Before prescribing ZYTIGA (abiraterone acetate), please see accompanying full Prescribing Information. Help simplify starting and staying on ZYTIGA

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1 Before prescribing ZYTIGA (abiraterone acetate), please see accompanying full Prescribing Information. Help simplify starting and staying on ZYTIGA

2 Janssen CarePath helps your patients start and stay on ZYTIGA (abiraterone acetate) Access and affordability are important considerations We re committed to providing ongoing support for you and your patients Whether you dispense ZYTIGA in your office or work with specialty pharmacy providers, Janssen CarePath can provide customized support for your practice and patients. When you write a prescription for ZYTIGA, simply call 877-CarePath ( ) and our dedicated care coordinators can determine how we can best support you and your patient. In addition to the clinical aspects of treating your patients, you may be concerned about ensuring that they have access to their chosen therapy. Writing a prescription is only the first step in providing a medication to your patient. Getting your patients started on therapy can sometimes be challenging. Your patients may have different levels of insurance coverage and may be eligible for different affordability options. Janssen CarePath is here to help you and your patients navigate the options. If you are using a specialty pharmacy provider: Janssen CarePath can assist you with identifying specialty pharmacy options that fit each patient s insurance plan and coordinating shipment of ZYTIGA directly to the patient Janssen CarePath can also help provide information about affordability options and deliver educational and adherence tools If you are dispensing ZYTIGA : Janssen CarePath can support your in-office dispensing practice by providing: ZYTIGA (abiraterone acetate) has broad coverage 1 >70% of Medicare patients are covered by a plan that requires prior failure with or intolerance to ZYTIGA before they will authorize Xtandi (enzalutamide) 1 In a retrospective analysis of claims for new Medicare Part D patients between January 2014 and September 2015, ZYTIGA had a lower rate of prior authorization rejection than Xtandi * 1 ZYTIGA is available nationwide through a broad network of specialty pharmacy providers Access support: Verifying your patient s insurance coverage and assisting with prior authorization support Affordability support: Helping you find out what affordability assistance may be available for your patients We help your patients get on track Education and adherence tools: Resources that help your patients stay on track throughout their journey * Based on Symphony Health Solutions, Dynamic Claims Lifecycle, January 2014 September 2015, data that included 19,000 new patient claims in the Medicare Part D channel (approximately 11,000 ZYTIGA claims and 9,000 Xtandi claims) from January 2014 through September 2015, limited to a 30-day drug supply per month. Rejection due to prior authorization (PA) rates was determined on both an initial rejection (1,200 ZYTIGA /1,400 Xtandi initial rejections due to PA) and final rejection (500 ZYTIGA /900 Xtandi final rejections due to PA) basis. Xtandi is a registered trademark of Astellas Pharma US, Inc. Reference: 1. Data on file. Janssen Biotech, Inc. 2 3

