating and it is now in-line with the pricing for non-orphan specialty products in the US. We have updated our model with revised BPe USD/AUD currency assumptions for 2019 onwards (0.75). We have rolled forward our DCF model. Following the above changes, the net result is an increase in our Net loss forecasts for FY19 and FY20 by 17% and 9% respectively, driven by both higher interest expense forecasts related to the NovaQuest debt facility and higher opex forecasts on adding selling and marketing expense related to direct sales of the GvHD paediatric product in the US. The short term NPAT adjustments were offset by higher long term revenue forecasts and rolling forward of our DCF model, leading to a modest increase in our valuation for MSB to A$4.06/sh (was A$3.95/sh). We retain our Buy (speculative) recommendation. Table 1 - Key Changes to our last published FY19-20 Forecasts ALL AMOUNTS IN USD IN MILLIONS EXCEPT EPS. SOURCE: BELL POTTER SECURITIES ESTIMATES Old FY2019E New FY2020E Change (%) Old New Change (%) Revenues % % Interest Income % % Interest Expense % % Opex % % EBITDA % % EBIT % % NPAT (adjusted) % % Adjusted Diluted EPS (cents) % % Our DCF valuation model is based on a WACC of 21% and a terminal growth rate of 1%. Table 2 - Summary of Revised Valuation Forecasts Base case (US$m) Base case (A$m) Enterprise Value from DCF Add: Cash at end 1QFY Add: cash receivable from Tasly Less: Debt Equity Value Total diluted shares (million) Value per share (US$/A$) $3.14 $4.06 Current Share price (A$) $2.18 Expected Capital Growth 86.2% SOURCE: BELL POTTER SECURITIES ESTIMATES Table 3 - MSB- Probability-Weighted Sum-of parts Valuation Summary Asset Identifier Stage Partnering Status ALL ASSETS ABOVE SHADED IN GREY ARE TIER 1 PRODUCTS AND THE KEY FOCUS FOR MSB. GLOBAL PEAK SALES ARE PRE-RISK ADJUSTMENT AND ROYALTIES. SOURCE: BELL POTTER SECURITIES ESTIMATES First Fiscal Year of sales (Est.) Peak Market share Peak Sales Global (US$m) Probability of success Probability adjusted NPV (US$m) Value per share (US$) % Mix SR Acute GvHD (Japan) TEMCELL Approved JCR Pharma % $ % $41 $ % Steroid Refractory Acute GvHD (Pediatric) -Ex- MSC-100-IV Phase III Will launch directly in US. Not likely to 2020 (US); 2021 (ROW) 50.0% $224 85% (US), (54% $144 $ % Japan partner ROW) Revascor - End Stage CHF with LVAD (US) MPC-150-IM Phase IIb NIH Funding Trial, will look to partner % $ % $30 $ % Chronic Discogenic lower back pain (CLDBP) MPC-06-ID Phase III In negotiations with potential partners % $4, % $385 $ % Revascor - Congestive Heart Failure (CHF) MPC-150-IM Phase III Will look to partner % $7, % $1,023 $ % Diabetic Nephropathy MPC-300-IV Phase II Will look to partner % $1, % $54 $ % Rheumatoid Arthritis (RA) MPC-300-IV Phase II Will look to partner % $1, % $136 $ % Other Pipeline/Non-allocated NA NA NA NA NA NA ($211) -$ % Cash NA NA NA NA NA NA $95 $ % Debt NA NA NA NA NA NA ($59) -$ % Equity Value $1,637 $ % Page 3
4 Upside risk to our valuation Under the Tasly deal on MSB s cardiovascular products for China, MSB also stands to receive US$25 million each on achievement of product regulatory approvals in China for both MPC-150-IM and MPC-25-IC, double-digit escalating royalties on net product sales and six additional undisclosed escalating milestone payments upon the product candidates reaching certain sales thresholds. At this stage we do not model royalties or the US$50m in product approval milestones or the undisclosed 6 sales milestones attached to the deal. We intend to model royalties and approval and sales milestones once we get greater clarity on the timelines and regulatory path forward for China, which represents a potential upside to our estimates. At this stage we only model MSC-100-IV for Steroid refractory acute GvHD in children for both US and EU. We do not include any value for the MSC-100-IV for the expanded indication into high risk adults (those with gut and liver involvement). It is MSB s intention to pursue a trial in this high risk adult GvHD population in future to expand the label for MSC-100-IV. We also do not include any value at this stage for potential offlabel usage in adults following the approval of the product for children. We also expect the FDA would require commitment from MSB to run a trial in the adults population