3 Our dedicated care coordinators can provide customized support for your patients, regardless of their insurance status We can provide access support for you and your patients*: Perform a rapid investigation and assessment of patient eligibility and insurance coverage (within 4 to 6 business hours) Provide assistance with prior authorization and appeals process Call patients to explain their insurance benefits and cost-support options We can identify affordability options for your patients*: Support for patients with commercial or private insurance: The Janssen CarePath Savings Program can help your patients pay for ZYTIGA. Eligible patients pay no more than $10 per month for their ZYTIGA prescription after activating their card Signing up is easy simply hand your patient a card and they can activate it by phone (1-855-ZYTIGA-1 [ ]) or online ( To receive or replenish a supply of Janssen CarePath Savings Program cards, contact your local Janssen Oncology representative or call 877-CarePath ( ) Per calendar year, subject to a $12,000 annual program benefit or one-year supply, whichever comes first. Not valid for patients enrolled in Medicare, such as Medicare Part D, and Medicaid. Support for patients who are uninsured*: The Johnson & Johnson Patient Assistance Foundation, Inc. (JJPAF) is committed to providing access to uninsured patients who lack the financial resources to pay for their medicines If your patients need ZYTIGA and are uninsured and unable to pay for their medicine, please have them contact a JJPAF program specialist at or visit the foundation website at to see if they may qualify for assistance Support for patients with Medicare Part D*: Janssen CarePath can refer patients to Medicare programs, state programs, and independent foundations. The Medicare Savings Program 0 For eligible patients, this program helps pay for Medicare Part A and B deductibles and premiums Medicare Part D Extra Help Low-Income Subsidy 0 Helps pay premium, deductible, co-insurance, and co-payments for patients on Medicare Part D for those with limited resources and income State Pharmaceutical Assistance Programs (SPAPs) 0 May be able to help pay premiums and/or drug costs for eligible medical conditions For more information about the above programs, visit Independent Foundations* 0 May be able to provide financial assistance CancerCare Good Days Patient Access Network Foundation Patient Advocate Foundation Support for military personnel and veterans*: ZYTIGA is covered with prior authorization by TRICARE, which has low co-pays for all prescription drugs Coverage for ZYTIGA is available through the VA to patients with Criteria for Use (based on VA clinical guidelines) 4 * The information provided represents no statement, promise, or guarantee of Janssen Biotech, Inc., concerning levels of reimbursement, payment, or charge. Please consult your payer organization with regard to local or actual coverage, reimbursement policies, and determination processes. Information is subject to change without notice. Nothing herein may be construed as an endorsement, approval, recommendation, representation, or warranty of any kind by any plan or insurer referenced herein. This communication is solely the responsibility of Janssen Biotech, Inc. We do not fill out any information that requires the medical judgment of the prescriber, and only the prescriber can determine whether to pursue a prior authorization. SPAPs are not limited to Medicare Part D. Note that not every SPAP is a Medicare Part D participant. Independent foundations and organizations may require certain financial criteria for eligibility. Patients with other insurance types may also qualify for assistance from independent foundations and organizations. 5

4 If needed, we can identify specialty pharmacy providers to deliver ZYTIGA (abiraterone acetate) to your patients We provide education and adherence tools to help your patients stay on track throughout their journey ZYTIGA is available nationwide through a broad network of specialty pharmacy providers If your office does not dispense ZYTIGA, we can help you and your patients identify a specialty pharmacy provider. We can coordinate with a specialty pharmacy provider to arrange for efficient handling and shipment of ZYTIGA. For a list of specialty pharmacies that distribute ZYTIGA, visit Specialty pharmacies may offer services to verify insurance coverage, identify potential patient assistance programs, and provide additional information to patients to increase adherence. ZYTIGA is distributed by specialty pharmacy providers that are equipped to facilitate product fulfillment and provide patient support. The specialty pharmacy providers listed at were selected for the ZYTIGA network based on their geographic coverage, payer coverage, and ability to fulfill and dispense oral oncolytics. Educational Materials Janssen CarePath can provide educational materials related to ZYTIGA to your patient by or deliver them to their front door.* Personalized Refill Reminders A Janssen CarePath care coordinator can call your patient 7 days before their ZYTIGA prescription needs to be refilled and remind them to do so.* Advocacy Connector This tool provides web-based oncology resources to help your patients find advocacy groups based on their needs. Care4Today Mobile Health Manager This free smartphone app and website lets your patients set up reminders for any kind of prescription, over-the-counter medication, or nutritional supplement. It uses two-way messaging, enabling patients to share their progress reports with their healthcare providers. Janssen Prescription Assistance An online tool that provides customized referrals to cost-support options based on medication and insurance status. Highlights eligibility requirements to help patients narrow their focus. We provide personalized support 6 *For patients who opt-in. 7

5 Janssen CarePath helps your patients start and stay on ZYTIGA (abiraterone acetate) We re committed to providing ongoing support for you and your patients Our dedicated care coordinators can deliver customized support, including: Performing benefit investigations and providing prior authorization assistance Helping your patients understand their affordability options based on their specific needs Coordinating with specialty pharmacy providers to deliver ZYTIGA to your patients Providing education and adherence tools to help your patients stay on track throughout their journey Learn more about Janssen CarePath Visit Call 877-CarePath ( ) Monday Friday, 8:00 am 8:00 pm ET Help simplify starting and staying on ZYTIGA. Janssen Pharmaceuticals, Inc /

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