given the potential for off label use as a condition for marketing approval in the paediatric indication. Once MSB initiates clinical trials in the high risk adult population, it would be a source of considerable upside to our valuation, given the adult opportunity is expected to be 3x times that of the paediatric opportunity. MSB has recently expanded its relationship with partner JCR pharmaceuticals in Japan for Temcell to include now a second indication for wound healing in patients with Epidermolysis Bullosa (EB). EB is an orphan disease for which JCR has already obtained an orphan drug designation for Temcell in Japan. JCR intends to pursue label expansion for Temcell by obtaining approval for EB in future (Temcell is already approved and marketed for GvHD in Japan). MSB is eligible to receive undisclosed royalties on sales of Temcell for EB in Japan. They could also potentially use all data generated in Japan to pursue the EB indication for MSC-100-IV in other markets including US. At this stage we include no value from EB for Temcell in Japan or in other markets and hence this opportunity represents a source of upside to our valuation in future. Under MSB s December 2017 patent license agreement with Tigenix (now a wholly owned subsidiary of Takeda), apart from the initial 10m that we modelled, MSB also stands to receive an additional 10.0m when Takeda reaches certain product regulatory milestones and single digit royalties on net sales of Alofisel. Alofisel was approved in Europe in March 2018 for the treatment of complex perianal fistulas in adult patients with nonactive/mildly active luminal Crohn s disease, when fistulas have shown an inadequate response to at least one conventional or biologic therapy. We understand Takeda is currently involved with the NICE and other regulatory authorities on pricing and reimbursement for the product. A US launch is expected for the product subject to trial results in As per EvaluatePharma in 2024, worldwide consensus sales for Alofisel are forecast to reach US$529 million. At this stage we do not model the regulatory milestones ( 10.0m) or royalties from Alofisel, which represents a potential upside to our valuation. Page 4
5 FY18 Result Summary Table 4 - FY18 result summary A summary of the reported FY18 result is shown in the Table below: Result vs PCP Result vs Forecast Comments FY17A FY18A % change FY18E Variance (%) Revenues NM % Revenue slightly higher driven by higher JCR milestone and royalty revenue from Temcell and slightly higher R&D tax incentive R&D including manufacturing commercialization % % Close to in-line with our forecast with variance due to modestly lower manufacturing commercialisation expense G&A % % G&A in-line Operating costs % % Opex close to in-line with our forecast EBITDA % % EBITDA loss modestly lower than forecast primarily driven by higher revenue Depreciation and Amortisation % % D&A modestly lower due to lower depreciation EBIT % % Lower EBIT loss consistent with EBITDA variance Net Interest Income/(expense) NM -0.6 NM Higher interest expense than forecast Other Income/(expense) NM % Higher non-cash gain. Includes Fx gain of $0.2m, $0.7m of foreign withholding tax and ~$10.5m gain related to remeasurement of contingent consideration payable to Osiris Pretax Income (Loss) % % Net Income (Loss) after tax - normalised % % Modestly lower than expected loss driven by higher revenue and non-cash other income adjustments Diluted EPS/Share (cps) % % Abnormal items NM % Relates to non-cash income tax benefit related to net change in recognised deferred tax asset and liabilities following US corporate tax rate change Reported Net Income (Loss) after tax % % Lower reported net loss than forecast, driven by non-cash tax benefit Diluted Reported EPS (cps) % % ALL AMOUNTS IN USD EXCEPT EPS. SOURCE: COMPANY DATA AND BELL POTTER SECURITIES ESTIMATES Cash position provides over 12 months runway MSB s current cash position on a proforma basis is US$95.1m (including US$55.1m cash at end of Sep 18 and US$40m received from Tasly pharmaceuticals in October 18). The company reduced its operating cash flows by 21% or US$20.5m in FY18 vs. pcp. In 4QCY18 MSB expects to receive another US$5.9m milestone from Tigenix, with no remaining conditions of trigger to be satisfied, implying the receipt is certain. The company is burning ~US$22m a quarter. Based on this we estimate MSB s cash provides over 12 months runway partway through 4QCY19. Additionally, MSB also has the ability to raise up to US$50m through its existing financing agreements with Hercules Capital and NovaQuest subject to achievement of certain milestones. We assume that the company draws down US$15m of this in 4QCY18. MSB also has the ability to raise up to US$90m over the next 9 months through the Kentgrove equity financing facility it established in Cash injection through upfront payments from a partnering deal in CY19 either global or regional deals for CLBP or CHF products could potentially extend this runway. Page 5
6 Key Near-term Catalysts Results from Phase IIb trial in end stage Heart Failure patients requiring LVAD with MPC-150-IM on 12 th November 18: Full data read out (safety and efficacy) from the US National Institutes of Health (NIH) run and funded 159 patient Phase IIb end stage HF trial will be presented in a late-breaking scientific session by independent investigators at the prestigious AHA conference in the US on 11 th November (12 th November in Australia). Strong results could potentially allow MSB to pursue an accelerated pathway to market under the 21 st Century Cures Act for MPC-150-IM as well as trigger a partnering deal in CY19. We note that the product already has an RMAT (Regenerative Medicine Advanced Therapy) designation from the FDA. FDA BLA meetings for MSC-100-IV following successful completion of Phase 3 paediatric GvHD trial in 4QCY18- MSC-100-IV successfully met its Day 28 primary endpoint showing improved overall response (69% vs. 45% historical controls, p =0.0003) and continued to show safety and improved overall survival at both Day 100 (75%, with 87% survival in Day 28 responders) and Day 180 (Overall Survival 69%, with 79% survival in Day 28 responders) in the recently completed Phase 3 paediatric GvHD trial in the US. MSB will now meet with the FDA (pre-bla meeting expected in 4QCY18), ahead of BLA submission in 1HCY19. We note that the product has a Fast Track designation which will allow for rolling submission as well as priority review. We expect approval by end CY19. MSB will be launching this product commercially int he US directly by establishing a small sales force (10-20 sales reps). Completion of enrolment in ongoing Phase III CHF Program (Class II - III) in 4QCY18: The Phase 3 trial for MPC-150-IM in advanced heart failure patients (Class II/III) is 85% enrolled (~510 patients of total 600). The company passed a successful futility analysis on first 270 patients in April 2017, and since then has also passed interim review on 465 patients by the DMC, which recommended the trial continue as planned. MSB is already in discussions with potential partners. They will also engage with the FDA on potential accelerated pathways for this programme including the recently implemented RMAT designation under the 21st Century Cures Act. MSB expects to complete enrolment of the Phase 3 trial in 4QCY18. Increase in royalties from TEMCELL in Japan: JCR Pharmaceuticals launched its acute Graft versus Host Disease (GvHD) product TEMCELL on 24th Feb 16. MSB has received in 4QCY15 US$3.5m in pre-commercial milestones triggered by the approval of TEMCELL. Under the deal sales milestones (BPe ~US$3m) as well as royalties in the mid 20% range are also payable by JCR. MSB recorded US$1.4m in royalty revenues and sales milestone revenue of US$0.5m in FY17. Royalties increased by 152% in FY18 to US$3.6m and MSB also received another US$1.5m sales milestone. We assume that at peak penetration (peak sales of US$79m); MSB will receive ~US$20m in annual royalty revenues from TEMCELL and could potentially receive another US$1m in sales milestones in FY19. Potential global or regional partnering deal for MSB s chronic discogenic lower back pain (CLBP) product in FY20: MSB is in active discussions with several potential strategic partners for its CLBP product. The company finished enrolment in the first Phase 3 trial for this product in 1QCY18. There is possibility to get an interim look in 1HCY19. We assume that a deal for CLBP is inked in 1HFY20 and model a US$60m upfront in our forecasts. Page 6
7 Mesoblast (ASX: MSB, NASDAQ:MESO) COMPANY DESCRIPTION MSB has 3 late stage Tier 1 products The Melbourne-based Mesoblast (MSB) is a biotechnology company commercialising the therapeutic use of mesenchymal lineage cells (MPCs and MSCs) a kind of adult stem cell. MSB s MPC technology allows these cells to be extracted from the bone marrow of donors, grown into therapeutic quantities and administered allogeneically ie, to patients that are not related to the donor. It has one of the most diversified pipelines, with 3 Tier 1 products in late stage. The first commercial for GvHD launched in Japan in 1QCY16. Substantial shareholders include CEO Silviu Itescu, M&G, Thorney and Capital Group. INVESTMENT STRATEGY MSB is the leading allogeneic stem cell player with several late-stage clinical assets in multiple therapeutic indications. We expect progress of the Tier 1 products towards commercial launch and monetisation to be the key value driver for MSB. In recent months MSB has successfully organised non-dilutive financing both through debt facility agreements with Hercules capital and NovaQuest and through its strategic licensing agreement with Tasly pharmaceuticals for China. The company now has over 12 months of cash runway. With MSB s balance sheet strengthened ahead of key inflexion points, will now allow the market to focus on key trial results from the end stage CHF patients with LVAD due to report next week. This is expected to be followed by a pre-bla meeting with the FDA and BLA submission for its GvHD product in children, which could potentially become the first allogeneic stem cell product to be approved in the US (BPe 2HCY19). The company s first marketed product Temcell for GvHD in Japan is also doing well, with both royalties and sales milestones increasing in FY18. A partnership deal in 2019 for the back pain or CHF products could result in substantial cash injection, extend MSB s cash runway and trigger a re-rating. KEY RISKS We see the following key stock specific risks to our investment thesis on Mesoblast: Clinical risk: There is a risk that MSB s clinical trials fail to reach their endpoints. Failure of a Phase III trial may significantly impact markets confidence on Mesoblast s technology and in case of an un-partnered product will reduce its partnering prospects. Commercialisation risk: MSB needs a partner to undertake commercialization for its pipeline products. The ability of MSB s products to finally reach the market will depend on them doing a partnering deal. We currently assume the back pain asset is partnered in FY20. Delays or failure in attracting a suitable partner at terms as we have postulated will negatively impact our forecasts. Manufacturing risk: The key success of Mesoblast s business model is dependent on its ability to manufacture its stem cells on commercial scale as well as at a costeffective price. Mesoblast has partnered with Lonza to manufacture its stem cells. Our underlying assumption is that together the companies will be able to drive down the COGS by driving efficiencies in the manufacturing process. Failure to cost-effectively manufacture would impact our valuation. Regulatory risk: Successful commercialisation of MSB s products is ultimately dependent on getting approval from the regulatory authorities to commercially launch the product. Failure to satisfy regulatory requirements could mean that the product will fail to reach the market. Funding risk: MSB has cash runway partway through 4QCY19, with further extension expected through additional drawdown on its existing debt facilities and partnering deals. Failure to attract a partner is likely to impact MSB s ability to service its debt and would require MSB to raise additional capital. There is no guarantee that such funds will be available or at suitable terms. Page 7
8 Mesoblast as at 9 November 2018 Recommendation Buy, Speculative Price $2.18 Valuation $4.06 Mesoblast (MSB) 9 November 2018 Table 5 - Financial summary Mesoblast (MSB) Share price (A$) $2.180 As at 9 November 2018 Market cap (A$m) Profit and Loss Valuation data Y/e June 30 (US$m) 2017A 2018A 2019E 2020E 2021E Y/e June A 2018A 2019E 2020E 2021E Revenue Net profit (US$m) Gross profit (loss) adjusted EPS (c) Total Operating costs EPS growth (%) N/A N/A N/A N/A NM EBITDA P/E ratio (x) N/A N/A N/A N/A N/A Depreciation & Amortisation CFPS (c) EBIT Price/CF (x) Net interest & Other Income/(expense) DPS ( c ) Pre-tax profit (loss) Yield (%) 0.0% 0.0% 0.0% 0.0% 0.0% Tax Franking (%) N/A N/A N/A N/A N/A Adjusted Net Profit (Loss) EV/EBITDA Less minority interests EV/EBIT Net profit (loss) to shareholders Reported net profit (loss) to shareholders Share price now (A$) $2.18 Cashflow Valuation: (A$) $4.06 Y/e June 30 (US$m) 2017A 2018A 2019E 2020E 2021E Premium (discount) to price 86.2% Reported NPAT Recommendation: Buy Non-cash items Risk Rating Speculative Working capital Profitability ratios Other operating cash flow Y/e June A 2018A 2019E 2020E 2021E Operating cashflow EBITDA/revenue (%) N/A N/A N/A N/A N/A EBIT/revenue (%) N/A N/A N/A N/A N/A Capex Return on assets (%) -13.8% -9.5% -12.3% -7.1% -12.4% Investments Return on equity (%) -17.5% -12.1% -16.2% -10.2% -16.5% Other investing cash flow Return on funds empl d (%) -17.5% -10.9% -14.1% -8.2% -14.3% Investing cashflow Dividend cover (x) N/A N/A N/A N/A N/A Effective tax rate (%) 0.0% 0.0% 0.0% 0.0% 0.0% Change in borrow ings Equity issued Liquidity and leverage ratios Dividends paid Y/e June A 2018A 2019E 2020E 2021E Other financing cash flow Net cash (debt) (US$m) Financing cashflow Net debt/equity (%) N/A -4.0% -6.5% -15.2% -10.0% Net interest cover (x) N/A N/A N/A N/A N/A Net change in cash Current ratio (x) Cash at end of period* * I nc l ude s e f f e c t of e x c ha nge r a t e f luc t ua t i ons on c a sh ba l a nc e Free cash flow Balance sheet Interims Y/e June 30 (US$m) 2017A 2018A 2019E 2020E 2021E Y/e June 30 (US$m) 2H17A 1H18A 2H18A 1H19E 2H19E Cash Revenue Current receivables EBITDA Inventories Depreciation & Amortisation Other current assets EBIT Current assets Net interest & Other Income/(expense) Pre-tax profit (loss) PPE Tax Non-current receivables Adjusted Net Profit (loss) Intangible assets Less minority interests Other non-current assets Net profit (loss) to shareholders Non-current assets Reported net profit (loss) to shareholders Total assets Payables Debt Provisions Other liabilities Total liabilities Shareholders equity Minorities Total shareholders funds Total funds employed W/A shares on issue SOURCE: BELL POTTER SECURITIES ESTIMATES Page 8
9 Recommendation structure Buy: Expect >15% total return on a 12 month view. For stocks regarded as Speculative a return of >30% is expected. Research Team Staff Member TS Lim Sam Haddad Chris Savage Title/Sector Head of Research Phone tslim shaddad csavage Hold: Expect total return between -5% Jonathan Snape jsnape and 15% on a 12 month view Tim Piper tpiper Sell: Expect <-5% total return on a 12 month view John Hester Tanushree Jain Financials Healthcare Healthcare/Biotech jhester tnjain Speculative Investments are either start-up enterprises with nil or only prospective operations or recently commenced operations with only forecast cash flows, or companies that have commenced operations or have been in operation for some time but have only forecast cash flows and/or a stressed balance sheet. Such investments may carry an exceptionally high level of capital risk and TS Lim Lafitani Sotiriou Resources Peter Arden David Coates Stuart Howe Analysts James Filius Alexander McLean Damien Williamson Banks/Regionals Diversified Financials/Fintech Resources Resources Resources Analyst Analyst Analyst tslim lsotiriou parden dcoates showe jfilius amclean dwilliamson volatility of returns. Bell Potter Securities Limited ABN Level 38, Aurora Place 88 Phillip Street, Sydney 2000 Telephone The following may affect your legal rights. Important Disclaimer: This document is a private communication to clients and is not intended for public circulation or for the use of any third party, without the prior approval of Bell Potter Securities Limited. In the USA and the UK this research is only for institutional investors. It is not for release, publication or distribution in whole or in part to any persons in the two specified countries. In Hong Kong this research is being distributed by Bell Potter Securities (HK) Limited which is licensed and regulated by the Securities and Futures Commission, Hong Kong. This is general investment advice only and does not constitute personal advice to any person. Because this document has been prepared without consideration of any specific client s financial situation, particular needs and investment objectives ( relevant personal circumstances ), a Bell Potter Securities Limited investment adviser (or the financial services licensee, or the representative of such licensee, who has provided you with this report by arrangement with Bell Potter Securities Limited) should be made aware of your relevant personal circumstances and consulted before any investment decision is made on the basis of this document. While this document is based on information from sources which are considered reliable, Bell Potter Securities Limited has not verified independently the information contained in the document and Bell Potter Securities Limited and its directors, employees and consultants do not represent, warrant or guarantee, expressly or impliedly, that the information contained in this document is complete or accurate. Nor does Bell Potter Securities Limited accept any responsibility for updating any advice, views opinions, or recommendations contained in this document or for correcting any error or omission which may become apparent after the document has been issued. Except insofar as liability under any statute cannot be excluded. Bell Potter Securities Limited and its directors, employees and consultants do not accept any liability (whether arising in contract, in tort or negligence or otherwise) for any error or omission in this document or for any resulting loss or damage (whether direct, indirect, consequential or otherwise) suffered by the recipient of this document or any other person. Disclosure of interest: Bell Potter Securities Limited, its employees, consultants and its associates within the meaning of Chapter 7 of the Corporations Law may receive commissions, underwriting and management fees from transactions involving securities referred to in this document (which its representatives may directly share) and may from time to time hold interests in the securities referred to in this document. Disclosure: Bell Potter Securities acted as lead manager and underwriter in the March and September 2017 placements and received fees for that service. Biotechnology Risk Warning: The stocks of biotechnology companies without strong revenue streams from product sales or ongoing service revenue should always be regarded as speculative in character. The fact that the intellectual property base of a typical biotechnology company lies in science not generally regarded as accessible to the layman adds further to the riskiness with which biotechnology investments ought to be regarded. Clinical and regulatory risks are inherent in biotechnology stocks. Biotechnology developers usually seek US FDA approval for their technology which is a long and arduous three phase process to prove the safety, effectiveness and appropriate application or use of the developed drug and even after approval a drug can be the subject of an FDA investigation of subsequently discovered possible links between the drug and other diseases not previously diagnosed. Furthermore, the Australian exchange listed biotechnology sector is subject to influence by the global biotechnology sector, particularly that in the USA. Consequently, Australian exchange listed biotechnology stocks can experience sharp movements, both upwards and downwards, in both valuations and share prices, as a result of a re-rating of the sector both globally and in the USA, in particular. Investors are advised to be cognisant of these risks before buying such a stock including Mesoblast. For a list of risks specific to Mesoblast please refer to Page 7 of this note. ANALYST CERTIFICATION: Each research analyst primarily responsible for the content of this research report, in whole or in part, certifies that with respect to each security or issuer that the analyst covered in this report: (1) all of the views expressed accurately reflect his or her personal views about those securities or issuers and were prepared in an independent manner and (2) no part of his or her compensation was, is, or will be, directly or indirectly, related to the specific recommendations or views expressed by that research analyst in the research report. Page 9
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